PL3565905T5 - Sekwencjonowanie kwasów nukleinowych z zastosowaniem odczynników powinowactwa - Google Patents
Sekwencjonowanie kwasów nukleinowych z zastosowaniem odczynników powinowactwaInfo
- Publication number
- PL3565905T5 PL3565905T5 PL18736171.2T PL18736171T PL3565905T5 PL 3565905 T5 PL3565905 T5 PL 3565905T5 PL 18736171 T PL18736171 T PL 18736171T PL 3565905 T5 PL3565905 T5 PL 3565905T5
- Authority
- PL
- Poland
- Prior art keywords
- nucleic acid
- acid sequences
- affinity reagents
- affinity
- reagents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
- C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Saccharide Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762442263P | 2017-01-04 | 2017-01-04 | |
| US201762490511P | 2017-04-26 | 2017-04-26 | |
| PCT/US2018/012425 WO2018129214A1 (en) | 2017-01-04 | 2018-01-04 | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL3565905T3 PL3565905T3 (pl) | 2022-09-26 |
| PL3565905T5 true PL3565905T5 (pl) | 2025-09-22 |
Family
ID=62791177
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18736171.2T PL3565905T5 (pl) | 2017-01-04 | 2018-01-04 | Sekwencjonowanie kwasów nukleinowych z zastosowaniem odczynników powinowactwa |
| PL22174722.3T PL4112741T3 (pl) | 2017-01-04 | 2018-01-04 | Stopniowe sekwencjonowanie przy użyciu nieznakowanych odwracalnie terminatorowych lub naturalnych nukleotydów |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL22174722.3T PL4112741T3 (pl) | 2017-01-04 | 2018-01-04 | Stopniowe sekwencjonowanie przy użyciu nieznakowanych odwracalnie terminatorowych lub naturalnych nukleotydów |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10851410B2 (pl) |
| EP (3) | EP4575499A3 (pl) |
| JP (2) | JP2020508037A (pl) |
| KR (1) | KR102349259B1 (pl) |
| CN (2) | CN120485343A (pl) |
| AU (2) | AU2018205472B2 (pl) |
| BR (1) | BR112019013715B1 (pl) |
| CA (1) | CA3048486A1 (pl) |
| DK (2) | DK3565905T4 (pl) |
| ES (2) | ES2924223T5 (pl) |
| FI (2) | FI4112741T3 (pl) |
| HU (2) | HUE059673T2 (pl) |
| IL (1) | IL267836B2 (pl) |
| MX (2) | MX2019008016A (pl) |
| PL (2) | PL3565905T5 (pl) |
| PT (2) | PT4112741T (pl) |
| RS (2) | RS66810B1 (pl) |
| WO (1) | WO2018129214A1 (pl) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4575499A3 (en) | 2017-01-04 | 2025-07-09 | MGI Tech Co., Ltd. | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
| WO2019067635A1 (en) | 2017-09-27 | 2019-04-04 | Ultima Genomics, Inc. | METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING |
| JP7332235B2 (ja) * | 2018-11-07 | 2023-08-23 | イージーアイ テック （シェン チェン） カンパニー， リミテッド | ポリヌクレオチドを配列決定する方法 |
| EP3877548A4 (en) * | 2018-11-09 | 2022-10-05 | MGI Tech Co., Ltd. | MASSIVE PARALLEL SEQUENCING USING UNLABELED NUCLEOTIDES |
| US12497649B2 (en) | 2018-12-05 | 2025-12-16 | Qingdao MGI Tech Co., Ltd | Rolling circle amplification method, method for preparing sequencing library, and DNA nanosphere prepared therefrom |
| US11293061B2 (en) | 2018-12-26 | 2022-04-05 | Illumina Cambridge Limited | Sequencing methods using nucleotides with 3′ AOM blocking group |
| EP3702474A1 (en) * | 2019-02-26 | 2020-09-02 | QIAGEN GmbH | Sequencing method and kit |
