PL341661A1 - Novel fluorescent reporter particles and their application in combination with testing capsizes - Google Patents

Novel fluorescent reporter particles and their application in combination with testing capsizes

Info

Publication number
PL341661A1
PL341661A1 PL98341661A PL34166198A PL341661A1 PL 341661 A1 PL341661 A1 PL 341661A1 PL 98341661 A PL98341661 A PL 98341661A PL 34166198 A PL34166198 A PL 34166198A PL 341661 A1 PL341661 A1 PL 341661A1
Authority
PL
Poland
Prior art keywords
capsizes
testing
combination
application
fluorescent reporter
Prior art date
Application number
PL98341661A
Other languages
English (en)
Inventor
Eckard Weber
Sui Xiong Cai
John F W Keana
John A Drewe
Han-Zhong Zhang
Original Assignee
Cytovia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytovia filed Critical Cytovia
Publication of PL341661A1 publication Critical patent/PL341661A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL98341661A 1997-10-10 1998-10-09 Novel fluorescent reporter particles and their application in combination with testing capsizes PL341661A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6158297P 1997-10-10 1997-10-10
US3366198A 1998-03-03 1998-03-03

Publications (1)

Publication Number Publication Date
PL341661A1 true PL341661A1 (en) 2001-04-23

Family

ID=26709974

Family Applications (1)

Application Number Title Priority Date Filing Date
PL98341661A PL341661A1 (en) 1997-10-10 1998-10-09 Novel fluorescent reporter particles and their application in combination with testing capsizes

Country Status (15)

Country Link
EP (1) EP1026988A4 (fr)
JP (1) JP2001519368A (fr)
KR (1) KR20010031056A (fr)
CN (1) CN1281346A (fr)
AU (1) AU754634B2 (fr)
BR (1) BR9814816A (fr)
CA (1) CA2308125A1 (fr)
EA (1) EA200000408A1 (fr)
HU (1) HUP0100079A2 (fr)
IL (1) IL135365A0 (fr)
IS (1) IS5414A (fr)
NO (1) NO20001322L (fr)
NZ (1) NZ503619A (fr)
PL (1) PL341661A1 (fr)
WO (1) WO1999018856A1 (fr)

