PL3288637T3 - Kierowanie nad+ do leczenia indukowanych chemioterapią i radioterapią zaburzenia funkcji poznawczych, neuropatii i nieaktywności - Google Patents

Kierowanie nad+ do leczenia indukowanych chemioterapią i radioterapią zaburzenia funkcji poznawczych, neuropatii i nieaktywności

Info

Publication number
PL3288637T3
PL3288637T3 PL16787140.9T PL16787140T PL3288637T3 PL 3288637 T3 PL3288637 T3 PL 3288637T3 PL 16787140 T PL16787140 T PL 16787140T PL 3288637 T3 PL3288637 T3 PL 3288637T3
Authority
PL
Poland
Prior art keywords
neuropathies
inactivity
cognitive impairment
induced cognitive
radiotherapy induced
Prior art date
Application number
PL16787140.9T
Other languages
English (en)
Inventor
David A. Sinclair
Lindsay Wu
Original Assignee
Newsouth Innovations Pty Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newsouth Innovations Pty Limited filed Critical Newsouth Innovations Pty Limited
Publication of PL3288637T3 publication Critical patent/PL3288637T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02012—Nicotinamide phosphoribosyltransferase (2.4.2.12), i.e. visfatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07001—Nicotinamide-nucleotide adenylyltransferase (2.7.7.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PL16787140.9T 2015-04-28 2016-04-28 Kierowanie nad+ do leczenia indukowanych chemioterapią i radioterapią zaburzenia funkcji poznawczych, neuropatii i nieaktywności PL3288637T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562153876P 2015-04-28 2015-04-28
PCT/US2016/029765 WO2016176437A1 (en) 2015-04-28 2016-04-28 Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity

Publications (1)

Publication Number Publication Date
PL3288637T3 true PL3288637T3 (pl) 2022-12-19

Family

ID=57198851

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16787140.9T PL3288637T3 (pl) 2015-04-28 2016-04-28 Kierowanie nad+ do leczenia indukowanych chemioterapią i radioterapią zaburzenia funkcji poznawczych, neuropatii i nieaktywności

Country Status (12)

