PL327820A1 - Hydroxamic acid based collagenase inhibitors - Google Patents

Hydroxamic acid based collagenase inhibitors

Info

Publication number: PL327820A1
Authority: PL; Poland
Prior art keywords: hydroxamic acid; acid based; collagenase inhibitors; based collagenase; inhibitors
Prior art date: 1996-01-17

Application number

PL97327820A

Other languages

English (en)

Inventor

Stuart Bailey

Derek Richard Buckle

Andrew Faller

David Glynn Smith

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-17

Filing date

1997-01-14

Publication date

1999-01-04

1997-01-14 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-01-04 Publication of PL327820A1 publication Critical patent/PL327820A1/xx

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
239000002253 acid Substances 0.000 title 1
239000002442 collagenase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL97327820A 1996-01-17 1997-01-14 Hydroxamic acid based collagenase inhibitors PL327820A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9601041.8A GB9601041D0 (en)	1996-01-17	1996-01-17	Novel compounds
PCT/EP1997/000196 WO1997026257A1 (fr)	1996-01-17	1997-01-14	Inhibiteurs de la collagenase, a base d'acide hydroxamique

Publications (1)

Publication Number	Publication Date
PL327820A1 true PL327820A1 (en)	1999-01-04

Family

ID=10787226

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL97327820A PL327820A1 (en)	1996-01-17	1997-01-14	Hydroxamic acid based collagenase inhibitors

Country Status (19)

Country	Link
EP (1)	EP0912545A1 (fr)
JP (1)	JP2000503312A (fr)
KR (1)	KR19990077325A (fr)
CN (1)	CN1213368A (fr)
AR (1)	AR005472A1 (fr)
AU (1)	AU725056B2 (fr)
BR (1)	BR9707024A (fr)
CA (1)	CA2242913A1 (fr)
CZ (1)	CZ222498A3 (fr)
GB (1)	GB9601041D0 (fr)
HU (1)	HUP9901022A3 (fr)
IL (1)	IL125381A0 (fr)
NO (1)	NO983283L (fr)
NZ (1)	NZ326352A (fr)
PL (1)	PL327820A1 (fr)
TR (1)	TR199801380T2 (fr)
TW (1)	TW462967B (fr)
WO (1)	WO1997026257A1 (fr)
ZA (1)	ZA97345B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6548084B2 (en)	1995-07-20	2003-04-15	Smithkline Beecham Plc	Controlled release compositions
GB9609795D0 (en) *	1996-05-10	1996-07-17	Smithkline Beecham Plc	Novel compounds
AU1960100A (en) *	1999-01-06	2000-07-24	Mcmaster University	Method of preventing immune and hypersensitivity reactions
GB9922825D0 (en) *	1999-09-25	1999-11-24	Smithkline Beecham Biolog	Medical use
AU2001271068A1 (en) *	2000-07-18	2002-01-30	Chugai Seiyaku Kabushiki Kaisha	Matrix metalloprotease inhibitors
WO2003064472A2 (fr) *	2002-01-28	2003-08-07	Aimsco Limited	Traitement
US7521563B2 (en)	2004-08-10	2009-04-21	Shizuoka Coffein Co., Ltd.	Hydroxamic acid derivative and medicine containing the same as active ingredient
KR100844277B1 (ko) *	2005-04-29	2008-07-07	(주)아모레퍼시픽	히드록삼산 유도체 및 이의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4743587A (en) *	1985-09-10	1988-05-10	G. D. Searle & Co.	Hydroxamic acid based collagenase inhibitors
GB8827305D0 (en) *	1988-11-23	1988-12-29	British Bio Technology	Compounds
GB9504084D0 (en) *	1995-03-01	1995-04-19	British Biotech Pharm	Synthesis of carboxylic and hydroxamic acid derivatives

