PL3413892T3 - Pochodne tetrahydroizochinoliny - Google Patents

Pochodne tetrahydroizochinoliny

Info

Publication number: PL3413892T3
Authority: PL; Poland
Prior art keywords: tetrahydroisoquinoline derivatives; tetrahydroisoquinoline; derivatives
Prior art date: 2016-02-12

Application number

PL17750801T

Other languages

English (en)

Inventor

Ippei Sato

Takashi Kamikubo

Masanori Miura

Yuji Matsushima

Hiroaki Tanaka

Yasuhiro Shiina

Susumu Yamaki

Tomoyuki Saito

Hiroshi Kiyohara

Munemichi OHE

Kayoko Mihara

Bradley Paul Morgan

Fady Malik

Scott Emile Collibee

Luke Ashcraft

Pu-Ping Lu

Jeffrey Michael Warrington

Marc GARARD

Original Assignee

Cytokinetics, Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-02-12

Filing date

2017-02-10

Publication date

2022-06-13

2017-02-10 Application filed by Cytokinetics, Incorporated filed Critical Cytokinetics, Incorporated

2022-06-13 Publication of PL3413892T3 publication Critical patent/PL3413892T3/pl

Links

125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
- C12N2509/10—Mechanical dissociation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Hospice & Palliative Care (AREA)
Cell Biology (AREA)
Child & Adolescent Psychology (AREA)
General Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL17750801T 2016-02-12 2017-02-10 Pochodne tetrahydroizochinoliny PL3413892T3 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201662285039P	2016-02-12	2016-02-12
PCT/US2017/017295 WO2017139526A1 (en)	2016-02-12	2017-02-10	Tetrahydroisoquinoline derivatives
EP17750801.7A EP3413892B1 (en)	2016-02-12	2017-02-10	Tetrahydroisoquinoline derivatives

Publications (1)

Publication Number	Publication Date
PL3413892T3 true PL3413892T3 (pl)	2022-06-13

Family

ID=59561239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL17750801T PL3413892T3 (pl)	2016-02-12	2017-02-10	Pochodne tetrahydroizochinoliny

Country Status (34)

Country	Link
US (5)	US9914741B2 (pl)
EP (2)	EP4032877A1 (pl)
JP (2)	JP6832943B2 (pl)
KR (1)	KR20180120701A (pl)
CN (2)	CN113666938A (pl)
AR (1)	AR107592A1 (pl)
AU (1)	AU2017217663B2 (pl)
BR (1)	BR112018016475A2 (pl)
CA (1)	CA3012839A1 (pl)
CL (1)	CL2018002287A1 (pl)
CO (1)	CO2018007920A2 (pl)
CY (1)	CY1125222T1 (pl)
DK (1)	DK3413892T3 (pl)
ES (1)	ES2913423T3 (pl)
HR (1)	HRP20220655T1 (pl)
HU (1)	HUE058820T2 (pl)
IL (1)	IL261055B (pl)
LT (1)	LT3413892T (pl)
MA (1)	MA44018B1 (pl)
MD (1)	MD3413892T2 (pl)
MX (1)	MX379159B (pl)
NZ (1)	NZ746311A (pl)
PH (1)	PH12018501694B1 (pl)
PL (1)	PL3413892T3 (pl)
PT (1)	PT3413892T (pl)
RS (1)	RS63240B1 (pl)
RU (1)	RU2743424C2 (pl)
SG (1)	SG11201806416XA (pl)
SI (1)	SI3413892T1 (pl)
SM (1)	SMT202200201T1 (pl)
TW (2)	TWI773118B (pl)
UA (1)	UA124879C2 (pl)
WO (1)	WO2017139526A1 (pl)
ZA (1)	ZA201804947B (pl)

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SG11201806416XA (en) *	2016-02-12	2018-08-30	Astellas Pharma Inc	Tetrahydroisoquinoline derivatives
GB201905721D0 (en)	2019-04-24	2019-06-05	Univ Dundee	Compounds
JP7825618B2 (ja)	2020-11-06	2026-03-06	サイトキネティックス，インコーポレイテッド	二環式１，４－ジアゼパノン及びその治療的使用
WO2025080100A1 (ko) *	2023-10-11	2025-04-17	한국화학연구원	신규한 디-아미드 화합물, 이의 제조방법, 이를 유효성분으로 포함하는 암 또는 자가면역질환의 예방 또는 치료용 약학적 조성물
CN117379425B (zh) *	2023-11-14	2026-07-03	广州日聚商贸发展有限公司	喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用

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SG11201806416XA (en) *	2016-02-12	2018-08-30	Astellas Pharma Inc	Tetrahydroisoquinoline derivatives