| AU2019445584B2 (en) * | 2019-05-15 | 2024-09-05 | Qingdao MGI Tech Co., Ltd. | Single-channel sequencing method based on self-luminescence |
| CN114245830A (zh) | 2019-08-07 | 2022-03-25 | 深圳华大基因科技有限公司 | 含吖啶酯的化合物及将其用于基于化学发光的单色测序的方法 |
| CA3135280A1 (en) | 2019-12-16 | 2021-06-24 | Illumina, Inc. | Kits and flow cells |
| CN114829368B (zh) * | 2019-12-18 | 2024-06-04 | 豪夫迈·罗氏有限公司 | 通过使用连续标记方案的合成进行测序的方法 |
| US12448648B2 (en) | 2019-12-23 | 2025-10-21 | Mgi Tech Co., Ltd. | Controlled strand-displacement for paired end sequencing |
| US12110548B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Bi-directional in situ analysis |
| WO2021185320A1 (en) | 2020-03-18 | 2021-09-23 | Mgi Tech Co., Ltd. | Restoring phase in massively parallel sequencing |
| WO2021213321A1 (en) | 2020-04-20 | 2021-10-28 | Mgi Tech Co., Ltd. | Dna protection agent in dna imaging buffer |
| EP4143333A1 (en) | 2020-04-30 | 2023-03-08 | Dimensiongen | Devices and methods for macromolecular manipulation |
| EP4168421A1 (en) | 2020-06-22 | 2023-04-26 | Illumina Cambridge Limited | Nucleosides and nucleotides with 3' acetal blocking group |
| US11981964B2 (en) | 2020-07-28 | 2024-05-14 | Illumina Cambridge Limited | Substituted coumarin dyes and uses as fluorescent labels |
| EP4225933A4 (en) * | 2020-10-09 | 2024-11-27 | BGI Shenzhen Co., Limited | Methods and compositions for bioluminescence-based sequencing |
| GB2599729A (en) * | 2020-10-12 | 2022-04-13 | Sumitomo Chemical Co | Method comprising light emitting marker |
| WO2022078319A1 (en) * | 2020-10-12 | 2022-04-21 | Mgi Tech Co., Ltd. | Protein detection and tracking using nucleoside tags |
| KR20230107259A (ko) | 2020-10-21 | 2023-07-14 | 비지아이 션전 | 변형된 뉴클레오사이드 또는 뉴클레오타이드 |
| US20220195196A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Alkylpyridinium coumarin dyes and uses in sequencing applications |
| US20220195516A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Methods, systems and compositions for nucleic acid sequencing |
| US20220195517A1 (en) | 2020-12-17 | 2022-06-23 | Illumina Cambridge Limited | Long stokes shift chromenoquinoline dyes and uses in sequencing applications |
| US20220195518A1 (en) * | 2020-12-22 | 2022-06-23 | Illumina Cambridge Limited | Methods and compositions for nucleic acid sequencing |
| US20240158839A1 (en) | 2021-03-15 | 2024-05-16 | President And Fellows Of Harvard College | Methods for in situ sequencing |
| JP2024513207A (ja) | 2021-04-01 | 2024-03-22 | ビージーアイ シェンチェン | シークエンシングのためのヌクレオチド類似体 |
| AU2022269804A1 (en) | 2021-05-05 | 2023-11-02 | Illumina Cambridge Limited | Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing |
| CN113372402A (zh) * | 2021-06-15 | 2021-09-10 | 中国人民解放军军事科学院军事医学研究院 | 3’-o-可逆封闭的核苷酸及其在无模板酶促核酸合成中的应用 |
| WO2023114896A1 (en) | 2021-12-16 | 2023-06-22 | Illumina Cambridge Limited | Methods for metal directed cleavage of surface-bound polynucleotides |
| WO2023122499A1 (en) | 2021-12-20 | 2023-06-29 | Illumina Cambridge Limited | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
| WO2023122491A1 (en) | 2021-12-20 | 2023-06-29 | Illumina Cambridge Limited | Periodate compositions and methods for chemical cleavage of surface-bound polynucleotides |
| CA3223125A1 (en) | 2022-03-29 | 2023-10-05 | Illumina, Inc. | Chromenoquinoline dyes and uses in sequencing |
