MA44018B1 - Dérivés de tétrahydroisoquinoline - Google Patents

Dérivés de tétrahydroisoquinoline

Info

Publication number
MA44018B1
MA44018B1 MA44018A MA44018A MA44018B1 MA 44018 B1 MA44018 B1 MA 44018B1 MA 44018 A MA44018 A MA 44018A MA 44018 A MA44018 A MA 44018A MA 44018 B1 MA44018 B1 MA 44018B1
Authority
MA
Morocco
Prior art keywords
muscle
troponin
disorders
tetrahydroisoquinoline
treating
Prior art date
Application number
MA44018A
Other languages
English (en)
Other versions
MA44018A (fr
Inventor
Hiroaki Tanaka
Ippei Sato
Takashi Kamikubo
Masanori Miura
Yuji Matsushima
Yasuhiro Shiina
Susumu Yamaki
Tomoyuki Saito
Hiroshi Kiyohara
Munemichi OHE
Kayoko Mihara
Bradley MORGAN
Fady Malik
Scott Collibee
Luke Ashcraft
Pu-Ping Lu
Jeffrey Warrington
Marc Garard
Original Assignee
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytokinetics Inc filed Critical Cytokinetics Inc
Publication of MA44018A publication Critical patent/MA44018A/fr
Publication of MA44018B1 publication Critical patent/MA44018B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne de nouveaux composés dérivés de la tétrahydroisoquinoline qui peuvent être utilisés à titre de principe actif pour une composition pharmaceutique, et en particulier, pour une composition pharmaceutique utile pour prévenir ou traiter une maladie ou une affection sensible à la modulation de la contractilité du sarcomère squelettique. L'objectif est atteint, par exemple, par modulation du complexe de troponine du sarcomère du muscle squelettique rapide par l'intermédiaire d'un ou de plusieurs des filaments suivants : myosine squelettique rapide, actine, tropomyosine, troponine c, troponine i et troponine t, leurs fragments et isoformes. Les composés dérivés de la tétrahydroisoquinoline peuvent ainsi être utilisés comme agent pour prévenir ou traiter 1) les troubles neuromusculaires, 2) les troubles du muscle volontaire, 3) les troubles du snc dans lesquels la faiblesse, l'atrophie, et la fatigue musculaires sont des symptômes importants, 4) les symptômes musculaires provenant de troubles systémiques, et 5) les dysfonctions du plancher pelvien et du muscle sphincter urétral/anal.
MA44018A 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline MA44018B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662285039P 2016-02-12 2016-02-12
PCT/US2017/017295 WO2017139526A1 (fr) 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline

Publications (2)

Publication Number Publication Date
MA44018A MA44018A (fr) 2018-12-19
MA44018B1 true MA44018B1 (fr) 2022-05-31

Family

ID=59561239

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44018A MA44018B1 (fr) 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline

Country Status (34)

Country Link
US (5) US9914741B2 (fr)
EP (2) EP3413892B1 (fr)
JP (2) JP6832943B2 (fr)
KR (1) KR20180120701A (fr)
CN (2) CN109069498B (fr)
AR (1) AR107592A1 (fr)
AU (1) AU2017217663B2 (fr)
BR (1) BR112018016475A2 (fr)
CA (1) CA3012839A1 (fr)
CL (1) CL2018002287A1 (fr)
CO (1) CO2018007920A2 (fr)
CY (1) CY1125222T1 (fr)
DK (1) DK3413892T3 (fr)
ES (1) ES2913423T3 (fr)
HR (1) HRP20220655T1 (fr)
HU (1) HUE058820T2 (fr)
IL (1) IL261055B (fr)
LT (1) LT3413892T (fr)
MA (1) MA44018B1 (fr)
MD (1) MD3413892T2 (fr)
MX (1) MX379159B (fr)
NZ (1) NZ746311A (fr)
PH (1) PH12018501694B1 (fr)
PL (1) PL3413892T3 (fr)
PT (1) PT3413892T (fr)
RS (1) RS63240B1 (fr)
RU (1) RU2743424C2 (fr)
SG (1) SG11201806416XA (fr)
SI (1) SI3413892T1 (fr)
SM (1) SMT202200201T1 (fr)
TW (2) TWI773118B (fr)
UA (1) UA124879C2 (fr)
WO (1) WO2017139526A1 (fr)
ZA (1) ZA201804947B (fr)

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HRP20220655T1 (hr) 2022-06-24
CN109069498B (zh) 2021-08-17
IL261055B (en) 2021-03-25
AU2017217663B2 (en) 2021-06-17
NZ746311A (en) 2022-08-26
TW201741316A (zh) 2017-12-01
US11479561B2 (en) 2022-10-25
JP7137650B2 (ja) 2022-09-14
MD3413892T2 (ro) 2022-06-30
MX379159B (es) 2025-03-10
CY1125222T1 (el) 2025-03-28
EP3413892B1 (fr) 2022-04-20
PL3413892T3 (pl) 2022-06-13
CN109069498A (zh) 2018-12-21
PH12018501694B1 (en) 2023-08-30
TW202138373A (zh) 2021-10-16
MX2018009759A (es) 2018-11-29
HUE058820T2 (hu) 2022-09-28
WO2017139526A8 (fr) 2018-08-16
CA3012839A1 (fr) 2017-08-17
US20200270266A1 (en) 2020-08-27
US20180148458A1 (en) 2018-05-31
LT3413892T (lt) 2022-06-10
WO2017139526A1 (fr) 2017-08-17
AU2017217663A1 (en) 2018-10-04
US10259821B2 (en) 2019-04-16
PT3413892T (pt) 2022-05-30
RU2018130002A (ru) 2020-03-12
JP2021073270A (ja) 2021-05-13
UA124879C2 (uk) 2021-12-08
JP2019509267A (ja) 2019-04-04
US20190194220A1 (en) 2019-06-27
US10689393B2 (en) 2020-06-23
US20170233402A1 (en) 2017-08-17
DK3413892T3 (da) 2022-05-23
KR20180120701A (ko) 2018-11-06
US20230125280A1 (en) 2023-04-27
US9914741B2 (en) 2018-03-13
JP6832943B2 (ja) 2021-02-24
SMT202200201T1 (it) 2022-07-21
MA44018A (fr) 2018-12-19
RU2743424C2 (ru) 2021-02-18
TWI773118B (zh) 2022-08-01
CO2018007920A2 (es) 2018-12-14
BR112018016475A2 (en) 2018-12-26
EP4032877A1 (fr) 2022-07-27
PH12018501694A1 (en) 2019-01-28
ZA201804947B (en) 2024-05-30
AR107592A1 (es) 2018-05-16
ES2913423T3 (es) 2022-06-02
RU2018130002A3 (fr) 2020-03-24
SG11201806416XA (en) 2018-08-30
CN113666938A (zh) 2021-11-19
EP3413892A1 (fr) 2018-12-19
EP3413892A4 (fr) 2019-08-14
TWI719138B (zh) 2021-02-21
IL261055A (en) 2018-10-31
RS63240B1 (sr) 2022-06-30
SI3413892T1 (sl) 2022-06-30
CL2018002287A1 (es) 2019-01-04

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