PL2900676T3 - Ulepszony sposób acylowania majtansynolu - Google Patents

Ulepszony sposób acylowania majtansynolu

Info

Publication number: PL2900676T3
Authority: PL; Poland
Prior art keywords: majtansinol; acylate; improved way; improved; way
Prior art date: 2012-09-26

Application number

PL13774881T

Other languages

English (en)

Inventor

Wayne C. Widdison

Robert Yongxin Zhao

Original Assignee

Immunogen, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-09-26

Filing date

2013-09-26

Publication date

2019-06-28

2013-09-26 Application filed by Immunogen, Inc. filed Critical Immunogen, Inc.

2019-06-28 Publication of PL2900676T3 publication Critical patent/PL2900676T3/pl

Links

ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R12/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, specially adapted for printed circuits, e.g. printed circuit boards [PCB], flat or ribbon cables, or like generally planar structures, e.g. terminal strips, terminal blocks; Coupling devices specially adapted for printed circuits, flat or ribbon cables, or like generally planar structures; Terminals specially adapted for contact with, or insertion into, printed circuits, flat or ribbon cables, or like generally planar structures
- H01R12/50—Fixed connections
- H01R12/51—Fixed connections for rigid printed circuits or like structures
- H01R12/55—Fixed connections for rigid printed circuits or like structures characterised by the terminals
- H01R12/58—Fixed connections for rigid printed circuits or like structures characterised by the terminals terminals for insertion into holes
- H01R12/585—Terminals having a press fit or a compliant portion and a shank passing through a hole in the printed circuit board
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/0201—Thermal arrangements, e.g. for cooling, heating or preventing overheating
- H05K1/0203—Cooling of mounted components
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
- H05K1/115—Via connections; Lands around holes or via connections
- H05K1/116—Lands, clearance holes or other lay-out details concerning the surrounding of a via
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/18—Printed circuits structurally associated with non-printed electric components
- H05K1/181—Printed circuits structurally associated with non-printed electric components associated with surface mounted components

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Microelectronics & Electronic Packaging (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polyamides (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL13774881T 2012-09-26 2013-09-26 Ulepszony sposób acylowania majtansynolu PL2900676T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201261705731P	2012-09-26	2012-09-26
EP13774881.0A EP2900676B1 (en)	2012-09-26	2013-09-26	Improved method for the acylation of maytansinol
PCT/US2013/061839 WO2014052537A1 (en)	2012-09-26	2013-09-26	Improved methods for the acylation of maytansinol

Publications (1)

Publication Number	Publication Date
PL2900676T3 true PL2900676T3 (pl)	2019-06-28

Family

ID=49328648

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL18213678T PL3486248T3 (pl)	2012-09-26	2013-09-26	Ulepszone sposoby acylacji majtansynolu
PL13774881T PL2900676T3 (pl)	2012-09-26	2013-09-26	Ulepszony sposób acylowania majtansynolu

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL18213678T PL3486248T3 (pl)	2012-09-26	2013-09-26	Ulepszone sposoby acylacji majtansynolu

Country Status (27)

Country	Link
US (9)	US9012629B2 (pl)
EP (3)	EP2900676B1 (pl)
JP (7)	JP6517693B2 (pl)
CN (2)	CN104768955B (pl)
AU (4)	AU2013323572B2 (pl)
BR (2)	BR122021022582B1 (pl)
CA (2)	CA2884873C (pl)
CY (2)	CY1121415T1 (pl)
DK (2)	DK3486248T3 (pl)
ES (2)	ES2880754T3 (pl)
HR (2)	HRP20190473T1 (pl)
HU (2)	HUE055443T2 (pl)
IL (2)	IL237899A (pl)
LT (2)	LT3486248T (pl)
MX (2)	MX366701B (pl)
MY (1)	MY169250A (pl)
NZ (2)	NZ739573A (pl)
PL (2)	PL3486248T3 (pl)
PT (2)	PT2900676T (pl)
RS (2)	RS62075B1 (pl)
RU (2)	RU2648992C2 (pl)
SG (1)	SG11201501918UA (pl)
SI (2)	SI2900676T1 (pl)
SM (2)	SMT202100390T1 (pl)
TR (1)	TR201903625T4 (pl)
WO (1)	WO2014052537A1 (pl)
ZA (1)	ZA201501898B (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LT3486248T (lt) *	2012-09-26	2021-08-25	Immunogen, Inc.	Patobulinti maitansinolio acilinimo būdai
CN105585579A (zh) *	2014-10-24	2016-05-18	南京联宁生物制药有限公司	一种化合物及其制备方法以及美登素dm1的制备方法
MX376146B (es)	2015-03-17	2025-03-07	Regeneron Pharma	Reactivos de acilacion de aminoacidos y metodos para usar los mismos.
EP3554544A4 (en)	2016-12-16	2020-07-29	Bluefin Biomedicine, Inc.	ANTI-PROTEIN 1 ANTIBODY CONTAINING AN ANTI-CUB DOMAIN (CDCP1), ANTIBODY-DRUG CONJUGATES AND THEIR METHODS OF USE
US11420981B2 (en)	2019-04-18	2022-08-23	Indena S.P.A.	Diasteroselective process for the preparation of thiol- or disulfide-containing maytansinoid esters and intermediates thereof
JP7772363B2 (ja)	2019-11-29	2025-11-18	日本マイクロバイオファーマ株式会社	メイタンシノールの酵素的生産方法
EP4685150A1 (en)	2023-04-28	2026-01-28	Chugai Seiyaku Kabushiki Kaisha	Method for producing amide group-containing compound using n-carboxyamino acid anhydride

