|
US8399643B2
(en)
|
2009-02-26 |
2013-03-19 |
Transposagen Biopharmaceuticals, Inc. |
Nucleic acids encoding hyperactive PiggyBac transposases
|
|
EP2449112A1
(en)
|
2009-07-01 |
2012-05-09 |
Transposagen Biopharmaceuticals, Inc. |
Genetically modified rat models for severe combined immunodeficiency (scid)
|
|
US9719068B2
(en)
|
2010-05-06 |
2017-08-01 |
Children's Hospital Medical Center |
Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
|
|
CA2831144A1
(en)
|
2011-03-23 |
2012-09-27 |
Pioneer Hi-Bred International, Inc. |
Methods for producing a complex transgenic trait locus
|
|
US10323236B2
(en)
|
2011-07-22 |
2019-06-18 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
GB201117313D0
(en)
|
2011-10-07 |
2011-11-16 |
Gt Biolog Ltd |
Bacterium for use in medicine
|
|
EP3604555B1
(en)
|
2011-10-14 |
2024-12-25 |
President and Fellows of Harvard College |
Sequencing by structure assembly
|
|
ES2991004T3
(es)
|
2011-12-22 |
2024-12-02 |
Harvard College |
Métodos para la detección de analitos
|
|
GB201122458D0
(en)
|
2011-12-30 |
2012-02-08 |
Univ Wageningen |
Modified cascade ribonucleoproteins and uses thereof
|
|
WO2013119602A1
(en)
|
2012-02-06 |
2013-08-15 |
President And Fellows Of Harvard College |
Arrdc1-mediated microvesicles (armms) and uses thereof
|
|
SG11201406547YA
(en)
|
2012-04-25 |
2014-11-27 |
Regeneron Pharma |
Nuclease-mediated targeting with large targeting vectors
|
|
WO2013163628A2
(en)
|
2012-04-27 |
2013-10-31 |
Duke University |
Genetic correction of mutated genes
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP3196301B1
(en)
|
2012-07-11 |
2018-10-17 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of monogenic diseases
|
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
|
AU2013293270B2
(en)
*
|
2012-07-25 |
2018-08-16 |
Massachusetts Institute Of Technology |
Inducible DNA binding proteins and genome perturbation tools and applications thereof
|
|
AU2013335451C1
(en)
|
2012-10-23 |
2024-07-04 |
Toolgen Incorporated |
Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
|
|
CA2891510C
(en)
|
2012-11-16 |
2022-10-18 |
Transposagen Biopharmaceuticals, Inc. |
Site-specific enzymes and methods of use
|
|
PL3360964T3
(pl)
|
2012-12-06 |
2020-03-31 |
Sigma-Aldrich Co. Llc |
Modyfikacja i regulacja genomu oparta na crispr
|
|
EP3031921B1
(en)
|
2012-12-12 |
2025-03-12 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US20140186843A1
(en)
|
2012-12-12 |
2014-07-03 |
Massachusetts Institute Of Technology |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
CN113355357B
(zh)
|
2012-12-12 |
2024-12-03 |
布罗德研究所有限公司 |
对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化
|
|
WO2014093655A2
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2840140B2
(en)
|
2012-12-12 |
2023-02-22 |
The Broad Institute, Inc. |
Crispr-Cas based method for mutation of prokaryotic cells
|
|
DK2931891T3
(da)
|
2012-12-17 |
2019-08-19 |
Harvard College |
Rna-styret modificering af menneskelige genomer
|
|
CA2898184A1
(en)
|
2013-01-16 |
2014-07-24 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
|
EP2971184B1
(en)
|
2013-03-12 |
2019-04-17 |
President and Fellows of Harvard College |
Method of generating a three-dimensional nucleic acid containing matrix
|
|
RU2662932C2
(ru)
|
2013-03-14 |
2018-07-31 |
Карибо Биосайенсиз, Инк. |
Композиции и способы с участием нуклеиновых кислот, нацеленных на нуклеиновые кислоты
|
|
WO2014204578A1
(en)
|
2013-06-21 |
2014-12-24 |
The General Hospital Corporation |
Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
CN112301024A
(zh)
*
|
2013-03-15 |
2021-02-02 |
通用医疗公司 |
使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
US9828582B2
(en)
|
2013-03-19 |
2017-11-28 |
Duke University |
Compositions and methods for the induction and tuning of gene expression
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
GB201306536D0
(en)
|
2013-04-10 |
2013-05-22 |
Gt Biolog Ltd |
Polypeptide and immune modulation
|
|
US20150056629A1
(en)
*
|
2013-04-14 |
2015-02-26 |
Katriona Guthrie-Honea |
Compositions, systems, and methods for detecting a DNA sequence
|
|
DK3456831T3
(da)
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
|
SG10201913068PA
(en)
|
2013-06-04 |
2020-02-27 |
Harvard College |
Rna-guided transcriptional regulation
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
CN105492611A
(zh)
|
2013-06-17 |
2016-04-13 |
布罗德研究所有限公司 |
用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
|
|
WO2014204724A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
|
|
MX374532B
(es)
|
2013-06-17 |
2025-03-06 |
Broad Inst Inc |
Suministro, uso y aplicaciones terapéuticas de los sistemas y composiciones crispr-cas, para actuar sobre trastornos y enfermedades utilizando componentes víricos.
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
RU2716420C2
(ru)
|
2013-06-17 |
2020-03-11 |
Те Брод Инститьют Инк. |
Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
|
|
EP3019595A4
(en)
|
2013-07-09 |
2016-11-30 |
|
THERAPEUTIC USES OF A GENERIC CHANGE WITH CRISPR / CAS SYSTEMS
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
CN120574876A
(zh)
|
2013-08-22 |
2025-09-02 |
纳幕尔杜邦公司 |
使用向导rna/cas内切核酸酶系统的植物基因组修饰及其使用方法
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
EP3988649B1
(en)
|
2013-09-18 |
2024-11-27 |
Kymab Limited |
Methods, cells and organisms
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
WO2015066119A1
(en)
|
2013-10-30 |
2015-05-07 |
North Carolina State University |
Compositions and methods related to a type-ii crispr-cas system in lactobacillus buchneri
|
|
CN106459995B
(zh)
|
2013-11-07 |
2020-02-21 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
KR102170502B1
(ko)
|
2013-12-11 |
2020-10-28 |
리제너론 파마슈티칼스 인코포레이티드 |
게놈의 표적화된 변형을 위한 방법 및 조성물
|
|
JP7103750B2
(ja)
|
2013-12-12 |
2022-07-20 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用
|
|
SG10201804975PA
(en)
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders
|
|
JP6712948B2
(ja)
|
2013-12-12 |
2020-06-24 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
組成物、及びヌクレオチドリピート障害におけるcrispr−cas系の使用方法
|
|
EP3470089A1
(en)
|
2013-12-12 |
2019-04-17 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
US20150165054A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting caspase-9 point mutations
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能CRISPR−Cas系による配列操作のための系、方法および組成物
|
|
EP3080259B1
(en)
|
2013-12-12 |
2023-02-01 |
The Broad Institute, Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
US10787654B2
(en)
|
2014-01-24 |
2020-09-29 |
North Carolina State University |
Methods and compositions for sequence guiding Cas9 targeting
|
|
US10286084B2
(en)
|
2014-02-18 |
2019-05-14 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
EP3110971B1
(en)
|
2014-02-27 |
2019-05-08 |
The Broad Institute Inc. |
T cell balance gene expression and methods of use thereof
|
|
US11028388B2
(en)
|
2014-03-05 |
2021-06-08 |
Editas Medicine, Inc. |
CRISPR/Cas-related methods and compositions for treating Usher syndrome and retinitis pigmentosa
|
|
US11339437B2
(en)
|
2014-03-10 |
2022-05-24 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
ES2745769T3
(es)
|
2014-03-10 |
2020-03-03 |
Editas Medicine Inc |
Procedimientos y composiciones relacionados con CRISPR/CAS para tratar la amaurosis congénita de Leber 10 (LCA10)
|
|
US11141493B2
(en)
|
2014-03-10 |
2021-10-12 |
Editas Medicine, Inc. |
Compositions and methods for treating CEP290-associated disease
|
|
EP3122880B1
(en)
|
2014-03-26 |
2021-05-05 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating sickle cell disease
|
|
EP3540061A1
(en)
|
2014-04-02 |
2019-09-18 |
Editas Medicine, Inc. |
Crispr/cas-related methods and compositions for treating primary open angle glaucoma
|
|
JP2017512481A
(ja)
*
|
2014-04-08 |
2017-05-25 |
ノースカロライナ ステート ユニバーシティーNorth Carolina State University |
Crispr関連遺伝子を用いた、rna依存性の転写抑制のための方法および組成物
|
|
SG10201801654RA
(en)
|
2014-05-28 |
2018-04-27 |
Childrens Hospital Med Ct |
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
|
|
WO2015184259A1
(en)
|
2014-05-30 |
2015-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods to treat latent viral infections
|
|
CN106536056B
(zh)
|
2014-06-13 |
2021-07-16 |
儿童医学中心公司 |
分离线粒体的产品和方法
|
|
CA2952618A1
(en)
*
|
2014-06-17 |
2015-12-23 |
Poseida Therapeutics, Inc. |
Methods and compositions for in vivo non-covalent linking
|
|
CN106604994B
(zh)
|
2014-06-23 |
2021-12-14 |
通用医疗公司 |
通过测序评估的DSBs的全基因组无偏鉴定(GUIDE-Seq)
|
|
WO2016007839A1
(en)
|
2014-07-11 |
2016-01-14 |
President And Fellows Of Harvard College |
Methods for high-throughput labelling and detection of biological features in situ using microscopy
|
|
US10676754B2
(en)
|
2014-07-11 |
2020-06-09 |
E I Du Pont De Nemours And Company |
Compositions and methods for producing plants resistant to glyphosate herbicide
|
|
CA2954791C
(en)
|
2014-07-14 |
2025-11-18 |
The Regents Of The University Of California |
CRISPR/CAS TRANSCRIPTIONAL MODULATION
|
|
CN104152414B
(zh)
*
|
2014-07-18 |
2018-03-13 |
中国科学院广州生物医药与健康研究院 |
对细胞基因组的预定位点进行基因改造的方法
|
|
US10077453B2
(en)
|
2014-07-30 |
2018-09-18 |
President And Fellows Of Harvard College |
CAS9 proteins including ligand-dependent inteins
|
|
EP4194557A1
(en)
|
2014-08-06 |
2023-06-14 |
Institute for Basic Science |
Genome editing using campylobacter jejuni crispr/cas system-derived rgen
|
|
WO2016022931A1
(en)
*
|
2014-08-07 |
2016-02-11 |
The Rockefeller University |
Compositions and methods for transcription-based crispr-cas dna editing
|
|
WO2016028682A1
(en)
|
2014-08-17 |
2016-02-25 |
The Broad Institute Inc. |
Genome editing using cas9 nickases
|
|
EP3183358B1
(en)
*
|
2014-08-19 |
2020-10-07 |
President and Fellows of Harvard College |
Rna-guided systems for probing and mapping of nucleic acids
|
|
SG11201701245QA
(en)
|
2014-08-27 |
2017-03-30 |
Caribou Biosciences Inc |
Methods for increasing cas9-mediated engineering efficiency
|
|
EP3186375A4
(en)
|
2014-08-28 |
2019-03-13 |
North Carolina State University |
Novel CAS9 PROTEINS AND CHARACTERISTICS FOR DNA TARGETING AND GENOME EDITING
|
|
EP3188763B1
(en)
|
2014-09-02 |
2020-05-13 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification
|
|
MX2017002930A
(es)
|
2014-09-12 |
2017-06-06 |
Du Pont |
Generacion de sitios de integracion especifica de sitio para loci de rasgos complejos en maiz y soja, y metodos de uso.