2017
- 2017-02-10 SG SG11201806416XA patent/SG11201806416XA/en unknown
- 2017-02-10 EP EP22160176.8A patent/EP4032877A1/en not_active Withdrawn
- 2017-02-10 SM SM20220201T patent/SMT202200201T1/it unknown
- 2017-02-10 TW TW110103986A patent/TWI773118B/zh not_active IP Right Cessation
- 2017-02-10 BR BR112018016475-5A patent/BR112018016475A2/en not_active IP Right Cessation
- 2017-02-10 PH PH1/2018/501694A patent/PH12018501694B1/en unknown
- 2017-02-10 CN CN202110837700.6A patent/CN113666938A/zh active Pending
- 2017-02-10 UA UAA201809258A patent/UA124879C2/uk unknown
- 2017-02-10 AR ARP170100336A patent/AR107592A1/es unknown
- 2017-02-10 CA CA3012839A patent/CA3012839A1/en active Pending
- 2017-02-10 ES ES17750801T patent/ES2913423T3/es active Active
- 2017-02-10 RU RU2018130002A patent/RU2743424C2/ru active
- 2017-02-10 PT PT177508017T patent/PT3413892T/pt unknown
- 2017-02-10 JP JP2018541693A patent/JP6832943B2/ja not_active Expired - Fee Related
- 2017-02-10 CN CN201780010949.1A patent/CN109069498B/zh not_active Expired - Fee Related
- 2017-02-10 RS RS20220483A patent/RS63240B1/sr unknown
- 2017-02-10 PL PL17750801T patent/PL3413892T3/pl unknown
- 2017-02-10 MX MX2018009759A patent/MX379159B/es unknown
- 2017-02-10 KR KR1020187026486A patent/KR20180120701A/ko not_active Withdrawn
- 2017-02-10 NZ NZ746311A patent/NZ746311A/en not_active IP Right Cessation
- 2017-02-10 DK DK17750801.7T patent/DK3413892T3/da active
- 2017-02-10 SI SI201731142T patent/SI3413892T1/sl unknown
- 2017-02-10 HU HUE17750801A patent/HUE058820T2/hu unknown
- 2017-02-10 WO PCT/US2017/017295 patent/WO2017139526A1/en not_active Ceased
- 2017-02-10 AU AU2017217663A patent/AU2017217663B2/en not_active Ceased
- 2017-02-10 HR HRP20220655TT patent/HRP20220655T1/hr unknown
- 2017-02-10 US US15/429,738 patent/US9914741B2/en active Active
- 2017-02-10 EP EP17750801.7A patent/EP3413892B1/en active Active
- 2017-02-10 LT LTEPPCT/US2017/017295T patent/LT3413892T/lt unknown
- 2017-02-10 MA MA44018A patent/MA44018B1/fr unknown
- 2017-02-10 TW TW106104493A patent/TWI719138B/zh not_active IP Right Cessation
- 2017-02-10 MD MDE20181214T patent/MD3413892T2/ro unknown
2018
- 2018-01-17 US US15/873,571 patent/US10259821B2/en active Active
- 2018-07-23 ZA ZA2018/04947A patent/ZA201804947B/en unknown
- 2018-07-30 CO CONC2018/0007920A patent/CO2018007920A2/es unknown
- 2018-08-08 IL IL261055A patent/IL261055B/en active IP Right Grant
- 2018-08-10 CL CL2018002287A patent/CL2018002287A1/es unknown
2019
- 2019-03-04 US US16/291,481 patent/US10689393B2/en active Active
2020
- 2020-05-11 US US16/871,532 patent/US11479561B2/en active Active
2021
- 2021-02-01 JP JP2021014223A patent/JP7137650B2/ja not_active Expired - Fee Related
2022
- 2022-06-03 CY CY20221100392T patent/CY1125222T1/el unknown
- 2022-09-13 US US17/944,060 patent/US20230125280A1/en not_active Abandoned

Also Published As

Publication number	Publication date
UA124879C2 (uk)	2021-12-08
RS63240B1 (sr)	2022-06-30
KR20180120701A (ko)	2018-11-06
HUE058820T2 (hu)	2022-09-28
WO2017139526A8 (en)	2018-08-16
TW201741316A (zh)	2017-12-01
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RU2018130002A (ru)	2020-03-12
RU2743424C2 (ru)	2021-02-18
MX2018009759A (es)	2018-11-29
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EP4032877A1 (en)	2022-07-27
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PH12018501694B1 (en)	2023-08-30
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CN109069498A (zh)	2018-12-21
CY1125222T1 (el)	2025-03-28
EP3413892B1 (en)	2022-04-20
MD3413892T2 (ro)	2022-06-30
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CN109069498B (zh)	2021-08-17
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AU201616673S (en)	2016-12-21	tallboy
AU2016303V (en)	2016-11-09	Desse1601 Desmanthus virgatus
AP2016001138S (en)	2016-09-05	Chisa kooka