Country Link
US (2) US10603334B2 (pl)
EP (1) EP3288637B1 (pl)
JP (2) JP7193232B2 (pl)
KR (1) KR20180006389A (pl)
CN (2) CN113244396A (pl)
AU (1) AU2016255853B2 (pl)
CA (1) CA2984379C (pl)
DK (1) DK3288637T3 (pl)
ES (1) ES2927894T3 (pl)
PL (1) PL3288637T3 (pl)
PT (1) PT3288637T (pl)
WO (1) WO2016176437A1 (pl)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3068364B1 (en) * 2013-11-14 2021-11-03 Metro Biotech NSW Pty Ltd Nad+ precursor selected from nmn, naad, namn, or a pharmaceutically acceptable salt thereof, for use in treating a side effect of chemotherapy and/or radiotherapy in a subject
CA2984379C (en) 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity
CA3069555A1 (en) 2016-07-15 2018-01-18 H2 Water Technologies Ltd Composition for producing hydrogen rich water and other products
US20200179441A1 (en) * 2017-04-27 2020-06-11 H2 Water Technologies Ltd. Synergistic compositions for increasing mitochondrial function and energy
CN107213159B (zh) * 2017-06-05 2020-06-23 苏州人本药业有限公司 Nadph在制备抗焦虑药物中的应用
CN107213160B (zh) * 2017-06-06 2020-07-24 重庆纳德福实业集团有限公司 Nadph在拮抗药物致线粒体毒性中的应用
CN107233352A (zh) * 2017-06-20 2017-10-10 同济大学 烟酰胺腺嘌呤二核苷酸在制备治疗炎性痛药物中的应用
CN107158021A (zh) * 2017-06-20 2017-09-15 同济大学 烟酰胺腺嘌呤二核苷酸在制备治疗癌性疼痛药物的应用
JP2020526511A (ja) * 2017-06-30 2020-08-31 エリジウム・ヘルス・インコーポレイテッド ニコチンアミドリボシドの合成方法
CN108578403A (zh) * 2018-01-31 2018-09-28 南京中医药大学 小檗碱用于制备防治化疗诱导的周围神经病变药物的用途
WO2019165372A1 (en) * 2018-02-26 2019-08-29 President And Fellows Of Harvard College Compositions of parp14 modulators and/or mutants and therapeutic use thereof
WO2019221528A1 (en) * 2018-05-17 2019-11-21 Helixmith Co., Ltd. Treatment of neuropathic pain associated with chemotherapy-induced peripheral neuropathy
EP3972593B1 (en) * 2019-05-23 2025-07-02 Board of Regents, The University of Texas System Inhibitor of mnk for the treatment of neuropathic pain
CN110237089A (zh) * 2019-06-19 2019-09-17 泓博元生命科技（深圳）有限公司 Nadh和/或nmn防治男性勃起功能障碍的应用
JP7675061B2 (ja) 2019-07-19 2025-05-12 バイオシント アクチェンゲゼルシャフト ニコチンアミドリボフラノシド塩の製造方法、ニコチンアミドリボフラノシド塩自体、およびその使用
CN110507695A (zh) * 2019-08-20 2019-11-29 泓博元生命科技（深圳）有限公司 Nadh和/或nmn在制备脑功能恢复的药物、保健品中的应用
CN114423439B (zh) * 2019-09-09 2024-12-31 努瓦米德股份有限公司 Nmn用于预防和/或治疗疼痛的用途及相应组合物
FR3100449B1 (fr) * 2019-09-09 2022-08-26 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la douleur et compositions correspondantes
CN112569243A (zh) * 2019-09-30 2021-03-30 神农医药科技有限公司 制备治疗阿尔茨海默病的药物
CN110974781A (zh) * 2020-01-02 2020-04-10 崔立峰 一种用于皮肤创面修复的凝胶
FR3106056B1 (fr) * 2020-01-13 2021-12-17 Nuvamid Utilisation de NMN pour la prévention et/ou le traitement d’une douleur articulaire induite par l’activité physique et compositions correspondantes
FR3108032B1 (fr) * 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur musculaire, ligamentaire ou tendineuse induite par l’activité physique et compositions correspondantes
FR3108031B1 (fr) * 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur dorsale et compositions correspondantes
JP7633238B2 (ja) * 2020-05-11 2025-02-19 サントリーホールディングス株式会社 ニコチンアミドアデニンジヌクレオチド（ｎａｄ）濃度上昇剤
US20230270770A1 (en) * 2020-07-30 2023-08-31 Moises HERNANDEZ-VAZQUEZ Nutritional supplements for repairing muscle and defending against deterioration from human aging
CN112076204A (zh) * 2020-09-29 2020-12-15 深圳雾件科技有限公司 一种烟酰胺单核苷酸在运动神经元修复的应用
CN114432309A (zh) * 2020-11-06 2022-05-06 中国科学院深圳先进技术研究院 一种提高烟酰胺磷酸核糖转移酶活性的方法及其组合物
WO2022094916A1 (zh) * 2020-11-06 2022-05-12 中国科学院深圳先进技术研究院 一种提高烟酰胺磷酸核糖转移酶活性的方法及其组合物
CN112891364A (zh) * 2021-03-15 2021-06-04 深圳市新靶向生物科技有限公司 一种用于防治细胞受γ射线和中子核辐射损伤的药物
CN114045288A (zh) * 2021-10-21 2022-02-15 浙江大学 靶向敲降SIRT2基因的shRNA及烟酰胺腺嘌呤二核苷酸的前体在制备治疗神经退行性疾病的药物中的应用
CN113750242A (zh) * 2021-10-28 2021-12-07 复旦大学附属中山医院 Nmn联合cd38抑制剂在制备预防或治疗阿霉素所致心脏毒性药物中的应用
CN116236498A (zh) * 2021-12-08 2023-06-09 深圳先进技术研究院 二氢烟酰胺核糖和烟酰胺单核苷酸在治疗青春期自伤和恶劣环境因素诱导抑郁中的应用
US12552760B2 (en) 2022-04-22 2026-02-17 The Board Of Trustees Of The University Of Illinois Compounds for increasing the nicotinamide adenine dinucleotide in a subject and methods of use thereof
CN114807189A (zh) * 2022-05-27 2022-07-29 河南大学淮河医院 一种增加海马神经元树突分支及树突棘数量的靶基因、药物及应用
WO2024086306A1 (en) * 2022-10-19 2024-04-25 Vitakey Inc. Formulated food products
WO2024100421A1 (en) * 2022-11-12 2024-05-16 Cambridge Enterprise Limited Sarm1 inhibitors for use in therapy and cosmetics
WO2024201281A1 (en) * 2023-03-28 2024-10-03 Wonderfeel Methods and compositions for treatment of pain
CN116251089A (zh) * 2023-04-24 2023-06-13 安徽科技学院 一种改善抑郁症的组合物及其在保健品、食品或药物中的应用
CN121152567A (zh) 2023-05-12 2025-12-16 明治控股股份有限公司 用于促进儿童的发育的组合物
WO2024258622A1 (en) * 2023-06-13 2024-12-19 Alkahest, Inc. Blood plasma fractions as a treatment for chemotherapy induced cognitive disorders
CN117338802A (zh) * 2023-10-12 2024-01-05 复旦大学附属眼耳鼻喉科医院 氧化型烟酰胺腺嘌呤二核苷酸的补充剂的新用途
CN118319935A (zh) * 2024-04-17 2024-07-12 音芙医药科技(上海)有限公司 一种还原型β-烟酰胺单核苷酸的药物用途
EP4643856A1 (en) * 2024-05-03 2025-11-05 Centre National de la Recherche Scientifique Carbazole derivatives used as neuroprotectants and in the treatment of disorders with reduced nad metabolism

