PL3522876T3 - Sposoby hamowania przemiany choliny w trimetyloaminę (tma) - Google Patents
Sposoby hamowania przemiany choliny w trimetyloaminę (tma)Info
- Publication number
- PL3522876T3 PL3522876T3 PL18792732T PL18792732T PL3522876T3 PL 3522876 T3 PL3522876 T3 PL 3522876T3 PL 18792732 T PL18792732 T PL 18792732T PL 18792732 T PL18792732 T PL 18792732T PL 3522876 T3 PL3522876 T3 PL 3522876T3
- Authority
- PL
- Poland
- Prior art keywords
- tma
- trimethylamine
- choline
- methods
- inhibiting conversion
- Prior art date
Links
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 title 2
- 238000006243 chemical reaction Methods 0.000 title 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title 1
- 229960001231 choline Drugs 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/39—Heterocyclic compounds having sulfur as a ring hetero atom having oxygen in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762566975P | 2017-10-02 | 2017-10-02 | |
| PCT/US2018/053924 WO2019070676A1 (en) | 2017-10-02 | 2018-10-02 | METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA) |
| EP18792732.2A EP3522876B1 (en) | 2017-10-02 | 2018-10-02 | Methods for inhibiting conversion of choline to trimethylamine (tma) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3522876T3 true PL3522876T3 (pl) | 2021-06-28 |
Family
ID=63963526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18792732T PL3522876T3 (pl) | 2017-10-02 | 2018-10-02 | Sposoby hamowania przemiany choliny w trimetyloaminę (tma) |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10751301B2 (pl) |
| EP (1) | EP3522876B1 (pl) |
| CN (1) | CN111163763B (pl) |
| AU (1) | AU2018345747B2 (pl) |
| BR (1) | BR112020006108A2 (pl) |
| CA (1) | CA3076195C (pl) |
| MX (1) | MX390163B (pl) |
| PL (1) | PL3522876T3 (pl) |
| WO (1) | WO2019070676A1 (pl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110959862B (zh) * | 2019-11-14 | 2021-08-13 | 南方医科大学 | 一种具有清除氧化三甲胺和抗炎功能的组合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1524922A (fr) * | 1966-06-01 | 1968-05-10 | Basf Ag | Agents entravant la croissance et modifiant l'habitus des plantes |
| DE1542826B1 (de) * | 1966-06-01 | 1971-04-08 | Basf Ag | Sulfoniumverbindungen und deren Verwendung |
| FR1559102A (pl) | 1968-01-23 | 1969-03-07 | ||
| US3644531A (en) * | 1968-08-13 | 1972-02-22 | Sankyo Co | 2-propynylsulfonium salts |
| US3651222A (en) * | 1969-09-15 | 1972-03-21 | Monsanto Co | Nematocidal use of substituted dimethylsulfonium tetraphenylborates |
| DE2331185A1 (de) | 1973-06-19 | 1975-01-16 | Bayer Ag | Mittel zur regulierung des pflanzenwachstums |
| EP0555058B1 (en) | 1992-02-07 | 1997-05-07 | Toyo Ink Manufacturing Co., Ltd. | (Oxo)sulfonium complex, polymerizable composition containing the complex, and method of polymerizing composition |
| JP4999043B2 (ja) * | 2006-02-13 | 2012-08-15 | 株式会社Ａｄｅｋａ | スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物 |
| WO2009073839A1 (en) | 2007-12-05 | 2009-06-11 | The Cleveland Clinic Foundation | Trimethylamine compounds as risk predictors of cardiovascular disease |
| AU2013274406B2 (en) * | 2012-06-11 | 2017-02-02 | The Cleveland Clinic Foundation | Treatment and prevention of cardiovascular disease and thrombosis |
| WO2017095995A1 (en) | 2015-12-01 | 2017-06-08 | The Procter & Gamble Company | Methods for inhibiting conversion of carnitine to trimethylamine (tma) |
| AU2017291211B2 (en) | 2016-06-29 | 2020-06-25 | Cleveland Clinic Innovation | Methods for inhibiting conversion of choline to trimethylamine (TMA) |
-
2018
- 2018-10-02 WO PCT/US2018/053924 patent/WO2019070676A1/en not_active Ceased
- 2018-10-02 EP EP18792732.2A patent/EP3522876B1/en active Active
- 2018-10-02 CA CA3076195A patent/CA3076195C/en active Active
- 2018-10-02 CN CN201880064575.6A patent/CN111163763B/zh active Active
- 2018-10-02 MX MX2020003080A patent/MX390163B/es unknown
- 2018-10-02 BR BR112020006108-5A patent/BR112020006108A2/pt unknown
- 2018-10-02 AU AU2018345747A patent/AU2018345747B2/en active Active
- 2018-10-02 US US16/149,882 patent/US10751301B2/en active Active
- 2018-10-02 PL PL18792732T patent/PL3522876T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3522876A1 (en) | 2019-08-14 |
| AU2018345747A1 (en) | 2020-04-09 |
| BR112020006108A2 (pt) | 2020-09-24 |
| AU2018345747B2 (en) | 2021-03-18 |
| MX390163B (es) | 2025-03-20 |
| WO2019070676A1 (en) | 2019-04-11 |
| US10751301B2 (en) | 2020-08-25 |
| MX2020003080A (es) | 2022-02-18 |
| CN111163763B (zh) | 2023-08-22 |
| EP3522876B1 (en) | 2021-02-24 |
| CA3076195C (en) | 2022-06-21 |
| CN111163763A (zh) | 2020-05-15 |
| US20190099384A1 (en) | 2019-04-04 |
| CA3076195A1 (en) | 2019-04-11 |
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