PL2970376T3 - Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej - Google Patents

Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej

Info

Publication number
PL2970376T3
PL2970376T3 PL14709972T PL14709972T PL2970376T3 PL 2970376 T3 PL2970376 T3 PL 2970376T3 PL 14709972 T PL14709972 T PL 14709972T PL 14709972 T PL14709972 T PL 14709972T PL 2970376 T3 PL2970376 T3 PL 2970376T3
Authority
PL
Poland
Prior art keywords
vitamin
anion exchange
exchange chromatography
purification method
dependent proteins
Prior art date
Application number
PL14709972T
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Dominik MITTERGRADNEGGER
Original Assignee
Baxalta Incorporated
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Incorporated, Baxalta GmbH filed Critical Baxalta Incorporated
Publication of PL2970376T3 publication Critical patent/PL2970376T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL14709972T 2013-03-15 2014-03-14 Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej PL2970376T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792772P 2013-03-15 2013-03-15
PCT/EP2014/055120 WO2014140289A1 (en) 2013-03-15 2014-03-14 Purification method for vitamin k dependent proteins by anion exchange chromatography
EP14709972.5A EP2970376B1 (en) 2013-03-15 2014-03-14 Purification method for vitamin k dependent proteins by anion exchange chromatography

Publications (1)

Publication Number Publication Date
PL2970376T3 true PL2970376T3 (pl) 2018-10-31

Family

ID=50277247

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14709972T PL2970376T3 (pl) 2013-03-15 2014-03-14 Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej

Country Status (12)

Country Link
US (1) US10202417B2 (pl)
EP (1) EP2970376B1 (pl)
JP (1) JP6571011B2 (pl)
AU (1) AU2014230101B2 (pl)
DK (1) DK2970376T3 (pl)
ES (1) ES2682928T3 (pl)
HU (1) HUE037677T2 (pl)
NZ (1) NZ629845A (pl)
PL (1) PL2970376T3 (pl)
SI (1) SI2970376T1 (pl)
TR (1) TR201808584T4 (pl)
WO (1) WO2014140289A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI684599B (zh) * 2014-08-12 2020-02-11 美商巴克斯歐塔公司 因子ｘ活化

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981952A (en) 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
WO1998035689A1 (en) 1997-02-14 1998-08-20 American Red Cross Expression of active human factor ix in mammary tissue of transgenic animals
DK0658168T3 (da) 1992-08-27 2001-01-22 Sanquin Bloedvoorziening Antistoffer, som er specifikke for et hæmostatisk protein, anvendelse heraf til isolering af intakt protein, hæmostatiske p
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
DE60138111D1 (de) 2000-07-21 2009-05-07 Chemo Sero Therapeut Res Inst Verfahren zur reinigung eines kalziumionen-bindenden proteins
JP2008514216A (ja) * 2004-09-29 2008-05-08 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト Ｄｅｓｇｌａ−ｖｉｉ因子ポリペプチド構造の除去による、ｖｉｉ因子ポリペプチドの原体の精製
JP2008525381A (ja) 2004-12-23 2008-07-17 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 関心のあるビタミンｋ依存性タンパク質を含んでなる組成物中におけるタンパク質混入物の量の減少
WO2007026020A1 (en) 2005-09-01 2007-03-08 Novo Nordisk Health Care Ag Purification of coagulation factor vii polypeptides
FR2901796A1 (fr) 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
DK2125866T3 (da) * 2007-02-28 2013-07-29 Baxter Int Fremgangsmåde til rensning af rekombinant blodkoagulationsfaktor IX, som er beriget med sulfaterede og/eller phosphorylerede molekyler
EP3715356B1 (en) 2009-12-18 2023-10-11 CSL Limited Method of purifying polypeptides
JP5883849B2 (ja) * 2010-04-29 2016-03-15 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 陰イオン交換樹脂を用いる二価カチオン結合タンパク質の精製方法
LT2748179T (lt) * 2011-10-14 2022-04-11 Takeda Pharmaceutical Company Limited Baltymų gryninimas anijonų mainų chromatografija
EP2748180B1 (en) * 2011-10-14 2018-08-15 Baxalta GmbH Protein purification by anion exchange chromatography

Also Published As

Publication number Publication date
NZ629845A (en) 2016-10-28
SI2970376T1 (sl) 2018-09-28
WO2014140289A1 (en) 2014-09-18
AU2014230101B2 (en) 2018-04-19
DK2970376T3 (en) 2018-07-02
US20160039869A1 (en) 2016-02-11
US10202417B2 (en) 2019-02-12
HK1219285A1 (en) 2017-03-31
HUE037677T2 (hu) 2018-09-28
ES2682928T3 (es) 2018-09-24
JP6571011B2 (ja) 2019-09-04
AU2014230101A1 (en) 2015-10-08
EP2970376A1 (en) 2016-01-20
JP2016512215A (ja) 2016-04-25
TR201808584T4 (tr) 2018-07-23
EP2970376B1 (en) 2018-05-23

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