PL3468966T3 - Inhibitory interakcji menina-mll - Google Patents
Inhibitory interakcji menina-mllInfo
- Publication number
- PL3468966T3 PL3468966T3 PL17739383T PL17739383T PL3468966T3 PL 3468966 T3 PL3468966 T3 PL 3468966T3 PL 17739383 T PL17739383 T PL 17739383T PL 17739383 T PL17739383 T PL 17739383T PL 3468966 T3 PL3468966 T3 PL 3468966T3
- Authority
- PL
- Poland
- Prior art keywords
- menin
- interaction inhibitors
- mll interaction
- mll
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662348496P | 2016-06-10 | 2016-06-10 | |
| PCT/US2017/036506 WO2017214367A1 (en) | 2016-06-10 | 2017-06-08 | Inhibitors of the menin-mll interaction |
| EP17739383.2A EP3468966B1 (en) | 2016-06-10 | 2017-06-08 | Inhibitors of the menin-mll interaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3468966T3 true PL3468966T3 (pl) | 2021-04-06 |
Family
ID=59325631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17739383T PL3468966T3 (pl) | 2016-06-10 | 2017-06-08 | Inhibitory interakcji menina-mll |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US10683302B2 (pl) |
| EP (2) | EP3468966B1 (pl) |
| JP (4) | JP7007302B2 (pl) |
| KR (3) | KR102916887B1 (pl) |
| CN (1) | CN109743875B (pl) |
| AU (3) | AU2017278950B2 (pl) |
| BR (1) | BR122024002146A2 (pl) |
| CA (2) | CA3024180A1 (pl) |
| CY (1) | CY1124834T1 (pl) |
| DK (1) | DK3468966T3 (pl) |
| ES (1) | ES2831084T3 (pl) |
| HR (1) | HRP20201771T1 (pl) |
| HU (1) | HUE051451T2 (pl) |
| IL (4) | IL298381B2 (pl) |
| LT (1) | LT3468966T (pl) |
| MX (3) | MX381228B (pl) |
| PL (1) | PL3468966T3 (pl) |
| PT (1) | PT3468966T (pl) |
| SI (1) | SI3468966T1 (pl) |
| WO (1) | WO2017214367A1 (pl) |
| ZA (1) | ZA201900150B (pl) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040330A1 (en) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| AR104020A1 (es) | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
| EP3407884B1 (en) | 2016-01-26 | 2025-07-09 | Memorial Sloan-Kettering Cancer Center | Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1 |
| MX387806B (es) | 2016-03-16 | 2025-03-19 | Kura Oncology Inc | Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso |
| EP3429591B1 (en) | 2016-03-16 | 2023-03-15 | Kura Oncology, Inc. | Substituted thieno[2,3-d]pyrimidine derivatives as inhibitors of menin-mll and methods of use |
| KR20190015275A (ko) | 2016-05-02 | 2019-02-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 메닌 억제제로서의 피페리딘 |
| KR102916887B1 (ko) | 2016-06-10 | 2026-01-22 | 비타이 파마슈티컬즈, 엘엘씨 | 메닌-mll 상호 작용의 억제제 |
| EP3512858B1 (en) | 2016-09-14 | 2023-11-08 | Janssen Pharmaceutica NV | Fused bicyclic inhibitors of menin-mll interaction |
| ES2872003T3 (es) | 2016-09-14 | 2021-11-02 | Janssen Pharmaceutica Nv | Inhibidores espirobicíclicos de la interacción de menina-MLL |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| KR102513564B1 (ko) | 2016-12-15 | 2023-03-22 | 얀센 파마슈티카 엔.브이. | 메닌-mll 상호작용의 아제판 억제제 |
| EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
| KR20190133224A (ko) | 2017-03-31 | 2019-12-02 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 공유 메닌 억제제로서의 피페리딘 |
