MA44018A - Dérivés de tétrahydroisoquinoline - Google Patents

Dérivés de tétrahydroisoquinoline

Info

Publication number
MA44018A
MA44018A MA044018A MA44018A MA44018A MA 44018 A MA44018 A MA 44018A MA 044018 A MA044018 A MA 044018A MA 44018 A MA44018 A MA 44018A MA 44018 A MA44018 A MA 44018A
Authority
MA
Morocco
Prior art keywords
tetrahydroisoquinoline derivatives
tetrahydroisoquinoline
derivatives
Prior art date
Application number
MA044018A
Other languages
English (en)
Other versions
MA44018B1 (fr
Inventor
Luke Ashcraft
Scott Emile Collibee
Marc Garard
Takashi Kamikubo
Hiroshi Kiyohara
Pu-Ping Lu
Fady Malik
Yuji Matsushima
Kayoko Mihara
Masanori Miura
Bradley Paul Morgan
Munemichi OHE
Tomoyuki Saito
Ippei Sato
Yasuhiro Shiina
Hiroaki Tanaka
Jeffrey Michael Warrington
Susumu Yamaki
Original Assignee
Astellas Pharma Inc
Cytokinetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc, Cytokinetics Inc filed Critical Astellas Pharma Inc
Publication of MA44018A publication Critical patent/MA44018A/fr
Publication of MA44018B1 publication Critical patent/MA44018B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658—Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
MA44018A 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline MA44018B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662285039P 2016-02-12 2016-02-12
PCT/US2017/017295 WO2017139526A1 (fr) 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline

Publications (2)

Publication Number Publication Date
MA44018A true MA44018A (fr) 2018-12-19
MA44018B1 MA44018B1 (fr) 2022-05-31

Family

ID=59561239

Family Applications (1)

Application Number Title Priority Date Filing Date
MA44018A MA44018B1 (fr) 2016-02-12 2017-02-10 Dérivés de tétrahydroisoquinoline

Country Status (34)

Country Link
US (5) US9914741B2 (fr)
EP (2) EP4032877A1 (fr)
JP (2) JP6832943B2 (fr)
KR (1) KR20180120701A (fr)
CN (2) CN113666938A (fr)
AR (1) AR107592A1 (fr)
AU (1) AU2017217663B2 (fr)
BR (1) BR112018016475A2 (fr)
CA (1) CA3012839A1 (fr)
CL (1) CL2018002287A1 (fr)
CO (1) CO2018007920A2 (fr)
CY (1) CY1125222T1 (fr)
DK (1) DK3413892T3 (fr)
ES (1) ES2913423T3 (fr)
HR (1) HRP20220655T1 (fr)
HU (1) HUE058820T2 (fr)
IL (1) IL261055B (fr)
LT (1) LT3413892T (fr)
MA (1) MA44018B1 (fr)
MD (1) MD3413892T2 (fr)
MX (1) MX379159B (fr)
NZ (1) NZ746311A (fr)
PH (1) PH12018501694B1 (fr)
PL (1) PL3413892T3 (fr)
PT (1) PT3413892T (fr)
RS (1) RS63240B1 (fr)
RU (1) RU2743424C2 (fr)
SG (1) SG11201806416XA (fr)
SI (1) SI3413892T1 (fr)
SM (1) SMT202200201T1 (fr)
TW (2) TWI719138B (fr)
UA (1) UA124879C2 (fr)
WO (1) WO2017139526A1 (fr)
ZA (1) ZA201804947B (fr)

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SMT202200201T1 (it) 2016-02-12 2022-07-21 Cytokinetics Inc Derivati di tetraidroisochinolina
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
JP7825618B2 (ja) * 2020-11-06 2026-03-06 サイトキネティックス， インコーポレイテッド 二環式１，４－ジアゼパノン及びその治療的使用
WO2025080100A1 (fr) * 2023-10-11 2025-04-17 한국화학연구원 Nouveau composé di-amide, son procédé de préparation et composition pharmaceutique pour la prévention ou le traitement du cancer ou de maladies auto-immunes le comprenant en tant que principe actif
CN117379425A (zh) * 2023-11-14 2024-01-12 广州日聚商贸发展有限公司 喹啉-4-羧酸在抗衰老产品以及保护肝脏、促进肝脏再生产品制备中的应用

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Also Published As

Publication number Publication date
RS63240B1 (sr) 2022-06-30
US11479561B2 (en) 2022-10-25
HUE058820T2 (hu) 2022-09-28
JP7137650B2 (ja) 2022-09-14
JP2019509267A (ja) 2019-04-04
PH12018501694A1 (en) 2019-01-28
JP6832943B2 (ja) 2021-02-24
BR112018016475A2 (en) 2018-12-26
ES2913423T3 (es) 2022-06-02
RU2018130002A (ru) 2020-03-12
US20190194220A1 (en) 2019-06-27
NZ746311A (en) 2022-08-26
WO2017139526A1 (fr) 2017-08-17
MA44018B1 (fr) 2022-05-31
CA3012839A1 (fr) 2017-08-17
US20180148458A1 (en) 2018-05-31
US9914741B2 (en) 2018-03-13
EP3413892A1 (fr) 2018-12-19
EP3413892A4 (fr) 2019-08-14
CN109069498B (zh) 2021-08-17
CN109069498A (zh) 2018-12-21
IL261055A (en) 2018-10-31
SI3413892T1 (sl) 2022-06-30
CL2018002287A1 (es) 2019-01-04
TWI773118B (zh) 2022-08-01
CY1125222T1 (el) 2025-03-28
EP3413892B1 (fr) 2022-04-20
TW202138373A (zh) 2021-10-16
WO2017139526A8 (fr) 2018-08-16
MX379159B (es) 2025-03-10
PL3413892T3 (pl) 2022-06-13
KR20180120701A (ko) 2018-11-06
US20200270266A1 (en) 2020-08-27
HRP20220655T1 (hr) 2022-06-24
RU2743424C2 (ru) 2021-02-18
US20170233402A1 (en) 2017-08-17
UA124879C2 (uk) 2021-12-08
CN113666938A (zh) 2021-11-19
MX2018009759A (es) 2018-11-29
EP4032877A1 (fr) 2022-07-27
AU2017217663B2 (en) 2021-06-17
PH12018501694B1 (en) 2023-08-30
MD3413892T2 (ro) 2022-06-30
AR107592A1 (es) 2018-05-16
JP2021073270A (ja) 2021-05-13
TW201741316A (zh) 2017-12-01
CO2018007920A2 (es) 2018-12-14
ZA201804947B (en) 2024-05-30
SMT202200201T1 (it) 2022-07-21
PT3413892T (pt) 2022-05-30
AU2017217663A1 (en) 2018-10-04
US10259821B2 (en) 2019-04-16
US10689393B2 (en) 2020-06-23
IL261055B (en) 2021-03-25
RU2018130002A3 (fr) 2020-03-24
SG11201806416XA (en) 2018-08-30
LT3413892T (lt) 2022-06-10
TWI719138B (zh) 2021-02-21
US20230125280A1 (en) 2023-04-27
DK3413892T3 (da) 2022-05-23

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