|
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
|
US10040048B1
(en)
|
2014-09-25 |
2018-08-07 |
Synthego Corporation |
Automated modular system and method for production of biopolymers
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
AU2015330699B2
(en)
*
|
2014-10-10 |
2021-12-02 |
Editas Medicine, Inc. |
Compositions and methods for promoting homology directed repair
|
|
GB201418965D0
(pl)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
EP3212788A2
(en)
|
2014-10-27 |
2017-09-06 |
The Broad Institute, Inc. |
Compositions, methods and use of synthetic lethal screening
|
|
EP3212165B1
(en)
|
2014-10-30 |
2024-02-28 |
President and Fellows of Harvard College |
Delivery of negatively charged proteins using cationic lipids
|
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
|
EP3215623A4
(en)
|
2014-11-06 |
2018-09-26 |
President and Fellows of Harvard College |
Cells lacking b2m surface expression and methods for allogeneic administration of such cells
|
|
EP4464338A3
(en)
|
2014-11-07 |
2025-02-12 |
Editas Medicine, Inc. |
Systems for improving crispr/cas-mediated genome-editing
|
|
KR102531016B1
(ko)
|
2014-11-21 |
2023-05-10 |
리제너론 파마슈티칼스 인코포레이티드 |
쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물
|
|
EP3224381B1
(en)
|
2014-11-25 |
2019-09-04 |
The Brigham and Women's Hospital, Inc. |
Method of identifying a person having a predisposition to or afflicted with a cardiometabolic disease
|
|
CA2969145A1
(en)
|
2014-11-26 |
2016-06-02 |
The Regents Of The University Of California |
Therapeutic compositions comprising transcription factors and methods of making and using the same
|
|
GB201421096D0
(en)
|
2014-11-27 |
2015-01-14 |
Imp Innovations Ltd |
Genome editing methods
|
|
CA2969619A1
(en)
|
2014-12-03 |
2016-06-09 |
Agilent Technologies, Inc. |
Guide rna with chemical modifications
|
|
CN116059378A
(zh)
|
2014-12-10 |
2023-05-05 |
明尼苏达大学董事会 |
用于治疗疾病的遗传修饰的细胞、组织和器官
|
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
|
EP3889260A1
(en)
|
2014-12-12 |
2021-10-06 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016094880A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of crispr systems and compositions for genome editing as to hematopoietic stem cells (hscs)
|
|
WO2016094872A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
|
EP3234192B1
(en)
|
2014-12-19 |
2021-07-14 |
The Broad Institute, Inc. |
Unbiased identification of double-strand breaks and genomic rearrangement by genome-wide insert capture sequencing
|
|
EP3400953A1
(en)
|
2014-12-23 |
2018-11-14 |
4D Pharma Research Limited |
Pirin polypeptide and immune modulation
|
|
WO2016106239A1
(en)
*
|
2014-12-23 |
2016-06-30 |
The Regents Of The University Of California |
Methods and compositions for nucleic acid integration
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
AR103260A1
(es)
|
2014-12-23 |
2017-04-26 |
4D Pharma Res Ltd |
Modulación inmunitaria
|
|
CA2970370A1
(en)
|
2014-12-24 |
2016-06-30 |
Massachusetts Institute Of Technology |
Crispr having or associated with destabilization domains
|
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
|
EP3245232B1
(en)
|
2015-01-12 |
2021-04-21 |
The Regents of The University of California |
Heterodimeric cas9 and methods of use thereof
|
|
US9650617B2
(en)
|
2015-01-28 |
2017-05-16 |
Pioneer Hi-Bred International. Inc. |
CRISPR hybrid DNA/RNA polynucleotides and methods of use
|
|
EP3250689B1
(en)
|
2015-01-28 |
2020-11-04 |
The Regents of The University of California |
Methods and compositions for labeling a single-stranded target nucleic acid
|
|
WO2016130600A2
(en)
|
2015-02-09 |
2016-08-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
WO2016138488A2
(en)
|
2015-02-26 |
2016-09-01 |
The Broad Institute Inc. |
T cell balance gene expression, compositions of matters and methods of use thereof
|
|
EP3265560B1
(en)
|
2015-03-02 |
2021-12-08 |
Sinai Health System |
Homologous recombination factors
|
|
KR20230156800A
(ko)
|
2015-03-03 |
2023-11-14 |
더 제너럴 하스피탈 코포레이션 |
변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제
|
|
WO2016149422A1
(en)
*
|
2015-03-16 |
2016-09-22 |
The Broad Institute, Inc. |
Encoding of dna vector identity via iterative hybridization detection of a barcode transcript
|
|
BR112017017260A2
(pt)
|
2015-03-27 |
2018-04-17 |
Du Pont |
construções de dna, vetor, célula, plantas, semente, método de expressão de rna e método de modificação de local alvo
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
JP2018522249A
(ja)
|
2015-04-24 |
2018-08-09 |
エディタス・メディシン、インコーポレイテッド |
Cas9分子/ガイドrna分子複合体の評価
|
|
WO2016182893A1
(en)
|
2015-05-08 |
2016-11-17 |
Teh Broad Institute Inc. |
Functional genomics using crispr-cas systems for saturating mutagenesis of non-coding elements, compositions, methods, libraries and applications thereof
|
|
CN107921148A
(zh)
|
2015-05-08 |
2018-04-17 |
哈佛学院校长同事会 |
通用供体干细胞和相关方法
|
|
CA2986310A1
(en)
|
2015-05-11 |
2016-11-17 |
Editas Medicine, Inc. |
Optimized crispr/cas9 systems and methods for gene editing in stem cells
|
|
CA2985650A1
(en)
*
|
2015-05-13 |
2016-11-17 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Enhancing endonuclease based gene editing in primary cells
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
EA201792663A1
(ru)
|
2015-05-29 |
2018-04-30 |
Норт Каролина Стейт Юниверсити |
Способы скрининга бактерий, архей, водорослей и дрожжей с использованием нуклеиновых кислот crispr
|
|
CN108025188A
(zh)
|
2015-06-01 |
2018-05-11 |
天普大学-联邦高等教育系统 |
用于hiv感染的rna导向治疗的方法和组合物
|
|
WO2016196655A1
(en)
|
2015-06-03 |
2016-12-08 |
The Regents Of The University Of California |
Cas9 variants and methods of use thereof
|
|
EP3303585A4
(en)
|
2015-06-03 |
2018-10-31 |
Board of Regents of the University of Nebraska |
Dna editing using single-stranded dna
|
|
EP3302525A2
(en)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Methods and compositions for diagnosing, treating, and monitoring treatment of shank3 deficiency associated disorders
|
|
CN108026526B
(zh)
|
2015-06-09 |
2023-05-12 |
爱迪塔斯医药公司 |
用于改善移植的crispr/cas相关方法和组合物
|
|
SMT201900588T1
(it)
|
2015-06-15 |
2019-11-13 |
4D Pharma Res Limited |
Blautia stercoris e wexlerae per uso nel trattamento di malattie infiammatorie ed autoimmuni
|
|
NZ737752A
(en)
|
2015-06-15 |
2022-02-25 |
4D Pharma Res Ltd |
Compositions comprising bacterial strains
|
|
WO2016205276A1
(en)
|
2015-06-15 |
2016-12-22 |
North Carolina State University |
Methods and compositions for efficient delivery of nucleic acids and rna-based antimicrobials
|
|
MA41010B1
(fr)
|
2015-06-15 |
2020-01-31 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
WO2016203221A1
(en)
|
2015-06-15 |
2016-12-22 |
4D Pharma Research Limited |
Compositions comprising bacterial strains
|
|
MA41060B1
(fr)
|
2015-06-15 |
2019-11-29 |
4D Pharma Res Ltd |
Compositions comprenant des souches bactériennes
|
|
JP2018518182A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
ゲノム編集のためのcrispr/cas9複合体
|
|
JP2018518181A
(ja)
|
2015-06-17 |
2018-07-12 |
ザ ユーエービー リサーチ ファンデーション |
血液細胞系列の細胞に機能的ポリペプチドを導入するためのCRISPR/Cas9複合体
|
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
|
US11473082B2
(en)
|
2015-06-17 |
2022-10-18 |
Poseida Therapeutics, Inc. |
Compositions and methods for directing proteins to specific loci in the genome
|
|
TWI906646B
(zh)
|
2015-06-18 |
2025-12-01 |
美商博得學院股份有限公司 |
降低脫靶效應的crispr酶突變
|
|
US10954513B2
(en)
*
|
2015-06-18 |
2021-03-23 |
University Of Utah Research Foundation |
RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
|
|
AU2016279077A1
(en)
|
2015-06-18 |
2019-03-28 |
Omar O. Abudayyeh |
Novel CRISPR enzymes and systems
|
|
WO2016205745A2
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Cell sorting
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
WO2017004261A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
CN108350446A
(zh)
*
|
2015-07-02 |
2018-07-31 |
约翰霍普金斯大学 |
基于crispr/cas9的治疗
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
US9580727B1
(en)
|
2015-08-07 |
2017-02-28 |
Caribou Biosciences, Inc. |
Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
|
|
EP4512819A3
(en)
|
2015-08-12 |
2025-08-06 |
The General Hospital Corporation |
Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders
|
|
CA3033909A1
(en)
|
2015-08-14 |
2017-02-23 |
The University Of Sydney |
Connexin 45 inhibition for therapy
|
|
WO2017031370A1
(en)
|
2015-08-18 |
2017-02-23 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
WO2017035416A2
(en)
|
2015-08-25 |
2017-03-02 |
Duke University |
Compositions and methods of improving specificity in genomic engineering using rna-guided endonucleases
|
|
JP6799586B2
(ja)
|
2015-08-28 |
2020-12-16 |
ザ ジェネラル ホスピタル コーポレイション |
遺伝子操作CRISPR−Cas9ヌクレアーゼ
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017044843A1
(en)
|
2015-09-11 |
2017-03-16 |
The General Hospital Corporation |
Full interrogation of nuclease dsbs and sequencing (find-seq)
|
|
EP3353296B1
(en)
|
2015-09-24 |
2020-11-04 |
Editas Medicine, Inc. |
Use of exonucleases to improve crispr/cas-mediated genome editing
|
|
EP3356533A1
(en)
|
2015-09-28 |
2018-08-08 |
North Carolina State University |
Methods and compositions for sequence specific antimicrobials
|
|
JP2018529353A
(ja)
|
2015-09-30 |
2018-10-11 |
ザ ジェネラル ホスピタル コーポレイション |
配列決定法による切断事象の包括的生体外報告(CIRCLE−seq)
|
|
US12241053B2
(en)
|
2015-10-09 |
2025-03-04 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
EP4089175A1
(en)
|
2015-10-13 |
2022-11-16 |
Duke University |
Genome engineering with type i crispr systems in eukaryotic cells
|
|
CN116814590A
(zh)
|
2015-10-22 |
2023-09-29 |
布罗德研究所有限公司 |
Vi-b型crispr酶和系统
|
|
WO2017070598A1
(en)
|
2015-10-23 |
2017-04-27 |
Caribou Biosciences, Inc. |
Engineered crispr class 2 cross-type nucleic-acid targeting nucleic acids
|
|
IL310721B2
(en)
|
2015-10-23 |
2025-11-01 |
Harvard College |
Nucleobase editors and uses thereof
|
|
EP3368687B1
(en)
|
2015-10-27 |
2021-09-29 |
The Broad Institute, Inc. |
Compositions and methods for targeting cancer-specific sequence variations
|
|
US11092607B2
(en)
|
2015-10-28 |
2021-08-17 |
The Board Institute, Inc. |
Multiplex analysis of single cell constituents
|
|
WO2017075465A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
|
|
WO2017075478A2
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
|
|
WO2017075294A1
(en)
|
2015-10-28 |
2017-05-04 |
The Board Institute Inc. |
Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
|
|
WO2017075451A1
(en)
|
2015-10-28 |
2017-05-04 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
|
|
CN115491373A
(zh)
|
2015-10-30 |
2022-12-20 |
爱迪塔斯医药公司 |
治疗单纯疱疹病毒的crispr/cas相关方法及组合物
|
|
AU2016349288A1
(en)
|
2015-11-03 |
2018-05-31 |
President And Fellows Of Harvard College |
Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix
|
|
WO2017083722A1
(en)
*
|
2015-11-11 |
2017-05-18 |
Greenberg Kenneth P |
Crispr compositions and methods of using the same for gene therapy
|
|
EP4036228A1
(en)
|
2015-11-13 |
2022-08-03 |
Avellino Lab USA, Inc. |
Methods for the treatment of corneal dystrophies
|
|
AU2016355178B9
(en)
|
2015-11-19 |
2019-05-30 |
Massachusetts Institute Of Technology |
Lymphocyte antigen CD5-like (CD5L)-interleukin 12B (p40) heterodimers in immunity
|
|
CN108513545B
(zh)
|
2015-11-20 |
2020-11-03 |
4D制药研究有限公司 |
包含细菌菌株的组合物
|
|
GB201520497D0
(en)
|
2015-11-20 |
2016-01-06 |
4D Pharma Res Ltd |
Compositions comprising bacterial strains
|
|
US11903974B2
(en)
|
2015-11-30 |
2024-02-20 |
Flagship Pioneering Innovations V, Inc. |
Methods and compositions relating to chondrisomes from cultured cells
|
|
CN108473981B
(zh)
|
2015-12-04 |
2022-04-12 |
卡里布生物科学公司 |
工程化靶向核酸的核酸
|
|
US9988624B2
(en)
|
2015-12-07 |
2018-06-05 |
Zymergen Inc. |
Microbial strain improvement by a HTP genomic engineering platform
|
|
US11208649B2
(en)
|
2015-12-07 |
2021-12-28 |
Zymergen Inc. |
HTP genomic engineering platform
|
|
BR112018011503A2
(pt)
|
2015-12-07 |
2018-12-04 |
Zymergen Inc |
promotores da corynebacterium glutamicum
|
|
US11542466B2
(en)
|
2015-12-22 |
2023-01-03 |
North Carolina State University |
Methods and compositions for delivery of CRISPR based antimicrobials
|
|
RU2018127657A
(ru)
|
2015-12-30 |
2020-01-31 |
Новартис Аг |
Виды терапии на основе иммуноэффекторных клеток с улучшенной эффективностью
|
|
MX2018008345A
(es)
|
2016-01-11 |
2018-12-06 |
Univ Leland Stanford Junior |
Proteínas quiméricas y métodos de inmunoterapia.