1996
- 1996-01-17 GB GBGB9601041.8A patent/GB9601041D0/en active Pending
1997
- 1997-01-14 NZ NZ326352A patent/NZ326352A/xx unknown
- 1997-01-14 KR KR1019980705472A patent/KR19990077325A/ko not_active Withdrawn
- 1997-01-14 AU AU14436/97A patent/AU725056B2/en not_active Ceased
- 1997-01-14 JP JP9525693A patent/JP2000503312A/ja active Pending
- 1997-01-14 CA CA002242913A patent/CA2242913A1/fr not_active Abandoned
- 1997-01-14 BR BR9707024A patent/BR9707024A/pt unknown
- 1997-01-14 TR TR1998/01380T patent/TR199801380T2/xx unknown
- 1997-01-14 HU HU9901022A patent/HUP9901022A3/hu unknown
- 1997-01-14 EP EP97901055A patent/EP0912545A1/fr not_active Withdrawn
- 1997-01-14 IL IL12538197A patent/IL125381A0/xx unknown
- 1997-01-14 PL PL97327820A patent/PL327820A1/xx unknown
- 1997-01-14 WO PCT/EP1997/000196 patent/WO1997026257A1/fr not_active Ceased
- 1997-01-14 CZ CZ982224A patent/CZ222498A3/cs unknown
- 1997-01-14 CN CN97192982A patent/CN1213368A/zh active Pending
- 1997-01-15 AR ARP970100153A patent/AR005472A1/es unknown
- 1997-01-16 ZA ZA97345A patent/ZA97345B/xx unknown
- 1997-01-30 TW TW086101017A patent/TW462967B/zh active
1998
- 1998-07-16 NO NO983283A patent/NO983283L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2000503312A (ja)	2000-03-21
HUP9901022A3 (en)	2001-11-28
NO983283D0 (no)	1998-07-16
TW462967B (en)	2001-11-11
CN1213368A (zh)	1999-04-07
NZ326352A (en)	2000-03-27
EP0912545A1 (fr)	1999-05-06
CA2242913A1 (fr)	1997-07-24
AU725056B2 (en)	2000-10-05
TR199801380T2 (xx)	1998-10-21
BR9707024A (pt)	1999-07-20
ZA97345B (en)	1998-07-16
WO1997026257A1 (fr)	1997-07-24
NO983283L (no)	1998-09-16
IL125381A0 (en)	1999-03-12
CZ222498A3 (cs)	1999-03-17
AU1443697A (en)	1997-08-11
HUP9901022A2 (hu)	1999-07-28
GB9601041D0 (en)	1996-03-20
AR005472A1 (es)	1999-06-23
KR19990077325A (ko)	1999-10-25

Publication	Publication Date	Title
HRP980438B1 (en)	2003-04-30	Aryloxyarylsulfonylamino hydroxamic acid derivatives
PL331895A1 (en)	1999-08-16	Arylosulphonylamino derivatives of hydroxamic acid
IL128665A0 (en)	2000-01-31	Bidenatate metalloprotease inhibitors
HUP9901022A3 (en)	2001-11-28	Hydroxamic acid based collagenase inhibitors
GB9624817D0 (en)	1997-01-15	Metalloproteinase inhibitors
GB9707333D0 (en)	1997-05-28	Metalloproteinase inhibitors
DK0929517T3 (da)	2002-10-07	Hydroxamsyrederivater
GB9401034D0 (en)	1994-03-16	Metalloproteinase inhibitors
GB9710490D0 (en)	1997-07-16	Metalloproteinase inhibitors
HK1019746A (en)	2000-02-25	Hydroxamic acid based collagenase inhibitors
GB2299334B (en)	1998-05-13	Metalloproteinase inhibitors
ZA964668B (en)	1998-02-25	Hydroxamic acid and amino-carboxylate compounds as metalloprotease and TNF inhibitors.
GB9612727D0 (en)	1996-08-21	Hydroxamic acid derivatives as metalloproteinase inhibitors
SI1003720T1 (en)	2004-06-30	Aryloxyarylsulfonylamino hydroxamic acid derivatives
GB9625871D0 (en)	1997-01-29	Metalloproteinase inhibitors
GB9626672D0 (en)	1997-02-12	Metalloproteinase inhibitors
GB9625154D0 (en)	1997-01-22	Metalloproteinase inhibitors
GB9610985D0 (en)	1996-07-31	Metalloproteinase inhibitors
GB2315750B (en)	1998-07-01	Metalloproteinase inhibitors
GB9415619D0 (en)	1994-09-21	Metalloprotease inhibitors
GB9707313D0 (en)	1997-05-28	Metalloproteinase Inhibitors
GB9723758D0 (en)	1998-01-07	Metalloproteinase inhibitors
GB9713472D0 (en)	1997-09-03	Metalloproteinase inhibitors
GB9708571D0 (en)	1997-06-18	Metalloproteinase inhibitors
GB9706212D0 (en)	1997-05-14	Metalloproteinase inhibitors