| WO2018190350A1 (ja) * | 2017-04-10 | 2018-10-18 | 三井化学アグロ株式会社 | ピリドン化合物およびそれを有効成分とする農園芸用殺菌剤 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TW201920170A (zh) | 2017-09-20 | 2019-06-01 | 美商庫拉腫瘤技術股份有限公司 | 經取代之menin-mll 抑制劑及使用方法 |
| JP7307729B2 (ja) * | 2017-12-20 | 2023-07-12 | ヤンセン ファーマシューティカ エヌ．ベー． | メニン－ｍｌｌ相互作用のエキソ－アザスピロ阻害剤 |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| CN112105621B (zh) | 2018-03-30 | 2024-02-20 | 住友制药株式会社 | 光学活性桥型环状仲胺衍生物 |
| US10815241B2 (en) | 2018-08-27 | 2020-10-27 | Sumitomo Dainippon Pharma Co., Ltd. | Optically active azabicyclo ring derivative |
| JP6671574B1 (ja) * | 2018-08-27 | 2020-03-25 | 大日本住友製薬株式会社 | 光学活性なアザビシクロ環誘導体 |
| WO2020114474A1 (zh) * | 2018-12-06 | 2020-06-11 | 苏州信诺维医药科技有限公司 | 一种杂环化合物、其应用及含其的药物组合物 |
| MX2021006696A (es) | 2018-12-06 | 2021-07-07 | Daiichi Sankyo Co Ltd | Derivado de cicloalcano-1,3-diamina. |
| JP7536767B2 (ja) | 2018-12-31 | 2024-08-20 | バイオメア フュージョン，インコーポレイテッド | メニン－ｍｌｌ相互作用の不可逆的阻害剤 |
| US11174263B2 (en) | 2018-12-31 | 2021-11-16 | Biomea Fusion, Inc. | Inhibitors of menin-MLL interaction |
| JP7618567B2 (ja) | 2019-09-27 | 2025-01-21 | 住友ファーマ株式会社 | 架橋型光学活性２級アミン誘導体 |
| CN114555592B (zh) | 2019-10-09 | 2024-09-06 | 诺华股份有限公司 | 作为m4激动剂的2-氮杂螺[3.4]辛烷衍生物 |
| PE20221454A1 (es) * | 2019-10-09 | 2022-09-21 | Novartis Ag | Derivados de 2-azaespiro[3.4]octano como agonistas de m4 |
| TWI878414B (zh) * | 2019-12-19 | 2025-04-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| JP7454520B2 (ja) * | 2020-02-26 | 2024-03-22 | 住友ファーマ株式会社 | 光学活性なアザビシクロ環誘導体からなる医薬 |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| WO2021207335A1 (en) * | 2020-04-07 | 2021-10-14 | Syndax Pharmaceuticals, Inc. | Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof |
| WO2022086986A1 (en) * | 2020-10-21 | 2022-04-28 | Kura Oncology, Inc. | Treatment of hematological malignancies with inhibitors of menin |
| CN114516873A (zh) * | 2020-11-18 | 2022-05-20 | 苏州优理生物医药科技有限公司 | 一种螺环类化合物、包含其药物组合物及其应用 |
| RU2752079C1 (ru) * | 2020-12-01 | 2021-07-22 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" | (Е)-(6-(2-гидроксифенил)-2-иминио-4,7,8-триоксо-1,3-дифенил-1,3,6-триазаспиро[4.4]нонан-9-илиден)(4-метоксифенил)метаноат, обладающий противомикробной активностью, и способ его получения |
| WO2022237626A1 (en) | 2021-05-08 | 2022-11-17 | Janssen Pharmaceutica Nv | Substituted spiro derivatives |
| AU2022275192A1 (en) | 2021-05-08 | 2024-01-04 | Janssen Pharmaceutica Nv | Substituted spiro derivatives |
| KR20240006638A (ko) * | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| KR20240006631A (ko) * | 2021-05-11 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 조합 요법 |
| CA3213074A1 (en) * | 2021-05-14 | 2022-11-17 | Salvacion Cacatian | Inhibitors of the menin-mll interaction |
| IL308862A (en) | 2021-06-01 | 2024-01-01 | Janssen Pharmaceutica Nv | Altered phenyl-1H-pyrrolo[3,2-c]pyridine histories |
| WO2022253309A1 (zh) * | 2021-06-03 | 2022-12-08 | 首药控股(北京)股份有限公司 | 取代的杂环化合物及其应用 |
| BR112023025436A2 (pt) | 2021-06-03 | 2024-02-27 | Janssen Pharmaceutica Nv | Piridazinas ou 1,2,4-triazinas substituídas por aminas espirocíclicas |
