PL357116A1 - Sposób wytwarzania geminalnych bisfosfonianów - Google Patents

Sposób wytwarzania geminalnych bisfosfonianów

Info

Publication number: PL357116A1
Authority: PL; Poland
Prior art keywords: substituted; unsubstituted; unsaturated; saturated; hydrogen
Prior art date: 2000-02-01

Application number

PL01357116A

Other languages

English (en)

Other versions

PL207617B1 (pl

Inventor

Fredrick Dana Cazer

Gregory Eugene Perry

Dennis Michael Billings

William Douglas Cramer

Original Assignee

The Procter & Gamble Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-01

Filing date

2001-02-01

Publication date

2004-07-12

2001-02-01 Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company

2004-07-12 Publication of PL357116A1 publication Critical patent/PL357116A1/pl

2011-01-31 Publication of PL207617B1 publication Critical patent/PL207617B1/pl

Links

229940122361 Bisphosphonate Drugs 0.000 title abstract 3
150000004663 bisphosphonates Chemical group 0.000 title abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
229920006395 saturated elastomer Polymers 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
-1 -NR4- Substances 0.000 abstract 2
KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000003368 amide group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
150000007942 carboxylates Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
229910052711 selenium Inorganic materials 0.000 abstract 1
239000011669 selenium Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL357116A 2000-02-01 2001-02-01 Sposób wytwarzania geminalnego bisfosfonianu PL207617B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17950600P	2000-02-01	2000-02-01
PCT/US2001/003309 WO2001057052A1 (en)	2000-02-01	2001-02-01	Process for making geminal bisphosphonates

Publications (2)

Publication Number	Publication Date
PL357116A1 true PL357116A1 (pl)	2004-07-12
PL207617B1 PL207617B1 (pl)	2011-01-31

Family

ID=22656872

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL357116A PL207617B1 (pl)	2000-02-01	2001-02-01	Sposób wytwarzania geminalnego bisfosfonianu

Country Status (27)

Country	Link
US (1)	US6562974B2 (pl)
EP (1)	EP1252169B1 (pl)
JP (1)	JP4534185B2 (pl)
KR (1)	KR100681740B1 (pl)
CN (1)	CN1223598C (pl)
AT (1)	ATE269343T1 (pl)
AU (1)	AU784385B2 (pl)
BR (1)	BRPI0107952B8 (pl)
CA (1)	CA2399974C (pl)
CO (1)	CO5430222A1 (pl)
CZ (1)	CZ304038B6 (pl)
DE (1)	DE60103851T2 (pl)
DK (1)	DK1252169T3 (pl)
ES (1)	ES2221887T3 (pl)
HK (1)	HK1051045A1 (pl)
HU (1)	HU228980B1 (pl)
IL (2)	IL150512A0 (pl)
MX (1)	MXPA02007418A (pl)
NO (1)	NO330273B1 (pl)
NZ (1)	NZ519967A (pl)
PE (1)	PE20011065A1 (pl)
PL (1)	PL207617B1 (pl)
PT (1)	PT1252169E (pl)
RU (1)	RU2002123362A (pl)
SK (1)	SK10992002A3 (pl)
TR (1)	TR200402317T4 (pl)
WO (1)	WO2001057052A1 (pl)