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US4151042A (en)	1977-03-31	1979-04-24	Takeda Chemical Industries, Ltd.	Method for producing maytansinol and its derivatives
US4137230A (en)	1977-11-14	1979-01-30	Takeda Chemical Industries, Ltd.	Method for the production of maytansinoids
US4265814A (en)	1978-03-24	1981-05-05	Takeda Chemical Industries	Matansinol 3-n-hexadecanoate
JPS5562090A (en)	1978-10-27	1980-05-10	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS5566585A (en)	1978-11-14	1980-05-20	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS55164687A (en)	1979-06-11	1980-12-22	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS55162791A (en)	1979-06-05	1980-12-18	Takeda Chem Ind Ltd	Antibiotic c-15003pnd and its preparation
JPS55164685A (en)	1979-06-08	1980-12-22	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS55164686A (en)	1979-06-11	1980-12-22	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
US4309428A (en)	1979-07-30	1982-01-05	Takeda Chemical Industries, Ltd.	Maytansinoids
JPS5622790A (en) *	1979-07-31	1981-03-03	Takeda Chem Ind Ltd	Novel maytansinoid compound and its preparation
JPS5645483A (en)	1979-09-19	1981-04-25	Takeda Chem Ind Ltd	C-15003phm and its preparation
JP3054741B2 (ja) *	1989-09-29	2000-06-19	武田薬品工業株式会社	Ｔａｎ―１３１３およびそのアシル誘導体
US5208020A (en)	1989-10-25	1993-05-04	Immunogen Inc.	Cytotoxic agents comprising maytansinoids and their therapeutic use
AU775373B2 (en) *	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6441163B1 (en)	2001-05-31	2002-08-27	Immunogen, Inc.	Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
TWI298067B (en) *	2002-01-31	2008-06-21	Daiso Co Ltd	New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof
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MXPA05011811A (es) *	2003-05-20	2006-02-17	Immunogen Inc	Agentes citotoxicos mejorados que comprenden nuevos maitansinoides.
CN1894259A (zh) *	2003-08-22	2007-01-10	活跃生物工艺学公司	利福霉素类似物及其应用
DK1791565T3 (en)	2004-09-23	2016-08-01	Genentech Inc	Cysteingensplejsede antibodies and conjugates
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ATE535529T1 (de) *	2005-08-09	2011-12-15	Millennium Pharm Inc	Verfahren zur acylierung von maytansinol mit chiralen aminosäuren
TW200837067A (en) *	2006-11-06	2008-09-16	Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag	Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
JP2008288289A (ja)	2007-05-16	2008-11-27	Oki Electric Ind Co Ltd	電界効果トランジスタとその製造方法
SG10201810743WA (en)	2009-06-03	2018-12-28	Immunogen Inc	Conjugation methods
US8754207B2 (en) *	2009-09-25	2014-06-17	Cadila Healthcare Limited	Process for the preparation of rapamycin derivatives
US20120121615A1 (en)	2010-11-17	2012-05-17	Flygare John A	Alaninyl maytansinol antibody conjugates
LT3486248T (lt)	2012-09-26	2021-08-25	Immunogen, Inc.	Patobulinti maitansinolio acilinimo būdai

