PL3297654T3 - Leczenie pobariatrycznej hipoglikemii eksendyną (9-39) - Google Patents

Leczenie pobariatrycznej hipoglikemii eksendyną (9-39)

Info

Publication number: PL3297654T3
Authority: PL; Poland
Prior art keywords: exendin; post; treatment; bariatric hypoglycemia; bariatric
Prior art date: 2015-05-22

Application number

PL16800621T

Other languages

English (en)

Inventor

Tracey L. MCLAUGHLIN

Colleen M. CRAIG

Original Assignee

The Board Of Trustees Of The Leland Stanford Junior University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-05-22

Filing date

2016-05-23

Publication date

2021-12-20

2016-05-23 Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University

2021-12-20 Publication of PL3297654T3 publication Critical patent/PL3297654T3/pl

Links

WSEVKKHALHSUMB-RYVRVIGHSA-N (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O WSEVKKHALHSUMB-RYVRVIGHSA-N 0.000 title 1
208000013016 Hypoglycemia Diseases 0.000 title 1
108010024703 exendin (9-39) Proteins 0.000 title 1
230000002218 hypoglycaemic effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Dispersion Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL16800621T 2015-05-22 2016-05-23 Leczenie pobariatrycznej hipoglikemii eksendyną (9-39) PL3297654T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201562165743P	2015-05-22	2015-05-22
US201562254175P	2015-11-11	2015-11-11
US201662329850P	2016-04-29	2016-04-29
PCT/US2016/033837 WO2016191395A1 (en)	2015-05-22	2016-05-23	Treatment of post-bariatric hypoglycemia with exendin(9-39)
EP16800621.1A EP3297654B1 (en)	2015-05-22	2016-05-23	Treatment of post-bariatric hypoglycemia with exendin(9-39)

Publications (1)

Publication Number	Publication Date
PL3297654T3 true PL3297654T3 (pl)	2021-12-20

Family

ID=57393681

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL16800620T PL3297653T3 (pl)	2015-05-22	2016-05-23	Leczenie hipoglikemii po operacji bariatrycznej antagonistami GLP-1
PL16800621T PL3297654T3 (pl)	2015-05-22	2016-05-23	Leczenie pobariatrycznej hipoglikemii eksendyną (9-39)

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PL16800620T PL3297653T3 (pl)	2015-05-22	2016-05-23	Leczenie hipoglikemii po operacji bariatrycznej antagonistami GLP-1

Country Status (18)

Country	Link
US (10)	US10639354B2 (pl)
EP (4)	EP3297654B1 (pl)
AU (6)	AU2016267057B2 (pl)
BR (2)	BR112017025000A2 (pl)
CA (2)	CA3024353A1 (pl)
CL (2)	CL2017002911A1 (pl)
CY (2)	CY1124616T1 (pl)
DK (2)	DK3297653T3 (pl)
ES (2)	ES2897955T3 (pl)
HR (2)	HRP20211768T1 (pl)
HU (2)	HUE055728T2 (pl)
LT (2)	LT3297654T (pl)
PL (2)	PL3297653T3 (pl)
PT (2)	PT3297653T (pl)
RS (2)	RS62368B1 (pl)
SI (2)	SI3297654T1 (pl)
SM (2)	SMT202100668T1 (pl)
WO (2)	WO2016191394A1 (pl)

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US10653753B2 (en)	2016-03-04	2020-05-19	Eiger Biopharmaceuticals, Inc.	Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
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BR112020014719A2 (pt) *	2018-01-23	2020-12-08	Xeris Pharmaceuticals, Inc.	Tratamento de hipoglicemia pós-bariátrica usando glucagon estável em minidose
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CA3115527A1 (en) *	2018-10-15	2020-04-23	Eiger Biopharmaceuticals, Inc.	Avexitide for the treatment of hyperinsulinemic hypoglycemia
WO2020144378A1 (en) *	2019-01-11	2020-07-16	Universitätsspital Basel	Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery
WO2024042518A1 (en) *	2022-08-21	2024-02-29	M. Arkin (1999) Ltd	Glp-1 receptor antagonist and methods of use thereof
CN121219002A (zh) *	2023-04-21	2025-12-26	小利兰斯坦福大学董事会	Glp-1r拮抗作用改善胃肠外科手术后的营养
WO2025235995A1 (en) *	2024-05-10	2025-11-13	The Board Of Trustees Of The Leland Stanford Junior University	Use of glp-1 receptor agonists alone or in combination with other gastrointestinal hormones that delay gastric emptying for treatment of postbariatric hypoglycemia