| EP4499871A1 (en) | 2022-03-30 | 2025-02-05 | Illumina, Inc. | Methods for chemical cleavage of surface-bound polynucleotides |
| US20230357845A1 (en) | 2022-03-31 | 2023-11-09 | Illumina, Inc. | Compositions and methods for improving sequencing signals |
| US20230332197A1 (en) * | 2022-03-31 | 2023-10-19 | Illumina Singapore Pte. Ltd. | Nucleosides and nucleotides with 3' vinyl blocking group |
| US20240084378A1 (en) | 2022-05-11 | 2024-03-14 | 10X Genomics, Inc. | Compositions and methods for in situ sequencing |
| CN119604513A (zh) | 2022-06-28 | 2025-03-11 | 因美纳公司 | 含有稠合四环双硼杂环的荧光染料及其在测序中的用途 |
| CN119790161A (zh) | 2022-09-09 | 2025-04-08 | 深圳华大生命科学研究院 | 杂芳环化合物在核酸检测中的用途 |
| WO2024067674A1 (zh) | 2022-09-28 | 2024-04-04 | 深圳华大智造科技股份有限公司 | 测序方法 |
| US20240140939A1 (en) | 2022-09-30 | 2024-05-02 | Illumina Cambridge Limited | Compositions and methods for reducing photo damage during sequencing |
| WO2024123866A1 (en) | 2022-12-09 | 2024-06-13 | Illumina, Inc. | Nucleosides and nucleotides with 3´ blocking groups and cleavable linkers |
| US20240247311A1 (en) | 2022-12-22 | 2024-07-25 | Illumina, Inc. | Palladium catalyst compositions and methods for sequencing by synthesis |
| EP4638795A1 (en) | 2022-12-22 | 2025-10-29 | Illumina, Inc. | Transition-metal catalyst compositions and methods for sequencing by synthesis |
| CA3246559A1 (en) | 2022-12-27 | 2024-07-04 | Illumina, Inc. | SEQUENCE PROCESSES USING ALLYL 3' BLOCKED NUCLEOTIDES |
| CA3257416A1 (en) | 2023-03-29 | 2024-10-03 | Illumina, Inc. | NAPHTHALIMIDE DYES AND USES IN NUCLEIC ACID SEQUENCING |
| WO2024206394A1 (en) | 2023-03-30 | 2024-10-03 | Illumina, Inc. | Compositions and methods for nucleic acid sequencing |
| WO2024216163A1 (en) * | 2023-04-13 | 2024-10-17 | Esbiolab Llc | Methods and compositions for nucleic acid sequencing using predominantly unlabeled nucleotides |
| CN119061122A (zh) * | 2023-05-30 | 2024-12-03 | 深圳市真迈生物科技有限公司 | 单分子测序方法 |
| CN116536399A (zh) * | 2023-07-07 | 2023-08-04 | 之江实验室 | 一种基于微珠测序的基因芯片编解码方法及基因芯片 |
| WO2025090596A1 (en) | 2023-10-26 | 2025-05-01 | Illumina, Inc. | 4,5-substituted naphthalimide dyes and uses in nucleic acid sequencing |
| US20250215493A1 (en) | 2023-12-28 | 2025-07-03 | Illumina, Inc. | Nucleotides with enzymatically cleavable 3'-o-glycoside blocking groups for sequencing |
| WO2025144711A1 (en) | 2023-12-29 | 2025-07-03 | Illumina, Inc. | Tricyclic polymethine dyes for nucleic acid sequencing |
| WO2025184226A1 (en) | 2024-02-28 | 2025-09-04 | Illumina, Inc. | Nucleotides with terminal phosphate capping |
| WO2025188906A1 (en) | 2024-03-08 | 2025-09-12 | Illumina, Inc. | Modified adenosine nucleotides |
| WO2025230914A1 (en) | 2024-04-29 | 2025-11-06 | Illumina, Inc. | Nucleotides with enzyme-triggered self-immolative linkers for sequencing by synthesis |
| CN118496347B (zh) * | 2024-05-30 | 2024-10-25 | 北京航空航天大学杭州创新研究院 | 一种用于抗体寡核苷酸偶联的方法 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2713102A (en) | 1952-06-25 | 1955-07-12 | Railroad Accessories Corp | Test terminal |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4351760A (en) | 1979-09-07 | 1982-09-28 | Syva Company | Novel alkyl substituted fluorescent compounds and polyamino acid conjugates |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5053336A (en) * | 1989-07-17 | 1991-10-01 | Regents Of The University Of California | Monoclonal antibodies for the separate detection of halodeoxyuridines and method for their use |