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US20040052843A1 (en) *	2001-12-24	2004-03-18	Lerner E. Itzhak	Controlled release dosage forms
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ITMI20020908A1 (it) *	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
IL165227A0 (en) *	2002-05-17	2005-12-18	Tva Pharmaceutical Ind Ltd	Cus of certain diluents for making bisphosphonic acids
EP1656386B1 (en)	2003-08-21	2009-12-09	Sun Pharmaceuticals Industries Ltd.	A process for preparation of bisphosphonic acid compounds
US20050260272A1 (en) *	2004-05-05	2005-11-24	Alkermes Controlled Therapeutics, Inc.	Method of forming microparticles that include a bisphosphonate and a polymer
EP1802641B8 (en) *	2004-10-08	2012-03-07	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US8012949B2 (en) *	2004-10-08	2011-09-06	The Board Of Trustees Of The University Of Illinois	Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS
US7214818B2 (en)	2004-10-29	2007-05-08	Hoffmann-La Roche Inc.	Method for synthesizing bisphosphonate
PL199215B1 (pl) *	2004-12-28	2008-08-29	Politechnika Gdanska	Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
EP1888606A2 (en) *	2005-05-28	2008-02-20	PLIVA HRVATSKA d.o.o.	Process and novel salt
EP1891081B1 (en)	2005-06-13	2014-08-20	Jubilant Organosys Limited	Process for producing bisphosphonic acids and forms thereof
EP1775302A1 (en)	2005-10-11	2007-04-18	Sandoz A/S	Method for preparing crystalline sodium risedronate
KR100860666B1 (ko)	2006-01-06	2008-09-26	삼성전자주식회사	통신 시스템에서 신호 수신 장치 및 방법
JP2009530414A (ja) *	2006-03-17	2009-08-27	ザボードオブトラスティーズオブザユニヴァーシティーオブイリノイ	ビスホスホネート化合物及び方法
JP5354858B2 (ja) *	2006-05-09	2013-11-27	株式会社Ａｄｅｋａ	スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
BRPI0710421A2 (pt)	2006-05-11	2011-08-09	Ind Swift Ltd	processo para a preparação de ácido risedrÈnico puro ou sais
PT103600B (pt) *	2006-11-06	2009-01-30	Hovione Farmaciencia Sa	Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis
AU2008238058B2 (en)	2007-04-11	2010-12-02	F. Hoffmann-La Roche Ag	Multi step synthesis of ibandronate
WO2008152518A2 (en) *	2007-05-16	2008-12-18	Actavis Group Ptc Ehf	Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) *	2007-06-20	2009-04-23	Alkem Laboratories Ltd	Novel process for preparing risedronic acid
KR100877667B1 (ko) *	2007-06-28	2009-01-08	보령제약 주식회사	리세드로네이트의 제조 방법
JP2011515535A (ja) *	2008-03-17	2011-05-19	キャボットコーポレイション	リン酸塩遊離が低減した改質顔料、ならびにそれからの分散体およびインクジェットインク組成物
JP5258370B2 (ja) *	2008-05-08	2013-08-07	ダイト株式会社	リセドロン酸の工業的製造方法
CN102639545B (zh)	2009-10-02	2016-08-03	施里特马克控股公司	制备氨基羟基二膦酸的方法

