CL2017002913A1 - Tratamiento de la hipoglucemia posbariátrica con exendina (9-39) - Google Patents
Tratamiento de la hipoglucemia posbariátrica con exendina (9-39)Info
- Publication number
- CL2017002913A1 CL2017002913A1 CL2017002913A CL2017002913A CL2017002913A1 CL 2017002913 A1 CL2017002913 A1 CL 2017002913A1 CL 2017002913 A CL2017002913 A CL 2017002913A CL 2017002913 A CL2017002913 A CL 2017002913A CL 2017002913 A1 CL2017002913 A1 CL 2017002913A1
- Authority
- CL
- Chile
- Prior art keywords
- postbariatric
- exendin
- hypoglycemia
- treatment
- hypoglucemia
- Prior art date
Links
- WSEVKKHALHSUMB-RYVRVIGHSA-N (4S)-4-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-5-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-carboxypropanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-4-amino-1-[[2-[[2-[(2S)-2-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(N)=O WSEVKKHALHSUMB-RYVRVIGHSA-N 0.000 title 1
- 208000013016 Hypoglycemia Diseases 0.000 title 1
- 108010024703 exendin (9-39) Proteins 0.000 title 1
- 230000002218 hypoglycaemic effect Effects 0.000 title 1
- 230000000910 hyperinsulinemic effect Effects 0.000 abstract 2
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000007681 bariatric surgery Methods 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
<p>SE PROPORCIONAN COMPOSICIONES Y MÉTODOS PARA TRATAR LA HIPOGLUCEMIA HIPERINSULINÉMICA, TAL COMO LA HIPOGLUCEMIA HIPERINSULINÉMICA DESPUÉS DE LA CIRUGÍA BARIÁTRICA. EN ALGUNAS MODALIDADES, UNA CANTIDAD EFICAZ DEL ANTAGONISTA DEL RECEPTOR DEL PÉPTIDO SIMILAR AL GLUCAGÓN TIPO 1, EXENDINA (9-39), SE ADMINISTRA POR VÍA SUBCUTÁNEA DOS VECES AL DÍA.</p>
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562165743P | 2015-05-22 | 2015-05-22 | |
| US201562254175P | 2015-11-11 | 2015-11-11 | |
| US201662329850P | 2016-04-29 | 2016-04-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017002913A1 true CL2017002913A1 (es) | 2018-06-01 |
Family
ID=57393681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002911A CL2017002911A1 (es) | 2015-05-22 | 2017-11-16 | Tratamiento de la hipoglucemia posbariátrica con antagonistas de glp-1. |
| CL2017002913A CL2017002913A1 (es) | 2015-05-22 | 2017-11-16 | Tratamiento de la hipoglucemia posbariátrica con exendina (9-39) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017002911A CL2017002911A1 (es) | 2015-05-22 | 2017-11-16 | Tratamiento de la hipoglucemia posbariátrica con antagonistas de glp-1. |
Country Status (18)
| Country | Link |
|---|---|
| US (10) | US10639354B2 (es) |
| EP (4) | EP3297654B1 (es) |
| AU (6) | AU2016267057B2 (es) |
| BR (2) | BR112017025000A2 (es) |
| CA (2) | CA3024353A1 (es) |
| CL (2) | CL2017002911A1 (es) |
| CY (2) | CY1124616T1 (es) |
| DK (2) | DK3297653T3 (es) |
| ES (2) | ES2897955T3 (es) |
| HR (2) | HRP20211768T1 (es) |
| HU (2) | HUE055728T2 (es) |
| LT (2) | LT3297654T (es) |
| PL (2) | PL3297653T3 (es) |
| PT (2) | PT3297653T (es) |
| RS (2) | RS62368B1 (es) |
| SI (2) | SI3297654T1 (es) |
| SM (2) | SMT202100668T1 (es) |
| WO (2) | WO2016191394A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2818181B1 (en) | 2007-01-08 | 2018-10-24 | The Trustees Of The University Of Pennsylvania | Compositions and medical uses thereof |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| RS62368B1 (sr) | 2015-05-22 | 2021-10-29 | Univ Leland Stanford Junior | Lečenje postbarijatrijske hipoglikemije eksendinom(9-39) |
