PL3424930T3 - Kryształ związku wykazującego aktywność hamującą JAK - Google Patents

Kryształ związku wykazującego aktywność hamującą JAK

Info

Publication number
PL3424930T3
PL3424930T3 PL17759943T PL17759943T PL3424930T3 PL 3424930 T3 PL3424930 T3 PL 3424930T3 PL 17759943 T PL17759943 T PL 17759943T PL 17759943 T PL17759943 T PL 17759943T PL 3424930 T3 PL3424930 T3 PL 3424930T3
Authority
PL
Poland
Prior art keywords
jak
crystal
compound
inhibiting activity
inhibiting
Prior art date
Application number
PL17759943T
Other languages
English (en)
Inventor
Fumi Higuchi
Original Assignee
Nippon Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co., Ltd. filed Critical Nippon Shinyaku Co., Ltd.
Publication of PL3424930T3 publication Critical patent/PL3424930T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PL17759943T 2016-03-01 2017-02-28 Kryształ związku wykazującego aktywność hamującą JAK PL3424930T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2016039315 2016-03-01
PCT/JP2017/007594 WO2017150477A1 (ja) 2016-03-01 2017-02-28 Ｊａｋ阻害作用を有する化合物の結晶
EP17759943.8A EP3424930B1 (en) 2016-03-01 2017-02-28 Crystal of compound having jak-inhibiting activity

Publications (1)

Publication Number Publication Date
PL3424930T3 true PL3424930T3 (pl) 2021-05-04

Family

ID=59743962

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17759943T PL3424930T3 (pl) 2016-03-01 2017-02-28 Kryształ związku wykazującego aktywność hamującą JAK

Country Status (22)

Country Link
US (2) US10822350B2 (pl)
EP (1) EP3424930B1 (pl)
JP (1) JP6791239B2 (pl)
KR (1) KR102653231B1 (pl)
CN (1) CN108699082B (pl)
BR (1) BR112018016523B1 (pl)
CA (3) CA3264321A1 (pl)
CY (1) CY1123607T1 (pl)
DK (1) DK3424930T3 (pl)
ES (1) ES2844978T3 (pl)
HR (1) HRP20210062T1 (pl)
HU (1) HUE051615T2 (pl)
LT (1) LT3424930T (pl)
MX (1) MX385381B (pl)
PL (1) PL3424930T3 (pl)
PT (1) PT3424930T (pl)
RS (1) RS61238B1 (pl)
RU (1) RU2705721C1 (pl)
SI (1) SI3424930T1 (pl)
SM (1) SMT202000717T1 (pl)
TW (1) TWI712604B (pl)
WO (1) WO2017150477A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI712604B (zh) * 2016-03-01 2020-12-11 日商日本新藥股份有限公司 具jak抑制作用之化合物之結晶
BE1028574B1 (nl) * 2020-09-14 2022-12-06 Eurochem Antwerpen Heterocyclische verbindingen gebruikt als nitrificatieremmer
WO2025216268A1 (ja) * 2024-04-09 2025-10-16 国立研究開発法人国立循環器病研究センター 重症肺高血圧症又は膠原病の予防又は治療薬
JP7742516B1 (ja) * 2025-07-31 2025-09-19 日本新薬株式会社 好酸球性多発血管炎性肉芽腫症の処置剤

