PL3522878T3 - Sposoby hamowania przemiany choliny w trimetyloaminę (tma) - Google Patents

Sposoby hamowania przemiany choliny w trimetyloaminę (tma)

Info

Publication number
PL3522878T3
PL3522878T3 PL18792734T PL18792734T PL3522878T3 PL 3522878 T3 PL3522878 T3 PL 3522878T3 PL 18792734 T PL18792734 T PL 18792734T PL 18792734 T PL18792734 T PL 18792734T PL 3522878 T3 PL3522878 T3 PL 3522878T3
Authority
PL
Poland
Prior art keywords
tma
trimethylamine
choline
methods
inhibiting conversion
Prior art date
Application number
PL18792734T
Other languages
English (en)
Inventor
Jose Carlos Garcia-Garcia
George Franklin Gerberick
John August Wos
Stanley Leon Hazen
Xiaodong Gu
Original Assignee
The Procter & Gamble Company
The Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company, The Cleveland Clinic Foundation filed Critical The Procter & Gamble Company
Publication of PL3522878T3 publication Critical patent/PL3522878T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL18792734T 2017-10-02 2018-10-02 Sposoby hamowania przemiany choliny w trimetyloaminę (tma) PL3522878T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566992P 2017-10-02 2017-10-02
PCT/US2018/053926 WO2019070677A1 (en) 2017-10-02 2018-10-02 METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA)
EP18792734.8A EP3522878B1 (en) 2017-10-02 2018-10-02 Methods for inhibiting conversion of choline to trimethylamine (tma)

Publications (1)

Publication Number Publication Date
PL3522878T3 true PL3522878T3 (pl) 2021-08-23

Family

ID=63963528

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18792734T PL3522878T3 (pl) 2017-10-02 2018-10-02 Sposoby hamowania przemiany choliny w trimetyloaminę (tma)

Country Status (9)

Country Link
US (1) US10675256B2 (pl)
EP (1) EP3522878B1 (pl)
CN (1) CN111163765B (pl)
AU (1) AU2018345748B2 (pl)
BR (1) BR112020006121B1 (pl)
CA (1) CA3076232C (pl)
MX (1) MX390468B (pl)
PL (1) PL3522878T3 (pl)
WO (1) WO2019070677A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11331280B2 (en) 2018-11-06 2022-05-17 The Procter & Gamble Company Methods for inhibiting conversion of choline to trimethylamine (TMA)
KR20210112319A (ko) * 2018-12-06 2021-09-14 센다 바이오사이언시즈, 인크. 파킨슨병을 치료하기 위한 데카르복실라제 억제제

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542826B1 (de) 1966-06-01 1971-04-08 Basf Ag Sulfoniumverbindungen und deren Verwendung
FR1559102A (pl) * 1968-01-23 1969-03-07
US3644531A (en) 1968-08-13 1972-02-22 Sankyo Co 2-propynylsulfonium salts
US3651222A (en) 1969-09-15 1972-03-21 Monsanto Co Nematocidal use of substituted dimethylsulfonium tetraphenylborates
DE2331185A1 (de) 1973-06-19 1975-01-16 Bayer Ag Mittel zur regulierung des pflanzenwachstums
EP0555058B1 (en) 1992-02-07 1997-05-07 Toyo Ink Manufacturing Co., Ltd. (Oxo)sulfonium complex, polymerizable composition containing the complex, and method of polymerizing composition
JP4999043B2 (ja) * 2006-02-13 2012-08-15 株式会社Adeka スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物
MX2014015197A (es) 2012-06-11 2015-11-16 Cleveland Clinic Foundation Tratamiento y prevencion de la enfermedad cardiovascular y trombosis.
BR112018010873A2 (pt) 2015-12-01 2019-04-30 The Procter & Gamble Company compostos e métodos para inibir a produção de trimetilamina
PL3478276T3 (pl) 2016-06-29 2021-12-27 The Procter And Gamble Company Sposoby hamowania przemiany choliny w trimetyloaminę (tma)

Also Published As

Publication number Publication date
CA3076232A1 (en) 2019-04-11
AU2018345748A1 (en) 2020-04-09
WO2019070677A1 (en) 2019-04-11
CN111163765B (zh) 2023-05-09
CA3076232C (en) 2023-05-16
MX390468B (es) 2025-03-20
EP3522878B1 (en) 2021-03-31
BR112020006121A2 (pt) 2020-09-24
CN111163765A (zh) 2020-05-15
EP3522878A1 (en) 2019-08-14
BR112020006121B1 (pt) 2022-05-24
US10675256B2 (en) 2020-06-09
AU2018345748B2 (en) 2021-03-18
US20190099389A1 (en) 2019-04-04
MX2020003082A (es) 2022-03-07

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