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US6342611B1 (en) 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
EP1100520B1 (fr) 1998-07-21 2004-09-22 Cytovia, Inc. Nouveaux colorants fluorescents et leurs applications dans des methodes de criblage par fluorescence de cellules entieres pour des caspases, peptidases, proteases et autres enzymes ainsi que leurs procedes d' utilisation
DE50003728D1 (en) * 1999-03-12 2003-10-23 Evotec Technologies Gmbh Chemosensitivitätsmessung über caspase-aktivität
EP1055929A1 (fr) * 1999-05-26 2000-11-29 Tibotec N.V. Moyens et procédé pour la découverte des médicaments et la caractérisation des cellules
AU4906100A (en) * 1999-05-27 2000-12-18 Merck Frosst Canada & Co. Assays for caspase activity using green fluorescent proteins
US6261794B1 (en) * 1999-10-14 2001-07-17 Saint Louis University Methods for identifying inhibitors of methionine aminopeptidases
AU781986B2 (en) 1999-11-05 2005-06-23 Cytovia, Inc. Substituted 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof
GB9927331D0 (en) 1999-11-18 2000-01-12 Fluorescience Ltd Assay for measuring enzyme activity in vivo
EP1324993A2 (fr) 2000-04-18 2003-07-09 Cytovia, Inc. Thiazepine-1,4 substituee et analogues de celle-ci activateurs de caspases et inducteurs d'apoptose, et utilisation
WO2002012545A2 (fr) * 2000-08-03 2002-02-14 Cytovia, Inc. Procédé d'identification d'agents immunosuppresseurs
DE10053747C2 (de) * 2000-10-30 2002-10-24 Deutsches Krebsforsch Verfahren zur gleichzeitigen Bestimmung zweier Fluoreszenz-Emissionen mit einem Einlaser-Durchflußzytometer
EP1205540A1 (fr) 2000-11-10 2002-05-15 Evotec OAI AG Procédé pour déterminer la vitalité de cellules
WO2002102301A2 (fr) 2000-12-07 2002-12-27 Cytovia, Inc. Benzylidene-hydrazides d'acide indole-2-carboxylique substitues et analogues utilises comme activateurs de caspases et inducteurs d'apoptose, et leur utilisation
US6716851B2 (en) 2000-12-12 2004-04-06 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
US7256219B2 (en) 2001-03-14 2007-08-14 Cytovia, Inc. Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof
US6979530B2 (en) 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
EP1472238B1 (fr) 2002-02-01 2012-07-04 Promega Corporation Dosage bioluminescent de la protease
US7476741B2 (en) 2002-05-16 2009-01-13 Cytovia, Inc. Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
CN100349887C (zh) 2002-05-16 2007-11-21 西托维亚公司 取代的4－芳基－4h－吡咯并[2,3－h]色烯和类似物及其药物组合物和用途
DE60235652D1 (de) * 2002-07-08 2010-04-22 Ge Healthcare Uk Ltd Reagenzien sowie ein verfahren zur sättigungsmarkierung von proteinen
AU2003299378A1 (en) * 2002-10-11 2004-05-04 Board Of Regents, The University Of Texas System Method and compounds for inhibiting hec1 activity for the treatment of proliferative diseases
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MXPA06001601A (es) 2003-08-13 2006-08-25 Takeda Pharmaceutical Derivados de 4-pirimidona y su uso como inhibidores de dipeptidilpeptidasa.
WO2005047245A2 (fr) 2003-11-14 2005-05-26 Wisconsin Alumni Research Foundation Dosages par fluorescence à sensibilité améliorée
EP1704257A2 (fr) 2004-01-16 2006-09-27 Applera Corporation Essais fluorogeniques pour kinase et substrats
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KR100909996B1 (ko) * 2007-09-19 2009-07-29 한국생명공학연구원 카스파제-3(ｃａｓｐａｓｅ-3)의 활성 검출용 융합 단백질및 이를 이용한 카스파제-3의 활성 검출방법
CN102603695B (zh) * 2012-02-10 2014-06-18 山东大学 一种氨基酸-荧光团类化合物及其应用
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CN104458709A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选钙激活中性蛋白酶-1抑制剂高通量筛选方法
WO2016006678A1 (fr) * 2014-07-11 2016-01-14 国立大学法人 東京大学 Sonde fluorescente pour la détection de la dipeptidyle peptidase iv
CN104263356B (zh) * 2014-09-29 2016-02-24 辽宁大学 一种含有甲硫氨酸结构的罗丹明pH荧光探针及其应用
CN106146611B (zh) * 2015-05-14 2019-09-17 中国科学院大连化学物理研究所 一种测定二肽基肽酶iv活性的荧光探针底物及其应用
EP3475443B1 (fr) 2016-06-23 2025-02-12 Life Technologies Corporation Méthodes et compositions de détection ou de mesure de caspases ou d'apoptose
CA3037767A1 (fr) * 2016-09-28 2018-04-05 Georgia Tech Research Corporation Methodes et compositions permettant la detection non invasive des rejets de greffes d'organes
WO2018071556A1 (fr) 2016-10-11 2018-04-19 The Regents Of The University Of California Détection, identification et purification d'enzymes de dégradation et de non dégradation dans des échantillons biologiques
CN107987019A (zh) * 2018-01-08 2018-05-04 深圳市佶达德科技有限公司 一种若丹明双吡唑乙酸酯有机激光材料的制备方法
CN108129388A (zh) * 2018-01-08 2018-06-08 深圳市佶达德科技有限公司 一种若丹明双吡唑乙酸酯有机激光材料及其应用
CN108760234B (zh) * 2018-06-05 2020-05-15 哈尔滨工程大学 一种基于piv和ptv技术的流体流动与固体运动信息同步测试方法和装置
KR102138256B1 (ko) * 2018-09-13 2020-08-13 한국과학기술연구원 케스페이즈-1 활성 측정용 프로브, 이를 포함하는 염증성 질환 진단용 조성물
CN112961209B (zh) * 2021-04-07 2022-06-24 中国科学院武汉病毒研究所 caspase抑制剂及其应用
CN114107435A (zh) * 2021-11-30 2022-03-01 广东省人民医院 一种用于免疫治疗实时监测的可激活光声-荧光双模探针及应用
CN117143949B (zh) * 2023-08-31 2024-04-05 青岛海洋食品营养与健康创新研究院 一种南极磷虾源高f值寡肽及其在护肝中的应用
CN121449684A (zh) * 2025-10-30 2026-02-03 浙江大学 一种基于FRET的caspase-1响应性荧光探针、制备方法、应用及产品

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EP1100520B1 (fr) * 1998-07-21 2004-09-22 Cytovia, Inc. Nouveaux colorants fluorescents et leurs applications dans des methodes de criblage par fluorescence de cellules entieres pour des caspases, peptidases, proteases et autres enzymes ainsi que leurs procedes d' utilisation

Also Published As

Publication number Publication date
AU754634B2 (en) 2002-11-21
AU1072299A (en) 1999-05-03
JP2001519368A (ja) 2001-10-23
KR20010031056A (ko) 2001-04-16
NO20001322L (no) 2000-06-13
EA200000408A1 (ru) 2000-12-25
IL135365A0 (en) 2001-05-20
CN1281346A (zh) 2001-01-24
EP1026988A1 (fr) 2000-08-16
HUP0100079A2 (hu) 2001-05-28
EP1026988A4 (fr) 2005-03-30
IS5414A (is) 2000-03-24
NO20001322D0 (no) 2000-03-14
WO1999018856A1 (fr) 1999-04-22
NZ503619A (en) 2001-11-30
BR9814816A (pt) 2004-06-22
CA2308125A1 (fr) 1999-04-22

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