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3600390A1 (de) 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
CN100465173C (zh) 2004-01-12 2009-03-04 西托匹亚研究有限公司 选择性激酶抑制剂
RU2008117151A (ru) * 2005-09-30 2009-11-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Деазапурины, пригодные в качестве ингибиторов янус-киназ
JP5591471B2 (ja) 2006-01-17 2014-09-17 バーテックス ファーマシューティカルズ インコーポレイテッド ヤヌスキナーゼ阻害剤として有用なアザインドール
SI2288610T1 (sl) 2008-03-11 2016-11-30 Incyte Holdings Corporation Derivati azetidina in ciklobutana kot inhibitorji jak
JO3041B1 (ar) 2008-07-25 2016-09-05 Galapagos Nv مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية
US8524707B2 (en) 2008-12-19 2013-09-03 Nerviano Medical Sciences S.R.L. Bicyclic pyrazoles as protein kinase inhibitors
TWI462920B (zh) 2009-06-26 2014-12-01 葛萊伯格有限公司 用於治療退化性及發炎疾病之新穎化合物
JP5739446B2 (ja) 2009-12-18 2015-06-24 ファイザー・インク ピロロ［２，３−ｄ］ピリミジン化合物
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
JP2011136925A (ja) 2009-12-28 2011-07-14 Dainippon Sumitomo Pharma Co Ltd 含窒素二環性化合物
BR112012017269A2 (pt) 2010-01-12 2016-05-03 Hoffmann La Roche compostos heterocíclicos tricíclicos, composições e métodos de uso dos mesmos
UY33213A (es) 2010-02-18 2011-09-30 Almirall Sa Derivados de pirazol como inhibidores de jak
WO2012022045A1 (en) 2010-08-20 2012-02-23 Hutchison Medipharma Limited Pyrrolopyrimidine compounds and uses thereof
WO2012037132A1 (en) 2010-09-14 2012-03-22 Exelixis, Inc. Phtalazine derivatives as jak1 inhibitors
EP2629777B1 (en) 2010-10-22 2018-12-19 Merck Sharp & Dohme Corp. Bicyclic diamines as janus kinase inhibitors
WO2012085176A1 (en) 2010-12-23 2012-06-28 F. Hoffmann-La Roche Ag Tricyclic pyrazinone compounds, compositions and methods of use thereof as janus kinase inhibitors
WO2013025628A1 (en) * 2011-08-15 2013-02-21 Ligand Pharmaceuticals Incorporated Janus kinase inhibitor compounds and methods
TWI679205B (zh) * 2014-09-02 2019-12-11 日商日本新藥股份有限公司 吡唑并噻唑化合物及醫藥
TWI712604B (zh) * 2016-03-01 2020-12-11 日商日本新藥股份有限公司 具jak抑制作用之化合物之結晶

Also Published As

Publication number Publication date
RS61238B1 (sr) 2021-01-29
KR102653231B1 (ko) 2024-04-01
CA3015464C (en) 2024-04-23
HRP20210062T1 (hr) 2021-03-05
BR112018016523A2 (pt) 2018-12-26
SMT202000717T1 (it) 2021-01-05
BR112018016523B1 (pt) 2024-02-06
MX385381B (es) 2025-03-18
HUE051615T2 (hu) 2021-03-01
CA3264321A1 (en) 2025-10-30
CN108699082B (zh) 2021-04-09
DK3424930T3 (da) 2021-01-11
SI3424930T1 (sl) 2021-01-29
US20190048023A1 (en) 2019-02-14
CN108699082A (zh) 2018-10-23
PT3424930T (pt) 2020-12-04
TWI712604B (zh) 2020-12-11
WO2017150477A1 (ja) 2017-09-08
US20210017191A1 (en) 2021-01-21
LT3424930T (lt) 2021-01-11
MX2018010334A (es) 2018-11-09
EP3424930A4 (en) 2019-07-10
TW201731855A (zh) 2017-09-16
RU2705721C1 (ru) 2019-11-11
KR20180116341A (ko) 2018-10-24
US10822350B2 (en) 2020-11-03
CY1123607T1 (el) 2022-03-24
JP6791239B2 (ja) 2020-11-25
JPWO2017150477A1 (ja) 2018-12-27
US11377453B2 (en) 2022-07-05
ES2844978T3 (es) 2021-07-23
EP3424930B1 (en) 2020-11-04
EP3424930A1 (en) 2019-01-09
CA3015464A1 (en) 2017-09-08
CA3206830A1 (en) 2017-09-08

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