|
ES2234563T5
(es)
*
|
1999-02-12 |
2018-01-17 |
Daiichi Sankyo Company, Limited |
Nuevos análogos de nucleósidos y oligonucleótidos
|
|
JP4148662B2
(ja)
*
|
2000-08-10 |
2008-09-10 |
第一三共株式会社 |
ヌクレオシド及びオリゴヌクレオチド類縁体を含有する核酸試薬及び医薬
|
|
AU2001284268A1
(en)
*
|
2000-09-07 |
2002-03-22 |
Avecia Biotechnology, Inc. |
Synthons for oligonucleotide synthesis
|
|
KR20020069627A
(ko)
*
|
2001-02-27 |
2002-09-05 |
동부한농화학 주식회사 |
육환의 아자슈거를 가진 뉴클레오타이드 유도체를 포함한포스포로티오에이트 올리고뉴클레오타이드 및 이들의에이즈 치료제로서의 새로운 용도
|
|
EP1481983A4
(en)
*
|
2002-02-13 |
2008-04-02 |
Takeshi Imanishi |
NUCLEOSIDE ANALOGUE AND OLIGONUCLEOTIDE DERIVATIVES CONTAINING A NUCLEOTIDE ANALOGON THEREOF
|
|
US20040219565A1
(en)
|
2002-10-21 |
2004-11-04 |
Sakari Kauppinen |
Oligonucleotides useful for detecting and analyzing nucleic acids of interest
|
|
CN1833034B
(zh)
|
2003-06-20 |
2014-04-16 |
埃克斯魁恩公司 |
用于分析核酸混合物的探针、文库和试剂盒及其构建方法
|
|
US8415100B2
(en)
|
2003-08-14 |
2013-04-09 |
Case Western Reserve University |
Methods and compositions for detecting gastrointestinal and other cancers
|
|
EP1660683B1
(en)
*
|
2003-08-14 |
2017-04-19 |
Case Western Reserve University |
Methods and compositions for detecting colon cancers
|
|
WO2005045033A1
(ja)
*
|
2003-11-07 |
2005-05-19 |
Sankyo Company, Limited |
遺伝子多型の検出方法
|
|
US8192937B2
(en)
|
2004-04-07 |
2012-06-05 |
Exiqon A/S |
Methods for quantification of microRNAs and small interfering RNAs
|
|
EP1838870A2
(en)
|
2004-12-29 |
2007-10-03 |
Exiqon A/S |
NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF MICRORNAS AND THEIR TARGET MRNAs
|
|
US20070065840A1
(en)
*
|
2005-03-23 |
2007-03-22 |
Irena Naguibneva |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
WO2007090071A2
(en)
|
2006-01-27 |
2007-08-09 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
|
EP2505648A1
(en)
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of PTP1B
|
|
JP2009536222A
(ja)
|
2006-05-05 |
2009-10-08 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
Pcsk9の発現を調節するための化合物および方法
|
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
AU2007249349B2
(en)
*
|
2006-05-11 |
2012-03-08 |
Isis Pharmaceuticals, Inc. |
5'-Modified bicyclic nucleic acid analogs
|
|
ES2526295T5
(es)
|
2006-10-18 |
2021-05-04 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido
|
|
US8188255B2
(en)
|
2006-10-20 |
2012-05-29 |
Exiqon A/S |
Human microRNAs associated with cancer
|
|
EP2090665A2
(en)
|
2006-10-20 |
2009-08-19 |
Exiqon A/S |
Novel human microRNAs associated with cancer
|
|
CA2670563A1
(en)
*
|
2006-11-27 |
2008-06-05 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
EP3536788A1
(en)
|
2006-12-21 |
2019-09-11 |
QIAGEN GmbH |
Microrna target site blocking oligos and uses thereof
|
|
WO2008074328A2
(en)
*
|
2006-12-21 |
2008-06-26 |
Exiqon A/S |
Microrna target site blocking oligos and uses thereof
|
|
WO2008086807A2
(en)
|
2007-01-19 |
2008-07-24 |
Exiqon A/S |
Mediated cellular delivery of lna oligonucleotides
|
|
CA2688321A1
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
|
AU2008272918B2
(en)
*
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
WO2009067647A1
(en)
*
|
2007-11-21 |
2009-05-28 |
Isis Pharmaceuticals, Inc. |
Carbocyclic alpha-l-bicyclic nucleic acid analogs
|
|
EP4053546A1
(en)
|
2007-12-06 |
2022-09-07 |
Genalyte, Inc. |
Device and method for performing label-free monitoring of processes.
