PL353092A1 - Sposób wytwarzania estrów nitroksyalkilowych naproksenu - Google Patents

Sposób wytwarzania estrów nitroksyalkilowych naproksenu

Info

Publication number: PL353092A1
Authority: PL; Poland
Prior art keywords: preparation; nitroxyalkylesters; naproxene; naproxene nitroxyalkylesters; naphthyl
Prior art date: 1999-08-04

Application number

PL00353092A

Other languages

English (en)

Other versions

PL200165B1 (pl

Inventor

Francesca Benedini

Erminio Oldani

Graziano Castaldi

Antonio Tarquini

Original Assignee

Nicox S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-04

Filing date

2000-07-27

Publication date

2003-10-06

2000-07-27 Application filed by Nicox S.A. filed Critical Nicox S.A.

2003-10-06 Publication of PL353092A1 publication Critical patent/PL353092A1/pl

2008-12-31 Publication of PL200165B1 publication Critical patent/PL200165B1/pl

Links

CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title abstract 2
-1 4-nitroxybutyl ester Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

PL353092A 1999-08-04 2000-07-27 Sposób wytwarzania estrów nitroksyalkilowych naproksenu oraz ester nitroksybutylowy kwasu 2-(S)-(6-metoksy-2-naftylo)propanowego o wysokim nadmiarze enancjomerycznym PL200165B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI001753A IT1313596B1 (it)	1999-08-04	1999-08-04	Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en)	1999-08-04	2000-07-27	Process for the preparation of naproxene nitroxyalkylesters

Publications (2)

Publication Number	Publication Date
PL353092A1 true PL353092A1 (pl)	2003-10-06
PL200165B1 PL200165B1 (pl)	2008-12-31

Family

ID=11383500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL353092A PL200165B1 (pl)	1999-08-04	2000-07-27	Sposób wytwarzania estrów nitroksyalkilowych naproksenu oraz ester nitroksybutylowy kwasu 2-(S)-(6-metoksy-2-naftylo)propanowego o wysokim nadmiarze enancjomerycznym

Country Status (23)

Country	Link
US (2)	US6700011B1 (pl)
EP (2)	EP1384707B1 (pl)
JP (2)	JP4667691B2 (pl)
KR (1)	KR100687820B1 (pl)
CN (1)	CN1198786C (pl)
AT (2)	ATE297372T1 (pl)
AU (1)	AU778694B2 (pl)
BR (1)	BRPI0012915B1 (pl)
CA (1)	CA2380116C (pl)
DE (2)	DE60020753T2 (pl)
DK (2)	DK1200386T3 (pl)
ES (2)	ES2208390T3 (pl)
HU (1)	HU227109B1 (pl)
IL (1)	IL147639A0 (pl)
IT (1)	IT1313596B1 (pl)
MX (1)	MXPA02001256A (pl)
NO (1)	NO327669B1 (pl)
PL (1)	PL200165B1 (pl)
PT (2)	PT1200386E (pl)
RU (1)	RU2248348C2 (pl)
TR (1)	TR200200290T2 (pl)
WO (1)	WO2001010814A1 (pl)
ZA (2)	ZA200200478B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6297260B1 (en)	1998-10-30	2001-10-02	Nitromed, Inc.	Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
US6649629B2 (en)	1999-12-23	2003-11-18	Nitromed, Inc.	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
DE60122939T2 (de)	2000-12-21	2007-01-11	Nitromed, Inc., Bedford	Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
AU2002365372A1 (en) *	2001-11-27	2003-06-10	Astrazeneca Ab	New process
US7220749B2 (en)	2002-06-11	2007-05-22	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
WO2004004648A2 (en)	2002-07-03	2004-01-15	Nitromed, Inc.	Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en)	2002-07-29	2004-02-16	Nicox S.A.	Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it)	2002-08-29	2004-02-29	Nicox Sa	Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) *	2002-11-14	2004-05-15	Dinamite Dipharma S P A	Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
DK1978947T3 (da) *	2006-02-03	2014-11-03	Nicox Science Ireland	Nitrooxyderivater til anvendelse ved behandling af muskeldystrofier
CN100427475C (zh) *	2006-11-30	2008-10-22	华南理工大学	萘普生-2-芳基吗啉乙酯及其制备方法与应用
CN101730676A (zh)	2007-06-28	2010-06-09	尼科克斯公司	1,4-丁二醇单硝酸酯的制备方法
WO2009149053A2 (en) *	2008-06-02	2009-12-10	Dr. Reddy's Laboratories Ltd.	Naproxcinod process and solid dispersion
ITRM20080325A1 (it) *	2008-06-20	2009-12-21	Nicox Sa	Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en)	2010-03-31	2011-11-16	Lonza Ag	Process for the production of esters of nitric acid
TWI417276B (zh)	2011-03-01	2013-12-01	Everlight Chem Ind Corp	２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
WO2014111957A1 (en)	2013-01-21	2014-07-24	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents
US11660282B2 (en)	2020-02-10	2023-05-30	Nicox Sa	Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57145841A (en) *	1981-03-05	1982-09-09	Nissan Chem Ind Ltd	L-menthyl naphthylpropionate and its preparation
IT1243367B (it)	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
WO1995009831A1 (en) *	1993-10-06	1995-04-13	Nicox S.A.	Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
JP4043046B2 (ja) *	1994-05-10	2008-02-06	ニコックスエスエイ	消炎、鎮痛および抗血栓活性を有するニトロ化合物およびそれらの組成物
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) *	1995-08-25	1997-03-05	蔡雄	可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) *	1995-10-09	1997-04-17	Russinsky Limited	Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it)	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr)	1996-12-12	1999-12-17	Hoechst Marion Roussel Inc	Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