| US10653753B2 (en) | 2016-03-04 | 2020-05-19 | Eiger Biopharmaceuticals, Inc. | Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives |
| BR112019010236A2 (pt) * | 2016-11-21 | 2019-08-20 | Eiger Biopharmaceuticals, Inc | formulações tamponadas de exendina (9-39) |
| BR112020014719A2 (pt) * | 2018-01-23 | 2020-12-08 | Xeris Pharmaceuticals, Inc. | Tratamento de hipoglicemia pós-bariátrica usando glucagon estável em minidose |
| GB201816639D0 (en) * | 2018-10-12 | 2018-11-28 | Heptares Therapeutics Ltd | GLP-1 Receptor Antagonist |
| CA3115527A1 (en) * | 2018-10-15 | 2020-04-23 | Eiger Biopharmaceuticals, Inc. | Avexitide for the treatment of hyperinsulinemic hypoglycemia |
| WO2020144378A1 (en) * | 2019-01-11 | 2020-07-16 | Universitätsspital Basel | Sglt-2 inhibitors or il-1r antagonists for reduction of hypoglycaemia after bariatric surgery |
| WO2024042518A1 (en) * | 2022-08-21 | 2024-02-29 | M. Arkin (1999) Ltd | Glp-1 receptor antagonist and methods of use thereof |
| CN121219002A (zh) * | 2023-04-21 | 2025-12-26 | 小利兰斯坦福大学董事会 | Glp-1r拮抗作用改善胃肠外科手术后的营养 |
| WO2025235995A1 (en) * | 2024-05-10 | 2025-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Use of glp-1 receptor agonists alone or in combination with other gastrointestinal hormones that delay gastric emptying for treatment of postbariatric hypoglycemia |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9306551A (pt) | 1992-06-15 | 1998-09-15 | Pfizer | Derivados de peptídeo do tipo glucagona e de insulinotropina |
| US5424286A (en) | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US20040092443A1 (en) | 1996-08-06 | 2004-05-13 | Yeda Research And Development Co., Ltd | Long-acting exendins and exendin agonists |
| ES2359031T3 (es) | 1996-08-08 | 2011-05-17 | Amylin Pharmaceuticals, Inc. | Composición farmacéutica que comprende un péptido de exendina-4. |
| US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
| JP4798814B2 (ja) | 1997-01-07 | 2011-10-19 | アミリン・ファーマシューティカルズ，インコーポレイテッド | 食物摂取低減用のエキセンジンおよびそのアゴニストの使用 |
| JP3270761B2 (ja) | 1998-01-30 | 2002-04-02 | ノボ ノルディスク アクティーゼルスカブ | 注射器 |
| ES2233089T3 (es) | 1998-12-10 | 2005-06-01 | Agouron Pharmaceuticals, Inc. | Antagonistas no peptidos del receptor de glp-1 y metodos de uso. |
| EP1140145B2 (en) | 1999-01-14 | 2019-05-15 | Amylin Pharmaceuticals, LLC | Novel exendin agonist formulations and methods of administration thereof |
| DE60032331T2 (de) | 1999-01-14 | 2007-06-21 | Amylin Pharmaceuticals, Inc., San Diego | Exendine zur glucagon suppression |
| US6924264B1 (en) | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| US6903074B1 (en) | 1999-06-04 | 2005-06-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Neuromedin b and somatostatin receptor agonists |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| US6479065B2 (en) | 2000-08-10 | 2002-11-12 | Alkermes Controlled Therapeutics, Inc. | Process for the preparation of polymer-based sustained release compositions |
| US6824822B2 (en) | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
| SE0004462D0 (sv) | 2000-12-04 | 2000-12-04 | Pharmacia Ab | Novel method and use |
| WO2002066062A2 (en) | 2001-02-01 | 2002-08-29 | Drucker Daniel J | Enhancement of glp-2 activity |
