PL3522878T3 - Sposoby hamowania przemiany choliny w trimetyloaminę (tma) - Google Patents

Sposoby hamowania przemiany choliny w trimetyloaminę (tma)

Info

Publication number
PL3522878T3
PL3522878T3 PL18792734T PL18792734T PL3522878T3 PL 3522878 T3 PL3522878 T3 PL 3522878T3 PL 18792734 T PL18792734 T PL 18792734T PL 18792734 T PL18792734 T PL 18792734T PL 3522878 T3 PL3522878 T3 PL 3522878T3
Authority
PL
Poland
Prior art keywords
tma
trimethylamine
choline
methods
inhibiting conversion
Prior art date
Application number
PL18792734T
Other languages
English (en)
Inventor
Jose Carlos Garcia-Garcia
George Franklin Gerberick
John August Wos
Stanley Leon Hazen
Xiaodong Gu
Original Assignee
The Procter & Gamble Company
The Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Company, The Cleveland Clinic Foundation filed Critical The Procter & Gamble Company
Publication of PL3522878T3 publication Critical patent/PL3522878T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/14Quaternary ammonium compounds, e.g. edrophonium, choline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL18792734T 2017-10-02 2018-10-02 Sposoby hamowania przemiany choliny w trimetyloaminę (tma) PL3522878T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762566992P 2017-10-02 2017-10-02
PCT/US2018/053926 WO2019070677A1 (en) 2017-10-02 2018-10-02 METHODS OF INHIBITING CONVERSION FROM CHOLINE TO TRIMETHYLAMINE (TMA)
EP18792734.8A EP3522878B1 (en) 2017-10-02 2018-10-02 Methods for inhibiting conversion of choline to trimethylamine (tma)

Publications (1)

Publication Number Publication Date
PL3522878T3 true PL3522878T3 (pl) 2021-08-23

Family

ID=63963528

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18792734T PL3522878T3 (pl) 2017-10-02 2018-10-02 Sposoby hamowania przemiany choliny w trimetyloaminę (tma)

Country Status (9)

Country Link
US (1) US10675256B2 (pl)
EP (1) EP3522878B1 (pl)
CN (1) CN111163765B (pl)
AU (1) AU2018345748B2 (pl)
BR (1) BR112020006121B1 (pl)
CA (1) CA3076232C (pl)
MX (1) MX390468B (pl)
PL (1) PL3522878T3 (pl)
WO (1) WO2019070677A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021008657A2 (pt) 2018-11-06 2021-11-03 Cleveland Clinic Found Métodos para inibir a conversão de colina em trimetilamina (tma)
EP3891751A4 (en) * 2018-12-06 2023-05-31 Senda Biosciences, Inc. Quaternary ammonium salts as inhibitors of trimethylamine production

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1542826B1 (de) 1966-06-01 1971-04-08 Basf Ag Sulfoniumverbindungen und deren Verwendung
FR1559102A (pl) * 1968-01-23 1969-03-07
US3644531A (en) 1968-08-13 1972-02-22 Sankyo Co 2-propynylsulfonium salts
US3651222A (en) 1969-09-15 1972-03-21 Monsanto Co Nematocidal use of substituted dimethylsulfonium tetraphenylborates
DE2331185A1 (de) 1973-06-19 1975-01-16 Bayer Ag Mittel zur regulierung des pflanzenwachstums
DE69310401T2 (de) 1992-02-07 1997-08-21 Toyo Ink Mfg Co (Oxo)Sulfoniumkomplex, diese enthaltende polymerisierbare Zusammensetzung und Verfahren zur Polymerisation
JP4999043B2 (ja) * 2006-02-13 2012-08-15 株式会社Adeka スルホニウム塩化合物、カチオン重合開始剤および熱硬化性組成物
CA2876177C (en) 2012-06-11 2022-06-14 The Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis
CN108601753A (zh) 2015-12-01 2018-09-28 宝洁公司 抑制胆碱向三甲胺(tma)的转化的方法
CN109640967B (zh) 2016-06-29 2022-04-29 宝洁公司 抑制胆碱向三甲胺(tma)的转化的方法

Also Published As

Publication number Publication date
CN111163765B (zh) 2023-05-09
MX2020003082A (es) 2022-03-07
BR112020006121B1 (pt) 2022-05-24
EP3522878B1 (en) 2021-03-31
AU2018345748B2 (en) 2021-03-18
CA3076232A1 (en) 2019-04-11
WO2019070677A1 (en) 2019-04-11
EP3522878A1 (en) 2019-08-14
US10675256B2 (en) 2020-06-09
AU2018345748A1 (en) 2020-04-09
US20190099389A1 (en) 2019-04-04
CA3076232C (en) 2023-05-16
CN111163765A (zh) 2020-05-15
BR112020006121A2 (pt) 2020-09-24
MX390468B (es) 2025-03-20

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