PL3504214T3 - Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami - Google Patents

Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami

Info

Publication number
PL3504214T3
PL3504214T3 PL17771587T PL17771587T PL3504214T3 PL 3504214 T3 PL3504214 T3 PL 3504214T3 PL 17771587 T PL17771587 T PL 17771587T PL 17771587 T PL17771587 T PL 17771587T PL 3504214 T3 PL3504214 T3 PL 3504214T3
Authority
PL
Poland
Prior art keywords
tricycling
pyridasinone
orthomyxoviral
infection
condensed
Prior art date
Application number
PL17771587T
Other languages
English (en)
Inventor
Rama Jain
Dennis Christofer KOESTER
James R. MANNING
Vanessa Marx
Daniel Poon
James Clifford Sutton
Benjamin R. TAFT
Lifeng Wan
Aregahegn Yifru
Qian Zhao
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL3504214T3 publication Critical patent/PL3504214T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/5025Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/16Antivirals for RNA viruses for influenza or rhinoviruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL17771587T 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami PL3504214T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662380712P 2016-08-29 2016-08-29
EP17771587.7A EP3504214B1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections
PCT/IB2017/055137 WO2018042303A1 (en) 2016-08-29 2017-08-25 Fused tricyclic pyridazinone compounds useful to treat orthomyxovirus infections

Publications (1)

Publication Number Publication Date
PL3504214T3 true PL3504214T3 (pl) 2021-07-19

Family

ID=59923494

Family Applications (3)

Application Number Title Priority Date Filing Date
PL23217305.4T PL4356969T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami
PL17771587T PL3504214T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami
PL20210329.7T PL3848372T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL23217305.4T PL4356969T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu zakażenia ortomyksowirusami

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL20210329.7T PL3848372T3 (pl) 2016-08-29 2017-08-25 Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami

Country Status (20)

Country Link
US (4) US11098051B2 (pl)
EP (4) EP3848372B1 (pl)
JP (3) JP7221861B2 (pl)
CN (2) CN113683614B (pl)
AR (1) AR109438A1 (pl)
CA (1) CA3035302A1 (pl)
DK (1) DK4356969T3 (pl)
ES (3) ES2859510T3 (pl)
FI (1) FI4356969T3 (pl)
HR (1) HRP20250885T1 (pl)
HU (1) HUE072776T2 (pl)
JO (1) JOP20170169A1 (pl)
LT (1) LT4356969T (pl)
MX (1) MX383124B (pl)
PL (3) PL4356969T3 (pl)
PT (3) PT3848372T (pl)
SI (3) SI3504214T1 (pl)
TW (3) TWI803467B (pl)
UY (2) UY40872A (pl)
WO (1) WO2018042303A1 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015038655A1 (en) * 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
AU2016374416A1 (en) 2015-12-15 2018-06-14 Shionogi & Co., Ltd. Medicine for treating influenza characterized by comprising combination of cap-dependent endonuclease inhibitor with anti-influenza drug
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
RU2727962C1 (ru) 2016-08-10 2020-07-28 Сионоги Энд Ко., Лтд. Фармацевтические композиции, содержащие замещенные полициклические пиридоновые производные и их пролекарство
JOP20170169A1 (ar) * 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
CN111848615B (zh) 2018-01-17 2022-05-17 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
KR20230031990A (ko) 2018-02-28 2023-03-07 노파르티스 아게 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물
CN108440564B (zh) * 2018-04-11 2019-08-06 安帝康(无锡)生物科技有限公司 被取代的多环氨基甲酰基吡啶酮衍生物及其前药
MX2021004182A (es) * 2018-10-10 2021-09-08 Janssen Biopharma Inc Inhibidores macrocíclicos de endonucleasa de la gripe.
CN111909174B (zh) 2019-05-08 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物的晶型及制备方法和应用
CN118480041A (zh) * 2019-12-23 2024-08-13 石家庄迪斯凯威医药科技有限公司 取代的多环化合物及其药物组合物和用途
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
WO2022105669A1 (zh) * 2020-11-17 2022-05-27 南京明德新药研发有限公司 含Se大环类化合物
WO2024228401A1 (ja) * 2023-05-02 2024-11-07 国立大学法人 大分大学 新型コロナウイルス感染症の処置または予防用医薬としての置換三環式複素環化合物