|
|
IL260532B2
(en)
|
2016-01-11 |
2023-12-01 |
Univ Leland Stanford Junior |
Chimeric proteins- containing systems and uses thereof in regulating gene expression
|
|
WO2017124037A1
(en)
|
2016-01-15 |
2017-07-20 |
The Children's Medical Center Corporation |
Therapeutic use of mitochondria and combined mitochondrial agents
|
|
US10876129B2
(en)
|
2016-02-12 |
2020-12-29 |
Ceres, Inc. |
Methods and materials for high throughput testing of mutagenized allele combinations
|
|
WO2017142923A1
(en)
*
|
2016-02-16 |
2017-08-24 |
Emendobio Inc. |
Compositions and methods for promoting homology directed repair mediated gene editing
|
|
US20190249172A1
(en)
|
2016-02-18 |
2019-08-15 |
The Regents Of The University Of California |
Methods and compositions for gene editing in stem cells
|
|
US20190144942A1
(en)
|
2016-02-22 |
2019-05-16 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating immune phenotypes
|
|
ME03487B
(me)
|
2016-03-04 |
2020-01-20 |
4D Pharma Plc |
Kompozicije koje sadrže blautia bakterijske sojeve za liječenje visceralne hipersenzitivnosti
|
|
JP2019507610A
(ja)
|
2016-03-04 |
2019-03-22 |
インドア バイオテクノロジーズ インコーポレイテッド |
CRISPR−Casゲノム編集に基づく、Fel d1ノックアウト並びに関連組成物及び方法
|
|
GB201612191D0
(en)
|
2016-07-13 |
2016-08-24 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
CN109414414A
(zh)
|
2016-03-16 |
2019-03-01 |
戴维·格拉德斯通研究所 |
用于治疗肥胖症和/或糖尿病以及用于鉴定候选治疗剂的方法和组合物
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
US11427861B2
(en)
|
2016-03-17 |
2022-08-30 |
Massachusetts Institute Of Technology |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
US11512311B2
(en)
|
2016-03-25 |
2022-11-29 |
Editas Medicine, Inc. |
Systems and methods for treating alpha 1-antitrypsin (A1AT) deficiency
|
|
US11597924B2
(en)
|
2016-03-25 |
2023-03-07 |
Editas Medicine, Inc. |
Genome editing systems comprising repair-modulating enzyme molecules and methods of their use
|
|
US11236313B2
(en)
|
2016-04-13 |
2022-02-01 |
Editas Medicine, Inc. |
Cas9 fusion molecules, gene editing systems, and methods of use thereof
|
|
US20190127713A1
(en)
|
2016-04-13 |
2019-05-02 |
Duke University |
Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use
|
|
EP4613756A3
(en)
|
2016-04-25 |
2025-11-12 |
President And Fellows Of Harvard College |
Hybridization chain reaction methods for in situ molecular detection
|
|
CN113831407B
(zh)
|
2016-05-20 |
2024-06-11 |
瑞泽恩制药公司 |
用于使用多个引导rna来破坏免疫耐受性的方法
|
|
CA3209273A1
(en)
|
2016-06-02 |
2017-12-07 |
Sigma-Aldrich Co. Llc |
Using programmable dna binding proteins to enhance targeted genome modification
|
|
US10767175B2
(en)
|
2016-06-08 |
2020-09-08 |
Agilent Technologies, Inc. |
High specificity genome editing using chemically modified guide RNAs
|
|
CN109642231A
(zh)
|
2016-06-17 |
2019-04-16 |
博德研究所 |
Vi型crispr直向同源物和系统
|
|
WO2018005445A1
(en)
|
2016-06-27 |
2018-01-04 |
The Broad Institute, Inc. |
Compositions and methods for detecting and treating diabetes
|
|
US12595478B2
(en)
|
2016-06-29 |
2026-04-07 |
The Broad Institute, Inc. |
Crispr-Cas systems having destabilization domain
|
|
US10544390B2
(en)
|
2016-06-30 |
2020-01-28 |
Zymergen Inc. |
Methods for generating a bacterial hemoglobin library and uses thereof
|
|
EP3478845A4
(en)
|
2016-06-30 |
2019-07-31 |
Zymergen, Inc. |
METHOD OF GENERATING A GLUCOSE PERMEASE LIBRARY AND USES THEREOF
|
|
MA45670A
(fr)
|
2016-07-13 |
2019-05-22 |
Vertex Pharma |
Procédés, compositions et kits pour augmenter l'efficacité d'édition du génome
|
|
TWI802545B
(zh)
|
2016-07-13 |
2023-05-21 |
英商4D製藥有限公司 |
包含細菌菌株之組合物
|
|
JP7490211B2
(ja)
|
2016-07-19 |
2024-05-27 |
デューク ユニバーシティ |
Cpf1に基づくゲノム編集の治療適用
|
|
BR112019001887A2
(pt)
|
2016-08-02 |
2019-07-09 |
Editas Medicine Inc |
composições e métodos para o tratamento de doença associada a cep290
|
|
US11078481B1
(en)
|
2016-08-03 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for screening for cancer targets
|
|
CN110214183A
(zh)
|
2016-08-03 |
2019-09-06 |
哈佛大学的校长及成员们 |
腺苷核碱基编辑器及其用途
|
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018035364A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute Inc. |
Product and methods useful for modulating and evaluating immune responses
|
|
WO2018035387A1
(en)
|
2016-08-17 |
2018-02-22 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
|
EP3500967A1
(en)
|
2016-08-17 |
2019-06-26 |
The Broad Institute, Inc. |
Methods for identifying class 2 crispr-cas systems
|
|
EP4485466A3
(en)
|
2016-08-17 |
2025-04-02 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
|
JP2019524149A
(ja)
|
2016-08-20 |
2019-09-05 |
アベリノ ラボ ユーエスエー インコーポレイテッドAvellino Lab USA, Inc. |
一本鎖ガイドRNA、CRISPR/Cas9システム、及びそれらの使用方法
|
|
WO2020225754A1
(en)
|
2019-05-06 |
2020-11-12 |
Mcmullen Tara |
Crispr gene editing for autosomal dominant diseases
|
|
US11542509B2
(en)
|
2016-08-24 |
2023-01-03 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CN118853848A
(zh)
|
2016-08-31 |
2024-10-29 |
哈佛学院董事及会员团体 |
将生物分子的检测组合到使用荧光原位测序的单个试验的方法
|
|
US11078483B1
(en)
|
2016-09-02 |
2021-08-03 |
KSQ Therapeutics, Inc. |
Methods for measuring and improving CRISPR reagent function
|
|
US11525119B2
(en)
|
2016-09-06 |
2022-12-13 |
The Children's Medical Center Corporation |
Immune cells derived from induced pluripotent stem cell
|
|
WO2018049025A2
(en)
|
2016-09-07 |
2018-03-15 |
The Broad Institute Inc. |
Compositions and methods for evaluating and modulating immune responses
|
|
US20190225974A1
(en)
|
2016-09-23 |
2019-07-25 |
BASF Agricultural Solutions Seed US LLC |
Targeted genome optimization in plants
|
|
US12499971B2
(en)
|
2016-09-28 |
2025-12-16 |
The Broad Institute, Inc. |
Systematic screening and mapping of regulatory elements in non-coding genomic regions, methods, compositions, and applications thereof
|
|
MX2019003674A
(es)
|
2016-09-30 |
2021-01-08 |
Univ California |
Enzimas modificadoras de ácido nucleico guiadas por arn y métodos de uso de estas.
|
|
US11730823B2
(en)
|
2016-10-03 |
2023-08-22 |
President And Fellows Of Harvard College |
Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles
|
|
US10669539B2
(en)
|
2016-10-06 |
2020-06-02 |
Pioneer Biolabs, Llc |
Methods and compositions for generating CRISPR guide RNA libraries
|
|
US12447213B2
(en)
|
2016-10-07 |
2025-10-21 |
The Broad Institute, Inc. |
Modulation of novel immune checkpoint targets
|
|
KR102622411B1
(ko)
|
2016-10-14 |
2024-01-10 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
KR20190067209A
(ko)
|
2016-10-14 |
2019-06-14 |
더 제너럴 하스피탈 코포레이션 |
후성적으로 조절되는 부위-특이적 뉴클레아제
|
|
GB201617559D0
(en)
|
2016-10-17 |
2016-11-30 |
University Court Of The University Of Edinburgh The |
Swine comprising modified cd163 and associated methods
|
|
CN110520530A
(zh)
|
2016-10-18 |
2019-11-29 |
明尼苏达大学董事会 |
肿瘤浸润性淋巴细胞和治疗方法
|
|
US20180119141A1
(en)
*
|
2016-10-28 |
2018-05-03 |
Massachusetts Institute Of Technology |
Crispr/cas global regulator screening platform
|
|
EP3535396A1
(en)
|
2016-11-01 |
2019-09-11 |
Novartis AG |
Methods and compositions for enhancing gene editing
|
|
US20190264218A1
(en)
|
2016-11-04 |
2019-08-29 |
Flagship Pioneering Innovations V, Inc. |
Novel Plant Cells, Plants, and Seeds
|
|
EP4553082A3
(en)
|
2016-11-04 |
2025-08-20 |
Children's Hospital Medical Center |
Liver organoid compositions and methods of making and using same
|
|
WO2018089386A1
(en)
|
2016-11-11 |
2018-05-17 |
The Broad Institute, Inc. |
Modulation of intestinal epithelial cell differentiation, maintenance and/or function through t cell action
|
|
US9816093B1
(en)
|
2016-12-06 |
2017-11-14 |
Caribou Biosciences, Inc. |
Engineered nucleic acid-targeting nucleic acids
|
|
US12404514B2
(en)
|
2016-12-09 |
2025-09-02 |
The Broad Institute, Inc. |
CRISPR-systems for modifying a trait of interest in a plant
|
|
GB201621123D0
(en)
|
2016-12-12 |
2017-01-25 |
4D Pharma Plc |
Compositions comprising bacterial strains
|
|
AU2017378427A1
(en)
|
2016-12-14 |
2019-06-20 |
Ligandal, Inc. |
Methods and compositions for nucleic acid and protein payload delivery
|
|
EP3555297A1
(en)
|
2016-12-19 |
2019-10-23 |
Editas Medicine, Inc. |
Assessing nuclease cleavage
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
JP7229923B2
(ja)
|
2017-01-06 |
2023-02-28 |
エディタス・メディシン、インコーポレイテッド |
ヌクレアーゼ切断を評価する方法
|
|
WO2018140899A1
(en)
|
2017-01-28 |
2018-08-02 |
Inari Agriculture, Inc. |
Novel plant cells, plants, and seeds
|
|
TW201839136A
(zh)
|
2017-02-06 |
2018-11-01 |
瑞士商諾華公司 |
治療血色素異常症之組合物及方法
|
|
JP2020507312A
(ja)
|
2017-02-10 |
2020-03-12 |
ザイマージェン インコーポレイテッド |
複数の宿主用の複数のdnaコンストラクトのアセンブリ及び編集のためのモジュラーユニバーサルプラスミド設計戦略
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US11542496B2
(en)
|
2017-03-10 |
2023-01-03 |
President And Fellows Of Harvard College |
Cytosine to guanine base editor
|
|
WO2018170184A1
(en)
|
2017-03-14 |
2018-09-20 |
Editas Medicine, Inc. |
Systems and methods for the treatment of hemoglobinopathies
|
|
JP2020511141A
(ja)
|
2017-03-15 |
2020-04-16 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas13bオルソログCRISPR酵素及び系
|
|
WO2018170515A1
(en)
|
2017-03-17 |
2018-09-20 |
The Broad Institute, Inc. |
Methods for identifying and modulating co-occurant cellular phenotypes
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
WO2018175872A1
(en)
*
|
2017-03-24 |
2018-09-27 |
President And Fellows Of Harvard College |
Methods of genome engineering by nuclease-transposase fusion proteins
|
|
WO2018175924A1
(en)
|
2017-03-24 |
2018-09-27 |
The Broad Institute, Inc. |
Methods and compositions for regulating innate lymphoid cell inflammatory responses
|
|
US11963966B2
(en)
|
2017-03-31 |
2024-04-23 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating ovarian tumors
|
|
WO2018183921A1
(en)
|
2017-04-01 |
2018-10-04 |
The Broad Institute, Inc. |
Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
|
|
US12590288B2
(en)
|
2017-04-12 |
2026-03-31 |
The Broad Institute, Inc. |
Method of treating an inflammatory disease by administering an agent which binds a surface receptor on a tuft cell that induces an ILC class 2 inflammatory response
|
|
EP3610266A4
(en)
|
2017-04-12 |
2021-04-21 |
Massachusetts Eye and Ear Infirmary |
TUMOR SIGNATURE OF METASTASIS, COMPOSITIONS OF SUBSTANCES AND USES THEREOF
|
|
AU2018251801B2
(en)
|
2017-04-12 |
2024-11-07 |
Massachusetts Institute Of Technology |
Novel type VI CRISPR orthologs and systems
|
|
US12331319B2
(en)
|
2017-04-12 |
2025-06-17 |
The Broad Institute, Inc. |
Respiratory and sweat gland ionocytes
|
|
JP7248586B2
(ja)
|
2017-04-14 |
2023-03-29 |
チルドレンズ ホスピタル メディカル センター |
複数ドナー幹細胞組成物およびそれを作製する方法
|
|
WO2018191750A2
(en)
|
2017-04-14 |
2018-10-18 |
The Broad Institute Inc. |
Novel delivery of large payloads
|
|
MX2019012398A
(es)
|
2017-04-18 |
2020-09-25 |
Broad Inst Inc |
Composiciones para detectar secreciones y metodos de uso.
