PL3296312T3 - Synteza chronionych monomerów 3'-amino-5'-amidofosforanonukleozydowych - Google Patents

Synteza chronionych monomerów 3'-amino-5'-amidofosforanonukleozydowych

Info

Publication number
PL3296312T3
PL3296312T3 PL17184430T PL17184430T PL3296312T3 PL 3296312 T3 PL3296312 T3 PL 3296312T3 PL 17184430 T PL17184430 T PL 17184430T PL 17184430 T PL17184430 T PL 17184430T PL 3296312 T3 PL3296312 T3 PL 3296312T3
Authority
PL
Poland
Prior art keywords
synthesis
protected
amino
nucleoside monomers
phosphoramidite nucleoside
Prior art date
Application number
PL17184430T
Other languages
English (en)
Inventor
Sergei M. Gryaznov
Krisztina Pongracz
Daria Zielinska
Original Assignee
Geron Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corporation filed Critical Geron Corporation
Publication of PL3296312T3 publication Critical patent/PL3296312T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
PL17184430T 2004-07-02 2005-06-30 Synteza chronionych monomerów 3'-amino-5'-amidofosforanonukleozydowych PL3296312T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58519304P 2004-07-02 2004-07-02
EP05768112.4A EP1778711B1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3'-amino nucleoside monomers
EP17184430.1A EP3296312B1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3'-amino 5'-phosphoramidite nucleoside monomers
PCT/US2005/023633 WO2006014387A1 (en) 2004-07-02 2005-06-30 Synthesis of protected 3’-amino nucleoside monomers

Publications (1)

Publication Number Publication Date
PL3296312T3 true PL3296312T3 (pl) 2021-10-25

Family

ID=35478430

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17184430T PL3296312T3 (pl) 2004-07-02 2005-06-30 Synteza chronionych monomerów 3'-amino-5'-amidofosforanonukleozydowych
PL05768112T PL1778711T3 (pl) 2004-07-02 2005-06-30 Synteza chronionych monomerów 3'-aminonukleozydowych

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL05768112T PL1778711T3 (pl) 2004-07-02 2005-06-30 Synteza chronionych monomerów 3'-aminonukleozydowych

Country Status (17)

Country Link
US (9) US7485717B2 (pl)
EP (2) EP1778711B1 (pl)
KR (1) KR101279393B1 (pl)
CN (1) CN100558739C (pl)
CA (1) CA2571601C (pl)
CY (2) CY1119536T1 (pl)
DK (2) DK3296312T3 (pl)
ES (2) ES2643296T3 (pl)
HR (2) HRP20171705T1 (pl)
HU (2) HUE054463T2 (pl)
LT (2) LT1778711T (pl)
ME (1) ME02933B (pl)
PL (2) PL3296312T3 (pl)
PT (2) PT1778711T (pl)
RS (2) RS61840B1 (pl)
SI (2) SI1778711T1 (pl)
WO (1) WO2006014387A1 (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
DE602004031975D1 (de) 2003-11-04 2011-05-05 Geron Corp Rna-amidate und thioamidateur rnai
RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
WO2007127163A2 (en) * 2006-04-24 2007-11-08 Geron Corporation Cns-tumor treatment method and composition
EP4600359A2 (en) * 2006-10-30 2025-08-13 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
ES2407957T3 (es) * 2007-03-09 2013-06-17 Geron Corporation Tratamiento de carcinomas con una combinación de inhibidores de la vía EGF y de la telomerasa
EP3719139B1 (en) 2008-10-17 2022-11-30 Geron Corporation Method for identification of sensitivity of a patient to telomerase inhibition therapy
LT2925889T (lt) 2012-11-30 2018-12-27 Geron Corporation Diagnostiniai žymenys, skirti ląstelių prolifreracijos sutrikimų gydymui telomerazės inhibitoriais
PT3456333T (pt) 2012-12-07 2020-06-01 Geron Corp Utilização do inibidor de telomerase imetelstate para o tratamento de síndrome mielodisplásica
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
CN104231008B (zh) * 2013-06-07 2017-03-01 沈阳药科大学 核苷类药物5’‑位氨基酸酯的区域选择性合成方法
EP3052512A4 (en) 2013-09-30 2017-02-22 Geron Corporation Phosphorodiamidate backbone linkage for oligonucleotides
JOP20200257A1 (ar) 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها
JP2018513127A (ja) 2015-04-23 2018-05-24 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ 多価カチオン塩組成物を用いたポリヌクレオチド調製方法
ES2901099T3 (es) * 2017-07-10 2022-03-21 Geron Corp Proceso mejorado para la preparación de imetelstat
EP3658156B1 (en) 2017-07-28 2026-03-25 Geron Corporation Telomerase inhibitor for use in treating a myelodysplastic syndrome
CN113631719A (zh) 2018-11-29 2021-11-09 美国杰龙生物医药公司 治疗骨髓增生异常综合征的方法
CN117143942A (zh) * 2023-10-30 2023-12-01 泰兴合全药业有限公司 3’-氨基-2’,3’-双脱氧鸟苷5’-三磷酸的合成方法