1999
- 1999-08-04 IT IT1999MI001753A patent/IT1313596B1/it active
2000
- 2000-07-27 DE DE60020753T patent/DE60020753T2/de not_active Expired - Lifetime
- 2000-07-27 EP EP03102132A patent/EP1384707B1/en not_active Expired - Lifetime
- 2000-07-27 RU RU2002102860/04A patent/RU2248348C2/ru active
- 2000-07-27 HU HU0202435A patent/HU227109B1/hu not_active IP Right Cessation
- 2000-07-27 KR KR1020027000946A patent/KR100687820B1/ko not_active Expired - Fee Related
- 2000-07-27 PT PT00951456T patent/PT1200386E/pt unknown
- 2000-07-27 ES ES00951456T patent/ES2208390T3/es not_active Expired - Lifetime
- 2000-07-27 MX MXPA02001256A patent/MXPA02001256A/es active IP Right Grant
- 2000-07-27 DK DK00951456T patent/DK1200386T3/da active
- 2000-07-27 AT AT03102132T patent/ATE297372T1/de active
- 2000-07-27 JP JP2001515282A patent/JP4667691B2/ja not_active Expired - Lifetime
- 2000-07-27 CA CA2380116A patent/CA2380116C/en not_active Expired - Lifetime
- 2000-07-27 CN CNB008111588A patent/CN1198786C/zh not_active Expired - Fee Related
- 2000-07-27 US US10/031,412 patent/US6700011B1/en not_active Expired - Lifetime
- 2000-07-27 EP EP00951456A patent/EP1200386B1/en not_active Expired - Lifetime
- 2000-07-27 ES ES03102132T patent/ES2243859T3/es not_active Expired - Lifetime
- 2000-07-27 DE DE60005682T patent/DE60005682T2/de not_active Expired - Lifetime
- 2000-07-27 PL PL353092A patent/PL200165B1/pl unknown
- 2000-07-27 WO PCT/EP2000/007222 patent/WO2001010814A1/en not_active Ceased
- 2000-07-27 PT PT03102132T patent/PT1384707E/pt unknown
- 2000-07-27 DK DK03102132T patent/DK1384707T3/da active
- 2000-07-27 AU AU64385/00A patent/AU778694B2/en not_active Ceased
- 2000-07-27 BR BRPI0012915-1A patent/BRPI0012915B1/pt not_active IP Right Cessation
- 2000-07-27 TR TR2002/00290T patent/TR200200290T2/xx unknown
- 2000-07-27 AT AT00951456T patent/ATE251109T1/de active
- 2000-07-27 IL IL14763900A patent/IL147639A0/xx not_active IP Right Cessation
2002
- 2002-01-18 ZA ZA200200478A patent/ZA200200478B/en unknown
- 2002-02-01 NO NO20020515A patent/NO327669B1/no not_active IP Right Cessation
2003
- 2003-06-10 ZA ZA200304525A patent/ZA200304525B/xx unknown
- 2003-07-24 US US10/625,558 patent/US7238829B2/en not_active Expired - Lifetime
2010
- 2010-11-30 JP JP2010266860A patent/JP2011042690A/ja active Pending

