PL3442535T3 - Związki heterocykliczne jako inhibitory kinazy ret - Google Patents
Związki heterocykliczne jako inhibitory kinazy retInfo
- Publication number
- PL3442535T3 PL3442535T3 PL17719688.8T PL17719688T PL3442535T3 PL 3442535 T3 PL3442535 T3 PL 3442535T3 PL 17719688 T PL17719688 T PL 17719688T PL 3442535 T3 PL3442535 T3 PL 3442535T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- heterocyclic compounds
- ret kinase
- ret
- heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201606635 | 2016-04-15 | ||
| PCT/GB2017/051077 WO2017178845A1 (en) | 2016-04-15 | 2017-04-18 | Heterocyclic compounds as ret kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3442535T3 true PL3442535T3 (pl) | 2022-10-24 |
Family
ID=58633036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17719688.8T PL3442535T3 (pl) | 2016-04-15 | 2017-04-18 | Związki heterocykliczne jako inhibitory kinazy ret |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10844067B2 (pl) |
| EP (2) | EP3442535B1 (pl) |
| CY (1) | CY1125551T1 (pl) |
| DK (1) | DK3442535T3 (pl) |
| ES (1) | ES2925698T3 (pl) |
| HR (1) | HRP20221051T8 (pl) |
| HU (1) | HUE060082T2 (pl) |
| LT (1) | LT3442535T (pl) |
| PL (1) | PL3442535T3 (pl) |
| PT (1) | PT3442535T (pl) |
| RS (1) | RS63609B1 (pl) |
| SI (1) | SI3442535T1 (pl) |
| SM (1) | SMT202200348T1 (pl) |
| WO (1) | WO2017178845A1 (pl) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME03376B (me) | 2010-05-20 | 2020-01-20 | Array Biopharma Inc | Makrociklička jedinjenja kао inhibiтori trk kinaze |
| BR112018000808A2 (pt) | 2015-07-16 | 2018-09-04 | Array Biopharma Inc | compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase |
| SI3371171T1 (sl) | 2015-11-02 | 2024-03-29 | Blueprint Medicines Corporation | Inhibitorji ret |
| WO2017178844A1 (en) | 2016-04-15 | 2017-10-19 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
| SI3442535T1 (sl) | 2016-04-15 | 2023-01-31 | Cancer Research Technology Limited | Heterociklične spojine kot zaviralci RET-kinaze |
| TWI752098B (zh) | 2016-10-10 | 2022-01-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
| WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
| WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
| JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
| GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| TWI876442B (zh) | 2017-10-10 | 2025-03-11 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
| TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
| JP7060694B2 (ja) * | 2018-01-18 | 2022-04-26 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物 |
| EP3740490A1 (en) * | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| US11472802B2 (en) | 2018-01-18 | 2022-10-18 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors |
| PE20210096A1 (es) | 2018-04-03 | 2021-01-12 | Blueprint Medicines Corp | Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
| EP4157829A1 (en) | 2020-05-29 | 2023-04-05 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| KR20230104781A (ko) | 2020-10-05 | 2023-07-10 | 인라이븐 테라퓨틱스, 인크. | Bcr-abl 티로신 키나아제의 억제를 위한 5- 및 6-아자인돌 화합물 |
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| DE69720965T2 (de) | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
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| SI3442535T1 (sl) | 2016-04-15 | 2023-01-31 | Cancer Research Technology Limited | Heterociklične spojine kot zaviralci RET-kinaze |
| WO2017178844A1 (en) | 2016-04-15 | 2017-10-19 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
-
2017
- 2017-04-18 SI SI201731215T patent/SI3442535T1/sl unknown
- 2017-04-18 DK DK17719688.8T patent/DK3442535T3/da active
- 2017-04-18 US US16/093,858 patent/US10844067B2/en active Active
- 2017-04-18 PL PL17719688.8T patent/PL3442535T3/pl unknown
- 2017-04-18 HU HUE17719688A patent/HUE060082T2/hu unknown
- 2017-04-18 EP EP17719688.8A patent/EP3442535B1/en active Active
- 2017-04-18 PT PT177196888T patent/PT3442535T/pt unknown
- 2017-04-18 HR HRP20221051TT patent/HRP20221051T8/hr unknown
- 2017-04-18 ES ES17719688T patent/ES2925698T3/es active Active
- 2017-04-18 LT LTEPPCT/GB2017/051077T patent/LT3442535T/lt unknown
- 2017-04-18 WO PCT/GB2017/051077 patent/WO2017178845A1/en not_active Ceased
- 2017-04-18 SM SM20220348T patent/SMT202200348T1/it unknown
- 2017-04-18 EP EP22175251.2A patent/EP4104837A3/en active Pending
- 2017-04-18 RS RS20220803A patent/RS63609B1/sr unknown
-
2020
- 2020-10-20 US US17/075,004 patent/US11661423B2/en active Active
-
2022
- 2022-08-29 CY CY20221100579T patent/CY1125551T1/el unknown
-
2023
- 2023-04-18 US US18/302,313 patent/US20240116938A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RS63609B1 (sr) | 2022-10-31 |
| SMT202200348T1 (it) | 2022-11-18 |
| CY1125551T1 (el) | 2026-02-25 |
| US11661423B2 (en) | 2023-05-30 |
| US20240116938A1 (en) | 2024-04-11 |
| EP3442535A1 (en) | 2019-02-20 |
| EP3442535B1 (en) | 2022-06-01 |
| DK3442535T3 (da) | 2022-09-05 |
| US10844067B2 (en) | 2020-11-24 |
| EP4104837A2 (en) | 2022-12-21 |
| HRP20221051T8 (hr) | 2023-07-21 |
| LT3442535T (lt) | 2022-10-25 |
| ES2925698T3 (es) | 2022-10-19 |
| PT3442535T (pt) | 2022-09-05 |
| US20210047334A1 (en) | 2021-02-18 |
| HUE060082T2 (hu) | 2023-01-28 |
| US20190263819A1 (en) | 2019-08-29 |
| HRP20221051T1 (hr) | 2023-03-03 |
| SI3442535T1 (sl) | 2023-01-31 |
| EP4104837A3 (en) | 2023-04-26 |
| WO2017178845A1 (en) | 2017-10-19 |
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