|
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
US9290534B2
(en)
*
|
2008-04-04 |
2016-03-22 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds having at least one neutrally linked terminal bicyclic nucleoside
|
|
US8222221B2
(en)
|
2008-06-04 |
2012-07-17 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small RNA targeting of gene promoters
|
|
CA2732343C
(en)
|
2008-07-29 |
2017-05-09 |
The Board Of Regents Of The University Of Texas System |
Selective inhibition of polyglutamine protein expression
|
|
DK2356129T3
(da)
*
|
2008-09-24 |
2013-05-13 |
Isis Pharmaceuticals Inc |
Substituerede alpha-L-bicykliske nukleosider
|
|
EP3572796B8
(en)
|
2008-10-27 |
2023-01-18 |
Genalyte, Inc. |
Biosensors based on optical probing and sensing
|
|
WO2010124231A2
(en)
|
2009-04-24 |
2010-10-28 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression using oligomers that target gene regions downstream of 3' untranslated regions
|
|
EP2447273A4
(en)
|
2009-06-23 |
2013-06-19 |
Takeda Pharmaceutical |
PROCESS FOR SYNTHETIZING NUCLEIC ACID
|
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US20110110860A1
(en)
|
2009-11-02 |
2011-05-12 |
The Board Of Regents Of The University Of Texas System |
Modulation of ldl receptor gene expression with double-stranded rnas targeting the ldl receptor gene promoter
|
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011097388A1
(en)
|
2010-02-03 |
2011-08-11 |
Alnylam Pharmaceuticals, Inc. |
Selective inhibition of polyglutamine protein expression
|
|
US9193752B2
(en)
|
2010-03-17 |
2015-11-24 |
Isis Pharmaceuticals, Inc. |
5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2601204B1
(en)
|
2010-04-28 |
2016-09-07 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides and oligomeric compounds prepared therefrom
|
|
ES2465948T3
(es)
|
2010-04-30 |
2014-06-09 |
Exiqon A/S |
Procedimiento de hibridación in situ y tampón
|
|
US8957200B2
(en)
|
2010-06-07 |
2015-02-17 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2635710B1
(en)
|
2010-11-05 |
2017-08-09 |
Genalyte, Inc. |
Optical analyte detection systems and methods of use
|
|
EP2673361B1
(en)
|
2011-02-08 |
2016-04-13 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
ES2472965T3
(es)
|
2011-03-04 |
2014-07-03 |
F. Hoffmann-La Roche Ag |
Nuevo tipo de sondas universales para la detección de variantes gen�micas
|
|
US10202599B2
(en)
|
2011-08-11 |
2019-02-12 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
JP2015502365A
(ja)
|
2011-12-12 |
2015-01-22 |
オンコイミューニン,インコーポレイティド |
オリゴヌクレオチドのイン−ビボ送達
|
|
EP3907506A1
(en)
|
2012-03-12 |
2021-11-10 |
The Board of Trustees of the University of Illinois |
Optical analyte detection systems with magnetic enhancement and methods of their use
|
|
EP2831232A4
(en)
|
2012-03-30 |
2015-11-04 |
Univ Washington |
METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
|
|
EP2850092B1
(en)
|
2012-04-09 |
2017-03-01 |
Ionis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2013159108A2
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
WO2014045126A2
(en)
|
2012-09-18 |
2014-03-27 |
Uti Limited Partnership |
Treatment of pain by inhibition of usp5 de-ubiquitinase
|
|
KR101707437B1
(ko)
*
|
2012-09-21 |
2017-02-16 |
고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 |
구아니딘 가교를 갖는 인공 뉴클레오시드 및 올리고뉴클레오티드
|
|
WO2014051076A1
(ja)
|
2012-09-28 |
2014-04-03 |
株式会社Bna |
Bnaクランプ法
|
|
US9695418B2
(en)
|
2012-10-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US10723754B2
(en)
|
2012-10-22 |
2020-07-28 |
Idenix Pharmaceuticals Llc |
2′,4′-bridged nucleosides for HCV infection
|
|
WO2014093291A1
