PL3417883T3 - Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i ligand zawierający hydroksypirydynon - Google Patents

Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i ligand zawierający hydroksypirydynon

Info

Publication number
PL3417883T3
PL3417883T3 PL18163914T PL18163914T PL3417883T3 PL 3417883 T3 PL3417883 T3 PL 3417883T3 PL 18163914 T PL18163914 T PL 18163914T PL 18163914 T PL18163914 T PL 18163914T PL 3417883 T3 PL3417883 T3 PL 3417883T3
Authority
PL
Poland
Prior art keywords
hydroxypyridinone
containing ligand
particle emitting
emitting complexes
targeted alpha
Prior art date
Application number
PL18163914T
Other languages
English (en)
Inventor
Thomas Ramdahl
Original Assignee
Bayer As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer As filed Critical Bayer As
Publication of PL3417883T3 publication Critical patent/PL3417883T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1051—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from breast, e.g. the antibody being herceptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
PL18163914T 2010-02-12 2011-02-14 Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i ligand zawierający hydroksypirydynon PL3417883T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1002508.8A GB201002508D0 (en) 2010-02-12 2010-02-12 Product
EP11702857.1A EP2533817B1 (en) 2010-02-12 2011-02-14 Targeted alpha-particle emitting complexes comprising thorium radionuclide and hydroxypyridinone containing ligand
EP18163914.7A EP3417883B1 (en) 2010-02-12 2011-02-14 Targeted alpha-particle emitting complexes comprising thorium radionuclide and hydroxypyridinone containing ligand
PCT/EP2011/052158 WO2011098611A2 (en) 2010-02-12 2011-02-14 Alpha-emitting complexes

Publications (1)

Publication Number Publication Date
PL3417883T3 true PL3417883T3 (pl) 2020-08-24

Family

ID=42110714

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11702857T PL2533817T3 (pl) 2010-02-12 2011-02-14 Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i hydroksypirydynon zawierający ligand
PL18163914T PL3417883T3 (pl) 2010-02-12 2011-02-14 Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i ligand zawierający hydroksypirydynon

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL11702857T PL2533817T3 (pl) 2010-02-12 2011-02-14 Ukierunkowane kompleksy emitujące cząstki alfa zawierające radionuklid toru i hydroksypirydynon zawierający ligand

Country Status (27)

Country Link
US (2) US9724436B2 (pl)
EP (2) EP2533817B1 (pl)
JP (2) JP5878483B2 (pl)
KR (1) KR101931382B1 (pl)
CN (1) CN103608043B (pl)
AU (1) AU2011214281B2 (pl)
BR (1) BR112012020304B1 (pl)
CA (1) CA2789433C (pl)
CY (1) CY1120362T1 (pl)
DK (2) DK3417883T3 (pl)
EA (1) EA026305B1 (pl)
ES (2) ES2674875T3 (pl)
GB (1) GB201002508D0 (pl)
HR (2) HRP20180996T1 (pl)
HU (2) HUE038013T2 (pl)
IL (2) IL221416A (pl)
LT (2) LT2533817T (pl)
MX (1) MX343405B (pl)
NZ (1) NZ601867A (pl)
PL (2) PL2533817T3 (pl)
PT (2) PT2533817T (pl)
RS (2) RS57360B1 (pl)
SG (1) SG183279A1 (pl)
SI (2) SI2533817T1 (pl)
SM (1) SMT201800325T1 (pl)
TR (1) TR201809149T4 (pl)
WO (1) WO2011098611A2 (pl)