| US5188934A (en) | 1989-11-14 | 1993-02-23 | Applied Biosystems, Inc. | 4,7-dichlorofluorescein dyes as molecular probes |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US6401267B1 (en) | 1993-09-27 | 2002-06-11 | Radoje Drmanac | Methods and compositions for efficient nucleic acid sequencing |
| US6232465B1 (en) | 1994-09-02 | 2001-05-15 | Andrew C. Hiatt | Compositions for enzyme catalyzed template-independent creation of phosphodiester bonds using protected nucleotides |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US6174670B1 (en) | 1996-06-04 | 2001-01-16 | University Of Utah Research Foundation | Monitoring amplification of DNA during PCR |
| GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
| GB9626815D0 (en) | 1996-12-23 | 1997-02-12 | Cemu Bioteknik Ab | Method of sequencing DNA |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| US6432360B1 (en) | 1997-10-10 | 2002-08-13 | President And Fellows Of Harvard College | Replica amplification of nucleic acid arrays |
| US6743605B1 (en) | 1998-06-24 | 2004-06-01 | Enzo Life Sciences, Inc. | Linear amplification of specific nucleic acid sequences |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
| AU770993B2 (en) | 1998-09-15 | 2004-03-11 | Yale University | Molecular cloning using rolling circle amplification |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| GB9901475D0 (en) | 1999-01-22 | 1999-03-17 | Pyrosequencing Ab | A method of DNA sequencing |
| US20050191698A1 (en) | 1999-04-20 | 2005-09-01 | Illumina, Inc. | Nucleic acid sequencing using microsphere arrays |
| US6544732B1 (en) | 1999-05-20 | 2003-04-08 | Illumina, Inc. | Encoding and decoding of array sensors utilizing nanocrystals |
| EP1190233B1 (en) | 1999-05-20 | 2006-08-30 | Illumina, Inc. | Apparatus for retaining and presenting at least one microsphere array to solutions and/or to optical imaging systems |
| US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
| US6274320B1 (en) | 1999-09-16 | 2001-08-14 | Curagen Corporation | Method of sequencing a nucleic acid |
| US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
| EP1218543A2 (en) | 1999-09-29 | 2002-07-03 | Solexa Ltd. | Polynucleotide sequencing |
| JP2001245698A (ja) * | 1999-11-22 | 2001-09-11 | Xiao Bing Wang | 核酸検出法 |
| GB0002389D0 (en) | 2000-02-02 | 2000-03-22 | Solexa Ltd | Molecular arrays |
| JP3852555B2 (ja) | 2000-09-01 | 2006-11-29 | 三菱電機株式会社 | 熱制御装置、宇宙機および熱制御方法 |
| US6897023B2 (en) | 2000-09-27 | 2005-05-24 | The Molecular Sciences Institute, Inc. | Method for determining relative abundance of nucleic acid sequences |
| US6664079B2 (en) | 2000-10-06 | 2003-12-16 | The Trustees Of Columbia University In The City Of New York | Massive parallel method for decoding DNA and RNA |
| GB0105831D0 (en) * | 2001-03-09 | 2001-04-25 | Toumaz Technology Ltd | Method for dna sequencing utilising enzyme linked field effect transistors |