| WO2022257047A1 (en) * | 2021-06-09 | 2022-12-15 | Acerand Therapeutics (Hong Kong) Limited | Diazaspirobicylic compounds as protein-protein interaction inhibitors and applications thereof |
| PH12023553300A1 (en) | 2021-06-17 | 2024-04-08 | Janssen Pharmaceutica Nv | (r)-n-ethyl-5-fluoro-n-isopropyl-2-((5-(2-(6-((2-methoxyethyl)(methyl)amino)-2-methylhexan-3-yl)-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl)oxy)benzamide besylate salt for the treatment of diseases such as cancer |
| CN115515958B (zh) * | 2021-08-04 | 2023-09-29 | 成都苑东生物制药股份有限公司 | 一种新型磺酰胺类menin-MLL相互作用抑制剂、其制备方法及医药用途 |
| WO2023011446A1 (zh) * | 2021-08-04 | 2023-02-09 | 成都苑东生物制药股份有限公司 | 一种新型磺酰胺类menin-MLL相互作用抑制剂、其制备方法及医药用途 |
| CA3228627A1 (en) | 2021-08-11 | 2023-02-16 | Thomas Butler | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| KR20240087693A (ko) | 2021-08-20 | 2024-06-19 | 바이오메아 퓨전, 인크. | 암 치료를 위한 비가역적 메닌-mll 억제제인 n-[4-[4-(4-모르폴리닐)-7h-피롤로[2,3-d]피리미딘-6-일]페닐]-4-[[3(r)-[(1-옥소-2-프로펜-1-일)아미노]-1-피페리디닐]메틸]-2-피리딘카르복스아미드의 결정질 형태 |
| CN113769098B (zh) * | 2021-09-22 | 2022-09-30 | 中国医学科学院肿瘤医院深圳医院 | MLL-menin抑制剂组合物在制备抗肝癌药物中的应用 |
| MX2024006783A (es) * | 2021-12-03 | 2024-07-29 | Bionova Pharmaceuticals Shanghai Ltd | Compuestos de diazaspiro sustituidos con carbonilo y su uso. |
| CA3244647A1 (en) * | 2021-12-31 | 2025-06-13 | Hitgen Inc. | MENINO-MLL INHIBITOR AND ITS USE |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| CN117069719A (zh) * | 2022-08-17 | 2023-11-17 | 烨辉医药科技(上海)有限公司 | 二氮杂螺环-哒嗪化合物及其用途 |
| WO2024046457A1 (en) * | 2022-09-02 | 2024-03-07 | Hutchmed Limited | Triazine compounds and uses thereof |
| WO2024110649A1 (en) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
| CN118271341A (zh) * | 2022-12-30 | 2024-07-02 | 成都先导药物开发股份有限公司 | Menin抑制剂及其用途 |
| TW202430528A (zh) | 2023-01-18 | 2024-08-01 | 美商拜歐米富士恩股份有限公司 | Ｎ－［４－［４－（４－嗎啉基）－７ｈ－吡咯並［２，３－ｄ］嘧啶－６－基］苯基］－４－［［３（ｒ）－［（１－氧代－２－丙烯－１－基）氨基］－１－哌啶基］甲基］－２－吡啶甲醯胺的結晶形式作為ｍｅｎｉｎ－ｍｌｌ相互作用的共價抑制劑 |
| AR132185A1 (es) | 2023-03-24 | 2025-06-04 | Acerta Pharma Bv | COMPUESTOS DE 1-H-PIRROLO[2,3-c]PIRIDINA |
| CN121358726A (zh) * | 2023-04-13 | 2026-01-16 | 首药控股(北京)股份有限公司 | 取代的杂环化合物 |
| CN118994033B (zh) * | 2023-05-17 | 2025-09-16 | 成都先导药物开发股份有限公司 | 一种sdnx-5613的合成方法及其中间体化合物 |
| CN116969891A (zh) * | 2023-07-28 | 2023-10-31 | 杭州国瑞生物科技有限公司 | 一种7-甲基-5-醛基-1h-吲唑的合成方法 |
| TW202525797A (zh) * | 2023-08-28 | 2025-07-01 | 美商錫達斯醫藥股份有限公司 | 作為ｍｅｎｉｎ－ｍｌｌ交互作用之抑制劑的芳基醚類似物 |
| WO2025059366A1 (en) * | 2023-09-13 | 2025-03-20 | Kumquat Biosciences Inc. | Ras inhibitors |
| AU2024371790A1 (en) | 2023-11-04 | 2026-04-30 | Syndax Pharmaceuticals, Inc. | Salts and polymorphic forms of revumenib |
| WO2025188611A1 (en) * | 2024-03-04 | 2025-09-12 | Dana-Farber Cancer Institute, Inc. | Chemical matters for targeting leukemic complex proteins |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| US6124477A (en) | 1996-06-27 | 2000-09-26 | Bioavailability Systems, Llc | Anti-first-pass effect compounds |
| US5820915A (en) | 1996-06-27 | 1998-10-13 | Bioavailability Systems, L.L.C. | Method for the preparation of a first-pass effective citrus-derived substance and product thereof |
