TR200000907T2 - Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri. - Google Patents

Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.

Info

Publication number
TR200000907T2
TR200000907T2 TR2000/00907T TR200000907T TR200000907T2 TR 200000907 T2 TR200000907 T2 TR 200000907T2 TR 2000/00907 T TR2000/00907 T TR 2000/00907T TR 200000907 T TR200000907 T TR 200000907T TR 200000907 T2 TR200000907 T2 TR 200000907T2
Authority
TR
Turkey
Prior art keywords
pyrolopirolone
derivatives
neutrophil elastase
elastase inhibitors
compounds
Prior art date
Application number
TR2000/00907T
Other languages
English (en)
Turkish (tr)
Inventor
Duke Edward Clarke Geoffrey
Dennis Dowle Michael
Finch Harry
Andrew Harrison Lee
George Adam Inglis Graham
Redpath Johnson Martin
John Fawcett Macdonald Simon
Shah Pritom
Andrew Smith Robin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of TR200000907T2 publication Critical patent/TR200000907T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
TR2000/00907T 1997-09-09 1998-09-07 Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri. TR200000907T2 (tr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds

Publications (1)

Publication Number Publication Date
TR200000907T2 true TR200000907T2 (tr) 2000-11-21

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00907T TR200000907T2 (tr) 1997-09-09 1998-09-07 Nötrofil elastaz inhibitörleri olarak pirolopirolon türevleri.

Country Status (24)

Country Link
EP (1) EP1003748A2 (fr)
JP (1) JP2001515904A (fr)
KR (1) KR20010023766A (fr)
CN (1) CN1278820A (fr)
AP (1) AP2000001761A0 (fr)
AR (1) AR017072A1 (fr)
AU (1) AU9741298A (fr)
BR (1) BR9812062A (fr)
CA (1) CA2303176A1 (fr)
CO (1) CO4970719A1 (fr)
EA (1) EA200000204A1 (fr)
EE (1) EE200000138A (fr)
HU (1) HUP0004644A3 (fr)
ID (1) ID24452A (fr)
IL (1) IL134791A0 (fr)
IS (1) IS5391A (fr)
MA (1) MA26543A1 (fr)
NO (1) NO20001198L (fr)
NZ (1) NZ503130A (fr)
PE (1) PE107899A1 (fr)
PL (1) PL339176A1 (fr)
SK (1) SK3192000A3 (fr)
TR (1) TR200000907T2 (fr)
WO (1) WO1999012933A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
JP2007531755A (ja) 2004-03-31 2007-11-08 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 非イミダゾール系複素環式化合物
DE102004024772A1 (de) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituierte 5-Aminomethyl-1H-pyrrol-2-carbonsäureamide
TWI355380B (en) 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (ja) * 2004-05-27 2012-01-11 日本農薬株式会社 置換ピラジンカルボン酸アニリド誘導体又はその塩類、その中間体及び農園芸用薬剤並びにその使用方法
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
MX2007005137A (es) 2004-11-23 2007-06-22 Warner Lambert Co Derivados del acido 7-(2h-pyrazol-3-il)-3, 5-dihidroxi-heptanoico como inhibidores de hmg co-a reductasa para el tratamiento de lipidemia.
DE602007009095D1 (de) 2006-05-04 2010-10-21 Pulmagen Therapeutics Inflamma Tetrahydropyrrolopyrimidindione und ihre verwendung als inhibitoren der humanen neutrophilen elastase
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (fr) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tétrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones et leur utilisation thérapeutique
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
SI4106757T1 (sl) 2020-04-16 2023-11-30 Mereo Biopharma 4 Limited Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
IL312002A (en) 2021-10-20 2024-06-01 Mereo Biopharma 4 Ltd Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
AR006401A1 (es) * 1996-03-28 1999-08-25 Glaxo Group Ltd Compuestos de pirrolopirrolona, una composicion farmaceutica que los contiene, su uso en la fabricacion de un medicamento y en terapia, procesospara su preparación y compuestos intermediarios para dichos procesos.

Also Published As

Publication number Publication date
HUP0004644A2 (hu) 2001-09-28
AP2000001761A0 (en) 2000-03-31
KR20010023766A (ko) 2001-03-26
ID24452A (id) 2000-07-20
BR9812062A (pt) 2000-09-26
AU9741298A (en) 1999-03-29
WO1999012933A2 (fr) 1999-03-18
AR017072A1 (es) 2001-08-22
NZ503130A (en) 2001-08-31
CA2303176A1 (fr) 1999-03-18
EA200000204A1 (ru) 2000-10-30
NO20001198D0 (no) 2000-03-08
CO4970719A1 (es) 2000-11-07
JP2001515904A (ja) 2001-09-25
EE200000138A (et) 2001-02-15
PL339176A1 (en) 2000-12-04
IS5391A (is) 2000-02-29
PE107899A1 (es) 1999-11-17
CN1278820A (zh) 2001-01-03
EP1003748A2 (fr) 2000-05-31
IL134791A0 (en) 2001-04-30
HUP0004644A3 (en) 2002-01-28
NO20001198L (no) 2000-05-08
MA26543A1 (fr) 2004-12-20
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (fr) 1999-05-27

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