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2016
- 2016-05-23 RS RS20211073A patent/RS62368B1/sr unknown
- 2016-05-23 CA CA3024353A patent/CA3024353A1/en active Pending
- 2016-05-23 DK DK16800620.3T patent/DK3297653T3/da active
- 2016-05-23 RS RS20211458A patent/RS62627B1/sr unknown
- 2016-05-23 HR HRP20211768TT patent/HRP20211768T1/hr unknown
- 2016-05-23 US US15/576,647 patent/US10639354B2/en active Active
- 2016-05-23 HR HRP20211285TT patent/HRP20211285T1/hr unknown
- 2016-05-23 SM SM20210668T patent/SMT202100668T1/it unknown
- 2016-05-23 US US15/576,646 patent/US10660937B2/en active Active
- 2016-05-23 CA CA3024358A patent/CA3024358A1/en active Pending
- 2016-05-23 HU HUE16800621A patent/HUE055728T2/hu unknown
- 2016-05-23 SI SI201631300T patent/SI3297654T1/sl unknown
- 2016-05-23 EP EP16800621.1A patent/EP3297654B1/en active Active
- 2016-05-23 PT PT16800620T patent/PT3297653T/pt unknown
- 2016-05-23 AU AU2016267057A patent/AU2016267057B2/en active Active
- 2016-05-23 PT PT168006211T patent/PT3297654T/pt unknown
- 2016-05-23 BR BR112017025000-4A patent/BR112017025000A2/pt not_active Application Discontinuation
- 2016-05-23 LT LTEPPCT/US2016/033837T patent/LT3297654T/lt unknown
- 2016-05-23 HU HUE16800620A patent/HUE057301T2/hu unknown
- 2016-05-23 DK DK16800621.1T patent/DK3297654T3/da active
- 2016-05-23 AU AU2016267052A patent/AU2016267052B2/en active Active
- 2016-05-23 SM SM20210488T patent/SMT202100488T1/it unknown
- 2016-05-23 ES ES16800620T patent/ES2897955T3/es active Active
- 2016-05-23 BR BR112017024997-9A patent/BR112017024997A2/pt not_active Application Discontinuation
- 2016-05-23 EP EP21194982.1A patent/EP3978011A1/en active Pending
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2017
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2021
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2022
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2023
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2024
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Also Published As

