PL3245203T3 - Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3 - Google Patents

Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3

Info

Publication number
PL3245203T3
PL3245203T3 PL16700484T PL16700484T PL3245203T3 PL 3245203 T3 PL3245203 T3 PL 3245203T3 PL 16700484 T PL16700484 T PL 16700484T PL 16700484 T PL16700484 T PL 16700484T PL 3245203 T3 PL3245203 T3 PL 3245203T3
Authority
PL
Poland
Prior art keywords
hydroxyalkyl
receptor modulators
piperazine derivatives
cxcr3 receptor
cxcr3
Prior art date
Application number
PL16700484T
Other languages
English (en)
Inventor
Eva Caroff
Emmanuel Meyer
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of PL3245203T3 publication Critical patent/PL3245203T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL16700484T 2015-01-15 2016-01-14 Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3 PL3245203T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2015050696 2015-01-15
EP16700484.5A EP3245203B1 (en) 2015-01-15 2016-01-14 Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
PCT/EP2016/050645 WO2016113344A1 (en) 2015-01-15 2016-01-14 Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators

Publications (1)

Publication Number Publication Date
PL3245203T3 true PL3245203T3 (pl) 2019-05-31

Family

ID=55129886

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16700484T PL3245203T3 (pl) 2015-01-15 2016-01-14 Pochodne hydroksyalkilopiperazyny jako modulatory receptora cxcr3

Country Status (38)

Country Link
US (1) US10053457B2 (pl)
EP (1) EP3245203B1 (pl)
JP (1) JP6337218B2 (pl)
KR (1) KR101967083B1 (pl)
CN (1) CN107250133B (pl)
AR (1) AR103414A1 (pl)
AU (1) AU2016207988B2 (pl)
BR (1) BR112017015093A2 (pl)
CA (1) CA2972952C (pl)
CL (1) CL2017001831A1 (pl)
CO (1) CO2017008156A2 (pl)
CY (1) CY1121361T1 (pl)
DK (1) DK3245203T3 (pl)
EA (1) EA032927B1 (pl)
ES (1) ES2709985T3 (pl)
HK (1) HK1246789B (pl)
HR (1) HRP20190024T1 (pl)
HU (1) HUE042559T2 (pl)
IL (1) IL253411B (pl)
LT (1) LT3245203T (pl)
MA (1) MA41337A (pl)
MX (1) MX2017009288A (pl)
MY (1) MY187614A (pl)
NZ (1) NZ734542A (pl)
PE (1) PE20171100A1 (pl)
PH (1) PH12017501280B1 (pl)
PL (1) PL3245203T3 (pl)
PT (1) PT3245203T (pl)
RS (1) RS58349B1 (pl)
SA (1) SA517381905B1 (pl)
SG (1) SG11201705617XA (pl)
SI (1) SI3245203T1 (pl)
TN (1) TN2017000278A1 (pl)
TR (1) TR201900680T4 (pl)
TW (1) TWI693221B (pl)
UA (1) UA119805C2 (pl)
WO (1) WO2016113344A1 (pl)
ZA (1) ZA201705486B (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201600504TA (en) 2013-07-22 2016-02-26 Actelion Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR103399A1 (es) * 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
TWI693221B (zh) * 2015-01-15 2020-05-11 瑞士商愛杜西亞製藥有限公司 作為ｃｘｃｒ３受體調節劑之羥烷基六氫吡衍生物
WO2018011265A1 (en) * 2016-07-13 2018-01-18 Idorsia Pharmaceuticals Ltd Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
WO2020060964A1 (en) * 2018-09-18 2020-03-26 Alxerion Biotech Corp. 1, 2, 4-oxadiazole derivatives and uses thereof
JP2024504785A (ja) * 2021-01-28 2024-02-01 イドーシア ファーマシューティカルズ リミテッド ピペラジニル－チアゾール誘導体の結晶形
US20250381184A1 (en) 2022-09-09 2025-12-18 Idorsia Pharmaceuticals Ltd Pharmaceutical combination comprising an anti-cd3 antibody and a cxcr3 antagonist