Also Published As

Publication number	Publication date
CN1198786C (zh)	2005-04-27
JP2003506425A (ja)	2003-02-18
US6700011B1 (en)	2004-03-02
NO20020515D0 (no)	2002-02-01
ZA200304525B (en)	2004-04-28
JP4667691B2 (ja)	2011-04-13
EP1384707B1 (en)	2005-06-08
EP1200386B1 (en)	2003-10-01
PL200165B1 (pl)	2008-12-31
TR200200290T2 (tr)	2002-05-21
KR20020013974A (ko)	2002-02-21
JP2011042690A (ja)	2011-03-03
ES2243859T3 (es)	2005-12-01
HU227109B1 (en)	2010-07-28
ITMI991753A0 (it)	1999-08-04
HUP0202435A3 (en)	2004-03-01
EP1200386A1 (en)	2002-05-02
ZA200200478B (en)	2003-10-29
DK1384707T3 (da)	2005-08-15
MXPA02001256A (es)	2005-06-06
US20050119339A1 (en)	2005-06-02
ES2208390T3 (es)	2004-06-16
CA2380116A1 (en)	2001-02-15
IL147639A0 (en)	2002-08-14
BRPI0012915B1 (pt)	2015-09-01
KR100687820B1 (ko)	2007-02-28
US7238829B2 (en)	2007-07-03
AU778694B2 (en)	2004-12-16
PT1200386E (pt)	2004-02-27
RU2248348C2 (ru)	2005-03-20
ITMI991753A1 (it)	2001-02-04
NO20020515L (no)	2002-02-01
EP1384707A1 (en)	2004-01-28
ATE251109T1 (de)	2003-10-15
ATE297372T1 (de)	2005-06-15
CN1367773A (zh)	2002-09-04
DK1200386T3 (da)	2003-12-22
NO327669B1 (no)	2009-09-07
BR0012915A (pt)	2002-06-04
DE60005682D1 (de)	2003-11-06
DE60005682T2 (de)	2004-09-16
WO2001010814A1 (en)	2001-02-15
DE60020753D1 (de)	2005-07-14
PT1384707E (pt)	2005-08-31
HUP0202435A2 (hu)	2002-11-28
DE60020753T2 (de)	2006-03-16
CA2380116C (en)	2011-07-05
IT1313596B1 (it)	2002-09-09
AU6438500A (en)	2001-03-05

Publication	Publication Date	Title
IL147639A0 (en)	2002-08-14	Process for the preparation of naproxene nitroxyalkylesters
DE59704095D1 (de)	2001-08-30	Verfahren zur kontinuierlichen Herstellung von Alkylestern der (Meth)acrylsäure
ES8801920A1 (es)	1988-03-01	Procedimiento para la obtencio de enaminas
DE10084723T1 (de)	2002-08-14	Verfahren zur Herstellung von a-Sulfonfettsäurealkylestersalzen
IL98061A (en)	1992-03-29	Method for the enzymatic resolution of racemic carboxylic acid compounds
AU5591900A (en)	2001-01-22	Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid
DE69920568D1 (de)	2004-11-04	Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
HU9802586D0 (en)	1999-01-28	Racemizing process
NO993796D0 (no)	1999-08-06	Fremgangsmåte for omforestring av <alfa>-ketokarboksylsyreestre
GB8815180D0 (en)	1988-08-03	Compositions
IT1278448B1 (it)	1997-11-20	Procedimento per la produzione di miscugli di diesteri polietilenglicolici dell'acido 2-(4-cloro-2-metilfenossi)-propionico.
EP0997534A3 (de)	2003-09-03	Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
FR2778671B1 (fr)	2002-07-05	Nouveau procede de preparation d'intermediaires de synthese
DE3380024D1 (en)	1989-07-13	Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin
MY131378A (en)	2007-08-30	Enantiomeric cis-3-(4,6-dihydroxychroman-3-yl-methyl) benzoic acids
ATE263134T1 (de)	2004-04-15	Herstellung von optisch aktiver cyclohexylphenylglykolsäure und ihrer ester
DE69821755D1 (de)	2004-03-25	Verfahren zur Herstellung von alpha-Tocopherol-4-aminobenzoesäureester-Verbindungen
FR2769624B1 (fr)	2000-03-03	Procede de preparation d'acide carboxylique
FR2719042B1 (fr)	1996-05-15	Procédé de préparation d'un acide alpha-(hydroxyphénoxy)- alcanecarboxylique optiquement actif.
DZ2456A1 (fr)	2003-01-18	Procédé de préparation de sels de l'acide clavulanique.
ATE110720T1 (de)	1994-09-15	Verfahren zur herstellung von 2-mercapto-4-methyl-1,3-thiazol-5-yl-essigsäure und deren ester.
GR3036631T3 (en)	2001-12-31	Preparation and utilisation of pure enantiomers of 8-halogen-6-hydroxyoctanoic acid, their alkyl esters and their salts with pure enantiomers of alpha-methyl-benzylamines
ES2064544T3 (es)	1995-02-01	Procedimiento para la preparacion de esteres alquilicos inferiores de acido r-(+)-3-oxocicloalcanocarboxilico.
MA23803A1 (fr)	1996-10-01	Nouveau procede de decadmination d'acide phosphorique
DZ2434A1 (fr)	2003-01-11	Procédé de fabrication de l'acide phosphorique.