(en)
|
2012-12-10 |
2014-06-19 |
Advandx, Inc. |
Use of probes for mass spectrometric identification of microorganisms or cells and associated conditions of interest
|
|
US20150337002A1
(en)
*
|
2013-01-15 |
2015-11-26 |
Shionogi & Co., Ltd. |
Nucleoside and nucleotide having sulfonamide structure
|
|
WO2014134144A1
(en)
|
2013-02-28 |
2014-09-04 |
The General Hospital Corporation |
Mirna profiling compositions and methods of use
|
|
WO2014134179A1
(en)
|
2013-02-28 |
2014-09-04 |
The Board Of Regents Of The University Of Texas System |
Methods for classifying a cancer as susceptible to tmepai-directed therapies and treating such cancers
|
|
CN105264091B
(zh)
|
2013-03-14 |
2020-02-28 |
Ionis制药公司 |
用于调节tau表达的组合物和方法
|
|
US9273349B2
(en)
|
2013-03-14 |
2016-03-01 |
Affymetrix, Inc. |
Detection of nucleic acids
|
|
DK2992098T3
(da)
|
2013-05-01 |
2019-06-17 |
Ionis Pharmaceuticals Inc |
Sammensætninger og fremgangsmåder til modulering af hbv- og ttr-ekspression
|
|
TW202246503A
(zh)
|
2013-07-19 |
2022-12-01 |
美商百健Ma公司 |
用於調節τ蛋白表現之組合物
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
HUE050704T2
(hu)
|
2014-04-01 |
2020-12-28 |
Biogen Ma Inc |
Összetételek a SOD-1 expressziójának modulálására
|
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
EA036496B1
(ru)
|
2014-05-01 |
2020-11-17 |
Ионис Фармасьютикалз, Инк. |
Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b
|
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
|
AU2015327836B2
(en)
|
2014-10-03 |
2021-07-01 |
Cold Spring Harbor Laboratory |
Targeted augmentation of nuclear gene output
|
|
JP2018504380A
(ja)
|
2014-12-18 |
2018-02-15 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
Reversir(商標)化合物
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
CA3205381A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
CN108603230A
(zh)
|
2015-10-09 |
2018-09-28 |
南安普敦大学 |
基因表达的调节与蛋白质表达失调的筛选
|
|
EP3389670A4
(en)
|
2015-12-04 |
2020-01-08 |
Ionis Pharmaceuticals, Inc. |
METHODS OF TREATING BREAST CANCER
|
|
WO2017106377A1
(en)
|
2015-12-14 |
2017-06-22 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
|
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
|
PH12018501207B1
(en)
|
2015-12-21 |
2024-02-23 |
Novartis Ag |
Compositions and methods for decreasing tau expression
|
|
WO2017111137A1
(ja)
*
|
2015-12-22 |
2017-06-29 |
味の素株式会社 |
オリゴヌクレオチドの製造方法
|
|
EP3429690A4
(en)
|
2016-03-16 |
2019-10-23 |
Ionis Pharmaceuticals, Inc. |
METHOD FOR MODULATING KEAP1
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
AU2017286811A1
(en)
|
2016-06-17 |
2018-11-22 |
Ionis Pharmaceuticals, Inc. |
Modulation of gys1 expression
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
KR102533038B1
(ko)
|
2016-09-14 |
2023-05-17 |
얀센 바이오파마, 인크. |
변형된 올리고뉴클레오티드 및 사용 방법
|
|
HUE065170T2
(hu)
|
2016-09-29 |
2024-05-28 |
Biogen Ma Inc |
Vegyületek és módszerek a TAU expresszió csökkentésére
|
|
WO2018102745A1
(en)
|
2016-12-02 |
2018-06-07 |
Cold Spring Harbor Laboratory |
Modulation of lnc05 expression
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
WO2019036613A1
(en)
|
2017-08-18 |
2019-02-21 |
Ionis Pharmaceuticals, Inc. |
MODULATION OF THE NOTCH SIGNALING PATHWAY FOR THE TREATMENT OF RESPIRATORY DISORDERS
|
|
KR102318434B1
(ko)
|
2017-08-25 |
2021-11-01 |
스톡 테라퓨틱스, 인크. |
병태 및 질환 치료용 안티센스 올리고머
|
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
|
EA202090720A1
(ru)
|
2017-09-14 |
2020-07-07 |
Янссен Байофарма, Инк. |
ПРОИЗВОДНЫЕ GalNAc
|
|
MX2020009532A
(es)
|
2018-03-13 |
2020-10-05 |
Janssen Pharmaceutica Nv |
Oligonucleotidos modificados para uso en el tratamiento de tauopatias.