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2225112A (en) 1938-07-09 1940-12-17 Wright Aeronautical Corp Air cleaner
GB8501542D0 (en) 1985-01-22 1985-02-20 Erba Farmitalia 4 5 6 7-tetrahydro-imidazo(4 5-clpyridine derivatives
AUPM354694A0 (en) 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
BR0211750A (pt) 2001-08-10 2004-10-13 Shionogi & Co Agente antiviral
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
TW200510425A (en) 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
TW200526635A (en) 2003-12-22 2005-08-16 Shionogi & Co Hydroxypyrimidinone derivative having HIV integrase inhibitory activity
WO2005087766A1 (en) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
FR2901795A1 (fr) 2006-05-30 2007-12-07 Fourtillan Snc Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique
US9238657B2 (en) 2008-10-31 2016-01-19 Shionogi & Co., Ltd. Cephalosporin having catechol group
US8835461B2 (en) 2009-03-26 2014-09-16 Shionogi & Co., Ltd. Substituted 3-hydroxy-4-pyridone derivative
TWI518084B (zh) 2009-03-26 2016-01-21 鹽野義製藥股份有限公司 哌喃酮與吡啶酮衍生物之製造方法
LT2444400T (lt) 2009-06-15 2018-06-11 Shionogi & Co., Ltd. Pakeistasis policiklinis karbamoilpiridono darinys
US8541418B2 (en) 2009-12-23 2013-09-24 Elan Pharmaceutical, Inc. Inhibitors of polo-like kinase
TW201201813A (en) 2010-03-31 2012-01-16 Arqule Inc Substituted benzo-pyrido-triazolo-diazepine compounds
US20120195857A1 (en) 2010-08-12 2012-08-02 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
MX2013003139A (es) 2010-09-24 2013-06-18 Shionogi & Co Profarmaco de derivado de carbamoilpiridona policiclica substituida.
WO2012151567A1 (en) 2011-05-05 2012-11-08 St. Jude Children's Research Hospital Pyrimidinone compounds and methods for preventing and treating influenza
EP2774928B1 (en) * 2011-10-12 2017-08-30 Shionogi & Co., Ltd. Polycyclic pyridone derivative having integrase-inhibiting activity
AU2013318779B2 (en) 2012-09-20 2016-07-28 Celltrion, Inc. Dolastatin-10 derivative, method of producing the same and anticancer drug composition containing the same
CN104918942A (zh) 2013-01-08 2015-09-16 萨维拉制药有限公司 嘧啶酮衍生物和它们用于治疗、改善或预防病毒疾病的用途
NZ716822A (en) 2013-08-21 2017-10-27 Alios Biopharma Inc Antiviral compounds
CN105530946A (zh) 2013-09-11 2016-04-27 南加利福尼亚大学 具有高度表达的fas配体的干细胞组合物
WO2015038655A1 (en) 2013-09-12 2015-03-19 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
ES2724581T3 (es) 2013-09-12 2019-09-12 Janssen Biopharma Inc Compuestos de piridazinona y usos de los mismos
WO2016005330A1 (en) 2014-07-07 2016-01-14 F. Hoffmann-La Roche Ag Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases
WO2016145103A1 (en) 2015-03-11 2016-09-15 Alios Biopharma, Inc. Aza-pyridone compounds and uses thereof
ES2881776T3 (es) 2016-03-08 2021-11-30 Novartis Ag Compuestos tricíclicos útiles para tratar las infecciones por ortomixovirus
WO2017156407A1 (en) 2016-03-10 2017-09-14 Alios Biopharma, Inc. Method of preparing aza-pyridone compounds
EP3858835A1 (en) 2016-07-01 2021-08-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
WO2018005863A1 (en) 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Pyrimidine-based compounds for the treatment of cancer
RU2727962C1 (ru) 2016-08-10 2020-07-28 Сионоги Энд Ко., Лтд. Фармацевтические композиции, содержащие замещенные полициклические пиридоновые производные и их пролекарство
JOP20170169A1 (ar) 2016-08-29 2019-01-30 Novartis Ag مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
JP2019059697A (ja) * 2017-09-28 2019-04-18 塩野義製薬株式会社 置換された多環性ピリダジン誘導体およびそのプロドラッグ
CN111848615B (zh) 2018-01-17 2022-05-17 江西彩石医药科技有限公司 吡啶酮衍生物及包含其的抗流感病毒药物组合物
CN110041327B (zh) 2018-01-17 2022-01-21 江西彩石医药科技有限公司 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用
KR20200127177A (ko) 2018-02-28 2020-11-10 니뽄 다바코 산교 가부시키가이샤 포화 환 축합 디히드로피리미디논 또는 디히드로트리아지논 화합물 및 그의 의약 용도
RU2020131012A (ru) 2018-02-28 2022-03-28 Ф. Хоффманн-Ля Рош Аг 7-замещенные соединения сульфонимидоилпуринонов и их производные для лечения и профилактики рака печени
WO2019167981A1 (ja) 2018-02-28 2019-09-06 日本たばこ産業株式会社 4-メチルジヒドロピリミジノン化合物及びその医薬用途
KR20230031990A (ko) 2018-02-28 2023-03-07 노파르티스 아게 인플루엔자의 치료를 위한 오르토믹소바이러스 복제의 억제제로서의 10-(디(페닐)메틸)-4-히드록시-8,9,9a,10-테트라히드로-7h-피롤로[1',2':4,5]피라지노[1,2-b]피리다진-3,5-디온 유도체 및 관련 화합물

