PL339176A1 - Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase - Google Patents

Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase

Info

Publication number: PL339176A1
Authority: PL; Poland
Prior art keywords: pyrrolopyrrolone; inhibitors; derivatives; neutrophilic elastase; neutrophilic
Prior art date: 1997-09-09

Application number

PL98339176A

Other languages

English (en)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-09

Filing date

1998-09-07

Publication date

2000-12-04

1997-09-09 Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en

1997-09-09 Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en

1997-09-10 Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en

1998-02-21 Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en

1998-09-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2000-12-04 Publication of PL339176A1 publication Critical patent/PL339176A1/xx

Links

ACJSMQZKXAMMRA-UHFFFAOYSA-N 1h-pyrrolo[3,2-b]pyrrol-5-one Chemical class N1C=CC2=NC(=O)C=C21 ACJSMQZKXAMMRA-UHFFFAOYSA-N 0.000 title 1
102000016387 Pancreatic elastase Human genes 0.000 title 1
108010067372 Pancreatic elastase Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
230000003448 neutrophilic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

PL98339176A 1997-09-09 1998-09-07 Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase PL339176A1 (en)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GBGB9719189.4A GB9719189D0 (en)	1997-09-09	1997-09-09	New therapeutic method
GBGB9719183.7A GB9719183D0 (en)	1997-09-09	1997-09-09	Compounds
GBGB9719290.0A GB9719290D0 (en)	1997-09-10	1997-09-10	Compounds
GBGB9803611.4A GB9803611D0 (en)	1998-02-21	1998-02-21	Compounds
PCT/EP1998/005609 WO1999012933A2 (fr)	1997-09-09	1998-09-07	Derives de pyrrolopyrrolone en tant qu'inhibiteurs de neutrophile elastase

Publications (1)

Publication Number	Publication Date
PL339176A1 true PL339176A1 (en)	2000-12-04

Family

ID=27451698

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL98339176A PL339176A1 (en)	1997-09-09	1998-09-07	Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase

Country Status (24)

Country	Link
EP (1)	EP1003748A2 (fr)
JP (1)	JP2001515904A (fr)
KR (1)	KR20010023766A (fr)
CN (1)	CN1278820A (fr)
AP (1)	AP2000001761A0 (fr)
AR (1)	AR017072A1 (fr)
AU (1)	AU9741298A (fr)
BR (1)	BR9812062A (fr)
CA (1)	CA2303176A1 (fr)
CO (1)	CO4970719A1 (fr)
EA (1)	EA200000204A1 (fr)
EE (1)	EE200000138A (fr)
HU (1)	HUP0004644A3 (fr)
ID (1)	ID24452A (fr)
IL (1)	IL134791A0 (fr)
IS (1)	IS5391A (fr)
MA (1)	MA26543A1 (fr)
NO (1)	NO20001198L (fr)
NZ (1)	NZ503130A (fr)
PE (1)	PE107899A1 (fr)
PL (1)	PL339176A1 (fr)
SK (1)	SK3192000A3 (fr)
TR (1)	TR200000907T2 (fr)
WO (1)	WO1999012933A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9905418D0 (en) *	1999-03-09	1999-05-05	Glaxo Group Ltd	Process
JP2007531755A (ja)	2004-03-31	2007-11-08	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	非イミダゾール系複素環式化合物
DE102004024772A1 (de) *	2004-05-17	2005-12-22	Grünenthal GmbH	Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
TWI355380B (en)	2004-05-27	2012-01-01	Nihon Nohyaku Co Ltd	Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (ja) *	2004-05-27	2012-01-11	日本農薬株式会社	置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
GB2418427A (en)	2004-09-02	2006-03-29	Univ Cambridge Tech	Ligands for G-protein coupled receptors
MX2007005137A (es)	2004-11-23	2007-06-22	Warner Lambert Co	Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
DE602007009095D1 (de)	2006-05-04	2010-10-21	Pulmagen Therapeutics Inflamma	Tetrahydropyrrolopyrimidindione und ihre verwendung als inhibitoren der humanen neutrophilen elastase
US8198288B2 (en)	2006-05-04	2012-06-12	Pulmagen Therapeutics (Inflammation) Limited	Tetrahydropyrrolopyrimidinediones and their use in therapy
US7662967B2 (en)	2007-08-02	2010-02-16	Cambridge Enterprise Limited	Anti-inflammatory compounds and compositions
GB2452696B (en)	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (fr) *	2007-11-07	2009-05-14	Argenta Discovery Limited	3,4,6,7-tétrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones et leur utilisation thérapeutique
US20110212181A1 (en) *	2010-02-26	2011-09-01	The University Of Hong Kong	Compositions and methods for treating chronic respiratory inflammation
BR112022004861A2 (pt)	2019-09-17	2022-06-07	Univ Duke	Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
SI4106757T1 (sl)	2020-04-16	2023-11-30	Mereo Biopharma 4 Limited	Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
IL312002A (en)	2021-10-20	2024-06-01	Mereo Biopharma 4 Ltd	Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
GB9402680D0 (en) *	1994-02-11	1994-04-06	Zeneca Ltd	Pyrrolidine derivatives
AR006401A1 (es) *	1996-03-28	1999-08-25	Glaxo Group Ltd	Compuestos de pirrolopirrolona, una composicion farmaceutica que los contiene, su uso en la fabricacion de un medicamento y en terapia, procesospara su preparación y compuestos intermediarios para dichos procesos.