| US5990154A (en) | 1997-05-30 | 1999-11-23 | Bioavailability Systems, L.L.C. | Anti-first-pass effect compounds and citrus extract |
| US6248776B1 (en) | 1997-08-26 | 2001-06-19 | Bioavailability Systems, L.L.C. | Anti-first-pass effect compounds |
| US6063809A (en) | 1997-08-26 | 2000-05-16 | Bioavailability Systems, Llc | Anti-first-pass effect compounds |
| US20040058982A1 (en) | 1999-02-17 | 2004-03-25 | Bioavailability System, Llc | Pharmaceutical compositions |
| US5993887A (en) | 1998-06-29 | 1999-11-30 | Bioavailability Systems, L.L.C. | Safe citrus juice and process for preparation |
| JP2001270867A (ja) * | 2000-03-23 | 2001-10-02 | Sumitomo Chem Co Ltd | フェニルピリダジン化合物 |
| WO2004037827A1 (en) | 2000-10-20 | 2004-05-06 | Bioavailability Systems, Llc | Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates |
| JP3592301B2 (ja) * | 2002-02-07 | 2004-11-24 | 株式会社田窪工業所 | 簡易建造物の床パネルと側面パネルの接続構造 |
| US7968569B2 (en) | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| CA2559328A1 (en) | 2004-03-11 | 2005-09-22 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
| MXPA06012909A (es) | 2004-05-07 | 2007-09-06 | Sequoia Pharmaceuticals Inc | Inhibidores de proteasa retroviral repelente de resistencia. |
| US20090281114A1 (en) | 2008-05-08 | 2009-11-12 | Fabre-Kramer Pharmaceuticals, Inc. | Indolylalkyl derivatives of pyrimidinylpiperazine and metabolites thereof for treatment of anxiety, depression, and sexual dysfunction |
| AR071717A1 (es) | 2008-05-13 | 2010-07-07 | Array Biopharma Inc | Pirrolo[2,3-b]piridinas inhibidoras de quinasas chk1 y chk2,composiciones farmaceuticas que las contienen,proceso para prepararlas y uso de las mismas en el tratamiento y prevencion del cancer. |
| EA031153B1 (ru) | 2011-06-10 | 2018-11-30 | Мерк Патент Гмбх | Применение пиримидиновых соединений с btk ингибирующей активностью |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
| AU2013360866A1 (en) * | 2012-12-18 | 2015-07-02 | Almirall, S.A. | New cyclohexyl and quinuclidinyl carbamate derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activity |
| US9458124B2 (en) * | 2013-02-06 | 2016-10-04 | Wayne State University | Substituted pyran derivatives |
| US9216993B2 (en) | 2013-03-13 | 2015-12-22 | The Regents Of The University Of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
| DK3290407T3 (da) * | 2013-10-18 | 2020-03-23 | Celgene Quanticel Res Inc | Bromodomæneinhibitorer |
| WO2015108940A2 (en) | 2014-01-14 | 2015-07-23 | The Trustees Of The University Of Pennsylvania | Tailored combinatorial epigenetic therapies for p53 gain-of-function tumors |
| US20170119769A1 (en) | 2014-06-10 | 2017-05-04 | The Trustees Of The University Of Pennsylvania | Scaffolds for inhibitors of menin-mll interactions |
| CA2956962A1 (en) | 2014-08-13 | 2016-02-18 | Epizyme, Inc. | Combination therapy for treating cancer |
| CN105732636B (zh) | 2014-12-30 | 2020-04-21 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
| HK1246593A1 (zh) | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| CN108779116A (zh) | 2015-12-22 | 2018-11-09 | 生命医药公司 | 多发性内分泌瘤蛋白-mll相互作用的抑制剂 |
