PL2968346T3 - Sposoby i kompozycje do modulacji cyklu gamma-glutamylowego - Google Patents

Sposoby i kompozycje do modulacji cyklu gamma-glutamylowego

Info

Publication number
PL2968346T3
PL2968346T3 PL14763483.6T PL14763483T PL2968346T3 PL 2968346 T3 PL2968346 T3 PL 2968346T3 PL 14763483 T PL14763483 T PL 14763483T PL 2968346 T3 PL2968346 T3 PL 2968346T3
Authority
PL
Poland
Prior art keywords
gamma
modulation
compositions
methods
glutamyl cycle
Prior art date
Application number
PL14763483.6T
Other languages
English (en)
Inventor
David Rubin
Eyal Rubin
Original Assignee
Cancer Research Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technologies Llc filed Critical Cancer Research Technologies Llc
Publication of PL2968346T3 publication Critical patent/PL2968346T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL14763483.6T 2013-03-15 2014-03-15 Sposoby i kompozycje do modulacji cyklu gamma-glutamylowego PL2968346T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361801709P 2013-03-15 2013-03-15
PCT/US2014/030053 WO2014145314A2 (en) 2013-03-15 2014-03-15 Methods and compositions for gamma-glutamyl cycle modulation

Publications (1)

Publication Number Publication Date
PL2968346T3 true PL2968346T3 (pl) 2024-11-04

Family

ID=51529989

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14763483.6T PL2968346T3 (pl) 2013-03-15 2014-03-15 Sposoby i kompozycje do modulacji cyklu gamma-glutamylowego

Country Status (14)

Country Link
US (4) US9630936B2 (pl)
EP (1) EP2968346B1 (pl)
JP (2) JP6458000B2 (pl)
KR (2) KR20160003652A (pl)
CN (1) CN105246483A (pl)
AU (2) AU2014233168B2 (pl)
CA (2) CA3232320A1 (pl)
DK (1) DK2968346T3 (pl)
EA (1) EA030611B1 (pl)
ES (1) ES2977144T3 (pl)
FI (1) FI2968346T3 (pl)
IL (2) IL283717B (pl)
PL (1) PL2968346T3 (pl)
WO (1) WO2014145314A2 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6458000B2 (ja) 2013-03-15 2019-01-23 キャンサー リサーチ テクノロジー リミテッド ライアビリティ カンパニー ガンマグルタミル回路調節のための方法および組成物
JP6570512B2 (ja) * 2013-03-22 2019-09-04 ユニバーシティ・オブ・ハワイUniversity Of Hawaii 新規なStat3阻害剤
US10183056B2 (en) 2014-10-16 2019-01-22 Cleveland Biolabs, Inc. Methods and compositions for the treatment of radiation-related disorders
CN107382903B (zh) * 2017-05-22 2021-02-26 重庆南松凯博生物制药有限公司 一种抗癌药物中间体的制备方法
CA3162302A1 (en) * 2019-12-19 2021-06-24 Lyne Gagnon Cycloalkyl-containing carboxylic acids and uses thereof
WO2022174062A1 (en) * 2021-02-12 2022-08-18 Recovery Therapeutics, Inc. Methods and compositions for modulating fgf activity