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046720A (en) 1974-01-17 1977-09-06 California Institute Of Technology Crosslinked, porous, polyacrylate beads
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
US4678814A (en) 1981-03-30 1987-07-07 California Institute Of Technology Polyacrolein microspheres
US5185444A (en) 1985-03-15 1993-02-09 Anti-Gene Deveopment Group Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US4659774A (en) 1985-11-01 1987-04-21 American Hoechst Corporation Support for solid-phase oligonucleotide synthesis
DE69130333T2 (de) 1990-08-31 1999-03-04 Regents Of The University Of Minnesota, Minneapolis, Minn. Harze für die Feststoff-Peptidsynthese
US5281701A (en) 1991-07-12 1994-01-25 Applied Biosystems, Inc. Process and compounds for RNA synthesis
US5476925A (en) 1993-02-01 1995-12-19 Northwestern University Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
US5726297A (en) 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5599922A (en) 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
HUT76094A (en) 1994-03-18 1997-06-30 Lynx Therapeutics Oligonucleotide n3'-p5' phosphoramidates: synthesis and compounds; hybridization and nuclease resistance properties
US5705621A (en) 1995-11-17 1998-01-06 Isis Pharmaceuticals, Inc. Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
US5684143A (en) 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
US5859233A (en) 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
EP0951568A1 (en) 1996-12-20 1999-10-27 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US5998604A (en) * 1997-09-15 1999-12-07 The Perkin-Elmer Corporation Polynucleotide purification method
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
HK1049339B (en) 1999-09-10 2008-06-27 Geron Corporation Oligonucleotide n3'-p5' thiophosphoramidates: their synthesis and use
AU2001227965A1 (en) 2000-01-21 2001-07-31 Geron Corporation 2'-arabino-fluorooligonucleotide n3'-p5'phosphoramidates: their synthesis and use
JP2002060341A (ja) 2000-08-21 2002-02-26 Terumo Corp 止血剤
EP1365754A2 (en) 2001-01-30 2003-12-03 Medstar Research Institute Inhibition of proteasomes to prevent restenosis
AU2002245717A1 (en) 2001-03-23 2002-10-08 Geron Corporation Oligonucleotide conjugates
US7563618B2 (en) 2001-03-23 2009-07-21 Geron Corporation Oligonucleotide conjugates
US20120329858A1 (en) 2010-08-04 2012-12-27 Geron Corporation Modified oligonucleotides for telomerase inhibition
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
DE602004031975D1 (de) 2003-11-04 2011-05-05 Geron Corp Rna-amidate und thioamidateur rnai
RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
TWI442965B (zh) 2006-11-01 2014-07-01 Biogen Idec Inc 使用低ｐＨ及二價陽離子分離生物巨分子的方法
PT3456333T (pt) 2012-12-07 2020-06-01 Geron Corp Utilização do inibidor de telomerase imetelstate para o tratamento de síndrome mielodisplásica
JOP20200257A1 (ar) * 2014-05-01 2017-06-16 Geron Corp تركيبات أوليجو نوكليوتيد وطرق لتحضيرها