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DE3822650A1 (de)	1988-07-05	1990-02-01	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3917153A1 (de)	1989-05-26	1990-11-29	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
TW208013B (pl)	1990-03-01	1993-06-21	Daiichi Co Ltd
DE69108733T2 (de)	1990-08-21	1995-09-14	Upjohn Co	Bisphosphonsäurederivate als antiarthritische mittel.
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IT1246992B (it) *	1991-01-08	1994-12-12	Gentili Ist Spa	Procedimento per la preparazione di acidi difosfonici e loro sali
DK58291D0 (da)	1991-04-02	1991-04-02	Novo Nordisk As	Krystalinsk stof og dets fremstilling
SE501389C2 (sv)	1992-04-24	1995-01-30	Leiras Oy	Farmaceutiskt preparat och förfarande för dess framställning
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DK0647649T3 (da)	1992-06-23	1999-07-26	Yamanouchi Pharma Co Ltd	Ny krystal af heterocyklisk bis(phosphonsyre)monohydratderivat
FR2694558B1 (fr)	1992-08-05	1994-10-28	Sanofi Elf	Monohydrate du sel disodique de l'acide 4-chlorophénylthiométhylène bisphosphonique, sa préparation, les compositions pharmaceutiques en contenant.
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TW393488B (en)	1995-04-20	2000-06-11	Merck & Co Inc	Process for making 1-hydrox-ybisphosphonates
KR100192215B1 (ko)	1996-09-03	1999-06-15	강재헌	3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
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2001
- 2001-01-29 US US09/771,899 patent/US6562974B2/en not_active Expired - Lifetime
- 2001-01-29 PE PE2001000095A patent/PE20011065A1/es not_active Application Discontinuation
- 2001-01-30 CO CO01006627A patent/CO5430222A1/es not_active Application Discontinuation
- 2001-02-01 PT PT01908779T patent/PT1252169E/pt unknown
- 2001-02-01 BR BRPI0107952A patent/BRPI0107952B8/pt not_active IP Right Cessation
- 2001-02-01 AT AT01908779T patent/ATE269343T1/de active
- 2001-02-01 EP EP01908779A patent/EP1252169B1/en not_active Expired - Lifetime
- 2001-02-01 DK DK01908779T patent/DK1252169T3/da active
- 2001-02-01 HU HU0300890A patent/HU228980B1/hu active IP Right Revival
- 2001-02-01 SK SK1099-2002A patent/SK10992002A3/sk unknown
- 2001-02-01 CZ CZ20022515A patent/CZ304038B6/cs not_active IP Right Cessation
- 2001-02-01 CN CNB018043011A patent/CN1223598C/zh not_active Expired - Lifetime
- 2001-02-01 CA CA002399974A patent/CA2399974C/en not_active Expired - Lifetime
- 2001-02-01 PL PL357116A patent/PL207617B1/pl unknown
- 2001-02-01 RU RU2002123362/04A patent/RU2002123362A/ru unknown
- 2001-02-01 AU AU36613/01A patent/AU784385B2/en not_active Expired
- 2001-02-01 DE DE60103851T patent/DE60103851T2/de not_active Expired - Lifetime
- 2001-02-01 TR TR2004/02317T patent/TR200402317T4/xx unknown
- 2001-02-01 IL IL15051201A patent/IL150512A0/xx active IP Right Grant
- 2001-02-01 MX MXPA02007418A patent/MXPA02007418A/es active IP Right Grant
- 2001-02-01 ES ES01908779T patent/ES2221887T3/es not_active Expired - Lifetime
- 2001-02-01 KR KR1020027009032A patent/KR100681740B1/ko not_active Expired - Lifetime
- 2001-02-01 HK HK03101831.8A patent/HK1051045A1/zh unknown
- 2001-02-01 WO PCT/US2001/003309 patent/WO2001057052A1/en not_active Ceased
- 2001-02-01 JP JP2001557883A patent/JP4534185B2/ja not_active Expired - Lifetime
- 2001-02-01 NZ NZ519967A patent/NZ519967A/en not_active IP Right Cessation
2002
- 2002-07-01 IL IL150512A patent/IL150512A/en unknown
- 2002-07-31 NO NO20023646A patent/NO330273B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2221887T3 (es)	2005-01-16
NZ519967A (en)	2004-05-28
HUP0300890A3 (en)	2009-01-28
JP2003522181A (ja)	2003-07-22
TR200402317T4 (tr)	2004-12-21
PL207617B1 (pl)	2011-01-31
BRPI0107952B8 (pt)	2021-05-25
US20010041690A1 (en)	2001-11-15
KR100681740B1 (ko)	2007-02-15
HUP0300890A2 (hu)	2003-08-28
CN1396925A (zh)	2003-02-12
PT1252169E (pt)	2004-11-30
EP1252169A1 (en)	2002-10-30
AU784385B2 (en)	2006-03-23
IL150512A0 (en)	2003-02-12
EP1252169B1 (en)	2004-06-16
CA2399974A1 (en)	2001-08-09
HU228980B1 (en)	2013-07-29
DE60103851D1 (de)	2004-07-22
DE60103851T2 (de)	2005-06-23
ATE269343T1 (de)	2004-07-15
BR0107952A (pt)	2003-02-25
NO20023646L (no)	2002-09-30
CZ304038B6 (cs)	2013-09-04
DK1252169T3 (da)	2004-10-25
WO2001057052A1 (en)	2001-08-09
NO330273B1 (no)	2011-03-14
CO5430222A1 (es)	2004-06-01
KR20020063622A (ko)	2002-08-03
BRPI0107952B1 (pt)	2015-09-01
HK1051045A1 (zh)	2003-07-18
CA2399974C (en)	2005-08-16
CN1223598C (zh)	2005-10-19
US6562974B2 (en)	2003-05-13
SK10992002A3 (sk)	2003-02-04
NO20023646D0 (no)	2002-07-31
RU2002123362A (ru)	2004-01-10
IL150512A (en)	2006-10-31
PE20011065A1 (es)	2001-11-21
MXPA02007418A (es)	2002-12-09
JP4534185B2 (ja)	2010-09-01
AU3661301A (en)	2001-08-14

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