| EP3407884B1 (en) | 2016-01-26 | 2025-07-09 | Memorial Sloan-Kettering Cancer Center | Targeting chromatin regulators for inhibiting leukemogenic gene expression in npm1 |
| MX387806B (es) | 2016-03-16 | 2025-03-19 | Kura Oncology Inc | Inhibidores biciclicos con puente sustituidos de menina-mll y metodos de uso |
| KR20190015275A (ko) | 2016-05-02 | 2019-02-13 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 메닌 억제제로서의 피페리딘 |
| EP4483875A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| KR102916887B1 (ko) | 2016-06-10 | 2026-01-22 | 비타이 파마슈티컬즈, 엘엘씨 | 메닌-mll 상호 작용의 억제제 |
| JP2019529421A (ja) | 2016-09-16 | 2019-10-17 | ヴァイティー ファーマシューティカルズ，エルエルシー | ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤 |
| EP3601249A4 (en) | 2017-03-24 | 2020-12-16 | Kura Oncology, Inc. | METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA |
| JP7307729B2 (ja) | 2017-12-20 | 2023-07-12 | ヤンセン ファーマシューティカ エヌ．ベー． | メニン－ｍｌｌ相互作用のエキソ－アザスピロ阻害剤 |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| BR112020020059A2 (pt) | 2018-03-30 | 2021-03-30 | The Regents Of The University Of Michigan | Compostos de piperidina como inibidores de menin covalentes |
| JP7470105B2 (ja) | 2018-09-13 | 2024-04-17 | メルク・シャープ・アンド・ドーム・エルエルシー | 非マイクロサテライト高不安定性／ミスマッチ修復の良好な結腸直腸がんを処置するためのｐｄ－１アンタゴニストおよびｌａｇ３アンタゴニストの組み合わせ |
| JP2022503792A (ja) | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
| JP7536767B2 (ja) | 2018-12-31 | 2024-08-20 | バイオメア フュージョン，インコーポレイテッド | メニン－ｍｌｌ相互作用の不可逆的阻害剤 |
| WO2021207335A1 (en) | 2020-04-07 | 2021-10-14 | Syndax Pharmaceuticals, Inc. | Combinations of menin inhibitors and cyp3a4 inhibitors and methods of use thereof |
| JP2024520900A (ja) | 2021-05-12 | 2024-05-27 | シンダックス ファーマシューティカルズ， インコーポレイテッド | 癌の治療のための組合せ |
| CA3213074A1 (en) | 2021-05-14 | 2022-11-17 | Salvacion Cacatian | Inhibitors of the menin-mll interaction |
| CA3228627A1 (en) | 2021-08-11 | 2023-02-16 | Thomas Butler | Covalent inhibitors of menin-mll interaction for diabetes mellitus |
| WO2023114867A2 (en) | 2021-12-15 | 2023-06-22 | Dana-Farber Cancer Institute, Inc. | Therapeutic targeting of gastrointestinal stromal tumor (gist) by disrupting the menin-mll epigenetic complex |
-
2017
- 2017-06-08 KR KR1020227028964A patent/KR102916887B1/ko active Active
- 2017-06-08 US US16/308,739 patent/US10683302B2/en active Active
- 2017-06-08 JP JP2018564288A patent/JP7007302B2/ja active Active
- 2017-06-08 CA CA3024180A patent/CA3024180A1/en active Pending
- 2017-06-08 LT LTEP17739383.2T patent/LT3468966T/lt unknown
- 2017-06-08 PT PT177393832T patent/PT3468966T/pt unknown
- 2017-06-08 IL IL298381A patent/IL298381B2/en unknown
- 2017-06-08 DK DK17739383.2T patent/DK3468966T3/da active
- 2017-06-08 ES ES17739383T patent/ES2831084T3/es active Active
- 2017-06-08 CA CA3297462A patent/CA3297462A1/en active Pending
- 2017-06-08 BR BR122024002146-3A patent/BR122024002146A2/pt not_active Application Discontinuation
- 2017-06-08 HR HRP20201771TT patent/HRP20201771T1/hr unknown
- 2017-06-08 SI SI201730492T patent/SI3468966T1/sl unknown
- 2017-06-08 EP EP17739383.2A patent/EP3468966B1/en active Active