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1370558B1 (en) 2001-01-23 2005-08-24 Eli Lilly And Company Piperazine- and piperidine-derivatives as melanocortin receptor agonists
WO2002059107A1 (en) 2001-01-23 2002-08-01 Eli Lilly And Company Substituted piperidines/piperazines as melanocortin receptor agonists
WO2002079146A2 (en) 2001-03-02 2002-10-10 Bristol-Myers Squibb Company Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same
MXPA04012393A (es) 2002-06-12 2005-06-17 Chemocentryx Derivados de piperazina 1-aril-4-substituidos para utilizar como antagonistas ccr1 para tratamiento de inflamacion y desordenes inmunes.
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
GB0315203D0 (en) 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
WO2005035534A1 (ja) 2003-10-08 2005-04-21 Ono Pharmaceutical Co., Ltd. 複素ビシクロ環および複素トリシクロ環化合物およびその医薬
US20050124625A1 (en) 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
US20050119252A1 (en) 2003-10-22 2005-06-02 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
US20050130954A1 (en) 2003-11-21 2005-06-16 Mitchell Ian S. AKT protein kinase inhibitors
MY140489A (en) 2003-12-26 2009-12-31 Eisai R&D Man Co Ltd 1,2-di (cyclic) substituted benzene compounds
US20060276465A1 (en) 2003-12-26 2006-12-07 Eisai R&D Management Co., Ltd. 1,2-di(cyclic) substituted benzene compounds
ES2611604T3 (es) 2004-10-22 2017-05-09 Janssen Pharmaceutica Nv Inhibidores de la c fms quinasa
US7645755B2 (en) 2004-10-22 2010-01-12 Janssen Pharmaceutical N.V. Inhibitors of c-fms kinase
CN101163692B (zh) 2005-02-16 2012-01-18 先灵公司 具有cxcr3拮抗活性的杂环取代的哌嗪
CN101146793A (zh) 2005-02-16 2008-03-19 先灵公司 具有cxcr3拮抗剂活性的新的杂环取代了的吡啶或苯基化合物
US7879838B2 (en) 2005-02-16 2011-02-01 Schering Corporation Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity
MX2007010068A (es) 2005-02-16 2007-10-10 Schering Corp Piperazino-piperidinas con actividad antagonista de cxcr3.
CA2598460C (en) 2005-02-16 2013-05-07 Schering Corporation Amine-linked pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity
MX2007009946A (es) 2005-02-16 2007-09-26 Schering Corp Piperazin-piperidinas sustituidas con piridilo y fenilo con actividad antagonista de cxcr3.
EP1856098B1 (en) 2005-02-16 2012-08-01 Schering Corporation Pyrazinyl substituted piperazine-piperidines with cxcr3 antagonist activity
ZA200800309B (en) 2005-06-22 2009-10-28 Chemocentryx Inc Azaindazole compounds and methods of use
US7777035B2 (en) 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
US20080312215A1 (en) 2005-06-28 2008-12-18 Pharmacopeia Drug Discovery, Inc. Substituted [1,4]-diazepanes as CXCR3 antagonists and their use in the treatment of inflammatory disorders
US7754724B2 (en) 2005-06-30 2010-07-13 Dow Agrosciences Llc N-substituted piperazines
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
US7781437B2 (en) 2005-10-11 2010-08-24 Schering Corporation Substituted heterocyclic compounds with CXCR3 antagonist activity
EP1951234A2 (en) 2005-10-18 2008-08-06 Janssen Pharmaceutica N.V. Method of inhibiting flt3 kinase
US20090143413A1 (en) 2005-11-29 2009-06-04 Adams Alan D Thiazole Derivatives as CXCR3 Receptor Modulators
US20070126158A1 (en) 2005-12-01 2007-06-07 3M Innovative Properties Company Method of cleaning polymeric mold