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US8557601B2 (en) 2006-07-10 2013-10-15 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
WO2011025790A1 (en) 2009-08-24 2011-03-03 Lumiphore, Inc. Macrocyclic hopo chelators
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201208309D0 (en) * 2012-05-11 2012-06-27 Algeta As Complexes
EP3939972A1 (en) 2013-01-14 2022-01-19 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles
GB201310028D0 (en) 2013-06-05 2013-07-17 Algeta Asa Pharmaceutical preparation
MA41176A (fr) * 2014-12-17 2017-10-24 Bayer As Complexes radio-pharmaceutiques
US10434186B2 (en) * 2014-12-22 2019-10-08 Lumiphore, Inc. Functionalized linear ligands and complexes thereof
GB201504064D0 (en) 2015-03-10 2015-04-22 Accretion Biotechnology Ltd Method and kits for preparing radionuclide complexes
GB201600154D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
GB201600161D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope purification method
SG10202009424TA (en) 2016-03-24 2020-11-27 Bayer Pharma AG Radio-pharmaceutical complexes
CN109689115A (zh) 2016-06-10 2019-04-26 拜耳制药股份公司 放射性药物配合物
WO2018153975A1 (en) 2017-02-24 2018-08-30 Bayer As Combination therapy comprising a radiopharmaceutical and a dna-repair inhibitor
US20200297877A1 (en) 2017-12-13 2020-09-24 Sciencons AS Complex comprising a psma-targeting compound linked to a lead or thorium radionuclide
US20210187134A1 (en) 2018-08-28 2021-06-24 Bayer As Combination of pi3k-inhibitors and targeted thorium conjugates
US12194111B2 (en) 2018-10-16 2025-01-14 Nant Holdings Ip, Llc Alpha emitter compositions and methods
US20220125960A1 (en) 2019-02-21 2022-04-28 Bayer Aktiengesellschaft Combination of pd-1/pd-l1 inhibitors and targeted thorium conjugates
WO2020169538A1 (en) 2019-02-22 2020-08-27 Bayer Aktiengesellschaft Combination of ar antagonists and targeted thorium conjugates
WO2021013978A1 (en) 2019-07-25 2021-01-28 Bayer As Targeted radiopharmaceuticals for the diagnosis and treatment of prostate cancer
CN116745323A (zh) 2021-01-22 2023-09-12 拜耳股份有限公司 Lrrc15抗体及其缀合物
US11541134B1 (en) 2021-08-02 2023-01-03 Rayzebio, Inc. Stabilized compositions of radionuclides and uses thereof
CN121793988A (zh) 2023-09-13 2026-04-03 东丽株式会社 癌的治疗、预防和/或诊断用药物组合物
WO2025137443A1 (en) 2023-12-22 2025-06-26 Rayzebio, Inc. Radiopharmaceutical compositions targeting somatostatin receptors and uses thereof
US20250222146A1 (en) 2023-12-22 2025-07-10 Rayzebio, Inc. Radiopharmaceuticals Targeting Somatostatin Receptor 2 and Uses Thereof

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GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes

Also Published As

Publication number Publication date
WO2011098611A3 (en) 2015-07-02
CY1120362T1 (el) 2019-07-10
HUE049465T2 (hu) 2020-09-28
US10682430B2 (en) 2020-06-16
JP2016029114A (ja) 2016-03-03
SG183279A1 (en) 2012-09-27
BR112012020304A2 (pt) 2016-04-26
ES2674875T3 (es) 2018-07-04
HRP20200826T1 (hr) 2020-08-07
SI2533817T1 (en) 2018-08-31
CN103608043A (zh) 2014-02-26
SI3417883T1 (sl) 2020-07-31
GB201002508D0 (en) 2010-03-31
DK2533817T3 (en) 2018-07-16
EA201290712A1 (ru) 2014-12-30
IL221416A (en) 2016-03-31
IL243303A (en) 2017-09-28
PL2533817T3 (pl) 2018-08-31
LT3417883T (lt) 2020-07-10
NZ601867A (en) 2014-11-28
EA026305B1 (ru) 2017-03-31
TR201809149T4 (tr) 2018-07-23
KR20120130769A (ko) 2012-12-03
CN103608043B (zh) 2017-07-28
EP3417883B1 (en) 2020-03-25
US20130183235A1 (en) 2013-07-18
CA2789433C (en) 2019-01-15
SMT201800325T1 (it) 2018-09-13
AU2011214281B2 (en) 2014-01-16
JP5878483B2 (ja) 2016-03-08
IL221416A0 (en) 2012-10-31
RS60314B1 (sr) 2020-07-31
PT3417883T (pt) 2020-06-01
PT2533817T (pt) 2018-06-29
RS57360B1 (sr) 2018-08-31
EP3417883A1 (en) 2018-12-26
HRP20180996T1 (hr) 2018-08-10
IL243303A0 (en) 2016-04-21
WO2011098611A2 (en) 2011-08-18
HUE038013T2 (hu) 2018-09-28
ES2794853T3 (es) 2020-11-19
US9724436B2 (en) 2017-08-08
BR112012020304B1 (pt) 2019-12-10
MX2012009260A (es) 2013-02-07
US20170319721A1 (en) 2017-11-09
JP6125599B2 (ja) 2017-05-10
DK3417883T3 (da) 2020-06-08
LT2533817T (lt) 2018-07-10
KR101931382B1 (ko) 2018-12-20
MX343405B (es) 2016-11-03
CA2789433A1 (en) 2011-08-18
AU2011214281A1 (en) 2012-08-30
EP2533817B1 (en) 2018-03-28
EP2533817A2 (en) 2012-12-19
JP2013519658A (ja) 2013-05-30

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