|
|
KR102746223B1
(ko)
|
2017-04-20 |
2024-12-27 |
이제네시스, 인크. |
유전자 변형 동물의 생성 방법
|
|
US11591589B2
(en)
|
2017-04-21 |
2023-02-28 |
The General Hospital Corporation |
Variants of Cpf1 (Cas12a) with altered PAM specificity
|
|
US12208140B2
(en)
|
2017-04-21 |
2025-01-28 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
US11499151B2
(en)
|
2017-04-28 |
2022-11-15 |
Editas Medicine, Inc. |
Methods and systems for analyzing guide RNA molecules
|
|
US11591601B2
(en)
|
2017-05-05 |
2023-02-28 |
The Broad Institute, Inc. |
Methods for identification and modification of lncRNA associated with target genotypes and phenotypes
|
|
EP3622070A2
(en)
|
2017-05-10 |
2020-03-18 |
Editas Medicine, Inc. |
Crispr/rna-guided nuclease systems and methods
|
|
EP3622092A4
(en)
|
2017-05-11 |
2021-06-23 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS OF USE OF CD8 + TUMOR-INFILTRATING LYMPHOCYTE SUBTYPES AND GENE SIGNATURES THEREOF
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
WO2018213726A1
(en)
|
2017-05-18 |
2018-11-22 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
US11866697B2
(en)
|
2017-05-18 |
2024-01-09 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
DK3630136T3
(da)
|
2017-05-22 |
2021-05-25 |
4D Pharma Res Ltd |
Sammensætninger, der omfatter bakteriestammer
|
|
EP3630942B1
(en)
|
2017-05-24 |
2022-11-30 |
4D Pharma Research Limited |
Compositions comprising bacterial strain
|
|
EP3630849A4
(en)
|
2017-05-25 |
2021-01-13 |
The General Hospital Corporation |
BIPARTITE BASIC EDITOR (BBE) AND TYPE II-C-CAS9 ZINC FINGER EDITOR ARCHITECTURES
|
|
EP3409104A1
(en)
|
2017-05-31 |
2018-12-05 |
Vilmorin et Cie |
Tomato plant resistant to tomato yellow leaf curl virus, powdery mildew, and nematodes
|
|
EP3409106A1
(en)
|
2017-06-01 |
2018-12-05 |
Vilmorin et Cie |
Tolerance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus (tbrfv)
|
|
WO2020249996A1
(en)
|
2019-06-14 |
2020-12-17 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the tobamovirus tomato brown rugose fruit virus
|
|
CA3102054A1
(en)
|
2017-06-05 |
2018-12-13 |
Fred Hutchinson Cancer Research Center |
Genomic safe harbors for genetic therapies in human stem cells and engineered nanoparticles to provide targeted genetic therapies
|
|
WO2018226880A1
(en)
|
2017-06-06 |
2018-12-13 |
Zymergen Inc. |
A htp genomic engineering platform for improving escherichia coli
|
|
WO2018226900A2
(en)
|
2017-06-06 |
2018-12-13 |
Zymergen Inc. |
A htp genomic engineering platform for improving fungal strains
|
|
MX2019014640A
(es)
|
2017-06-09 |
2020-10-05 |
Editas Medicine Inc |
Nucleasas de repeticiones palíndromicas agrupadas y regularmente interespaciadas de proteina asociada 9 (cas9) genomanipuladas.
|
|
IL271275B1
(en)
|
2017-06-13 |
2026-04-01 |
Flagship Pioneering Innovations V Inc |
Preparations containing croons and their uses
|
|
SMT202000555T1
(it)
|
2017-06-14 |
2020-11-10 |
4D Pharma Res Limited |
Composizioni comprendenti un ceppo batterico del genere megaspaera e loro usi
|
|
WO2018232195A1
(en)
|
2017-06-14 |
2018-12-20 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
SMT202000695T1
(it)
|
2017-06-14 |
2021-01-05 |
4D Pharma Res Limited |
Composizioni comprendenti ceppi batterici
|
|
KR102761791B1
(ko)
|
2017-06-26 |
2025-02-05 |
더 브로드 인스티튜트, 인코퍼레이티드 |
표적화된 핵산 편집을 위한 crispr/cas-아데닌 데아미나아제 기반 조성물, 시스템 및 방법
|
|
EP3645021A4
(en)
|
2017-06-30 |
2021-04-21 |
Intima Bioscience, Inc. |
ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY
|
|
US20200140896A1
(en)
|
2017-06-30 |
2020-05-07 |
Novartis Ag |
Methods for the treatment of disease with gene editing systems
|
|
US12049643B2
(en)
|
2017-07-14 |
2024-07-30 |
The Broad Institute, Inc. |
Methods and compositions for modulating cytotoxic lymphocyte activity
|
|
US11866726B2
(en)
|
2017-07-14 |
2024-01-09 |
Editas Medicine, Inc. |
Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
|
|
EP3655961A4
(en)
*
|
2017-07-17 |
2021-09-01 |
Massachusetts Institute of Technology |
HEALTHY AND SICK BARRIER TISSUE CELL ATLAS
|
|
US12105089B2
(en)
|
2017-07-17 |
2024-10-01 |
The Broad Institute, Inc. |
Cell atlas of the healthy and ulcerative colitis human colon
|
|
US20190316101A1
(en)
|
2017-07-18 |
2019-10-17 |
Howard Hughes Medical Institute |
Methods and compositions for genetically manipulating genes and cells
|
|
US12239646B2
(en)
|
2017-07-19 |
2025-03-04 |
Dana-Farber Cancer Institute, Inc. |
Cancer diagnostic and treatment
|
|
CN111801345A
(zh)
|
2017-07-28 |
2020-10-20 |
哈佛大学的校长及成员们 |
使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
|
|
SG11202000840YA
(en)
|
2017-07-31 |
2020-02-27 |
Reflection Biotechnologies Ltd |
Cellular models of and therapies for ocular diseases
|
|
CA3073448A1
(en)
|
2017-08-23 |
2019-02-28 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases with altered pam specificity
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
US20190076814A1
(en)
|
2017-09-11 |
2019-03-14 |
Synthego Corporation |
Biopolymer synthesis system and method
|
|
CA3076249A1
(en)
|
2017-09-21 |
2019-03-28 |
The Brigham And Women's Hospital, Inc. |
Isolation, preservation, compositions and uses of extracts from justicia plants
|
|
AU2018338318B2
(en)
|
2017-09-21 |
2022-12-22 |
Massachusetts Institute Of Technology |
Systems, methods, and compositions for targeted nucleic acid editing
|
|
CA3073449A1
(en)
|
2017-09-25 |
2019-03-28 |
Agrospheres, Inc. |
Compositions and methods for scalable production and delivery of biologicals
|
|
KR102832035B1
(ko)
|
2017-09-29 |
2025-07-09 |
인텔리아 테라퓨틱스, 인크. |
지질 나노파티클을 이용한 mRNA 전달의 체외 방법
|
|
US20230140670A1
(en)
|
2017-09-29 |
2023-05-04 |
Intellia Therapeutics, Inc. |
Formulations
|
|
EP3688161A1
(en)
|
2017-09-29 |
2020-08-05 |
Intellia Therapeutics, Inc. |
Compositions and methods for ttr gene editing and treating attr amyloidosis
|
|
WO2019067910A1
(en)
|
2017-09-29 |
2019-04-04 |
Intellia Therapeutics, Inc. |
POLYNUCLEOTIDES, COMPOSITIONS AND METHODS FOR GENOMIC EDITION
|
|
WO2019070755A1
(en)
|
2017-10-02 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
EP3694603B1
(en)
|
2017-10-10 |
2026-04-08 |
Children's Hospital Medical Center |
Esophageal tissue and/or organoid compositions and methods of making same
|
|
WO2019075197A1
(en)
|
2017-10-11 |
2019-04-18 |
The General Hospital Corporation |
METHODS OF DETECTION OF INDIVIDUAL SITE-SPECIFIC PARASITE GENOMIC DEAMINATION BY BASE EDITING TECHNOLOGIES
|
|
KR20250107288A
(ko)
|
2017-10-16 |
2025-07-11 |
더 브로드 인스티튜트, 인코퍼레이티드 |
아데노신 염기 편집제의 용도
|
|
US11680296B2
(en)
|
2017-10-16 |
2023-06-20 |
Massachusetts Institute Of Technology |
Mycobacterium tuberculosis host-pathogen interaction
|
|
CA3079681A1
(en)
|
2017-10-20 |
2019-04-25 |
Fred Hutchinson Cancer Research Center |
Systems and methods to produce b cells genetically modified to express selected antibodies
|
|
WO2019135816A2
(en)
|
2017-10-23 |
2019-07-11 |
The Broad Institute, Inc. |
Novel nucleic acid modifiers
|
|
WO2019089803A1
(en)
|
2017-10-31 |
2019-05-09 |
The Broad Institute, Inc. |
Methods and compositions for studying cell evolution
|
|
EP3704245A1
(en)
|
2017-11-01 |
2020-09-09 |
Novartis AG |
Synthetic rnas and methods of use
|
|
US12221720B2
(en)
|
2017-11-13 |
2025-02-11 |
The Broad Institute, Inc. |
Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
|
|
EP3710039A4
(en)
|
2017-11-13 |
2021-08-04 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
|
|
WO2019094955A1
(en)
|
2017-11-13 |
2019-05-16 |
The Broad Institute, Inc. |
Methods and compositions for targeting developmental and oncogenic programs in h3k27m gliomas
|
|
CR20200251A
(es)
|
2017-11-17 |
2020-07-17 |
Iovance Biotherapeutics Inc |
Expansión de til de aspirados con aguja fina y biopsias por punción
|
|
EP3714041A1
(en)
|
2017-11-22 |
2020-09-30 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
|
WO2019113506A1
(en)
|
2017-12-07 |
2019-06-13 |
The Broad Institute, Inc. |
Methods and compositions for multiplexing single cell and single nuclei sequencing
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
EP3727394A4
(en)
|
2017-12-21 |
2021-09-08 |
Children's Hospital Medical Center |
DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
|
|
US11994512B2
(en)
|
2018-01-04 |
2024-05-28 |
Massachusetts Institute Of Technology |
Single-cell genomic methods to generate ex vivo cell systems that recapitulate in vivo biology with improved fidelity
|
|
AU2019207409B2
(en)
|
2018-01-12 |
2023-02-23 |
Basf Se |
Gene underlying the number of spikelets per spike qtl in wheat on chromosome 7a
|
|
BR112020013626A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
compostos de quinoxalinona, composições, métodos e kits para aumentar a eficiência de edição de genoma
|
|
MA51619A
(fr)
|
2018-01-17 |
2021-04-14 |
Vertex Pharma |
Inhibiteurs de la protéine kinase dépendante de l'adn
|
|
JP7466448B2
(ja)
|
2018-01-17 |
2024-04-12 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Dna-pk阻害剤
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11926835B1
(en)
|
2018-01-29 |
2024-03-12 |
Inari Agriculture Technology, Inc. |
Methods for efficient tomato genome editing
|
|
CN111699254A
(zh)
|
2018-02-08 |
2020-09-22 |
齐默尔根公司 |
使用crispr在棒状杆菌属中进行基因组编辑
|
|
WO2019165168A1
(en)
|
2018-02-23 |
2019-08-29 |
Pioneer Hi-Bred International, Inc. |
Novel cas9 orthologs
|
|
KR102907245B1
(ko)
|
2018-03-14 |
2026-01-05 |
에디타스 메디신, 인코포레이티드 |
혈색소병증 치료를 위한 시스템 및 방법
|
|
EP3592140A1
(en)
|
2018-03-19 |
2020-01-15 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
|
JP7522038B2
(ja)
|
2018-04-06 |
2024-07-24 |
ザ チルドレンズ メディカル センター コーポレーション |
体細胞リプログラミングおよびインプリンティングのモジュレートのための組成物および方法
|
|
US11898203B2
(en)
|
2018-04-17 |
2024-02-13 |
The General Hospital Corporation |
Highly sensitive in vitro assays to define substrate preferences and sites of nucleic-acid binding, modifying, and cleaving agents
|
|
KR102922694B1
(ko)
|
2018-04-19 |
2026-02-03 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
유전자 편집을 위한 조성물 및 방법
|
|
WO2019204585A1
(en)
|
2018-04-19 |
2019-10-24 |
Massachusetts Institute Of Technology |
Single-stranded break detection in double-stranded dna
|
|
HUE059223T2
(hu)
|
2018-04-24 |
2022-10-28 |
Kws Saat Se & Co Kgaa |
Jobb emészthetõségû növények és marker haplotípusok
|
|
US11957695B2
(en)
|
2018-04-26 |
2024-04-16 |
The Broad Institute, Inc. |
Methods and compositions targeting glucocorticoid signaling for modulating immune responses
|
|
WO2019210131A1
(en)
|
2018-04-27 |
2019-10-31 |
Iovance Biotherapeutics, Inc. |
Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
WO2019210268A2
(en)
|
2018-04-27 |
2019-10-31 |
The Broad Institute, Inc. |
Sequencing-based proteomics
|
|
EP3788094A2
(en)
|
2018-04-27 |
2021-03-10 |
Genedit Inc. |
Cationic polymer and use for biomolecule delivery
|
|
WO2019213660A2
(en)
|
2018-05-04 |
2019-11-07 |
The Broad Institute, Inc. |
Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
|
|
AU2019265019B2
(en)
|
2018-05-11 |
2025-11-06 |
Beam Therapeutics Inc. |
Methods of substituting pathogenic amino acids using programmable base editor systems
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
WO2019232542A2
(en)
|
2018-06-01 |
2019-12-05 |
Massachusetts Institute Of Technology |
Methods and compositions for detecting and modulating microenvironment gene signatures from the csf of metastasis patients
|
|
US11866719B1
(en)
|
2018-06-04 |
2024-01-09 |
Inari Agriculture Technology, Inc. |
Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants
|
|
KR20210018437A
(ko)
|
2018-06-07 |
2021-02-17 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
조혈 줄기 세포를 생산하기 위한 방법
|
|
WO2019241315A1
(en)
|
2018-06-12 |
2019-12-19 |
Obsidian Therapeutics, Inc. |
Pde5 derived regulatory constructs and methods of use in immunotherapy
|
|
US10227576B1
(en)
|
2018-06-13 |
2019-03-12 |
Caribou Biosciences, Inc. |
Engineered cascade components and cascade complexes
|
|
US12227776B2
(en)
|
2018-06-13 |
2025-02-18 |
Caribou Biosciences, Inc. |
Engineered cascade components and cascade complexes
|
|
US12036240B2
(en)
|
2018-06-14 |
2024-07-16 |
The Broad Institute, Inc. |
Compositions and methods targeting complement component 3 for inhibiting tumor growth
|
|
WO2020006036A1
(en)
|
2018-06-26 |
2020-01-02 |
Massachusetts Institute Of Technology |
Crispr effector system based amplification methods, systems, and diagnostics
|
|
EP3814519A1
(en)
|
2018-06-26 |
2021-05-05 |
The Broad Institute, Inc. |
Crispr/cas and transposase based amplification compositions, systems and methods
|
|
EP3823633A4
(en)
|
2018-06-29 |
2023-05-03 |
Editas Medicine, Inc. |
SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
|
|
EP3814369A1
(en)
|
2018-06-29 |
2021-05-05 |
Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis |
Tweak-receptor agonists for use in combination with immunotherapy of a cancer
|
|
US12522807B2
(en)
|
2018-07-09 |
2026-01-13 |
The Broad Institute, Inc. |
RNA programmable epigenetic RNA modifiers and uses thereof
|
|
JP2021530212A
(ja)
|
2018-07-13 |
2021-11-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California |
レトロトランスポゾンベースの送達媒体及びその使用方法
|
|
EP4678727A3
(en)
|
2018-07-26 |
2026-03-11 |
Children's Hospital Medical Center |
Hepato-biliary-pancreatic tissues and methods of making same
|
|
SG11202102068TA
(en)
|
2018-07-31 |
2021-03-30 |
Broad Inst Inc |
Novel crispr enzymes and systems
|
|
MX2021001070A
(es)
|
2018-07-31 |
2021-05-27 |
Intellia Therapeutics Inc |
Composiciones y métodos para editar el gen hidroxiácido oxidasa 1 (hao1) para tratar la hiperoxaluria primaria tipo 1 (ph1).