|
|
CA3099280A1
(en)
|
2018-05-04 |
2019-11-07 |
Stoke Therapeutics, Inc. |
Methods and compositions for treatment of cholesteryl ester storage disease
|
|
MX2020011570A
(es)
|
2018-05-07 |
2020-11-24 |
Alnylam Pharmaceuticals Inc |
Administracion extrahepatica.
|
|
CA3111562A1
(en)
|
2018-09-07 |
2020-04-02 |
The General Hospital Corporation |
Compositions and methods for immune checkpoint inhibition
|
|
WO2020069055A1
(en)
|
2018-09-28 |
2020-04-02 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna compositions and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
CR20210311A
(es)
|
2018-11-15 |
2021-07-22 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresión de irf5
|
|
WO2020139871A1
(en)
*
|
2018-12-26 |
2020-07-02 |
Twist Bioscience Corporation |
Highly accurate de novo polynucleotide synthesis
|
|
BR112021013369A2
(pt)
|
2019-01-31 |
2021-09-21 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de yap1
|
|
AU2020227825B2
(en)
|
2019-02-27 |
2026-03-26 |
Stoke Therapeutics, Inc. |
Antisense oligomers for treatment of conditions and diseases
|
|
AU2020227824B2
(en)
|
2019-02-27 |
2025-07-10 |
Ionis Pharmaceuticals, Inc. |
Modulators of MALAT1 expression
|
|
AU2020268798A1
(en)
|
2019-05-03 |
2021-11-04 |
Dicerna Pharmaceuticals, Inc. |
Double-stranded nucleic acid inhibitor molecules with shortened sense strands
|
|
AU2020279101B2
(en)
|
2019-05-17 |
2025-07-24 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
|
WO2021021673A1
(en)
|
2019-07-26 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
|
KR20220062517A
(ko)
|
2019-08-15 |
2022-05-17 |
아이오니스 파마수티컬즈, 인코포레이티드 |
결합 변형된 올리고머 화합물 및 이의 용도
|
|
WO2021092145A1
(en)
|
2019-11-06 |
2021-05-14 |
Alnylam Pharmaceuticals, Inc. |
Transthyretin (ttr) irna composition and methods of use thereof for treating or preventing ttr-associated ocular diseases
|
|
BR112022007795A2
(pt)
|
2019-11-06 |
2022-07-05 |
Alnylam Pharmaceuticals Inc |
Administração extra-hepática
|
|
EP4058032A4
(en)
|
2019-12-19 |
2024-01-10 |
Entrada Therapeutics, Inc. |
Compositions for delivery of antisense compounds
|
|
US20240092821A1
(en)
|
2020-03-31 |
2024-03-21 |
Janssen Biopharma, Inc. |
Synthesis of oligonucleotides and related compounds
|
|
CN115867657A
(zh)
|
2020-05-11 |
2023-03-28 |
斯托克制药公司 |
用于治疗疾患和疾病的opa1反义寡聚物
|
|
EP4271695A2
(en)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
2'-modified nucleoside based oligonucleotide prodrugs
|
|
EP4271696A2
(en)
|
2020-12-31 |
2023-11-08 |
Alnylam Pharmaceuticals, Inc. |
Cyclic-disulfide modified phosphate based oligonucleotide prodrugs
|
|
EP4314016A1
(en)
|
2021-03-31 |