| DE60208787T2 (de) * | 2001-06-14 | 2006-11-02 | Cavidi Tech Ab | Verfahren zum messen der polymerisierung von dna und anwendungen des verfahrens |
| US20030124560A1 (en) * | 2001-06-14 | 2003-07-03 | Yoshihiko Makino | Method for analyzing a target nucleic acid fragment and a kit for analyzing a target nucleic acid fragment |
| AU2002318434B2 (en) * | 2001-06-29 | 2008-05-15 | Proteome Sciences Plc | Methods and compositions for determining the purity of and purifying chemically synthesized nucleic acids |
| FR2836995B1 (fr) * | 2002-03-05 | 2006-09-22 | Centre Nat Rech Scient | Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications |
| US7595883B1 (en) | 2002-09-16 | 2009-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Biological analysis arrangement and approach therefor |
| AU2004209001B2 (en) * | 2003-01-29 | 2007-10-11 | 454 Life Sciences Corporation | Bead emulsion nucleic acid amplification |
| DE602004021235D1 (de) * | 2003-02-21 | 2009-07-09 | Geneform Technologies Ltd | Verfahren, kits und reagenzien zur nukleinsäuresequenzierung |
| JP4691014B2 (ja) | 2003-02-26 | 2011-06-01 | カリダ ゲノミクス，インコーポレーテッド | ハイブリダイゼーションによるランダムアレイｄｎａ分析 |
| GB0321306D0 (en) | 2003-09-11 | 2003-10-15 | Solexa Ltd | Modified polymerases for improved incorporation of nucleotide analogues |
| CN1950519A (zh) | 2004-02-27 | 2007-04-18 | 哈佛大学的校长及成员们 | 聚合酶群落荧光原位测序珠子 |
| US20060024711A1 (en) | 2004-07-02 | 2006-02-02 | Helicos Biosciences Corporation | Methods for nucleic acid amplification and sequence determination |
| WO2006073504A2 (en) | 2004-08-04 | 2006-07-13 | President And Fellows Of Harvard College | Wobble sequencing |
| EP1888743B1 (en) | 2005-05-10 | 2011-08-03 | Illumina Cambridge Limited | Improved polymerases |
| US8063019B2 (en) | 2005-06-10 | 2011-11-22 | Medical Research Council | Scaffold polypeptides for heterologous peptide display |
| US20090264299A1 (en) | 2006-02-24 | 2009-10-22 | Complete Genomics, Inc. | High throughput genome sequencing on DNA arrays |
| EP3257949A1 (en) | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| US7960104B2 (en) | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
| WO2007120208A2 (en) | 2005-11-14 | 2007-10-25 | President And Fellows Of Harvard College | Nanogrid rolling circle dna sequencing |
| EP2495337A1 (en) | 2006-02-24 | 2012-09-05 | Callida Genomics, Inc. | High throughput genome sequencing on DNA arrays |
| WO2008045575A2 (en) | 2006-10-13 | 2008-04-17 | J. Craig Venter Institute, Inc. | Sequencing method |
| WO2008070352A2 (en) | 2006-10-27 | 2008-06-12 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
| US8262900B2 (en) | 2006-12-14 | 2012-09-11 | Life Technologies Corporation | Methods and apparatus for measuring analytes using large scale FET arrays |
| EP2639578B1 (en) | 2006-12-14 | 2016-09-14 | Life Technologies Corporation | Apparatus for measuring analytes using large scale fet arrays |
| US8349167B2 (en) | 2006-12-14 | 2013-01-08 | Life Technologies Corporation | Methods and apparatus for detecting molecular interactions using FET arrays |
| US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| US7901890B2 (en) | 2007-11-05 | 2011-03-08 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
| US8518640B2 (en) | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