|
|
JP2021532815A
(ja)
|
2018-08-07 |
2021-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新規Cas12b酵素およびシステム
|
|
EP3607819A1
(en)
|
2018-08-10 |
2020-02-12 |
Vilmorin et Cie |
Resistance to xanthomonas campestris pv. campestris (xcc) in cauliflower
|
|
CA3107002A1
(en)
|
2018-08-15 |
2020-04-30 |
Zymergen Inc. |
Applications of crispri in high throughput metabolic engineering
|
|
US12421507B2
(en)
|
2018-08-20 |
2025-09-23 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of CRISPR-CAS9
|
|
US20210324357A1
(en)
|
2018-08-20 |
2021-10-21 |
The Brigham And Women's Hospital, Inc. |
Degradation domain modifications for spatio-temporal control of rna-guided nucleases
|
|
US12275964B2
(en)
|
2018-08-22 |
2025-04-15 |
The Regents Of The University Of California |
Variant type V CRISPR/Cas effector polypeptides and methods of use thereof
|
|
AU2019326408A1
(en)
|
2018-08-23 |
2021-03-11 |
Sangamo Therapeutics, Inc. |
Engineered target specific base editors
|
|
US12534743B2
(en)
|
2018-08-31 |
2026-01-27 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US11479762B1
(en)
|
2018-08-31 |
2022-10-25 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
US12545910B2
(en)
|
2018-08-31 |
2026-02-10 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2020051507A1
(en)
|
2018-09-06 |
2020-03-12 |
The Broad Institute, Inc. |
Nucleic acid assemblies for use in targeted delivery
|
|
EP3847254A4
(en)
|
2018-09-07 |
2022-08-10 |
Beam Therapeutics Inc. |
COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM
|
|
WO2020051562A2
(en)
|
2018-09-07 |
2020-03-12 |
Beam Therapeutics Inc. |
Compositions and methods for improving base editing
|
|
CA3112026A1
(en)
|
2018-09-12 |
2020-03-19 |
Children's Hospital Medical Center |
Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
|
|
WO2020056170A1
(en)
|
2018-09-12 |
2020-03-19 |
Fred Hutchinson Cancer Research Center |
Reducing cd33 expression to selectively protect therapeutic cells
|
|
AU2019343045A1
(en)
|
2018-09-18 |
2021-05-13 |
Vnv Newco Inc. |
ARC-based capsids and uses thereof
|
|
TW202028460A
(zh)
|
2018-09-28 |
2020-08-01 |
美商英特利亞醫療公司 |
用於乳酸脫氫酶(ldha)基因編輯之組合物及方法
|
|
US12203123B2
(en)
|
2018-10-01 |
2025-01-21 |
North Carolina State University |
Recombinant type I CRISPR-Cas system and uses thereof for screening for variant cells
|
|
WO2020072248A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system
|
|
WO2020072254A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for killing target cells
|
|
WO2020072250A1
(en)
|
2018-10-01 |
2020-04-09 |
North Carolina State University |
Recombinant type i crispr-cas system and uses thereof for genome modification and alteration of expression
|
|
WO2020076976A1
(en)
|
2018-10-10 |
2020-04-16 |
Readcoor, Inc. |
Three-dimensional spatial molecular indexing
|
|
US20220411783A1
(en)
|
2018-10-12 |
2022-12-29 |
The Broad Institute, Inc. |
Method for extracting nuclei or whole cells from formalin-fixed paraffin-embedded tissues
|
|
US20210379057A1
(en)
|
2018-10-16 |
2021-12-09 |
Massachusetts Institute Of Technology |
Nutlin-3a for use in treating a mycobacterium tuberculosis infection
|
|
CN113227374A
(zh)
|
2018-10-16 |
2021-08-06 |
因特利亚治疗公司 |
用于免疫疗法的组合物和方法
|
|
US20210386788A1
(en)
|
2018-10-24 |
2021-12-16 |
Obsidian Therapeutics, Inc. |
Er tunable protein regulation
|
|
US12116458B2
(en)
|
2018-10-24 |
2024-10-15 |
Genedit Inc. |
Cationic polymer with alkyl side chains and use for biomolecule delivery
|
|
US11407995B1
(en)
|
2018-10-26 |
2022-08-09 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
SG11202104409YA
(en)
|
2018-10-31 |
2021-05-28 |
Zymergen Inc |
Multiplexed deterministic assembly of dna libraries
|
|
US11434477B1
(en)
|
2018-11-02 |
2022-09-06 |
Inari Agriculture Technology, Inc. |
RNA-guided nucleases and DNA binding proteins
|
|
JP7854297B2
(ja)
|
2018-11-05 |
2026-05-01 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
改良された腫瘍反応性t細胞の選択
|
|
WO2020096927A1
(en)
|
2018-11-05 |
2020-05-14 |
Iovance Biotherapeutics, Inc. |
Expansion of tils utilizing akt pathway inhibitors
|
|
MY210603A
(en)
|
2018-11-05 |
2025-10-01 |
Iovance Biotherapeutics Inc |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
US12611427B2
(en)
|
2018-11-05 |
2026-04-28 |
Iovance Biotherapeutics, Inc. |
Treatment of NSCLC patients refractory for anti-PD-1 antibody
|
|
WO2020097445A1
(en)
|
2018-11-09 |
2020-05-14 |
Inari Agriculture, Inc. |
Rna-guided nucleases and dna binding proteins
|
|
US12165743B2
(en)
|
2018-11-09 |
2024-12-10 |
The Broad Institute, Inc. |
Compressed sensing for screening and tissue imaging
|
|
US12402610B2
(en)
|
2018-11-09 |
2025-09-02 |
The Broad Institute, Inc. |
Methods and compositions for modulating innate lymphoid cell pathogenic effectors
|
|
US11166996B2
(en)
|
2018-12-12 |
2021-11-09 |
Flagship Pioneering Innovations V, Inc. |
Anellovirus compositions and methods of use
|
|
WO2020123887A2
(en)
|
2018-12-14 |
2020-06-18 |
Pioneer Hi-Bred International, Inc. |
Novel crispr-cas systems for genome editing
|
|
US12264323B2
(en)
|
2018-12-17 |
2025-04-01 |
The Broad Institute, Inc. |
CRISPR CPF1 direct repeat variants
|
|
US20220062394A1
(en)
|
2018-12-17 |
2022-03-03 |
The Broad Institute, Inc. |
Methods for identifying neoantigens
|
|
CN113544266A
(zh)
|
2018-12-17 |
2021-10-22 |
博德研究所 |
Crispr相关转座酶系统和其使用方法
|
|
CA3123392A1
(en)
|
2018-12-19 |
2020-06-25 |
Iovance Biotherapeutics, Inc. |
Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof
|
|
US11739156B2
(en)
|
2019-01-06 |
2023-08-29 |
The Broad Institute, Inc. Massachusetts Institute of Technology |
Methods and compositions for overcoming immunosuppression
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
AU2020215730A1
(en)
|
2019-01-31 |
2021-07-29 |
Beam Therapeutics Inc. |
Nucleobase editors having reduced non-target deamination and assays for characterizing nucleobase editors
|
|
US12600943B2
(en)
|
2019-02-01 |
2026-04-14 |
The University Of Hong Kong |
Innervated organoid compositions and methods of making same
|
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
|
WO2020163856A1
(en)
|
2019-02-10 |
2020-08-13 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Modified mitochondrion and methods of use thereof
|
|
CA3128755C
(en)
|
2019-02-13 |
2024-06-04 |
Beam Therapeutics Inc. |
Compositions and methods for treating hemoglobinopathies
|
|
CN120174005A
(zh)
|
2019-02-13 |
2025-06-20 |
比姆医疗股份有限公司 |
具有用于修饰靶标序列中核碱基的腺苷脱氨酶碱基编辑器的经修饰的免疫细胞
|
|
US10913941B2
(en)
|
2019-02-14 |
2021-02-09 |
Metagenomi Ip Technologies, Llc |
Enzymes with RuvC domains
|
|
US20220298494A1
(en)
*
|
2019-02-14 |
2022-09-22 |
Metagenomi Ip Technologies, Llc |
Enzymes with ruvc domains
|
|
WO2020180733A1
(en)
|
2019-03-01 |
2020-09-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
MX2021010559A
(es)
|
2019-03-07 |
2021-12-15 |
Univ California |
Polipéptidos efectores de crispr-cas y métodos de uso de estos.
|
|
MX2021010840A
(es)
|
2019-03-08 |
2022-01-19 |
Obsidian Therapeutics Inc |
Composiciones de anhidrasa carbónica 2 (ca2) humana y métodos de regulación ajustable.
|
|
CN113728106A
(zh)
|
2019-03-08 |
2021-11-30 |
齐默尔根公司 |
微生物中的迭代基因组编辑
|
|
US11053515B2
(en)
|
2019-03-08 |
2021-07-06 |
Zymergen Inc. |
Pooled genome editing in microbes
|
|
US12534714B2
(en)
|
2019-03-18 |
2026-01-27 |
The Broad Institute, Inc. |
Type VII CRISPR proteins and systems
|
|
WO2020191233A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
AU2020248337A1
(en)
*
|
2019-03-28 |
2021-11-04 |
Intellia Therapeutics, Inc. |
Compositions and methods for ttr gene editing and treating ATTR amyloidosis comprising a corticosteroid or use thereof
|
|
JP7631215B2
(ja)
*
|
2019-03-28 |
2025-02-18 |
インテリア セラピューティクス,インコーポレイテッド |
Ttrガイドrnaと、rnaガイドdna結合剤をコードするポリヌクレオチドとを含む組成物および方法
|
|
MX2021011757A
(es)
|
2019-03-28 |
2021-12-10 |
Intellia Therapeutics Inc |
Polinucleótidos, composiciones y métodos para la expresión de polipéptidos.