US20100286191A1 (en) 2005-12-12 2010-11-11 Samuel Rachel G 2-Arylthiazole Derivatives as CXCR3 Receptor Modulators
WO2007076318A2 (en) 2005-12-21 2007-07-05 Smithkline Beecham Corporation Camphor-derived cxcr3 antagonists
US20090030012A1 (en) 2006-02-23 2009-01-29 Adams Alan D Pyridine, Pyrimidine and Pyrazine Derivatives as Cxcr3 Receptor Modulators
AU2007227425A1 (en) 2006-03-21 2007-09-27 Pharmacopeia, Inc. Heterocyclic substituted pyridine compounds with CXCR3 antagonist activity
EP2397138B1 (en) 2006-04-20 2013-12-11 Janssen Pharmaceutica NV Aromatic amide derivatives as C-KIT kinase inhibitors
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
FR2903405B1 (fr) 2006-07-04 2011-09-09 Pasteur Institut Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications
US7902199B2 (en) 2006-07-14 2011-03-08 Schering Corporation Heterocyclic substituted piperazine compounds with CXCR3 antagonist activity
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
MX2009006871A (es) 2006-12-22 2009-07-07 Schering Corp Compuestos heterociclicos con actividad antagonista de cxcr3.
WO2008091594A2 (en) 2007-01-24 2008-07-31 E. I. Du Pont De Nemours And Company Fungicidal mixtures
BRPI0806214A2 (pt) 2007-01-25 2011-08-30 Du Pont composto, método para o controla das doenças vegetais causadas por patogenos vegetais fúngicos oomycete e composições fungicidas
MX2010001400A (es) 2007-08-03 2010-04-22 Schering Corp Metodo para tratar enfermedades mediadas cxcr3 usando piperazinas heterociclicas sustituidas.
TWI428091B (zh) 2007-10-23 2014-03-01 Du Pont 殺真菌劑混合物
WO2009079490A1 (en) 2007-12-18 2009-06-25 Schering Corporation Process and intermediates for the synthesis of heterocyclic substituted piperazines with cxcr3 antagonist activity
JP5529044B2 (ja) 2008-01-25 2014-06-25 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 殺菌性複素環化合物
WO2009094407A2 (en) 2008-01-25 2009-07-30 E. I. Du Pont De Nemours And Company Fungicidal amides
PE20091576A1 (es) 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
PT2280965E (pt) 2008-04-30 2012-11-13 Bayer Cropscience Ag Ésteres e tioésteres de ácido tiazol-4-carboxílico como agentes para a protecção de plantas
KR20110067052A (ko) 2008-10-01 2011-06-20 바이엘 크롭사이언스 아게 식물 보호제로서의 헤테로사이클릴 치환된 티아졸
KR101052065B1 (ko) 2008-10-15 2011-07-27 한국과학기술연구원 칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법
PL2358709T3 (pl) 2008-12-02 2014-06-30 Du Pont Grzybobójcze związki heterocykliczne
CN102292334A (zh) 2008-12-11 2011-12-21 拜尔农作物科学股份公司 噻唑基肟醚和腙植物保护剂
JP5807971B2 (ja) * 2009-04-27 2015-11-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｘｃｒ３受容体アンタゴニスト
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
EP2272846A1 (de) 2009-06-23 2011-01-12 Bayer CropScience AG Thiazolylpiperidin Derivate als Fungizide
GEP20146079B (en) 2009-08-12 2014-04-25 Syngenta Participations Ag Microbiocidal heterocycles
UA107938C2 (en) 2009-08-12 2015-03-10 Syngenta Participations Ag Heterocycles with microbicidal properties
WO2011051243A1 (en) 2009-10-29 2011-05-05 Bayer Cropscience Ag Active compound combinations
WO2011051244A1 (de) 2009-10-30 2011-05-05 Bayer Cropscience Ag Heteroarylpiperidin und -piperazin derivate
KR101808074B1 (ko) 2009-12-21 2017-12-12 바이엘 크롭사이언스 악티엔게젤샤프트 살진균제로 사용되는 비스(디플루오로메틸)피라졸
US8952004B2 (en) 2010-01-07 2015-02-10 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