| AU2002257132A1 (en) | 2001-04-06 | 2002-10-21 | The Trustees Of The University Of Pennsylvania | Erbb interface peptidomimetics and methods of use thereof |
| CN1162446C (zh) | 2001-05-10 | 2004-08-18 | 上海华谊生物技术有限公司 | 促胰岛素分泌肽衍生物 |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| WO2003020201A2 (en) | 2001-08-28 | 2003-03-13 | Eli Lilly And Company | Pre-mixes of glp-1 and basal insulin |
| US7378385B2 (en) | 2002-08-08 | 2008-05-27 | University Of Cincinnati | Role for GLP-1 to mediate responses to disparate stressors |
| EP1609479A4 (en) | 2003-03-13 | 2010-01-20 | Mitsubishi Tanabe Pharma Corp | Tumorigenesis INHIBITOR |
| DK3300721T4 (da) | 2003-11-20 | 2025-03-03 | Novo Nordisk As | Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| WO2005110425A1 (en) | 2004-04-15 | 2005-11-24 | Alkermes, Inc. | Polymer-based sustained release device |
| US7456254B2 (en) | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
| DE102004043153B4 (de) | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| DK1888031T3 (da) | 2005-06-06 | 2013-02-18 | Camurus Ab | GLP-1-analogformuleringer |
| DK1971362T3 (en) | 2005-08-19 | 2015-01-26 | Amylin Pharmaceuticals Llc | Exendin for treating diabetes and reducing body weight |
| US8945564B2 (en) | 2006-04-21 | 2015-02-03 | Novartis Ag | Antagonist anti-CD40 antibody pharmaceutical compositions |
| KR20090031368A (ko) | 2006-05-26 | 2009-03-25 | 아밀린 파마슈티칼스, 인크. | 울혈성 심부전 치료용 조성물 및 방법 |
| EP2818181B1 (en) * | 2007-01-08 | 2018-10-24 | The Trustees Of The University Of Pennsylvania | Compositions and medical uses thereof |
| DE102007016811A1 (de) | 2007-04-05 | 2008-10-09 | Tecpharma Licensing Ag | Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle |
| PL2144649T3 (pl) | 2007-04-05 | 2012-01-31 | Tecpharma Licensing Ag | Aplikator wyposażony w człon napędowy z funkcją sterującą |
| ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
| CN105903005A (zh) | 2008-05-05 | 2016-08-31 | 奥拉姆德有限公司 | 用于口服给予艾塞那肽的方法和组合物 |
| US20110263496A1 (en) | 2008-05-21 | 2011-10-27 | Amylin Pharmaceuticals, Inc. | Exendins to lower cholesterol and triglycerides |
| US8071537B2 (en) | 2008-06-25 | 2011-12-06 | Endo Pharmaceuticals Solutions Inc. | Implantable device for the sustained release of a polypeptide |
| DK2310042T3 (da) | 2008-07-08 | 2013-03-04 | Novartis Ag | Anvendelse af pasireotid til behandling af endogen hyperinsulinæmisk hypoglykæmi |
| EP2341905B2 (en) | 2008-09-04 | 2023-09-13 | Amylin Pharmaceuticals, LLC | Sustained release formulations using non-aqueous carriers |
| BRPI1014065A2 (pt) | 2009-04-03 | 2016-04-12 | Nestec Sa | melhora na promoção do crescimento compensatório saudável |
| AU2010258898B8 (en) | 2009-06-08 | 2015-02-05 | Amunix Operating Inc. | Glucose-regulating polypeptides and methods of making and using same |
| WO2011109787A1 (en) | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Methods of administering insulinotropic peptides |
| WO2012012352A2 (en) | 2010-07-19 | 2012-01-26 | Amidebio, Llc | Modified peptides and proteins |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
| WO2013059323A1 (en) | 2011-10-18 | 2013-04-25 | Prolynx Llc | Peg conjugates of exenatide |
| WO2013120022A2 (en) | 2012-02-08 | 2013-08-15 | Seneb Biosciences, Inc. | Treatment of hypoglycemia |