|
|
WO2020206036A1
(en)
|
2019-04-01 |
2020-10-08 |
The Broad Institute, Inc. |
Novel nucleic acid modifier
|
|
US20220202957A1
(en)
|
2019-04-09 |
2022-06-30 |
The Regents Of The University Of California |
Long-lasting analgesia via targeted in vivo epigenetic repression
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CA3137382A1
(en)
|
2019-04-23 |
2020-10-29 |
Genedit Inc. |
Cationic polymer with alkyl side chains
|
|
US11162079B2
(en)
|
2019-05-10 |
2021-11-02 |
The Regents Of The University Of California |
Blood type O Rh-hypo-immunogenic pluripotent cells
|
|
WO2020229533A1
(en)
|
2019-05-13 |
2020-11-19 |
KWS SAAT SE & Co. KGaA |
Drought tolerance in corn
|
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
US12116583B2
(en)
|
2019-05-14 |
2024-10-15 |
Yield10 Bioscience, Inc. |
Modified plants comprising a polynucleotide comprising a non-cognate promoter operably linked to a coding sequence that encodes a transcription factor
|
|
WO2020236972A2
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
|
US20220235340A1
(en)
|
2019-05-20 |
2022-07-28 |
The Broad Institute, Inc. |
Novel crispr-cas systems and uses thereof
|
|
JP2022533713A
(ja)
|
2019-05-21 |
2022-07-25 |
サンガモ セラピューティクス, インコーポレイテッド |
調節性t細胞における制御された導入遺伝子発現
|
|
AR118995A1
(es)
|
2019-05-25 |
2021-11-17 |
Kws Saat Se & Co Kgaa |
Mejorador de la inducción de haploides
|
|
US20220340712A1
(en)
|
2019-05-28 |
2022-10-27 |
GenEdit, Inc. |
Polymer comprising multiple functionalized sidechains for biomolecule delivery
|
|
AU2020283048A1
(en)
|
2019-05-31 |
2021-12-23 |
Children's Hospital Medical Center |
Shaped organoid compositions and methods of making same
|
|
WO2020243661A1
(en)
|
2019-05-31 |
2020-12-03 |
The Broad Institute, Inc. |
Methods for treating metabolic disorders by targeting adcy5
|
|
US12497597B2
(en)
|
2019-05-31 |
2025-12-16 |
Children's Hospital Medical Center |
Methods of generating and expanding hematopoietic stem cells
|
|
WO2020252455A1
(en)
*
|
2019-06-13 |
2020-12-17 |
The General Hospital Corporation |
Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells
|
|
WO2020254850A1
(en)
|
2019-06-21 |
2020-12-24 |
Vilmorin & Cie |
Improvement of quality and permanence of green color of peppers at maturity and over-maturity
|
|
CN114630910A
(zh)
|
2019-06-25 |
2022-06-14 |
伊纳瑞农业技术有限公司 |
改善的同源依赖修复基因组编辑
|
|
SG11202111943UA
(en)
|
2019-07-02 |
2021-11-29 |
Hutchinson Fred Cancer Res |
Recombinant ad35 vectors and related gene therapy improvements
|
|
EP3999103A4
(en)
|
2019-07-19 |
2023-11-22 |
Inari Agriculture Technology, Inc. |
GENOMIC EDITING FOR ENHANCED HOMOLOGY-DIRECTED REPAIR
|
|
WO2021019272A1
(en)
|
2019-07-31 |
2021-02-04 |
Vilmorin & Cie |
Tolerance to tolcndv in cucumber
|
|
WO2021026294A1
(en)
|
2019-08-06 |
2021-02-11 |
Children's Medical Center Corporation |
Methods and compositions for reconstituting microglia
|
|
EP3772542A1
(en)
|
2019-08-07 |
2021-02-10 |
KWS SAAT SE & Co. KGaA |
Modifying genetic variation in crops by modulating the pachytene checkpoint protein 2
|
|
WO2021028359A1
(en)
|
2019-08-09 |
2021-02-18 |
Sangamo Therapeutics France |
Controlled expression of chimeric antigen receptors in t cells
|
|
EP4022057A1
(en)
|
2019-08-27 |
2022-07-06 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of disorders associated with repetitive dna
|
|
WO2021041922A1
(en)
|
2019-08-30 |
2021-03-04 |
The Broad Institute, Inc. |
Crispr-associated mu transposase systems
|
|
WO2021046451A1
(en)
|
2019-09-06 |
2021-03-11 |
Obsidian Therapeutics, Inc. |
Compositions and methods for dhfr tunable protein regulation
|
|
CN115175996A
(zh)
|
2019-09-20 |
2022-10-11 |
博德研究所 |
新颖vi型crispr酶和系统
|
|
EP4048807A1
(en)
|
2019-09-23 |
2022-08-31 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating apolipoprotein b (apob) gene expression
|
|
CN114729376A
(zh)
|
2019-09-23 |
2022-07-08 |
欧米茄治疗公司 |
用于调节肝细胞核因子4α(HNF4α)基因表达的组合物和方法
|
|
WO2021062196A1
(en)
|
2019-09-26 |
2021-04-01 |
President And Fellows Of Harvard College |
Minimal arrestin domain containing protein 1 (arrdc1) constructs
|
|
EP4034138A4
(en)
|
2019-09-27 |
2024-07-31 |
Beam Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF LIQUID CANCERS
|
|
US11981922B2
(en)
|
2019-10-03 |
2024-05-14 |
Dana-Farber Cancer Institute, Inc. |
Methods and compositions for the modulation of cell interactions and signaling in the tumor microenvironment
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
EP4045522A1
(en)
|
2019-10-17 |
2022-08-24 |
KWS SAAT SE & Co. KGaA |
Enhanced disease resistance of crops by downregulation of repressor genes
|
|
EP4048295A1
(en)
|
2019-10-25 |
2022-08-31 |
Iovance Biotherapeutics, Inc. |
Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy
|
|
GB201916020D0
(en)
|
2019-11-04 |
2019-12-18 |
Univ Of Essex Enterprise Limited |
Crispr-mediated identification of biotinylated proteins and chromatin regions
|
|
WO2021094805A1
(en)
|
2019-11-14 |
2021-05-20 |
Vilmorin & Cie |
Resistance to acidovorax valerianellae in corn salad
|
|
CA3158963A1
(en)
|
2019-11-22 |
2021-05-27 |
Samir Mitragotri |
Ionic liquids for drug delivery
|
|
US12516291B2
(en)
|
2019-12-11 |
2026-01-06 |
Iovance Biotherapeutics, Inc. |
Processes for the production of tumor infiltrating lymphocytes (TILs) and methods of using the same
|
|
EP4058032A4
(en)
|
2019-12-19 |
2024-01-10 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
WO2021146222A1
(en)
|
2020-01-13 |
2021-07-22 |
Sana Biotechnology, Inc. |
Modification of blood type antigens
|
|
WO2021150919A1
(en)
|
2020-01-23 |
2021-07-29 |
The Children's Medical Center Corporation |
Stroma-free t cell differentiation from human pluripotent stem cells
|
|
WO2021151085A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Crispr-cas enzymes with enhanced on-target activity
|
|
WO2021151073A2
(en)
|
2020-01-24 |
2021-07-29 |
The General Hospital Corporation |
Unconstrained genome targeting with near-pamless engineered crispr-cas9 variants
|
|
EP4097251A1
(en)
|
2020-01-29 |
2022-12-07 |
10X Genomics, Inc. |
Compositions and methods for analyte detection
|
|
BR112022015380A2
(pt)
|
2020-02-07 |
2022-09-27 |
Intellia Therapeutics Inc |
Composições e métodos para edição de gene de calicreína (klkb1)
|
|
CA3173528A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|
|
WO2021202568A1
(en)
|
2020-03-31 |
2021-10-07 |
Metagenomi Ip Technologies, Llc |
Class ii, type ii crispr systems
|
|
US12057197B2
(en)
|
2020-04-03 |
2024-08-06 |
Creyon Bio, Inc. |
Oligonucleotide-based machine learning
|
|
WO2021216623A1
(en)
|
2020-04-21 |
2021-10-28 |
Aspen Neuroscience, Inc. |
Gene editing of lrrk2 in stem cells and method of use of cells differentiated therefrom
|
|
US20250263752A1
(en)
|
2020-04-21 |
2025-08-21 |
Aspen Neuroscience, Inc. |
Gene editing of gba1 in stem cells and method of use of cells differentiated therefrom
|
|
WO2021217082A1
(en)
|
2020-04-23 |
2021-10-28 |
Genedit Inc. |
Polymer with cationic and hydrophobic side chains
|
|
CA3181340A1
(en)
|
2020-04-28 |
2021-11-04 |
Intellia Therapeutics, Inc. |
Methods of in vitro cell delivery
|
|
CA3176826A1
(en)
|
2020-05-04 |
2021-11-11 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
|
EP4146797A1
(en)
|
2020-05-06 |
2023-03-15 |
Orchard Therapeutics (Europe) Limited |
Treatment for neurodegenerative diseases
|
|
IL297761A
(en)
|
2020-05-08 |
2022-12-01 |
Broad Inst Inc |
Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
|
|
CN115698335A
(zh)
|
2020-05-22 |
2023-02-03 |
因斯特罗公司 |
使用机器学习模型预测疾病结果
|
|
AR122206A1
(es)
|
2020-05-29 |
2022-08-24 |
Kws Saat Se & Co Kgaa |
Inducción de haploides en plantas
|
|
WO2021245435A1
(en)
|
2020-06-03 |
2021-12-09 |
Vilmorin & Cie |
Melon plants resistant to scab disease, aphids and powdery mildew
|
|
AU2021285274A1
(en)
|
2020-06-05 |
2023-02-02 |
Vilmorin & Cie |
Resistance in plants of solanum lycopersicum to the TOBRFV
|
|
JP2023530234A
(ja)
|
2020-06-05 |
2023-07-14 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
新生物を治療するための組成物および方法
|
|
CA3189601A1
(en)
|
2020-07-24 |
2022-01-27 |
The General Hospital Corporation |
Enhanced virus-like particles and methods of use thereof for delivery to cells
|
|
WO2022034474A1
(en)
|
2020-08-10 |
2022-02-17 |
Novartis Ag |
Treatments for retinal degenerative diseases
|
|
US20220049303A1
(en)
|
2020-08-17 |
2022-02-17 |
Readcoor, Llc |
Methods and systems for spatial mapping of genetic variants
|
|
US20220096606A1
(en)
|
2020-09-09 |
2022-03-31 |
Vertex Pharmaceuticals Incorporated |
Compositions and Methods for Treatment of Duchenne Muscular Dystrophy
|
|
CN116368152A
(zh)
*
|
2020-09-13 |
2023-06-30 |
山东博安生物技术股份有限公司 |
通过受体tac技术的膜结合蛋白的下调
|
|
CA3196831A1
(en)
|
2020-09-25 |
2022-03-31 |
Beam Therapeutics Inc. |
Fratricide resistant modified immune cells and methods of using the same
|
|
EP4221492A1
(en)
|
2020-10-02 |
2023-08-09 |
Vilmorin & Cie |
Melon with extended shelf life
|
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
|
EP4232583A1
(en)
|
2020-10-21 |
2023-08-30 |
Massachusetts Institute of Technology |
Systems, methods, and compositions for site-specific genetic engineering using programmable addition via site-specific targeting elements (paste)
|
|
WO2022098933A1
(en)
|
2020-11-06 |
2022-05-12 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of dm1 with slucas9 and sacas9
|
|
KR102875461B1
(ko)
|
2020-11-09 |
2025-10-24 |
삼성전자주식회사 |
전자 장치 및 그의 연락처를 관리하는 방법
|
|
IL303102A
(en)
|
2020-12-03 |
2023-07-01 |
Vilmorin & Cie |
Tomato plants resistant to TOMMV, TOMV, TMV, TOBRFV and suitable resistant genes
|
|
MX2023006878A
(es)
|
2020-12-11 |
2023-07-31 |
Intellia Therapeutics Inc |
Composiciones y métodos para reducir el mhc de clase ii en una célula.