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4011233A (en) * 1973-06-28 1977-03-08 Givaudan Corporation 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine
JPS56133216A (en) * 1980-03-24 1981-10-19 Senjiyu Seiyaku Kk Antitumor agent
JPS57128625A (en) * 1981-01-30 1982-08-10 Rikagaku Kenkyusho Carcinostatic
ATE80801T1 (de) * 1984-12-18 1992-10-15 Clark Pharma Dev Antitumorzusammensetzungen enthaltend ein reaktionsprodukt zwischen einem cytotoxischen aldehyd und penicillamin und deren verwendung zur herstellung von arzneimitteln.
HU200177B (en) * 1985-06-18 1990-04-28 Biogal Gyogyszergyar Process for producing thiazolidinecarboxylic acids and pharmaceutical compositions comprising such compounds
JP2717257B2 (ja) * 1988-03-19 1998-02-18 参天製薬株式会社 光学活性化合物の製造法
US4970221A (en) 1989-07-28 1990-11-13 E. R. Squibb & Sons, Inc. 3,5-dihydroxypentanoic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
NL9001955A (nl) * 1990-09-05 1992-04-01 Cedona Pharm Bv Nieuwe thiazolidinederivaten.
US7425635B2 (en) * 1997-08-07 2008-09-16 University Of Utah Research Foundation Prodrugs and conjugates of thiol- and selenol-containing compounds and methods of use thereof
US6723711B2 (en) * 1999-05-07 2004-04-20 Texas Biotechnology Corporation Propanoic acid derivatives that inhibit the binding of integrins to their receptors
US20080220441A1 (en) * 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
US7064211B2 (en) * 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
KR101208266B1 (ko) * 2002-03-22 2012-12-05 에자이 알앤드디 매니지먼트 가부시키가이샤 헤미아스텔린 유도체 및 이의 용도
CA2541667A1 (en) 2003-10-14 2005-04-21 Pharmacia Corporation Substituted pyrazinone compounds for the treatment of inflammation
DE10348023A1 (de) 2003-10-15 2005-05-19 Imtm Gmbh Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
US20060014740A1 (en) * 2003-11-18 2006-01-19 Miller Duane D Analogs exhibiting inhibition of cell proliferation, methods of making, and uses thereof
JP2007513090A (ja) * 2003-11-18 2007-05-24 ユニバーシティ オブ テネシー リサーチ ファウンデーション チアゾリジノンアミド、チアゾリジンカルボン酸アミド、その製造方法、およびその使用方法
US20080176923A1 (en) * 2003-12-18 2008-07-24 Salama Zoser B Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors
BRPI0507612A (pt) * 2004-02-11 2007-07-03 Univ Ohio State Res Found análogos exibindo inibição de proliferação de célula e métodos para fabricação e uso destes
KR20060014740A (ko) 2004-08-12 2006-02-16 조정래 항균 수처리기
US7702430B2 (en) * 2004-11-19 2010-04-20 The Board Of Regents Of The University Of Texas System Method for designing a potential inhibitor of glutathione-aldehyde conjugate binding to aldose reductase
DE102004055998A1 (de) * 2004-11-19 2006-05-24 Rheinische Friedrich-Wilhelms-Universität Bonn Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie
JP4446922B2 (ja) 2005-04-21 2010-04-07 富士通メディアデバイス株式会社 フィルタおよび分波器
SI1934174T1 (sl) 2005-10-07 2011-08-31 Exelixis Inc Inhibitorji MEK in postopki za njihovo uporabo
WO2007139573A1 (en) * 2006-05-31 2007-12-06 The Trustees Of Columbia University In The City Of New York Ribosome and rna display of biologically active small molecules
US20090233972A1 (en) * 2008-03-12 2009-09-17 Yat Sun Or Substituted heterocycles as anti-infectives
KR100935543B1 (ko) 2008-04-02 2010-01-07 (주)예기산업 자연순환방식의 프리히팅장치 및 이를 이용한프리히팅시스템
KR20110022611A (ko) * 2008-06-20 2011-03-07 아스트라제네카 아베 베타2-아드레날린수용체 활성의 조절을 위한, 4-히드록시-2-옥소-2,3-디히드로-1,3-벤조티아졸-7-일 화합물을 포함하는 제약 조성물
JP5934645B2 (ja) * 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
KR20110092501A (ko) 2010-02-09 2011-08-18 주식회사 캐러스 하이브리드 항균 펩타이드 및 이의 용도
KR101395146B1 (ko) * 2011-02-09 2014-05-16 부산대학교 산학협력단 피부미백, 항산화 및 ppar 활성을 갖는 신규 화합물 및 이의 의학적 용도
WO2013168021A1 (en) * 2012-05-07 2013-11-14 Mahesh Kandula Compositions and methods for treatment of neuromuscular disorders and neurodegenerative disorders
JP6458000B2 (ja) * 2013-03-15 2019-01-23 キャンサー リサーチ テクノロジー リミテッド ライアビリティ カンパニー ガンマグルタミル回路調節のための方法および組成物

Also Published As

Publication number Publication date
US11186555B2 (en) 2021-11-30
US9630936B2 (en) 2017-04-25
ES2977144T3 (es) 2024-08-19
CA2909510A1 (en) 2014-09-18
JP6458000B2 (ja) 2019-01-23
AU2014233168A1 (en) 2015-11-05
AU2019201264A1 (en) 2019-03-14
EP2968346A2 (en) 2016-01-20
EA030611B1 (ru) 2018-08-31
CA3232320A1 (en) 2014-09-18
US20220324820A1 (en) 2022-10-13
CN105246483A (zh) 2016-01-13
JP2016515531A (ja) 2016-05-30
KR102707287B1 (ko) 2024-09-20
EA201500941A1 (ru) 2016-07-29
DK2968346T3 (da) 2024-05-06
US10323009B2 (en) 2019-06-18
US20140275187A1 (en) 2014-09-18
US20170226070A1 (en) 2017-08-10
IL241620B (en) 2021-06-30
JP2019065031A (ja) 2019-04-25
CA2909510C (en) 2024-04-02
WO2014145314A3 (en) 2014-11-13
AU2014233168B2 (en) 2018-11-22
IL283717B (en) 2022-09-01
IL283717A (en) 2021-07-29
JP6739509B2 (ja) 2020-08-12
AU2019201264B2 (en) 2020-07-16
KR20210144942A (ko) 2021-11-30
FI2968346T3 (fi) 2024-05-06
EP2968346B1 (en) 2024-02-07
WO2014145314A2 (en) 2014-09-18
US20190359580A1 (en) 2019-11-28
EP2968346A4 (en) 2017-02-08
KR20160003652A (ko) 2016-01-11

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