Also Published As

Publication number Publication date
EP3848372A1 (en) 2021-07-14
US11098051B2 (en) 2021-08-24
EP3504214B1 (en) 2020-12-02
UY37378A (es) 2018-03-23
CN113683614B (zh) 2024-11-08
EP4356969A2 (en) 2024-04-24
SI3848372T1 (sl) 2024-04-30
US20220041610A1 (en) 2022-02-10
SI3504214T1 (sl) 2021-04-30
JP2019532033A (ja) 2019-11-07
UY40872A (es) 2024-09-13
US10160764B2 (en) 2018-12-25
EP4356969A3 (en) 2024-05-22
ES3042460T3 (en) 2025-11-20
US20180057501A1 (en) 2018-03-01
AR109438A1 (es) 2018-11-28
WO2018042303A1 (en) 2018-03-08
TWI869757B (zh) 2025-01-11
LT4356969T (lt) 2025-09-10
CN113683614A (zh) 2021-11-23
HRP20250885T1 (hr) 2025-09-26
TW202517646A (zh) 2025-05-01
US11912715B2 (en) 2024-02-27
EP4356969B1 (en) 2025-07-09
PT4356969T (pt) 2025-10-02
SI4356969T1 (sl) 2025-10-30
PT3504214T (pt) 2021-03-04
EP4640279A2 (en) 2025-10-29
EP4640279A3 (en) 2025-12-24
TW202342482A (zh) 2023-11-01
JP2023027102A (ja) 2023-03-01
JP2025081322A (ja) 2025-05-27
DK4356969T3 (da) 2025-08-18
TWI803467B (zh) 2023-06-01
JP7221861B2 (ja) 2023-02-14
US20250011334A1 (en) 2025-01-09
FI4356969T3 (fi) 2025-08-15
PT3848372T (pt) 2024-03-22
HUE072776T2 (hu) 2025-12-28
CN109863151B (zh) 2021-09-10
EP3848372B1 (en) 2023-12-20
EP3504214A1 (en) 2019-07-03
CN109863151A (zh) 2019-06-07
PL3848372T3 (pl) 2024-04-22
CA3035302A1 (en) 2018-03-08
TW201811800A (zh) 2018-04-01
ES2974494T3 (es) 2024-06-27
ES2859510T3 (es) 2021-10-04
MX2019002438A (es) 2019-07-08
US20200123167A1 (en) 2020-04-23
MX383124B (es) 2025-03-13
PL4356969T3 (pl) 2025-10-20
JOP20170169A1 (ar) 2019-01-30

Similar Documents

Publication Publication Date Title
CY2022039I1 (el) Θεραπευτικες ενωσεις χρησιμες για την προφυλακτικη ή θεραπευτικη αγωγη μολυνσης ιου ηiv
PL3504214T3 (pl) Skondensowane trójpierścieniowe związki pirydazynonowe przydatne w leczeniu infekcji ortomyksowirusami
HUS2100037I1 (hu) Vegyületek gerinc eredetû izomsorvadás kezelésére
FI3684377T3 (fi) Menetelmiä hepatiitti b -infektion hoitamiseksi
DK3728271T3 (da) Makrocykliske forbindelser til behandling af sygdomme
HUE058737T2 (hu) Eljárások arenaviridae vírusok okozta fertõzések kezelésére
IL253062A0 (en) Pyrazine compounds for the treatment of infectious diseases
DK3511328T3 (da) Organiske monobactam-forbindelser til behandling af bakterieinfektioner
DK3347030T3 (da) Brug af pasteuriseret akkermansia til behandling af stofskiftesygdomme
DK3504187T3 (da) Anvendelse af pridopidin til behandling af funktionel tilbagegang
EP3359521C0 (en) NEW COMPOUNDS FOR THE TREATMENT OF MITOCHONDRIAL DISEASE
DK3436074T3 (da) Thiazolidforbindelser til behandling af virale infektioner
PL3600374T3 (pl) Leczenie zakażenia układu oddechowego
DK3294740T3 (da) Hidtil ukendte sulfonimidoylpurinonforbindelser og derivater til behandling og profylakse af virusinfektion
DK3318115T3 (da) Maskine til behandling af svinegylle
IL257355B (en) Selection of patients for combination therapy
LT3137078T (lt) Virusinio hepatito delta infekcijos gydymas
DK3578562T3 (da) L-valinatamidbenzoxaborolderivater til behandling af parasitiske sygdomme
DK3450436T3 (da) Kondenseret heterocyklisk forbindelse
EP3270968C0 (fr) Nouvelles compositions antivirales pour le traitement de la grippe
HUE042043T2 (hu) Malária megelõzésére vagy kezelésére alkalmas triaminopiridin-vegyületek
LT3209319T (lt) Grybelinių infekcijų gydymo būdas
DK3373931T3 (da) Heterocykliske forbindelser til behandling af sygdom
DK3471732T3 (da) Liposomer til behandling af virusinfektioner
DK3419628T3 (da) Medikament til behandling af diabetiske fodinfektioner