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
EP1042280A2 (en) 1997-12-24 2000-10-11 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
HK1046848B (zh) 2000-03-03 2006-04-13 李叔文 爱滋病特效药
US7012086B1 (en) 2000-06-30 2006-03-14 The Foundation For Innovative Therapies, Inc. Treatment of retrovirus induced derangements with niacin compounds
US7977049B2 (en) 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
CN1964627B (zh) 2004-06-04 2011-10-19 华盛顿大学 治疗神经病变的方法和组合物
ES2510690T3 (es) 2004-12-17 2014-10-21 Alan B. Cash Método para extender la esperanza de vida y retrasar la aparición de enfermedad relacionada con la edad
EP2805719A1 (en) * 2005-03-30 2014-11-26 Glaxosmithkline LLC Nicotinamide riboside and analogues thereof
CN100348202C (zh) 2005-04-28 2007-11-14 刘朝雄 一种治疗皮肤病的口服复方制剂
US7737158B2 (en) 2005-10-11 2010-06-15 Washington University Processes for regulating blood glucose in a mammal
WO2007061798A2 (en) 2005-11-18 2007-05-31 Cornell Research Foundation, Inc. Nicotinoyl riboside compositions and methods of use
US8148338B2 (en) 2006-02-22 2012-04-03 Supratek Pharma Inc. Doxorubicin formulations for anti-cancer use
WO2008011364A2 (en) 2006-07-17 2008-01-24 Thomas Christian Lines Quercetin-containing compositions
WO2009108999A1 (en) 2008-03-03 2009-09-11 Ross Stewart Grant Pharmaceutical formulations of resveratrol and methods of use thereof for treating cell disorders
ES2476602T3 (es) 2008-03-14 2014-07-15 Bionumerik Pharmaceuticals, Inc. Composiciones y métodos quimioprotectores
CA2748813C (en) 2009-01-09 2018-07-10 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US20110052676A1 (en) 2009-09-01 2011-03-03 James Vincent Gruber Composition For Delaying Cellular Senescence
CA2774375C (en) * 2009-09-17 2018-02-13 Bespoke Bioscience, Llc Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury
WO2012068539A1 (en) 2010-11-19 2012-05-24 Limerick Biopharma, Inc. Use and composition of quercetin-3'-o-sulfate for therapeutic treatment
US20120328526A1 (en) 2011-06-27 2012-12-27 University Of Maryland, Baltimore Modulation of Nad+ Activity in Neuropathophysiological Conditions and Uses Thereof
CA2859385A1 (en) 2011-12-13 2013-06-20 Buck Institute For Research On Aging Methods for improving medical therapies
CN102631385A (zh) 2012-05-10 2012-08-15 西北农林科技大学 一种复方槲皮素纳米乳抗衰老保健品
KR101435717B1 (ko) 2012-09-06 2014-09-01 영남대학교 산학협력단 퀘세틴-3-Ｏ-β-Ｄ-글루쿠로니드를 유효성분으로 함유하는 세포 노화 억제용 조성물
CN102973461A (zh) 2012-11-30 2013-03-20 汤燕 保湿润肤且可延缓衰老的化妆用复合物
AU2014203872A1 (en) 2013-01-07 2015-07-09 Catabasis Pharmaceuticals, Inc. Use of fatty acid niacin conjugates for treating diseases
US20140271812A1 (en) 2013-03-14 2014-09-18 Panacea Pharmaceuticals Treatment for chemotherapy-induced cognitive impairment
EP3068364B1 (en) 2013-11-14 2021-11-03 Metro Biotech NSW Pty Ltd Nad+ precursor selected from nmn, naad, namn, or a pharmaceutically acceptable salt thereof, for use in treating a side effect of chemotherapy and/or radiotherapy in a subject
CA2984379C (en) 2015-04-28 2024-06-11 Newsouth Innovations Pty Limited Targeting nad+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies, and inactivity