| RU2644214C2 (ru) | 2012-03-26 | 2018-02-08 | Санофи | СТАБИЛЬНЫЕ ПРЕПАРАТЫ СВЯЗЫВАЮЩЕГО СРЕДСТВА НА ОСНОВЕ IgG4 |
| WO2015022420A1 (en) | 2013-08-16 | 2015-02-19 | Medimmune Limited | Gip and glp-1 receptor dual-agonists for the treatment of diabetes |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| RS62368B1 (sr) | 2015-05-22 | 2021-10-29 | Univ Leland Stanford Junior | Lečenje postbarijatrijske hipoglikemije eksendinom(9-39) |
| US10653753B2 (en) | 2016-03-04 | 2020-05-19 | Eiger Biopharmaceuticals, Inc. | Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives |
| BR112019010236A2 (pt) | 2016-11-21 | 2019-08-20 | Eiger Biopharmaceuticals, Inc | formulações tamponadas de exendina (9-39) |
| WO2024030934A2 (en) | 2022-08-05 | 2024-02-08 | Indiana University Research And Technology Corporation | Glucagon-like peptide-1 receptor antagonists |
-
2016
- 2016-05-23 RS RS20211073A patent/RS62368B1/sr unknown
- 2016-05-23 CA CA3024353A patent/CA3024353A1/en active Pending
- 2016-05-23 DK DK16800620.3T patent/DK3297653T3/da active
- 2016-05-23 RS RS20211458A patent/RS62627B1/sr unknown
- 2016-05-23 HR HRP20211768TT patent/HRP20211768T1/hr unknown
- 2016-05-23 US US15/576,647 patent/US10639354B2/en active Active
- 2016-05-23 HR HRP20211285TT patent/HRP20211285T1/hr unknown
- 2016-05-23 SM SM20210668T patent/SMT202100668T1/it unknown
- 2016-05-23 US US15/576,646 patent/US10660937B2/en active Active
- 2016-05-23 CA CA3024358A patent/CA3024358A1/en active Pending
- 2016-05-23 HU HUE16800621A patent/HUE055728T2/hu unknown
- 2016-05-23 SI SI201631300T patent/SI3297654T1/sl unknown
- 2016-05-23 EP EP16800621.1A patent/EP3297654B1/en active Active
- 2016-05-23 PT PT16800620T patent/PT3297653T/pt unknown
- 2016-05-23 AU AU2016267057A patent/AU2016267057B2/en active Active
- 2016-05-23 PT PT168006211T patent/PT3297654T/pt unknown
- 2016-05-23 BR BR112017025000-4A patent/BR112017025000A2/pt not_active Application Discontinuation
- 2016-05-23 LT LTEPPCT/US2016/033837T patent/LT3297654T/lt unknown
- 2016-05-23 HU HUE16800620A patent/HUE057301T2/hu unknown
- 2016-05-23 DK DK16800621.1T patent/DK3297654T3/da active
- 2016-05-23 AU AU2016267052A patent/AU2016267052B2/en active Active
- 2016-05-23 SM SM20210488T patent/SMT202100488T1/it unknown
- 2016-05-23 ES ES16800620T patent/ES2897955T3/es active Active
- 2016-05-23 BR BR112017024997-9A patent/BR112017024997A2/pt not_active Application Discontinuation
- 2016-05-23 EP EP21194982.1A patent/EP3978011A1/en active Pending
- 2016-05-23 WO PCT/US2016/033836 patent/WO2016191394A1/en not_active Ceased
- 2016-05-23 ES ES16800621T patent/ES2887723T3/es active Active
- 2016-05-23 EP EP16800620.3A patent/EP3297653B1/en active Active
- 2016-05-23 WO PCT/US2016/033837 patent/WO2016191395A1/en not_active Ceased
- 2016-05-23 PL PL16800620T patent/PL3297653T3/pl unknown
- 2016-05-23 LT LTEPPCT/US2016/033836T patent/LT3297653T/lt unknown
- 2016-05-23 PL PL16800621T patent/PL3297654T3/pl unknown
- 2016-05-23 EP EP21176474.1A patent/EP3936143A1/en active Pending
- 2016-05-23 SI SI201631362T patent/SI3297653T1/sl unknown
-
2017
- 2017-11-16 CL CL2017002911A patent/CL2017002911A1/es unknown
- 2017-11-16 CL CL2017002913A patent/CL2017002913A1/es unknown
-
2020
- 2020-03-09 US US16/813,535 patent/US10993991B2/en active Active
