PL3522927T3 - Sposoby hamowania przemiany choliny w trimetyloaminę (tma) - Google Patents
Sposoby hamowania przemiany choliny w trimetyloaminę (tma)Info
- Publication number
- PL3522927T3 PL3522927T3 PL18792735T PL18792735T PL3522927T3 PL 3522927 T3 PL3522927 T3 PL 3522927T3 PL 18792735 T PL18792735 T PL 18792735T PL 18792735 T PL18792735 T PL 18792735T PL 3522927 T3 PL3522927 T3 PL 3522927T3
- Authority
- PL
- Poland
- Prior art keywords
- tma
- trimethylamine
- choline
- methods
- inhibiting conversion
- Prior art date
Links
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 title 2
- 238000006243 chemical reaction Methods 0.000 title 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 title 1
- 229960001231 choline Drugs 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762567010P | 2017-10-02 | 2017-10-02 | |
| PCT/US2018/053929 WO2019070678A1 (en) | 2017-10-02 | 2018-10-02 | METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA) |
| EP18792735.5A EP3522927B1 (en) | 2017-10-02 | 2018-10-02 | Methods for inhibiting conversion of choline to trimethylamine (tma) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3522927T3 true PL3522927T3 (pl) | 2021-06-28 |
Family
ID=63963529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18792735T PL3522927T3 (pl) | 2017-10-02 | 2018-10-02 | Sposoby hamowania przemiany choliny w trimetyloaminę (tma) |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10849866B2 (pl) |
| EP (1) | EP3522927B1 (pl) |
| CN (1) | CN111344016B (pl) |
| AU (1) | AU2018345749B2 (pl) |
| CA (1) | CA3076235C (pl) |
| MX (1) | MX390466B (pl) |
| PL (1) | PL3522927T3 (pl) |
| WO (1) | WO2019070678A1 (pl) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11331280B2 (en) | 2018-11-06 | 2022-05-17 | The Procter & Gamble Company | Methods for inhibiting conversion of choline to trimethylamine (TMA) |
| KR20210112319A (ko) * | 2018-12-06 | 2021-09-14 | 센다 바이오사이언시즈, 인크. | 파킨슨병을 치료하기 위한 데카르복실라제 억제제 |
| CN112029818A (zh) * | 2020-09-18 | 2020-12-04 | 中国药科大学 | 一种利用微生物筛选三甲胺裂解酶抑制剂的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1542826B1 (de) | 1966-06-01 | 1971-04-08 | Basf Ag | Sulfoniumverbindungen und deren Verwendung |
| FR1559102A (pl) | 1968-01-23 | 1969-03-07 | ||
| US3644531A (en) | 1968-08-13 | 1972-02-22 | Sankyo Co | 2-propynylsulfonium salts |
| US3651222A (en) | 1969-09-15 | 1972-03-21 | Monsanto Co | Nematocidal use of substituted dimethylsulfonium tetraphenylborates |
| DE2331185A1 (de) | 1973-06-19 | 1975-01-16 | Bayer Ag | Mittel zur regulierung des pflanzenwachstums |
| EP0555058B1 (en) | 1992-02-07 | 1997-05-07 | Toyo Ink Manufacturing Co., Ltd. | (Oxo)sulfonium complex, polymerizable composition containing the complex, and method of polymerizing composition |
| CA2538520C (en) * | 2003-07-24 | 2015-02-10 | The Queen's Medical Center | Preparation and use of alkylating agents |
| JP4999043B2 (ja) | 2006-02-13 | 2012-08-15 | 株式会社Ａｄｅｋａ | スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物 |
| AU2007230989A1 (en) * | 2006-03-22 | 2007-10-04 | President And Fellows Of Harvard College | Methods and compositions for treating hypercholesterolemia and atherosclerosis |
| EP2222220B1 (en) | 2007-12-05 | 2016-03-16 | The Cleveland Clinic Foundation | Trimethylamine compounds as risk predictors of cardiovascular disease |
| MX2014015197A (es) | 2012-06-11 | 2015-11-16 | Cleveland Clinic Foundation | Tratamiento y prevencion de la enfermedad cardiovascular y trombosis. |
| BR112018010873A2 (pt) | 2015-12-01 | 2019-04-30 | The Procter & Gamble Company | compostos e métodos para inibir a produção de trimetilamina |
| PL3478276T3 (pl) | 2016-06-29 | 2021-12-27 | The Procter And Gamble Company | Sposoby hamowania przemiany choliny w trimetyloaminę (tma) |
-
2018
- 2018-10-02 PL PL18792735T patent/PL3522927T3/pl unknown
- 2018-10-02 US US16/149,938 patent/US10849866B2/en active Active
- 2018-10-02 EP EP18792735.5A patent/EP3522927B1/en active Active
- 2018-10-02 CA CA3076235A patent/CA3076235C/en active Active
- 2018-10-02 CN CN201880064573.7A patent/CN111344016B/zh active Active
- 2018-10-02 MX MX2020003081A patent/MX390466B/es unknown
- 2018-10-02 AU AU2018345749A patent/AU2018345749B2/en active Active
- 2018-10-02 WO PCT/US2018/053929 patent/WO2019070678A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX390466B (es) | 2025-03-12 |
| CN111344016B (zh) | 2022-04-05 |
| AU2018345749B2 (en) | 2021-03-11 |
| US10849866B2 (en) | 2020-12-01 |
| CA3076235C (en) | 2022-06-21 |
| AU2018345749A1 (en) | 2020-04-09 |
| MX2020003081A (es) | 2022-03-07 |
| CN111344016A (zh) | 2020-06-26 |
| US20190099390A1 (en) | 2019-04-04 |
| EP3522927A1 (en) | 2019-08-14 |
| CA3076235A1 (en) | 2019-04-11 |
| EP3522927B1 (en) | 2020-11-25 |
| WO2019070678A1 (en) | 2019-04-11 |
| BR112020006085A2 (pt) | 2020-09-29 |
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