Also Published As

Publication number Publication date
CA2984379C (en) 2024-06-11
EP3288637A1 (en) 2018-03-07
WO2016176437A1 (en) 2016-11-03
AU2016255853A1 (en) 2017-11-30
US20200405736A1 (en) 2020-12-31
CN108025187A (zh) 2018-05-11
US20180125871A1 (en) 2018-05-10
JP2021073207A (ja) 2021-05-13
JP7193232B2 (ja) 2022-12-20
CN113244396A (zh) 2021-08-13
US10603334B2 (en) 2020-03-31
JP2018514548A (ja) 2018-06-07
US11389469B2 (en) 2022-07-19
CA2984379A1 (en) 2016-11-03
ES2927894T3 (es) 2022-11-11
EP3288637A4 (en) 2019-02-13
EP3288637B1 (en) 2022-09-14
PT3288637T (pt) 2022-10-11
AU2016255853B2 (en) 2021-08-05
DK3288637T3 (da) 2022-10-17
KR20180006389A (ko) 2018-01-17

Similar Documents

Publication Publication Date Title
PT3288637T (pt) Visar nad+ para tratar comprometimento cognitivo, neuropatias e inatividade induzidos por quimioterapia e radioterapia
IL259017A (en) Cancer cure is intended
GB2592821B (en) Modified cells and methods of therapy
SG10201912758TA (en) Gene therapy for treating mucopolysaccharidosis type i
PH12017500153B1 (en) Compositions and methods of use for treating metabolic disorders
EP3137606A4 (en) METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
IL249370A0 (en) Fap-enabled medical substances and related uses
MX2015011899A (es) Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer.
EP3171896A4 (en) Targeting dna-pkcs and b7-h1 to treat cancer
SG11201912631PA (en) Aav9-mediated gene therapy for treating mucopolysaccharidosis type i
PL3242947T3 (pl) Terapia genowa i elektroporacja do leczenia zmian złośliwych
EP3137082A4 (en) Methods to treat, prevent, and improve skin conditions
GB201611535D0 (en) Methods and compositions for treating cancer with siglec-9 activity modulators
IL275517A (en) Combined methods and treatment of cancer
IL310084B2 (en) Targeted combination therapy
IL254228A0 (en) Cell therapy agent for cancer treatment and combined therapy with it
IL245538A0 (en) Treatment methods for abnormal muscle activity
IL254066B (en) Gene therapy to improve vision
PL3383851T3 (pl) Pochodne dekstrorfanu o stłumionej nerwowej aktywności ośrodkowej
EP3068411A4 (en) Oncolytic viruses and increased cancer treatment regimens
GB201520600D0 (en) Treatment of central nervous tumours
PL3010508T3 (pl) Skojarzenie RO5503781, kapecytabiny i oksaliplatyny do leczenia raka
GB201519375D0 (en) Photodynamic therapy complex
HK1259198A1 (zh) 靶向癌症治疗
GB201511160D0 (en) Targeted Cell therapy and light-assisted endo/lysosomal releas