- 2020-03-09 US US16/813,536 patent/US10993992B2/en active Active
-
2021
- 2021-04-09 US US17/226,164 patent/US11617782B2/en active Active
- 2021-04-09 US US17/226,161 patent/US11622995B2/en active Active
- 2021-09-01 CY CY20211100779T patent/CY1124616T1/el unknown
- 2021-11-29 CY CY20211101046T patent/CY1125147T1/el unknown
-
2022
- 2022-03-22 AU AU2022201973A patent/AU2022201973B2/en active Active
- 2022-04-14 AU AU2022202506A patent/AU2022202506B2/en active Active
-
2023
- 2023-02-22 US US18/172,546 patent/US12102663B2/en active Active
- 2023-02-22 US US18/172,543 patent/US12220444B2/en active Active
-
2024
- 2024-06-17 US US18/745,091 patent/US20250082730A1/en active Pending
-
2025
- 2025-01-02 US US19/008,248 patent/US20250255935A1/en active Pending
- 2025-08-13 AU AU2025217292A patent/AU2025217292A1/en active Pending
- 2025-08-22 AU AU2025220813A patent/AU2025220813A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2017002913A1 (es) | Tratamiento de la hipoglucemia posbariátrica con exendina (9-39) | |
| ECSP20020410A (es) | Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos | |
| MX2024000348A (es) | Mavacamten para su uso en el tratamiento de la cardiomiopatia hipertrofica. | |
| CL2016002516A1 (es) | “compuestos derivados de espirociclo sustituidos, inhibidores atx; composición farmacéutica que los comprende; y su uso en el tratamiento del cáncer, inflamaciones, dolor neuropático, enfermedades fibróticas, trombosis, entre otros”. pct | |
| EA201690660A1 (ru) | Соединения и способы на основе двойного агониста гип и гпп-1 | |
| MX382671B (es) | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington | |
| UY36179A (es) | Derivados de exendina-4 como agonistas selectivos del receptor de glucagón | |
| EA201691845A1 (ru) | Фармацевтические композиции терапевтически активных соединений | |
| EA201691988A1 (ru) | Производные бороновой кислоты и их терапевтическое применение | |
| CL2016001918A1 (es) | Heteroaril amidas como inhibidores de agregación de proteína | |
| CL2017001718A1 (es) | Derivados de glucagón con estabilidad mejorada | |
| EA201791460A1 (ru) | N4-гидроксицитидин и связанные с ним производные и варианты противовирусного применения | |
| AR102712A1 (es) | Agonistas parciales del receptor de insulina | |
| EA201791304A1 (ru) | Производные изохинолина для лечения вич | |
| CL2015002698A1 (es) | Nuevos compuestos y composiciones para la inhibicion de fasn | |
| EA201691844A1 (ru) | Фармацевтические композиции терапевтически активных соединений | |
| CL2016000436A1 (es) | Método para el tratamiento de la enfermedad fibrótica | |
| CY1122264T1 (el) | Ppar ενωσεις για χρηση στην αντιμετωπιση των ινωτικων νοσων | |
| EA201692358A1 (ru) | Производные изоиндолина для применения в лечении вирусной инфекции | |
| CL2015002897A1 (es) | Inhibidores de bace1 | |
| MX389178B (es) | Formulacion de proporcion fija de insulina glargina/lixisenatida. | |
| MX381544B (es) | Composición de células estromales mesenquimatosas para usare en el tratamiento de la sepsis en un sujeto. | |
| MX381944B (es) | Lixisenatida para usarse en el tratamiento de diabetes mellitus de tipo 2 en pacientes pediàtricos. | |
| MX2018001720A (es) | Metodos de sedacion y formulacion parenteral para uso durante el tratamiento de cuidados criticos. | |
| CU20210008A7 (es) | Aspirasas solubilizadas |