| US7897344B2 (en) | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
| WO2009097368A2 (en) | 2008-01-28 | 2009-08-06 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| WO2009120374A2 (en) | 2008-03-28 | 2009-10-01 | Pacific Biosciences Of California, Inc. | Methods and compositions for nucleic acid sample preparation |
| GB0807065D0 (en) | 2008-04-18 | 2008-05-21 | Univ Leeds | Novel scaffolds |
| CN104263816B (zh) * | 2008-05-16 | 2018-10-19 | 生命技术公司 | 用于测量细胞增殖的双标记法 |
| US20100137143A1 (en) | 2008-10-22 | 2010-06-03 | Ion Torrent Systems Incorporated | Methods and apparatus for measuring analytes |
| EP2379748A4 (en) | 2008-12-23 | 2012-08-29 | Illumina Inc | MULTIBASE RELEASE FOR LONG READINGS IN SEQUENCING BY SYNTHESIS PROTOCOLS |
| WO2011143231A2 (en) | 2010-05-10 | 2011-11-17 | The Broad Institute | High throughput paired-end sequencing of large-insert clone libraries |
| US9005565B2 (en) | 2010-06-24 | 2015-04-14 | Hamid-Reza Jahangiri-Famenini | Method and apparatus for forming graphene |
| WO2012027623A2 (en) | 2010-08-25 | 2012-03-01 | Pacific Biosciences Of California, Inc. | Cyanine dyes |
| CA3104322C (en) * | 2011-09-23 | 2023-06-13 | Illumina, Inc. | Methods and compositions for nucleic acid sequencing |
| US8671811B2 (en) | 2011-09-30 | 2014-03-18 | Robert Bosch Gmbh | Pivoting saw system |
| GB201301178D0 (en) * | 2013-01-23 | 2013-03-06 | Dynamic Biosensors Gmbh | Method for sequencing a template nucleic acid immobilized on a substrate |
| US9650406B2 (en) | 2013-02-28 | 2017-05-16 | Centrillion Technology Holdings Corporation | Reversible terminator molecules and methods of their use |
| US9944924B2 (en) | 2014-01-16 | 2018-04-17 | Illumina, Inc. | Polynucleotide modification on solid support |
| CN107074904B (zh) | 2014-10-23 | 2022-12-23 | 深圳华大智造科技股份有限公司 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
| CN104448001A (zh) | 2014-11-14 | 2015-03-25 | 杭州博谱医药科技有限公司 | 抗5-甲基-胞嘧啶单克隆抗体及其应用 |
| EP3259372B1 (en) | 2015-02-17 | 2020-11-18 | MGI Tech Co., Ltd. | Dna sequencing using controlled strand displacement |
| CN105001292A (zh) * | 2015-07-14 | 2015-10-28 | 深圳市瀚海基因生物科技有限公司 | 一种光可断裂的荧光标记可逆终端化合物及其在dna或rna测序中的用途 |
| US20170240961A1 (en) | 2016-02-23 | 2017-08-24 | Complete Genomics, Inc. | Affinity tag labeled nucleosides and uses |
| CN109790196B (zh) † | 2016-04-22 | 2022-09-27 | 深圳华大智造科技股份有限公司 | 可逆封闭的核苷类似物及其用途 |
| EP4039824A1 (en) | 2016-08-15 | 2022-08-10 | Pacific Biosciences of California, Inc. | Method and system for sequencing nucleic acids |
| EP4575499A3 (en) | 2017-01-04 | 2025-07-09 | MGI Tech Co., Ltd. | Stepwise sequencing by non-labeled reversible terminators or natural nucleotides |
-
2018
- 2018-01-04 EP EP25160087.0A patent/EP4575499A3/en active Pending
- 2018-01-04 ES ES18736171T patent/ES2924223T5/es active Active
- 2018-01-04 IL IL267836A patent/IL267836B2/en unknown
- 2018-01-04 DK DK18736171.2T patent/DK3565905T4/da active
- 2018-01-04 DK DK22174722.3T patent/DK4112741T3/da active
- 2018-01-04 PL PL18736171.2T patent/PL3565905T5/pl unknown
- 2018-01-04 HU HUE18736171A patent/HUE059673T2/hu unknown
- 2018-01-04 RS RS20250404A patent/RS66810B1/sr unknown