1998
- 1998-09-04 PE PE1998000828A patent/PE107899A1/es not_active Application Discontinuation
- 1998-09-07 AP APAP/P/2000/001761A patent/AP2000001761A0/en unknown
- 1998-09-07 EE EEP200000138A patent/EE200000138A/xx unknown
- 1998-09-07 EA EA200000204A patent/EA200000204A1/ru unknown
- 1998-09-07 JP JP2000510740A patent/JP2001515904A/ja active Pending
- 1998-09-07 MA MA25243A patent/MA26543A1/fr unknown
- 1998-09-07 IL IL13479198A patent/IL134791A0/xx unknown
- 1998-09-07 KR KR1020007002422A patent/KR20010023766A/ko not_active Withdrawn
- 1998-09-07 AU AU97412/98A patent/AU9741298A/en not_active Abandoned
- 1998-09-07 EP EP98951348A patent/EP1003748A2/fr not_active Withdrawn
- 1998-09-07 CA CA002303176A patent/CA2303176A1/fr not_active Abandoned
- 1998-09-07 AR ARP980104458A patent/AR017072A1/es unknown
- 1998-09-07 WO PCT/EP1998/005609 patent/WO1999012933A2/fr not_active Ceased
- 1998-09-07 SK SK319-2000A patent/SK3192000A3/sk unknown
- 1998-09-07 PL PL98339176A patent/PL339176A1/xx not_active Application Discontinuation
- 1998-09-07 BR BR9812062-0A patent/BR9812062A/pt not_active Application Discontinuation
- 1998-09-07 ID IDW20000445A patent/ID24452A/id unknown
- 1998-09-07 HU HU0004644A patent/HUP0004644A3/hu unknown
- 1998-09-07 NZ NZ503130A patent/NZ503130A/en unknown
- 1998-09-07 CN CN98810954A patent/CN1278820A/zh active Pending
- 1998-09-07 TR TR2000/00907T patent/TR200000907T2/xx unknown
- 1998-09-08 CO CO98051488A patent/CO4970719A1/es unknown
2000
- 2000-02-29 IS IS5391A patent/IS5391A/is unknown
- 2000-03-08 NO NO20001198A patent/NO20001198L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0004644A2 (hu)	2001-09-28
AP2000001761A0 (en)	2000-03-31
KR20010023766A (ko)	2001-03-26
ID24452A (id)	2000-07-20
BR9812062A (pt)	2000-09-26
AU9741298A (en)	1999-03-29
WO1999012933A2 (fr)	1999-03-18
AR017072A1 (es)	2001-08-22
NZ503130A (en)	2001-08-31
CA2303176A1 (fr)	1999-03-18
EA200000204A1 (ru)	2000-10-30
NO20001198D0 (no)	2000-03-08
CO4970719A1 (es)	2000-11-07
TR200000907T2 (tr)	2000-11-21
JP2001515904A (ja)	2001-09-25
EE200000138A (et)	2001-02-15
IS5391A (is)	2000-02-29
PE107899A1 (es)	1999-11-17
CN1278820A (zh)	2001-01-03
EP1003748A2 (fr)	2000-05-31
IL134791A0 (en)	2001-04-30
HUP0004644A3 (en)	2002-01-28
NO20001198L (no)	2000-05-08
MA26543A1 (fr)	2004-12-20
SK3192000A3 (en)	2001-03-12
WO1999012933A3 (fr)	1999-05-27

Legal Events

Date	Code	Title	Description
2007-02-28	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL339551A1 (en)	2000-12-18	Derivatives of rezorcin
PL333918A1 (en)	2000-01-31	Derivatives of 6-phenylpyryidil-2-amine useful as nos inhibitors
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
SI1174431T1 (sl)	2012-09-28	2-fenil-substituirani imidazotriazinoni kot inhibitorji fosfodiesteraze
IL141445A0 (en)	2002-03-10	Benzazine derivatives as phosphodiesterase 4 inhibitors
PL337773A1 (en)	2000-09-11	Derivatives of benzimidazoles
PL331856A1 (en)	1999-08-16	Heterocyclic inhibitors of metaloprotease
ID24372A (id)	2000-07-13	SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
ZA98376B (en)	1998-07-23	Sulfamide-metalloprotease inhibitors
PL339660A1 (en)	2001-01-02	Derivatives of amidocarboxylic acids
PL329153A1 (en)	1999-03-15	Derivatives of pyrrolopyrolone as inhibitors of neutropil elastase
PL337645A1 (en)	2000-08-28	Novel amidine derivatives and their application as thrombosin inhibitors
HU0900792D0 (en)	2010-03-01	Use of renin-angiotensin inhibitors
AU2274299A (en)	1999-07-12	Benzazine derivatives phosphodiesterase 4 inhibitors
PL337725A1 (en)	2000-08-28	Inhibitors of proteases
PL339176A1 (en)	2000-12-04	Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase
PL337827A1 (en)	2000-09-11	Bactericidal derivatives of n-sulphoglycin alkynyloxyphenethylamide
PL340461A1 (en)	2001-02-12	Derivatives of isothiazocarboxylic acid
IL141446A0 (en)	2002-03-10	Benzazine derivatives as phosphodiesterase 4 inhibitors
ZA983065B (en)	1998-10-20	Inhibitors of protein farnesyltranferase
PL334769A1 (en)	2000-03-13	Derivatives of 5-aroylnaphtene
PL339186A1 (en)	2000-12-04	Derivatives of pyrrolopyrrolone as inhibitors of neutrophilic elastase
ZA985064B (en)	1998-08-28	Derivatives of pentaerythrits
PL338777A1 (en)	2000-11-20	Derivative of piperidinylmethyloxazolydinone
PL328221A1 (en)	1999-03-01	Novel derivatives of urea