PL3356529T3 - Kompozycje i sposoby hamowania ekspresji genu LPA - Google Patents

Kompozycje i sposoby hamowania ekspresji genu LPA

Info

Publication number: PL3356529T3
Authority: PL; Poland
Prior art keywords: compositions; methods; gene expression; lpa gene; inhibiting lpa
Prior art date: 2015-10-01

Application number

PL16852695T

Other languages

English (en)

Inventor

Stacey MELQUIST

Steven Kanner

David B. Rozema

David L. Lewis

Lauren J. Almeida

Darren H Wakefield

Vladimir S. Trubetskoy

Tao Pei

Zhen Li

Aaron ALMEIDA

Original Assignee

Arrowhead Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-10-01

Filing date

2016-09-30

Publication date

2021-12-20

2016-09-30 Application filed by Arrowhead Pharmaceuticals, Inc. filed Critical Arrowhead Pharmaceuticals, Inc.

2021-12-20 Publication of PL3356529T3 publication Critical patent/PL3356529T3/pl

Links

230000014509 gene expression Effects 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
101150091521 lpa gene Proteins 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

PL16852695T 2015-10-01 2016-09-30 Kompozycje i sposoby hamowania ekspresji genu LPA PL3356529T3 (pl)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US201562235816P	2015-10-01	2015-10-01
US201662346304P	2016-06-06	2016-06-06
US201662383221P	2016-09-02	2016-09-02
PCT/US2016/054729 WO2017059223A2 (en)	2015-10-01	2016-09-30	Compositions and methods for inhibiting gene expression of lpa
EP16852695.2A EP3356529B1 (en)	2015-10-01	2016-09-30	Compositions and methods for inhibiting gene expression of lpa

Publications (1)

Publication Number	Publication Date
PL3356529T3 true PL3356529T3 (pl)	2021-12-20

Family

ID=58424351

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL16852695T PL3356529T3 (pl)	2015-10-01	2016-09-30	Kompozycje i sposoby hamowania ekspresji genu LPA

Country Status (36)

Country	Link
US (4)	US9932586B2 (pl)
EP (2)	EP3356529B1 (pl)
JP (5)	JP6991966B2 (pl)
KR (1)	KR102728481B1 (pl)
CN (1)	CN108368506A (pl)
AU (3)	AU2016331084B2 (pl)
CA (1)	CA3000397A1 (pl)
CL (1)	CL2018000803A1 (pl)
CO (1)	CO2018003678A2 (pl)
CR (1)	CR20180231A (pl)
CY (1)	CY1125263T1 (pl)
DK (1)	DK3356529T3 (pl)
EA (1)	EA038478B1 (pl)
ES (1)	ES2896298T3 (pl)
HR (1)	HRP20211410T1 (pl)
HU (1)	HUE055942T2 (pl)
IL (3)	IL300438A (pl)
JO (2)	JOP20210043A1 (pl)
LT (1)	LT3356529T (pl)
MA (1)	MA43347B1 (pl)
MX (2)	MX2018003833A (pl)
MY (1)	MY195796A (pl)
PE (1)	PE20181139A1 (pl)
PH (1)	PH12018500713A1 (pl)
PL (1)	PL3356529T3 (pl)
PT (1)	PT3356529T (pl)
RS (1)	RS62523B1 (pl)
SG (1)	SG10202008530TA (pl)
SI (1)	SI3356529T1 (pl)
SM (1)	SMT202100622T1 (pl)
TN (1)	TN2018000094A1 (pl)
TW (3)	TWI836693B (pl)
UA (1)	UA121998C2 (pl)
UY (1)	UY36926A (pl)
WO (1)	WO2017059223A2 (pl)
ZA (1)	ZA202106265B (pl)

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2016
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Publication number	Publication date
AU2022283623A1 (en)	2023-02-02
JP6991966B2 (ja)	2022-02-03
WO2017059223A9 (en)	2017-08-17
MA43347A (fr)	2018-08-08
JP2024009262A (ja)	2024-01-19
PH12018500713A1 (en)	2018-10-15
US20170096665A1 (en)	2017-04-06
AU2025242219A1 (en)	2025-10-23
SMT202100622T1 (it)	2022-01-10
WO2017059223A2 (en)	2017-04-06
NZ741086A (en)	2023-11-24
EA038478B1 (ru)	2021-09-03
UY36926A (es)	2017-04-28
TWI836693B (zh)	2024-03-21
SG10202008530TA (en)	2020-10-29
MX2018003833A (es)	2018-06-18
TW202449154A (zh)	2024-12-16
JOP20210043A1 (ar)	2017-06-16
EP4029941A1 (en)	2022-07-20
CA3000397A1 (en)	2017-04-06
JP2022113835A (ja)	2022-08-04
US10662427B2 (en)	2020-05-26
ES2896298T3 (es)	2022-02-24
DK3356529T3 (da)	2021-11-08
JOP20160211B1 (ar)	2021-08-17
TW202332769A (zh)	2023-08-16
WO2017059223A3 (en)	2017-05-11
JP2026040461A (ja)	2026-03-09
JP7442574B2 (ja)	2024-03-04
CR20180231A (es)	2018-05-31
CY1125263T1 (el)	2023-03-24
JP7116212B2 (ja)	2022-08-09
IL300438A (en)	2023-04-01
US9932586B2 (en)	2018-04-03
NZ780687A (en)	2025-06-27
US20250115907A1 (en)	2025-04-10
KR102728481B1 (ko)	2024-11-12
TWI784934B (zh)	2022-12-01
TN2018000094A1 (en)	2019-07-08
BR112018006489A2 (pt)	2018-10-09
SI3356529T1 (sl)	2022-01-31
IL290566A (en)	2022-04-01
MA43347B1 (fr)	2021-11-30
TWI880645B (zh)	2025-04-11
CO2018003678A2 (es)	2018-11-30
HRP20211410T1 (hr)	2021-12-24
MX2022013010A (es)	2022-11-09
LT3356529T (lt)	2021-12-27
TW201726918A (zh)	2017-08-01
KR20180052703A (ko)	2018-05-18
JP2021087459A (ja)	2021-06-10
JP2018529732A (ja)	2018-10-11
HUE055942T2 (hu)	2022-01-28
IL258333A (en)	2018-05-31
CN108368506A (zh)	2018-08-03
RS62523B1 (sr)	2021-11-30
EA201890864A1 (ru)	2018-09-28
UA121998C2 (uk)	2020-08-25
AU2016331084A1 (en)	2018-04-19
ZA202106265B (en)	2023-08-30
US20200263179A1 (en)	2020-08-20
HK1259063A1 (en)	2019-11-22
KR20240162596A (ko)	2024-11-15
MY195796A (en)	2023-02-21
EP3356529A4 (en)	2019-09-04
IL290566B2 (en)	2023-07-01
EP3356529B1 (en)	2021-08-25
EP3356529A2 (en)	2018-08-08
PE20181139A1 (es)	2018-07-17
IL290566B1 (en)	2023-03-01
PT3356529T (pt)	2021-11-04
IL258333B (en)	2022-03-01
US20180195070A1 (en)	2018-07-12
AU2022283623B2 (en)	2025-07-10
CL2018000803A1 (es)	2018-08-31
AU2016331084B2 (en)	2022-09-08

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