2013
- 2013-09-26 LT LTEP18213678.8T patent/LT3486248T/lt unknown
- 2013-09-26 DK DK18213678.8T patent/DK3486248T3/da active
- 2013-09-26 RU RU2015111635A patent/RU2648992C2/ru active
- 2013-09-26 HU HUE18213678A patent/HUE055443T2/hu unknown
- 2013-09-26 ES ES18213678T patent/ES2880754T3/es active Active
- 2013-09-26 CA CA2884873A patent/CA2884873C/en active Active
- 2013-09-26 LT LTEP13774881.0T patent/LT2900676T/lt unknown
- 2013-09-26 PT PT13774881T patent/PT2900676T/pt unknown
- 2013-09-26 EP EP13774881.0A patent/EP2900676B1/en active Active
- 2013-09-26 RS RS20210825A patent/RS62075B1/sr unknown
- 2013-09-26 EP EP18213678.8A patent/EP3486248B1/en active Active
- 2013-09-26 WO PCT/US2013/061839 patent/WO2014052537A1/en not_active Ceased
- 2013-09-26 SM SM20210390T patent/SMT202100390T1/it unknown
- 2013-09-26 CA CA3133906A patent/CA3133906C/en active Active
- 2013-09-26 NZ NZ73957313A patent/NZ739573A/en unknown
- 2013-09-26 PL PL18213678T patent/PL3486248T3/pl unknown
- 2013-09-26 RU RU2018109295A patent/RU2765072C2/ru active
- 2013-09-26 BR BR122021022582-6A patent/BR122021022582B1/pt active IP Right Grant
- 2013-09-26 SI SI201331374T patent/SI2900676T1/sl unknown
- 2013-09-26 RS RS20190314A patent/RS58493B1/sr unknown
- 2013-09-26 EP EP21166484.2A patent/EP3904358A1/en active Pending
- 2013-09-26 SM SM20190170T patent/SMT201900170T1/it unknown
- 2013-09-26 TR TR2019/03625T patent/TR201903625T4/tr unknown
- 2013-09-26 PT PT182136788T patent/PT3486248T/pt unknown
- 2013-09-26 SG SG11201501918UA patent/SG11201501918UA/en unknown
- 2013-09-26 HR HRP20190473TT patent/HRP20190473T1/hr unknown
- 2013-09-26 CN CN201380049853.8A patent/CN104768955B/zh active Active
- 2013-09-26 SI SI201331899T patent/SI3486248T1/sl unknown
- 2013-09-26 PL PL13774881T patent/PL2900676T3/pl unknown
- 2013-09-26 CN CN201810251853.0A patent/CN108586487B/zh active Active
- 2013-09-26 MX MX2015003745A patent/MX366701B/es active IP Right Grant
- 2013-09-26 NZ NZ706019A patent/NZ706019A/en unknown
- 2013-09-26 JP JP2015534641A patent/JP6517693B2/ja active Active
- 2013-09-26 HU HUE13774881A patent/HUE043285T2/hu unknown
- 2013-09-26 MX MX2019008652A patent/MX390615B/es unknown
- 2013-09-26 US US14/037,657 patent/US9012629B2/en active Active
- 2013-09-26 DK DK13774881.0T patent/DK2900676T3/en active
- 2013-09-26 ES ES13774881T patent/ES2716561T3/es active Active
- 2013-09-26 AU AU2013323572A patent/AU2013323572B2/en active Active
- 2013-09-26 BR BR112015006505-8A patent/BR112015006505B1/pt active IP Right Grant
- 2013-09-26 MY MYPI2015000663A patent/MY169250A/en unknown
2015
- 2015-03-17 US US14/660,050 patent/US9469655B2/en active Active
- 2015-03-19 ZA ZA2015/01898A patent/ZA201501898B/en unknown
- 2015-03-23 IL IL237899A patent/IL237899A/en active IP Right Grant
2016
- 2016-09-19 US US15/269,163 patent/US9796731B2/en active Active
2017
- 2017-08-14 IL IL253988A patent/IL253988B/en active IP Right Grant
- 2017-09-19 US US15/708,346 patent/US10100062B2/en active Active
2018
- 2018-02-27 AU AU2018201392A patent/AU2018201392B2/en active Active
- 2018-02-27 JP JP2018032684A patent/JP2018109044A/ja not_active Ceased
- 2018-09-12 US US16/129,268 patent/US10461449B2/en active Active
2019
- 2019-03-13 CY CY20191100302T patent/CY1121415T1/el unknown
- 2019-09-18 US US16/574,718 patent/US10944190B2/en active Active
2020
- 2020-04-06 JP JP2020068137A patent/JP6735000B1/ja active Active
- 2020-06-10 AU AU2020203823A patent/AU2020203823B2/en active Active
- 2020-07-10 JP JP2020118929A patent/JP2020180150A/ja active Pending
2021
- 2021-06-29 HR HRP20211030TT patent/HRP20211030T1/hr unknown
- 2021-07-02 CY CY20211100594T patent/CY1124337T1/el unknown
2022
- 2022-02-28 JP JP2022029253A patent/JP2022068367A/ja active Pending
- 2022-03-07 AU AU2022201557A patent/AU2022201557A1/en not_active Abandoned
2023
- 2023-09-05 US US18/242,321 patent/US20240145953A1/en not_active Abandoned
- 2023-10-23 JP JP2023181529A patent/JP2024010055A/ja active Pending
2024
- 2024-01-19 US US18/417,406 patent/US20240313444A1/en not_active Abandoned
- 2024-05-31 US US18/679,863 patent/US20250007192A1/en active Pending
2025
- 2025-03-31 JP JP2025058629A patent/JP2025098242A/ja active Pending