|
|
EP4262827A1
(en)
|
2020-12-17 |
2023-10-25 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocytes
|
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
|
WO2022140587A1
(en)
|
2020-12-23 |
2022-06-30 |
Intellia Therapeutics, Inc. |
Compositions and methods for genetically modifying ciita in a cell
|
|
TW202235622A
(zh)
|
2020-12-23 |
2022-09-16 |
美商旗艦先鋒創新公司 |
包裹rna之指環病毒(anellovirus)蛋白殼之活體外組裝
|
|
CR20230320A
(es)
|
2020-12-23 |
2023-10-23 |
Intellia Therapeutics Inc |
Composiciones y métodos para reducir los hla-a en una célula
|
|
WO2022165260A1
(en)
|
2021-01-29 |
2022-08-04 |
Iovance Biotherapeutics, Inc. |
Methods of making modified tumor infiltrating lymphocytes and their use in adoptive cell therapy
|
|
US12171813B2
(en)
|
2021-02-05 |
2024-12-24 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
EP4288089A2
(en)
|
2021-02-08 |
2023-12-13 |
Intellia Therapeutics, Inc. |
T-cell immunoglobulin and mucin domain 3 (tim3) compositions and methods for immunotherapy
|
|
CN117042793A
(zh)
|
2021-02-08 |
2023-11-10 |
因特利亚治疗公司 |
用于免疫疗法的淋巴细胞活化基因3(lag3)组合物和方法
|
|
EP4288525A1
(en)
|
2021-02-08 |
2023-12-13 |
Intellia Therapeutics, Inc. |
Natural killer cell receptor 2b4 compositions and methods for immunotherapy
|
|
TW202302848A
(zh)
|
2021-02-26 |
2023-01-16 |
美商維泰克斯製藥公司 |
以crispr/sacas9治療第1型肌強直性營養不良之組合物及方法
|
|
EP4298221A1
(en)
|
2021-02-26 |
2024-01-03 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for treatment of myotonic dystrophy type 1 with crispr/slucas9
|
|
US20240191191A1
(en)
|
2021-03-19 |
2024-06-13 |
Iovance Biotherapeutics, Inc. |
Methods for infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
|
|
JP2024512029A
(ja)
|
2021-03-25 |
2024-03-18 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
T細胞共培養効力アッセイのための方法及び組成物、ならびに細胞療法製品との使用
|
|
EP4314016A1
(en)
|
2021-03-31 |
2024-02-07 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
|
WO2022208489A1
(en)
|
2021-04-02 |
2022-10-06 |
Vilmorin & Cie |
Semi-determinate or determinate growth habit trait in cucurbita
|
|
KR20240007651A
(ko)
|
2021-04-16 |
2024-01-16 |
빔 테라퓨틱스, 인크. |
간세포의 유전적 변형
|
|
IL307740A
(en)
|
2021-04-17 |
2023-12-01 |
Intellia Therapeutics Inc |
DNA-dependent protein kinase inhibitors and their compositions and uses
|
|
KR20240017793A
(ko)
|
2021-04-17 |
2024-02-08 |
인텔리아 테라퓨틱스, 인크. |
지질 나노입자 조성물
|
|
EP4322920A1
(en)
|
2021-04-17 |
2024-02-21 |
Intellia Therapeutics, Inc. |
Lipid nanoparticle compositions
|
|
CA3215830A1
(en)
|
2021-04-19 |
2022-10-27 |
Rafael CUBAS |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
|
WO2022229851A1
(en)
|
2021-04-26 |
2022-11-03 |
Crispr Therapeutics Ag |
Compositions and methods for using slucas9 scaffold sequences
|
|
WO2022235929A1
(en)
|
2021-05-05 |
2022-11-10 |
Radius Pharmaceuticals, Inc. |
Animal model having homologous recombination of mouse pth1 receptor
|
|
WO2022234519A1
(en)
|
2021-05-05 |
2022-11-10 |
Crispr Therapeutics Ag |
Compositions and methods for using sacas9 scaffold sequences
|
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
AU2022271873A1
(en)
|
2021-05-10 |
2024-01-04 |
Entrada Therapeutics, Inc. |
Compositions and methods for intracellular therapeutics
|
|
WO2022240760A2
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING mRNA SPLICING
|
|
JP2024519029A
(ja)
|
2021-05-17 |
2024-05-08 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Pd-1遺伝子編集された腫瘍浸潤リンパ球及び免疫療法におけるその使用
|
|
EP4347818A2
(en)
|
2021-06-01 |
2024-04-10 |
Arbor Biotechnologies, Inc. |
Gene editing systems comprising a crispr nuclease and uses thereof
|
|
US20240285781A1
(en)
|
2021-06-11 |
2024-08-29 |
GenEdit, Inc. |
Biodegradable polymer comprising side chains with polyamine and polyalkylene oxide groups
|
|
AU2022298774A1
(en)
|
2021-06-23 |
2023-12-14 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
|
EP4367242A2
(en)
|
2021-07-07 |
2024-05-15 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating secreted frizzled receptor protein 1 (sfrp1) gene expression
|
|
EP4373270A2
(en)
|
2021-07-22 |
2024-05-29 |
Iovance Biotherapeutics, Inc. |
Method for cryopreservation of solid tumor fragments
|
|
JP2024527961A
(ja)
|
2021-07-28 |
2024-07-26 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Kras阻害剤と併用した腫瘍浸潤リンパ球療法によるがん患者の治療
|
|
US20240252684A1
(en)
|
2021-07-30 |
2024-08-01 |
Tune Therapeutics, Inc. |
Compositions and methods for modulating expression of methyl-cpg binding protein 2 (mecp2)
|
|
CA3227103A1
(en)
|
2021-07-30 |
2023-02-02 |
Matthew P. GEMBERLING |
Compositions and methods for modulating expression of frataxin (fxn)
|
|
WO2023006933A1
(en)
|
2021-07-30 |
2023-02-02 |
KWS SAAT SE & Co. KGaA |
Plants with improved digestibility and marker haplotypes
|
|
MX2024001624A
(es)
|
2021-08-06 |
2024-04-30 |
Vilmorin & Cie |
Resistencia a leveillula taurica en el pimiento.
|
|
WO2023018637A1
(en)
|
2021-08-09 |
2023-02-16 |
Vertex Pharmaceuticals Incorporated |
Gene editing of regulatory elements
|
|
JP2024534114A
(ja)
|
2021-08-24 |
2024-09-18 |
インテリア セラピューティクス,インコーポレイテッド |
細胞療法用のプログラム細胞死タンパク質1(pd1)組成物及び方法
|
|
CN113444788B
(zh)
*
|
2021-08-27 |
2021-11-02 |
中国医学科学院北京协和医院 |
青光眼诊断产品及应用
|
|
AU2022335499A1
(en)
|
2021-08-27 |
2024-02-22 |
Metagenomi Therapeutics, Inc. |
Enzymes with ruvc domains
|
|
WO2023039444A2
(en)
|
2021-09-08 |
2023-03-16 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exon 51 for treatment of duchenne muscular dystrophy
|
|
JP2024534945A
(ja)
|
2021-09-10 |
2024-09-26 |
アジレント・テクノロジーズ・インク |
化学修飾を有するプライム編集のためのガイドrna
|
|
EP4596696A3
(en)
|
2021-09-28 |
2025-08-27 |
Acrigen Biosciences |
Compositions and methods for nucleic acid modifications
|
|
EP4412587A1
(en)
|
2021-10-08 |
2024-08-14 |
President And Fellows Of Harvard College |
Ionic liquids for drug delivery
|
|
WO2023077015A2
(en)
|
2021-10-27 |
2023-05-04 |
Iovance Biotherapeutics, Inc. |
Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
|
|
EP4426828A1
(en)
|
2021-11-01 |
2024-09-11 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
JP2024540723A
(ja)
|
2021-11-03 |
2024-11-01 |
インテリア セラピューティクス,インコーポレーテッド |
免疫療法のためのcd38組成物及び方法
|
|
CA3237482A1
(en)
|
2021-11-03 |
2023-05-11 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Precise genome editing using retrons
|
|
CA3237410A1
(en)
|
2021-11-10 |
2023-05-19 |
Friedrich Graf Finck VON FINCKENSTEIN |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
|
AU2022396533A1
(en)
|
2021-11-24 |
2024-05-02 |
Metagenomi Therapeutics, Inc. |
Endonuclease systems
|
|
WO2023093862A1
(en)
|
2021-11-26 |
2023-06-01 |
Epigenic Therapeutics Inc. |
Method of modulating pcsk9 and uses thereof
|
|
GB202118058D0
(en)
|
2021-12-14 |
2022-01-26 |
Univ Warwick |
Methods to increase yields in crops
|
|
US20250304934A1
(en)
*
|
2021-12-14 |
2025-10-02 |
The Broad Institute, Inc. |
Reprogrammable fanzor polynucleotides and uses thereof
|
|
US20230279442A1
(en)
|
2021-12-15 |
2023-09-07 |
Versitech Limited |
Engineered cas9-nucleases and method of use thereof
|
|
US20250059239A1
(en)
|
2021-12-17 |
2025-02-20 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae fusion glycoproteins
|
|
WO2023115041A1
(en)
|
2021-12-17 |
2023-06-22 |
Sana Biotechnology, Inc. |
Modified paramyxoviridae attachment glycoproteins
|
|
AU2022420615A1
(en)
|
2021-12-22 |
2024-07-04 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
|
JP2025501755A
(ja)
|
2021-12-23 |
2025-01-23 |
ユニバーシティー オブ マサチューセッツ |
脆弱x関連障害に対する治療的処置
|
|
EP4463135A2
(en)
|
2022-01-10 |
2024-11-20 |
Sana Biotechnology, Inc. |
Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
US20250134999A1
(en)
|
2022-01-14 |
2025-05-01 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene activation
|
|
US20250154503A1
(en)
|
2022-01-14 |
2025-05-15 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for programming t cell phenotypes through targeted gene repression
|
|
WO2023141602A2
(en)
|
2022-01-21 |
2023-07-27 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
EP4469065A1
(en)
|
2022-01-28 |
2024-12-04 |
Iovance Biotherapeutics, Inc. |
Cytokine associated tumor infiltrating lymphocytes compositions and methods
|
|
EP4472646A1
(en)
|
2022-02-01 |
2024-12-11 |
Sana Biotechnology, Inc. |
Cd3-targeted lentiviral vectors and uses thereof
|
|
WO2023150647A1
(en)
|
2022-02-02 |
2023-08-10 |
Sana Biotechnology, Inc. |
Methods of repeat dosing and administration of lipid particles or viral vectors and related systems and uses
|
|
CN119137268A
(zh)
|
2022-03-01 |
2024-12-13 |
埃皮克里斯皮尔生物技术公司 |
工程化核酸酶、组合物及其使用方法
|
|
WO2023172927A1
(en)
|
2022-03-08 |
2023-09-14 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exon 44, 50, and 53 for treatment of duchenne muscular dystrophy
|
|
WO2023172926A1
(en)
|
2022-03-08 |
2023-09-14 |
Vertex Pharmaceuticals Incorporated |
Precise excisions of portions of exons for treatment of duchenne muscular dystrophy
|
|
EP4256950A1
(en)
|
2022-04-06 |
2023-10-11 |
Vilmorin et Cie |
Tolerance to cgmmv in cucumber
|
|
WO2023196877A1
(en)
|
2022-04-06 |
2023-10-12 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
|
JP2025512401A
(ja)
|
2022-04-15 |
2025-04-17 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
特定のサイトカインの組み合わせ及び/またはAKTi処理を使用したTIL拡張プロセス
|
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
|
WO2023219933A1
(en)
|
2022-05-09 |
2023-11-16 |
Entrada Therapeutics, Inc. |
Compositions and methods for delivery of nucleic acid therapeutics
|
|
CA3251533A1
(en)
|
2022-05-10 |
2023-11-16 |
Iovance Biotherapeutics, Inc. |
TREATMENT OF CANCER PATIENTS WITH TUMOR-INFILTRATING LYMPHOCYTE THERAPIES IN COMBINATION WITH AN IL-15R AGONIST
|
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
|
AU2023276757A1
(en)
|
2022-05-25 |
2024-11-21 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulation of tumor suppressors and oncogenes
|
|
CN119563038A
(zh)
|
2022-05-25 |
2025-03-04 |
旗舰创业创新七公司 |
用于调节免疫应答的组合物和方法
|
|
WO2023230570A2
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and methods for modulating genetic drivers
|
|
US20250319115A1
(en)
|
2022-05-25 |
2025-10-16 |
Flagship Pioneering Innovations Vii, Llc |
Compositions and Methods for Modulating Cytokines
|
|
CA3254388A1
(en)
|
2022-05-25 |
2023-11-30 |
Flagship Pioneering Innovations Vii, Llc |
COMPOSITIONS AND METHODS OF MODULATING TRAFFIC FACTORS
|
|
IL317874A
(en)
|
2022-06-24 |
2025-02-01 |
Tune Therapeutics Inc |
Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
|
|
GB2621813A
(en)
|
2022-06-30 |
2024-02-28 |
Univ Newcastle |
Preventing disease recurrence in Mitochondrial replacement therapy
|
|
EP4299733A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005863A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
EP4299739A1
(en)
|
2022-06-30 |
2024-01-03 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
WO2024005864A1
(en)
|
2022-06-30 |
2024-01-04 |
Inari Agriculture Technology, Inc. |
Compositions, systems, and methods for genome editing
|
|
CA3261865A1
(en)
|
2022-07-12 |
2024-01-18 |
Tune Therapeutics, Inc. |
TARGETED TRANSCRIPTIONAL ACTIVATION COMPOSITIONS, SYSTEMS AND METHODS
|
|
EP4558634A1
(en)
|
2022-07-18 |
2025-05-28 |
Vertex Pharmaceuticals Incorporated |
Tandem guide rnas (tg-rnas) and their use in genome editing
|
|
JP2025525569A
(ja)