MX2012012460A (es) 2010-04-28 2012-11-21 Bayer Cropscience Ag Derivados de cetoheteroarilpiperidina y de cetoheteroarilpiperazin a como fungicidas.
US8815775B2 (en) 2010-05-18 2014-08-26 Bayer Cropscience Ag Bis(difluoromethyl)pyrazoles as fungicides
EP2571866A1 (en) 2010-05-20 2013-03-27 E.I. Du Pont De Nemours And Company Fungicidal oximes and hydrazones
BR112012030184A2 (pt) 2010-05-27 2015-12-29 Bayer Cropscience Ag derivados de ácido piridinilcarboxílico como fungicidas
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
UA112534C2 (uk) 2010-10-27 2016-09-26 Байєр Інтеллектуал Проперті Гмбх Похідні гетероарилпіперидину, проміжні сполуки, композиція для боротьби із шкідливими фітопатогенними грибами та спосіб її виготовлення
CN103228645A (zh) 2010-11-25 2013-07-31 先正达参股股份有限公司 杀微生物杂环
MX2013006936A (es) 2010-12-17 2013-07-22 Du Pont Ambas azociclicas fungicidas.
KR101848116B1 (ko) 2011-02-01 2018-04-11 바이엘 인텔렉쳐 프로퍼티 게엠베하 살진균제로서의 헤테로아릴 피페리딘 및 헤테로아릴 피페라진 유도체
WO2012107475A1 (en) 2011-02-10 2012-08-16 Syngenta Participations Ag Microbiocidal pyrazole derivatives
CN103347879A (zh) 2011-02-10 2013-10-09 先正达参股股份有限公司 杀微生物的吡唑衍生物
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
JP5959646B2 (ja) 2011-09-15 2016-08-02 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 殺菌剤としてのピペリジンピラゾール類
US20140243371A1 (en) 2011-10-18 2014-08-28 Syngenta Participations Ag Microbiocidal pyrazole derivatives
US20140228372A1 (en) 2011-10-18 2014-08-14 Syngenta Participations Ag Microbiocidal pyrazole derivatives
US8642774B2 (en) 2011-12-08 2014-02-04 Boehringer Ingelheim International Gmbh Compounds
US8889677B2 (en) 2012-01-17 2014-11-18 Boehringer Ingellheim International GmbH Substituted triazoles useful as mGlu5 receptor modulators
US20150011565A1 (en) 2012-01-25 2015-01-08 Spinifex Pharmaceuticals Pty Ltd Heterocyclic Compounds and Methods For Their Use
EP2809668B1 (en) * 2012-02-02 2017-04-12 Actelion Pharmaceuticals Ltd. 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives
US20160007606A1 (en) 2012-03-02 2016-01-14 Syngenta Participations Ag Microbiocidal pyrazole derivatives
IN2012DE00621A (pl) 2012-03-02 2015-07-17 Syngenta Participations Ag
TWI570120B (zh) * 2012-06-04 2017-02-11 艾克泰聯製藥有限公司 苯并咪唑脯胺酸衍生物
WO2014062938A1 (en) 2012-10-19 2014-04-24 Bristol-Myers Squibb Company Rory modulators
WO2014075873A1 (en) 2012-11-13 2014-05-22 Syngenta Participations Ag Microbiocidal pyrazole derivatives
WO2014075874A1 (en) 2012-11-13 2014-05-22 Syngenta Participations Ag Microbiocidal pyrazole derivatives
WO2014092100A1 (ja) 2012-12-11 2014-06-19 武田薬品工業株式会社 複素環化合物
JP6430494B2 (ja) 2013-06-24 2018-11-28 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 殺真菌剤としてのピペリジンカルボン酸誘導体
SG11201600504TA (en) * 2013-07-22 2016-02-26 Actelion Pharmaceuticals Ltd 1-(piperazin-1-yl)-2-([1,2,4]triazol-1-yl)-ethanone derivatives
US9718818B2 (en) 2013-08-22 2017-08-01 Merck Sharp & Dohme Corp. Compounds inhibiting leucine-rich repeat kinase enzyme activity
AR099789A1 (es) 2014-03-24 2016-08-17 Actelion Pharmaceuticals Ltd Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
AR103399A1 (es) 2015-01-15 2017-05-10 Actelion Pharmaceuticals Ltd Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3
TWI693221B (zh) * 2015-01-15 2020-05-11 瑞士商愛杜西亞製藥有限公司 作為ｃｘｃｒ３受體調節劑之羥烷基六氫吡衍生物