Also Published As

Publication number Publication date
US10035815B2 (en) 2018-07-31
EP3296312A1 (en) 2018-03-21
US20160362440A1 (en) 2016-12-15
US10738073B2 (en) 2020-08-11
CA2571601C (en) 2013-01-08
US20150038692A1 (en) 2015-02-05
US8748593B2 (en) 2014-06-10
LT1778711T (lt) 2017-10-25
PT1778711T (pt) 2017-10-19
DK3296312T3 (da) 2021-05-03
KR20070042155A (ko) 2007-04-20
ME02933B (me) 2018-04-20
US20190031707A1 (en) 2019-01-31
PL1778711T3 (pl) 2018-01-31
US20240034748A1 (en) 2024-02-01
PT3296312T (pt) 2021-05-11
LT3296312T (lt) 2021-06-10
US20230089101A1 (en) 2023-03-23
HRP20210787T1 (hr) 2021-06-25
WO2006014387A1 (en) 2006-02-09
HUE037166T2 (hu) 2018-08-28
KR101279393B1 (ko) 2013-07-04
RS56361B1 (sr) 2017-12-29
CY1119536T1 (el) 2018-03-07
US7485717B2 (en) 2009-02-03
RS61840B1 (sr) 2021-06-30
US20060009636A1 (en) 2006-01-12
ES2868452T3 (es) 2021-10-21
HUE054463T2 (hu) 2021-09-28
US9365606B2 (en) 2016-06-14
ES2643296T3 (es) 2017-11-22
SI3296312T1 (sl) 2021-08-31
EP3296312B1 (en) 2021-03-17
CY1124335T1 (el) 2022-07-22
CN100558739C (zh) 2009-11-11
CA2571601A1 (en) 2006-02-09
US20090105468A1 (en) 2009-04-23
CN1997658A (zh) 2007-07-11
HRP20171705T1 (hr) 2017-12-15
EP1778711A1 (en) 2007-05-02
DK1778711T3 (en) 2017-10-02
US20240300992A1 (en) 2024-09-12
HK1252664A1 (en) 2019-05-31
EP1778711B1 (en) 2017-08-16
US20200377543A1 (en) 2020-12-03
SI1778711T1 (sl) 2017-11-30

Similar Documents

Publication Publication Date Title
SI3296312T1 (sl) Sinteza zaščitenih 3'-amino 5'-fosforamiditnih nukleozidnih monomerov
SI3611266T1 (sl) Modificirani nukleozidi, ki vsebujejo RNA, in postopki za njihovo uporabo
GB0405884D0 (en) Modified nucleotides
GB2392893B (en) Rear Structure Of Motorcycle
IL176932A0 (en) Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
EP1639121A4 (en) SYNTHESIS OF BETA-L-2-DESOXYNUCLEOSIDES
GB2392894B (en) Rear Structure Of Motorcycle
IL165355A0 (en) Synthesis of diaryl pyrazoles
IL180513A0 (en) Process for synthesis of 4-4'-diamino-diphenyl-sulfone
AU2003290816A8 (en) Modified nucleosides as antiviral agents
GB0302465D0 (en) "13C-labelled synthesis"
EP1620451A4 (en) TO THE MOST EXTENSIVE NUCLEOSIDE SYNTHESIS
IL189547A0 (en) Synthesis of 1??-fluoro-25-hydroxy
PL369327A1 (pl) Synteza 2-aralkoksyadenozyn i 2-alkoksyadenozyn
GB0328323D0 (en) Synthesis of 2-substituted adenosines
TW573655U (en) Buckle structure for rear rack of bicycle
AU2002364160A8 (en) Preparation of intermediates useful in the synthesis of antiviral nucleosides
GB0328319D0 (en) Improved synthesis of 2-substituted adenosines
AU2003217354A8 (en) Synthesis of sulfamidates
GB0100044D0 (en) Improvements in or relating to synthesis of oligonucleotides
GB0202358D0 (en) Synthesis of fluorinating agents
HK1086039A (en) Synthesis of beta -l-2-deoxy nucleosides
PL370863A1 (pl) Sposoby wytwarzania 5'-deoksy-5'-chloroadenozyny i 5'-deoksy-5' metylotioadenozyny
GB0328318D0 (en) Synthesis of spongosine
TW576217U (en) Structure of single bar