- 2018-01-04 US US15/862,566 patent/US10851410B2/en active Active
- 2018-01-04 ES ES22174722T patent/ES3026859T3/es active Active
- 2018-01-04 KR KR1020197022620A patent/KR102349259B1/ko active Active
- 2018-01-04 AU AU2018205472A patent/AU2018205472B2/en active Active
- 2018-01-04 EP EP18736171.2A patent/EP3565905B2/en active Active
- 2018-01-04 CN CN202510375512.4A patent/CN120485343A/zh active Pending
- 2018-01-04 CA CA3048486A patent/CA3048486A1/en active Pending
- 2018-01-04 PT PT221747223T patent/PT4112741T/pt unknown
- 2018-01-04 MX MX2019008016A patent/MX2019008016A/es unknown
- 2018-01-04 BR BR112019013715-7A patent/BR112019013715B1/pt active IP Right Grant
- 2018-01-04 PL PL22174722.3T patent/PL4112741T3/pl unknown
- 2018-01-04 CN CN201880005910.5A patent/CN110418847B/zh active Active
- 2018-01-04 RS RS20220695A patent/RS63419B2/sr unknown
- 2018-01-04 EP EP22174722.3A patent/EP4112741B1/en active Active
- 2018-01-04 PT PT187361712T patent/PT3565905T/pt unknown
- 2018-01-04 FI FIEP22174722.3T patent/FI4112741T3/fi active
- 2018-01-04 FI FIEP18736171.2T patent/FI3565905T4/fi active
- 2018-01-04 JP JP2019536551A patent/JP2020508037A/ja not_active Withdrawn
- 2018-01-04 WO PCT/US2018/012425 patent/WO2018129214A1/en not_active Ceased
- 2018-01-04 HU HUE22174722A patent/HUE071446T2/hu unknown
-
2019
- 2019-07-03 MX MX2024006412A patent/MX2024006412A/es unknown
-
2020
- 2020-10-29 US US17/084,482 patent/US11788138B2/en active Active
-
2021
- 2021-12-27 JP JP2021212172A patent/JP7025595B1/ja active Active
-
2023
- 2023-03-14 AU AU2023201547A patent/AU2023201547B2/en active Active
- 2023-09-07 US US18/462,652 patent/US20240117425A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3565905T5 (pl) | Sekwencjonowanie kwasów nukleinowych z zastosowaniem odczynników powinowactwa | |
| IL271342A (en) | Nucleic acid-guided nucleases | |
| IL264966B (en) | De novo synthesized nucleic acid libraries | |
| IL254000B (en) | Nucleic acid sequence assembly | |
| EP3784799C0 (en) | METHOD FOR DETECTING NUCLEIC ACIDS | |
| IL259788A (en) | Adapter nucleic acid sequences, compositions comprising same and methods for duplex sequencing using same | |
| SG11201911430PA (en) | Novel nucleic acid molecules | |
| HUE047175T2 (hu) | Eljárások nukleinsavak tanulmányozására | |
| DK3523430T3 (da) | Manipulerede nukleinsyremålrettede nukleinsyrer | |
| DK3329012T3 (da) | Rumlig kortlægning af nukleinsyresekvensinformation | |
| DK3341482T3 (da) | Kunstige nukleinsyremolekyler | |
| DK3433368T3 (da) | Transreplikerende rna | |
| DK3351633T3 (da) | Antisense-nukleinsyre | |
| EP3636738A4 (en) | NUCLEIC ACID DETECTION CARTRIDGE | |
| DK3645717T3 (da) | Modulære nukleinsyreadaptere | |
| EP3366773A4 (en) | NUCLEIC COMPLEX | |
| EP4159872C0 (en) | DNA MARKING | |
| GB201506669D0 (en) | Nucleic acid sample enrichment | |
| EP4032551A4 (en) | NUCLEIC ACID COMPLEX | |
| EP4212628C0 (en) | NUCLEIC ACID SEQUENCING PROCESS | |
| EP3467835C0 (en) | IMPROVED ALIGNMENT METHOD FOR NUCLEIC ACID SEQUENCES | |
| DK3621596T3 (da) | Tabletter med nucleinsyrevektorer | |
| IL281941A (en) | Barcoding of nucleic acids | |
| EP3351251A4 (en) | Nucleic Acid MOLECULE | |
| IL271510A (en) | Determining the ratio between nucleic acids |