Also Published As

Publication number	Publication date
US20190013604A1 (en)	2019-01-10
SMT202100390T1 (it)	2021-09-14
RU2015111635A (ru)	2016-11-20
JP6517693B2 (ja)	2019-05-22
AU2013323572A1 (en)	2015-04-02
AU2018201392A1 (en)	2018-03-15
JP2025098242A (ja)	2025-07-01
CN108586487A (zh)	2018-09-28
BR112015006505A2 (pt)	2017-07-04
CN108586487B (zh)	2021-11-05
LT2900676T (lt)	2019-03-25
RS58493B1 (sr)	2019-04-30
JP2020117527A (ja)	2020-08-06
HRP20211030T1 (hr)	2021-10-01
RU2765072C2 (ru)	2022-01-25
IL253988B (en)	2019-02-28
ES2716561T3 (es)	2019-06-13
MY169250A (en)	2019-03-19
CA3133906A1 (en)	2014-04-03
US10461449B2 (en)	2019-10-29
BR122021022582B1 (pt)	2023-01-10
US20250007192A1 (en)	2025-01-02
TR201903625T4 (tr)	2019-04-22
AU2022201557A1 (en)	2022-03-31
ZA201501898B (en)	2019-06-26
CY1121415T1 (el)	2020-05-29
US20150191488A1 (en)	2015-07-09
JP2024010055A (ja)	2024-01-23
NZ706019A (en)	2018-03-23
HUE043285T2 (hu)	2019-08-28
DK3486248T3 (da)	2021-07-12
US9796731B2 (en)	2017-10-24
MX2015003745A (es)	2015-06-24
US20180099980A1 (en)	2018-04-12
IL237899A (en)	2017-08-31
PL3486248T3 (pl)	2021-10-25
HRP20190473T1 (hr)	2019-05-03
JP6735000B1 (ja)	2020-08-05
MX390615B (es)	2025-03-20
PT3486248T (pt)	2021-07-12
CA2884873A1 (en)	2014-04-03
AU2020203823B2 (en)	2021-12-09
AU2020203823A1 (en)	2020-07-02
MX2019008652A (es)	2019-09-13
US10944190B2 (en)	2021-03-09
US10100062B2 (en)	2018-10-16
ES2880754T3 (es)	2021-11-25
US20140142297A1 (en)	2014-05-22
CN104768955B (zh)	2018-04-27
PT2900676T (pt)	2019-03-29
EP3904358A1 (en)	2021-11-03
EP3486248A1 (en)	2019-05-22
LT3486248T (lt)	2021-08-25
EP2900676B1 (en)	2018-12-19
JP2022068367A (ja)	2022-05-09
US20240145953A1 (en)	2024-05-02
HK1212341A1 (en)	2016-06-10
MX366701B (es)	2019-07-22
HUE055443T2 (hu)	2021-11-29
CY1124337T1 (el)	2022-07-22
JP2016500657A (ja)	2016-01-14
RS62075B1 (sr)	2021-07-30
NZ739573A (en)	2019-11-29
SMT201900170T1 (it)	2019-05-10
SI3486248T1 (sl)	2021-10-29
US9469655B2 (en)	2016-10-18
SG11201501918UA (en)	2015-05-28
US20200153130A1 (en)	2020-05-14
RU2018109295A3 (pl)	2021-06-24
BR112015006505B1 (pt)	2022-03-15
IL253988A0 (en)	2017-10-31
JP2018109044A (ja)	2018-07-12
JP2020180150A (ja)	2020-11-05
EP2900676A1 (en)	2015-08-05
SI2900676T1 (sl)	2019-04-30
CA2884873C (en)	2021-11-23
CA3133906C (en)	2023-05-02
US9012629B2 (en)	2015-04-21
DK2900676T3 (en)	2019-04-08
RU2648992C2 (ru)	2018-03-29
WO2014052537A1 (en)	2014-04-03
EP3486248B1 (en)	2021-04-07
US20170137440A1 (en)	2017-05-18
CN104768955A (zh)	2015-07-08
US20240313444A1 (en)	2024-09-19
RU2018109295A (ru)	2019-02-26
AU2013323572B2 (en)	2017-12-07
AU2018201392B2 (en)	2020-03-12

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