Publication number	Publication date
EP3297653A1 (en)	2018-03-28
ES2887723T3 (es)	2021-12-27
HUE055728T2 (hu)	2021-12-28
WO2016191395A1 (en)	2016-12-01
RS62627B1 (sr)	2021-12-31
US12220444B2 (en)	2025-02-11
AU2016267057B2 (en)	2021-12-23
US20200276271A1 (en)	2020-09-03
PT3297654T (pt)	2021-09-06
US20210290731A1 (en)	2021-09-23
US10639354B2 (en)	2020-05-05
CA3024353A1 (en)	2016-12-01
US20210315974A1 (en)	2021-10-14
BR112017024997A2 (pt)	2018-07-31
US20230346890A1 (en)	2023-11-02
AU2022202506A1 (en)	2022-05-12
EP3297653B1 (en)	2021-09-15
SMT202100668T1 (it)	2022-01-10
HUE057301T2 (hu)	2022-05-28
EP3936143A1 (en)	2022-01-12
CA3024358A1 (en)	2016-12-01
US11617782B2 (en)	2023-04-04
SMT202100488T1 (it)	2021-11-12
AU2016267057A1 (en)	2017-12-14
DK3297654T3 (da)	2021-09-06
AU2016267052B2 (en)	2022-01-20
AU2022201973A1 (en)	2022-04-14
AU2025217292A1 (en)	2025-09-04
SI3297653T1 (sl)	2022-01-31
US20180147261A1 (en)	2018-05-31
US20250255935A1 (en)	2025-08-14
US10993991B2 (en)	2021-05-04
US10660937B2 (en)	2020-05-26
HRP20211285T1 (hr)	2022-01-07
US11622995B2 (en)	2023-04-11
CY1124616T1 (el)	2022-07-22
US20250082730A1 (en)	2025-03-13
AU2022202506B2 (en)	2025-06-05
PL3297653T3 (pl)	2022-01-31
LT3297654T (lt)	2021-10-25
EP3297654A4 (en)	2018-04-11
CL2017002913A1 (es)	2018-06-01
CY1125147T1 (el)	2023-03-24
WO2016191394A1 (en)	2016-12-01
BR112017025000A2 (pt)	2018-08-07
AU2025220813A1 (en)	2025-09-11
CL2017002911A1 (es)	2018-05-25
US20200276272A1 (en)	2020-09-03
US20180117122A1 (en)	2018-05-03
AU2016267052A1 (en)	2017-12-14
ES2897955T3 (es)	2022-03-03
AU2022201973B2 (en)	2025-05-15
EP3297654A1 (en)	2018-03-28
SI3297654T1 (sl)	2021-11-30
EP3978011A1 (en)	2022-04-06
RS62368B1 (sr)	2021-10-29
LT3297653T (lt)	2022-01-10
EP3297653A4 (en)	2018-12-26
HRP20211768T1 (hr)	2022-02-18
US10993992B2 (en)	2021-05-04
DK3297653T3 (da)	2021-10-18
PT3297653T (pt)	2021-10-25
US12102663B2 (en)	2024-10-01
US20240000894A1 (en)	2024-01-04
EP3297654B1 (en)	2021-07-07

Publication	Publication Date	Title
PT3297654T (pt)	2021-09-06	Tratamento de hipoglicemia pós-bariátrica com exendina(9-39)
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ZA201706059B (en)	2023-08-30	Method of treatment with tradipitant
GB201502137D0 (en)	2015-03-25	Treatment
IL252803A0 (en)	2017-08-31	Formulation with a constant ratio of insulin glargine/licisanitide
GB201522243D0 (en)	2016-01-27	Treatment
GB201519450D0 (en)	2015-12-16	Novel treatment
IL254500A0 (en)	2017-11-30	Treatment of patients with type 2 diabetes
GB201508841D0 (en)	2015-07-01	Treatment
PL3139948T3 (pl)	2020-08-10	Leczenie cukrzycy z zastosowaniem glp-1 i anty-il-21
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GB201513543D0 (en)	2015-09-16	Compositions for use in the treatment of diabetes
GB201503008D0 (en)	2015-04-08	Treatment
GB201414366D0 (en)	2014-09-24	Blood defence
AU2015904246A0 (en)	2015-11-05	Treatment of diabetes
HUE048860T2 (hu)	2020-09-28	1-es típusú cukorbetegség kezelése GLP-1 és anti-IL-21 alkalmazásával
AU2016901862A0 (en)	2016-06-02	Treatment of diabetes
GB201513922D0 (en)	2015-09-23	Treatment of hyperpigmentation
GB201518349D0 (en)	2015-12-02	Treatment
GB201515739D0 (en)	2015-10-21	Treatment
GB201514008D0 (en)	2015-09-23	Treatment
GB201604099D0 (en)	2016-04-20	Insulin biosensor
AU2015902668A0 (en)	2015-07-16	Fast acting hypoglycaemic treatment ( Hypo-fast)
EP3093013A4 (en)	2017-09-13	Agent for treating diabetes
GB201407396D0 (en)	2014-06-11	Confectionary treatment