Also Published As

Publication number Publication date
KR20170102010A (ko) 2017-09-06
TW201632519A (zh) 2016-09-16
MX2017009288A (es) 2017-10-11
JP6337218B2 (ja) 2018-06-06
ZA201705486B (en) 2019-06-26
PT3245203T (pt) 2019-02-08
IL253411A0 (en) 2017-09-28
PH12017501280A1 (en) 2018-01-15
SA517381905B1 (ar) 2021-04-01
EP3245203B1 (en) 2018-11-14
EA032927B1 (ru) 2019-08-30
US20180009799A1 (en) 2018-01-11
CA2972952C (en) 2021-01-05
AR103414A1 (es) 2017-05-10
PH12017501280B1 (en) 2020-10-23
TWI693221B (zh) 2020-05-11
IL253411B (en) 2020-08-31
BR112017015093A2 (pt) 2018-04-17
SG11201705617XA (en) 2017-08-30
CA2972952A1 (en) 2016-07-21
LT3245203T (lt) 2019-02-11
US10053457B2 (en) 2018-08-21
JP2018502161A (ja) 2018-01-25
PE20171100A1 (es) 2017-08-07
TN2017000278A1 (en) 2019-01-16
UA119805C2 (uk) 2019-08-12
MA41337A (fr) 2017-11-22
KR101967083B1 (ko) 2019-04-08
AU2016207988A1 (en) 2017-08-31
CN107250133B (zh) 2020-09-15
HRP20190024T1 (hr) 2019-02-22
HUE042559T2 (hu) 2019-07-29
CN107250133A (zh) 2017-10-13
RS58349B1 (sr) 2019-03-29
DK3245203T3 (en) 2019-02-18
CO2017008156A2 (es) 2017-11-30
WO2016113344A1 (en) 2016-07-21
CL2017001831A1 (es) 2018-05-11
EP3245203A1 (en) 2017-11-22
EA201791600A1 (ru) 2018-03-30
NZ734542A (en) 2023-02-24
ES2709985T3 (es) 2019-04-22
TR201900680T4 (tr) 2019-02-21
SI3245203T1 (sl) 2019-03-29
CY1121361T1 (el) 2020-05-29
MY187614A (en) 2021-10-04
AU2016207988B2 (en) 2019-08-15
HK1246789B (en) 2019-11-22

Similar Documents

Publication Publication Date Title
IL252554A0 (en) A history of mutated 2-anilinopyrimidines as egfr modulators
GB201514875D0 (en) Receptor
GB201518816D0 (en) Receptor
IL274537A (en) nuclear receptor modulators
ZA201700342B (en) Novel glp-1 receptor modulators
EP3180332A4 (en) Difluoropyrrolidines as orexin receptor modulators
IL246625A0 (en) Modulators of trpa1
ZA201800827B (en) Substituted 4-azaindoles and their use as glun2b receptor modulators
ZA201705486B (en) Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators
EP3224261A4 (en) Opioid receptor modulators
PL3303291T3 (pl) Modulatory ROR-gamma
PL3303290T3 (pl) Modulatory ROR-gamma
PL3303293T3 (pl) Modulatory ROR-gamma
IL250247A0 (en) History of piperazine as liver x-receptor modulators
HUE051142T2 (hu) Fogpótlásrögzítõ eszköz
PL3319942T3 (pl) MODULATORY ROR-GAMMA (RORγ)
IL252565A0 (en) New receptor modulators
PL3256469T3 (pl) Pochodne (r)-2-metylopiperazyny jako modulatory receptora cxcr3
PT3097076T (pt) Novos derivados cyp-eicosanoides
GB201512714D0 (en) Receptor modulator compounds
GB201504285D0 (en) Receptor modulation
GB201407888D0 (en) Novel specific kinase modulators
GB201405403D0 (en) Receptor modulation