2024-02-07 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
|
WO2022240760A2
(en)
|
2021-05-10 |
2022-11-17 |
Entrada Therapeutics, Inc. |
COMPOSITIONS AND METHODS FOR MODULATING mRNA SPLICING
|
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
|
AU2022271873A1
(en)
|
2021-05-10 |
2024-01-04 |
Entrada Therapeutics, Inc. |
Compositions and methods for intracellular therapeutics
|
|
AU2022298774A1
(en)
|
2021-06-23 |
2023-12-14 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
|
WO2023283403A2
(en)
|
2021-07-09 |
2023-01-12 |
Alnylam Pharmaceuticals, Inc. |
Bis-rnai compounds for cns delivery
|
|
MX2024000981A
(es)
|
2021-07-21 |
2024-02-12 |
Alnylam Pharmaceuticals Inc |
Composiciones de acido ribonucleico de interferencia (arni) de gen diana asociado con trastorno metabolico y sus metodos de uso.
|
|
MX2024002640A
(es)
|
2021-09-01 |
2024-07-19 |
Entrada Therapeutics Inc |
Compuestos y metodos para salto de exon 44 en la distrofia muscular de duchenne.
|
|
CN118369427A
(zh)
|
2021-10-15 |
2024-07-19 |
阿尔尼拉姆医药品有限公司 |
肝外递送irna组合物及其使用方法
|
|
EP4446429A4
(en)
|
2021-12-10 |
2025-04-02 |
Nitto Boseki Co., Ltd. |
Agents for increasing the melting temperature of double-stranded nucleic acid and uses therefor
|
|
CN118369437B
(zh)
|
2021-12-10 |
2025-03-25 |
日东纺绩株式会社 |
用于检测核酸的对象碱基序列中的变异的方法、选择性地抑制核酸的扩增的方法、及用于实施这些的试剂盒
|
|
KR102731759B1
(ko)
|
2021-12-10 |
2024-11-21 |
니토 보세키 가부시기가이샤 |
핵산의 대상 염기 서열 중에 있어서의 변이를 검출하기 위한 방법, 핵산의 증폭을 선택적으로 저해하는 방법, 및 이것들을 실시하기 위한 키트
|
|
EP4522742A2
(en)
|
2022-05-13 |
2025-03-19 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
JP2025522880A
(ja)
|
2022-06-30 |
2025-07-17 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
環状ジスルフィド修飾リン酸ベースのオリゴヌクレオチドプロドラッグ
|
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
|
WO2024073732A1
(en)
|
2022-09-30 |
2024-04-04 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
|
TW202449152A
(zh)
|
2023-02-09 |
2024-12-16 |
美商艾拉倫製藥股份有限公司 |
Reversir分子及其使用方法
|
|
KR20260009305A
(ko)
|
2023-04-12 |
2026-01-19 |
알닐람 파마슈티칼스 인코포레이티드 |
이중 가닥 rna 제제의 간외 전달
|
|
CN121079412A
(zh)
|
2023-04-28 |
2025-12-05 |
比姆医疗股份有限公司 |
经修饰的指导rna
|
|
WO2024233864A2
(en)
|
2023-05-10 |
2024-11-14 |
Dicerna Pharmaceuticals, Inc. |
Galnac-conjugated rnai oligonucleotides
|
|
EP4709855A2
(en)
|
2023-05-12 |
2026-03-18 |
Alnylam Pharmaceuticals, Inc. |
Single-stranded loop oligonucleotides
|
|
WO2025054459A1
(en)
|
2023-09-08 |
2025-03-13 |
Dicerna Pharmaceuticals, Inc. |
Rnai oligonucleotide conjugates
|
|
WO2025064660A2
(en)
|
2023-09-21 |
2025-03-27 |
Alnylam Pharmaceuticals, Inc. |
Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof
|