- 2017-06-08 KR KR1020197000269A patent/KR102436430B1/ko active Active
- 2017-06-08 PL PL17739383T patent/PL3468966T3/pl unknown
- 2017-06-08 KR KR1020257017598A patent/KR20250079083A/ko active Pending
- 2017-06-08 MX MX2018015252A patent/MX381228B/es unknown
- 2017-06-08 EP EP20189251.0A patent/EP3805215A1/en active Pending
- 2017-06-08 AU AU2017278950A patent/AU2017278950B2/en active Active
- 2017-06-08 HU HUE17739383A patent/HUE051451T2/hu unknown
- 2017-06-08 WO PCT/US2017/036506 patent/WO2017214367A1/en not_active Ceased
- 2017-06-08 CN CN201780035865.3A patent/CN109743875B/zh active Active
-
2018
- 2018-12-07 MX MX2023002982A patent/MX2023002982A/es unknown
- 2018-12-07 MX MX2021003939A patent/MX2021003939A/es unknown
- 2018-12-09 IL IL263586A patent/IL263586B/en active IP Right Grant
-
2019
- 2019-01-09 ZA ZA2019/00150A patent/ZA201900150B/en unknown
-
2020
- 2020-04-01 US US16/837,421 patent/US11479557B2/en active Active
- 2020-11-03 CY CY20201101035T patent/CY1124834T1/el unknown
-
2021
- 2021-05-19 IL IL283267A patent/IL283267B2/en unknown
- 2021-10-29 AU AU2021258089A patent/AU2021258089B2/en active Active
-
2022
- 2022-01-06 JP JP2022000946A patent/JP7461390B2/ja active Active
- 2022-09-02 US US17/902,432 patent/US12312359B2/en active Active
-
2024
- 2024-01-04 JP JP2024000278A patent/JP2024045176A/ja active Pending
- 2024-04-24 AU AU2024202700A patent/AU2024202700A1/en active Pending
-
2025
- 2025-04-16 US US19/180,560 patent/US20250326764A1/en active Pending
- 2025-05-19 JP JP2025083421A patent/JP2025113339A/ja active Pending
- 2025-06-30 IL IL321844A patent/IL321844A/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL263586A (en) | Inhibitors of the menin-mll interaction | |
| CY1125826T1 (el) | Ενωσεις αναστολεις της βητα-λακταμασης | |
| IL269196A (en) | Novel inhibitors | |
| EP3541932A4 (en) | INHIBITORS OF CRISPR-CAS9 | |
| DK3497103T3 (da) | Pyridopyrimdinon-cdk2/4/6-inhibitorer | |
| DK3442972T3 (da) | Bromdomænehæmmere | |
| LT3303334T (lt) | Tirozinkinazės inhibitoriai | |
| PL3154989T3 (pl) | Inhibitory beta-laktamaz | |
| DK3571192T3 (da) | Jak1-selektive inhibitorer | |
| HUE042335T2 (hu) | ROR-gamma dihidropirrolopiridin inhibitorai | |
| PL3209656T3 (pl) | Związki indolo-karboksyamidu użyteczne jako inhibitory kinazy | |
| EP3347008A4 (en) | BETA-Lactamase INHIBITORS | |
| IL261904A (en) | 6-hydroxy-4-oxo-1,4-dihydropyrimidine-5-carboxamides as apj agonists | |
| EP3313828A4 (en) | METALLO-BETA-Lactamase INHIBITORS | |
| MA47573A (fr) | Inhibiteurs de dihydrobenzofurane glycosidase substitués | |
| CU20160125A7 (es) | Inhibidores de diacilglicerol aciltransferasa 2 | |
| DK3341379T3 (da) | EZH2-hæmmere | |
| DK3186242T3 (da) | Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere | |
| DK3630744T3 (da) | Pyrazol-magl-inhibitorer | |
| MA43367A (fr) | Inhibiteurs de métallo-bêta-lactamases | |
| DK3114120T3 (da) | Tetrazolon-substituerede dihydropyridinon-mgat2-hæmmere | |
| DK3512536T3 (da) | Pd-1-peptidinhibitorer | |
| MA46889A (fr) | Inhibiteurs de gsk-3 | |
| EP3600301A4 (en) | KDM4 INHIBITORS | |
| MA46280A (fr) | Inhibiteurs de la dopamine-b-hydroxylase |