|
2022-07-18 |
2025-08-05 |
レナゲード セラピューティクス マネージメント インコーポレイテッド |
遺伝子編集成分、システム、及び使用方法
|
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
|
KR20250077608A
(ko)
|
2022-08-19 |
2025-05-30 |
튠 쎄라퓨틱스, 인코포레이티드 |
표적 유전자 억제를 통한 b형 간염 바이러스 조절용 조성물, 시스템 및 방법
|
|
US20260055146A1
(en)
|
2022-08-24 |
2026-02-26 |
Sana Biotechnology, Inc. |
Delivery of heterologous proteins
|
|
WO2024044723A1
(en)
|
2022-08-25 |
2024-02-29 |
Renagade Therapeutics Management Inc. |
Engineered retrons and methods of use
|
|
CA3265393A1
(en)
|
2022-08-26 |
2024-02-29 |
KWS SAAT SE & Co. KGaA |
USE OF PAIRED GENES FOR HYBRID SELECTION
|
|
WO2024064642A2
(en)
|
2022-09-19 |
2024-03-28 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for modulating t cell function
|
|
WO2024064838A1
(en)
|
2022-09-21 |
2024-03-28 |
Sana Biotechnology, Inc. |
Lipid particles comprising variant paramyxovirus attachment glycoproteins and uses thereof
|
|
WO2024081820A1
(en)
|
2022-10-13 |
2024-04-18 |
Sana Biotechnology, Inc. |
Viral particles targeting hematopoietic stem cells
|
|
EP4612277A1
(en)
|
2022-11-04 |
2025-09-10 |
Iovance Biotherapeutics, Inc. |
Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd103 selection
|
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
|
JP2025539816A
(ja)
|
2022-11-21 |
2025-12-09 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球の増幅のための2次元プロセス及びそれからの治療法
|
|
WO2024118836A1
(en)
|
2022-11-30 |
2024-06-06 |
Iovance Biotherapeutics, Inc. |
Processes for production of tumor infiltrating lymphocytes with shortened rep step
|
|
WO2024119157A1
(en)
|
2022-12-02 |
2024-06-06 |
Sana Biotechnology, Inc. |
Lipid particles with cofusogens and methods of producing and using the same
|
|
KR20250124819A
(ko)
|
2022-12-21 |
2025-08-20 |
인텔리아 테라퓨틱스, 인크. |
프로단백질 전환효소 서브틸리신 켁신 9(pcsk9) 편집을 위한 조성물 및 방법
|
|
WO2024138194A1
(en)
|
2022-12-22 |
2024-06-27 |
Tome Biosciences, Inc. |
Platforms, compositions, and methods for in vivo programmable gene insertion
|
|
CN120417757A
(zh)
|
2022-12-29 |
2025-08-01 |
维尔莫林公司 |
对抗性突破型tswv毒株具有抗性的番茄植物和相应的抗性基因
|
|
WO2024163683A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Systems, compositions, and methods for modulating expression of methyl-cpg binding protein 2 (mecp2) and x-inactive specific transcript (xist)
|
|
WO2024163678A2
(en)
|
2023-02-01 |
2024-08-08 |
Tune Therapeutics, Inc. |
Fusion proteins and systems for targeted activation of frataxin (fxn) and related methods
|
|
WO2024168265A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Aav delivery of rna guided recombination system
|
|
WO2024168253A1
(en)
|
2023-02-10 |
2024-08-15 |
Possible Medicines Llc |
Delivery of an rna guided recombination system
|
|
KR20250151430A
(ko)
|
2023-02-15 |
2025-10-21 |
아버 바이오테크놀로지스, 인크. |
스타스민 2(stmn2) 전사체에서 비정상적인 스플라이싱을 억제하는 유전자 편집 방법
|
|
TW202436622A
(zh)
|
2023-03-06 |
2024-09-16 |
美商英特利亞醫療公司 |
用於b型肝炎病毒(hbv)基因體編輯之組合物及方法
|
|
WO2024186971A1
(en)
|
2023-03-07 |
2024-09-12 |
Intellia Therapeutics, Inc. |
Cish compositions and methods for immunotherapy
|
|
US12225874B2
(en)
|
2023-03-27 |
2025-02-18 |
Redsea Science And Technology Inc. |
Tomato plant designated ‘X22-31’
|
|
WO2024206911A2
(en)
|
2023-03-30 |
2024-10-03 |
Children's Hospital Medical Center |
Clinical-grade organoids
|
|
WO2024211287A1
(en)
|
2023-04-03 |
2024-10-10 |
Seagen Inc. |
Production cell lines with targeted integration sites
|
|
EP4698666A1
(en)
|
2023-04-18 |
2026-02-25 |
Sana Biotechnology, Inc. |
Universal protein g fusogens and adapter systems thereof and related lipid particles and uses
|
|
WO2024220598A2
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Lentiviral vectors with two or more genomes
|
|
WO2024220560A1
(en)
|
2023-04-18 |
2024-10-24 |
Sana Biotechnology, Inc. |
Engineered protein g fusogens and related lipid particles and methods thereof
|
|
TW202449159A
(zh)
|
2023-04-19 |
2024-12-16 |
美商旗艦先鋒創新有限責任(Vii)公司 |
用於產生文庫之組合物及方法
|
|
EP4697940A1
(en)
|
2023-04-21 |
2026-02-25 |
Vib Vzw |
Allelic combinations in crops for yield increase
|
|
WO2024226499A1
(en)
|
2023-04-24 |
2024-10-31 |
The Broad Institute, Inc. |
Compositions and methods for modifying fertility
|
|
WO2024223900A1
(en)
|
2023-04-28 |
2024-10-31 |
Vilmorin & Cie |
Genetic determinants conferring improved tobrfv resistance
|
|
WO2024234006A1
(en)
|
2023-05-11 |
2024-11-14 |
Tome Biosciences, Inc. |
Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
|
|
WO2024236547A1
(en)
|
2023-05-18 |
2024-11-21 |
Inceptor Bio, Llc |
Modified phagocytic cells expressing chimeric antigen receptors comprising a herpes virus entry mediator (hvem) co-stimulatory domain and uses thereof
|
|
WO2024238977A2
(en)
|
2023-05-18 |
2024-11-21 |
Children's Hospital Medical Center |
Liver organoids with intrahepatic sympathetic nerves, and methods of use thereof
|
|
EP4712950A2
(en)
|
2023-05-19 |
2026-03-25 |
Intellia Therapeutics, Inc. |
Ionizable amine lipids
|
|
EP4716750A1
(en)
|
2023-05-23 |
2026-04-01 |
Sana Biotechnology, Inc. |
Tandem fusogens and related lipid particles
|
|
EP4716741A2
(en)
|
2023-05-23 |
2026-04-01 |
Flagship Labs 114, Inc. |
Compositions and methods for reducing cxcl9, cxcl10, and cxcl11 gene expression
|
|
EP4731750A2
(en)
|
2023-06-23 |
2026-04-29 |
Children's Hospital Medical Center |
Methods of matrix-free suspension culture
|
|
WO2025006419A1
(en)
|
2023-06-26 |
2025-01-02 |
Flagship Pioneering Innovations Vii, Llc |
Engineered plasmodia and related methods
|
|
EP4734755A1
(en)
|
2023-06-28 |
2026-05-06 |
Vilmorin & Cie |
Pepper resistance to meloidogyne enterolobii
|
|
CN121548346A
(zh)
|
2023-07-24 |
2026-02-17 |
维尔莫林公司 |
甜瓜对cysdv的抗性
|
|
CN121909284A
(zh)
|
2023-07-31 |
2026-04-21 |
图恩疗法股份有限公司 |
用于调节il-2基因表达的组合物和方法
|
|
WO2025029840A1
(en)
|
2023-07-31 |
2025-02-06 |
Tune Therapeutics, Inc. |
Compositions and methods for multiplexed activation and repression of t cell gene expression
|
|
WO2025038494A1
(en)
|
2023-08-11 |
2025-02-20 |
Tune Therapeutics, Inc. |
Compositions, systems, and methods for lymphoid cell differentiation using targeted gene activation
|
|
WO2025038637A1
(en)
|
2023-08-14 |
2025-02-20 |
Intellia Therapeutics, Inc. |
Compositions and methods for genetically modifying transforming growth factor beta receptor type 2 (tgfβr2)
|
|
WO2025038642A1
(en)
|
2023-08-14 |
2025-02-20 |
Intellia Therapeutics, Inc. |
Compositions and methods for genetically modifying cd70
|
|
WO2025038646A1
(en)
|
2023-08-14 |
2025-02-20 |
Intellia Therapeutics, Inc. |
Cd70 car-t compositions and methods for cell-based therapy
|
|
IL326191A
(en)
|
2023-08-14 |
2026-03-01 |
Intellia Therapeutics Inc |
Compositions and methods for genetic modification of transforming growth factor beta receptor type 2 (tgfβr2)
|
|
WO2025049481A1
(en)
|
2023-08-28 |
2025-03-06 |
Intellia Therapeutics, Inc. |
Methods of editing an hla-a gene in vitro
|
|
WO2025046513A1
(en)
|
2023-08-29 |
2025-03-06 |
Inceptor Bio, Llc |
Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof
|
|
AU2024335327A1
(en)
|
2023-09-01 |
2026-03-26 |
Renagade Therapeutics Management Inc. |
Gene editing systems, compositions, and methods for treatment of vexas syndrome
|
|
WO2025050069A1
(en)
|
2023-09-01 |
2025-03-06 |
Tome Biosciences, Inc. |
Programmable gene insertion using engineered integration enzymes
|
|
WO2025054202A1
(en)
|
2023-09-05 |
2025-03-13 |
Sana Biotechnology, Inc. |
Method of screening a sample comprising a transgene with a unique barcode
|
|
WO2025054540A1
(en)
|
2023-09-08 |
2025-03-13 |
Iovance Biotherapeutics, Inc. |
Methods of gene-editing using programmable nucleases
|
|
WO2025059073A1
(en)
|
2023-09-11 |
2025-03-20 |
Tune Therapeutics, Inc. |
Epigenetic editing methods and systems for differentiating stem cells
|
|
WO2025064408A1
(en)
|
2023-09-18 |
2025-03-27 |
The Broad Institute, Inc. |
Compositions and methods for treating cardiovascular disease
|
|
GB202314578D0
(en)
|
2023-09-22 |
2023-11-08 |
Univ Manchester |
Methods of producing homoplasmic modified plants or parts thereof
|
|
WO2025072803A1
(en)
|
2023-09-29 |
2025-04-03 |
Children's Hospital Medical Center |
Ntrk2 signaling-mediated alveolar capillary injury and repair
|
|
WO2025076141A1
(en)
|
2023-10-03 |
2025-04-10 |
Inari Agriculture Technology, Inc. |
Viral delivery of grna to the scion
|
|
AU2024357861A1
(en)
|
2023-10-12 |
2026-04-23 |
Renagade Therapeutics Management Inc. |
Nickase-retron template-based precision editing system and methods of use
|
|
WO2025096638A2
(en)
|
2023-10-30 |
2025-05-08 |
Turnstone Biologics Corp. |
Genetically modified tumor infilitrating lymphocytes and methods of producing and using the same
|
|
WO2025101484A1
(en)
|
2023-11-06 |
2025-05-15 |
Iovance Biotherapeutics, Inc. |
Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
|
|
WO2025151838A1
(en)
|
2024-01-12 |
2025-07-17 |
Sana Biotechnology, Inc. |
Safety switches to control in vitro and in vivo proliferation of cell therapy products
|
|
WO2025155753A2
(en)
|
2024-01-17 |
2025-07-24 |
Renagade Therapeutics Management Inc. |
Improved gene editing system, guides, and methods
|
|
WO2025168705A1
(en)
|
2024-02-08 |
2025-08-14 |
Vib Vzw |
Means and methods for the production of saponins with endosomal escape-enhancing properties
|
|
WO2025171210A1
(en)
|
2024-02-09 |
2025-08-14 |
Arbor Biotechnologies, Inc. |
Compositions and methods for gene editing via homology-mediated end joining
|
|
WO2025174765A1
(en)
|
2024-02-12 |
2025-08-21 |
Renagade Therapeutics Management Inc. |
Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents
|
|
WO2025184529A1
(en)
|
2024-03-01 |
2025-09-04 |
Sana Biotechnology, Inc. |
Viral particles with fusogen display and related compositions and methods
|
|
WO2025186284A1
(en)
|
2024-03-05 |
2025-09-12 |
Vilmorin & Cie |
Increased yield in cucumber
|
|
WO2025212920A1
(en)
|
2024-04-03 |
2025-10-09 |
Children's Hospital Medical Center |
Multi-zonal liver organoids
|
|
WO2025217202A1
(en)
|
2024-04-08 |
2025-10-16 |
Children's Hospital Medical Center |
Bile duct organoid
|
|
US20250332260A1
(en)
|
2024-04-10 |
2025-10-30 |
Garuda Therapeutics, Inc. |
Immune compatible cells for allogeneic cell therapies to cover global, ethnic, or disease-specific populations
|
|
EP4677108A1
(en)
|
2024-04-22 |
2026-01-14 |
Basecamp Research Ltd |
Method and compositions for detecting off-target editing
|
|
WO2025224182A2
(en)
|
2024-04-23 |
2025-10-30 |
Basecamp Research Ltd |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
|
WO2025240947A1
(en)
|
2024-05-17 |
2025-11-20 |
University Of Massachusetts |
Therapeutic treatment for fragile x-associated disorder
|
|
WO2025240946A1
(en)
|
2024-05-17 |
2025-11-20 |
Intellia Therapeutics, Inc. |
Lipid nanoparticles and lipid nanoparticle compositions
|
|
WO2025255308A1
(en)
|
2024-06-07 |
2025-12-11 |
Intellia Therapeutics, Inc. |
Cd8 co-receptor chimeric polypeptides in tcr cell therapy
|
|
US20250382627A1
(en)
|
2024-06-13 |
2025-12-18 |
J.R. Simplot Company |
Engineering remontant flowering in rosaceae
|
|
WO2025260068A1
(en)
|
2024-06-14 |
2025-12-18 |
Tune Therapeutics, Inc. |
Lipid nanoparticle formulation for delivery of nucleic acids to cells
|
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