PL362029A1 - Nowe pochodne 2,3-benzodiazepiny oraz kompozycje farmaceutyczne zawierające te pochodne jako składnik aktywny - Google Patents

Nowe pochodne 2,3-benzodiazepiny oraz kompozycje farmaceutyczne zawierające te pochodne jako składnik aktywny

Info

Publication number: PL362029A1
Authority: PL; Poland
Prior art keywords: sup; sub; novel; group; active ingredient
Prior art date: 2000-12-21

Application number

PL36202901A

Other languages

English (en)

Other versions

PL211495B1 (pl

Inventor

Istvan Ling

Jozsef Barkoczy

Gyula Simig

Zoltan Greff

Zoltan Ratkai

Geza Szabo

Miklos Vegh

Gabor Gigler

Gabor Szenasi

Marko Bernadett Martonne

György Levay

Laszlo Gabor Harsing

Original Assignee

Egis Gyogyszergyar Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-21

Filing date

2001-12-19

Publication date

2004-10-18

2001-12-19 Application filed by Egis Gyogyszergyar Rt. filed Critical Egis Gyogyszergyar Rt.

2004-10-18 Publication of PL362029A1 publication Critical patent/PL362029A1/pl

2012-05-31 Publication of PL211495B1 publication Critical patent/PL211495B1/pl

Links

RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Addiction (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL362029A 2000-12-21 2001-12-19 Pochodne 2,3-benzodiazepiny, kompozycja farmaceutyczna zawierająca te pochodne jako składnik aktywny i ich zastosowanie PL211495B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0004994A HU225100B1 (hu)	2000-12-21	2000-12-21	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk

Publications (2)

Publication Number	Publication Date
PL362029A1 true PL362029A1 (pl)	2004-10-18
PL211495B1 PL211495B1 (pl)	2012-05-31

Family

ID=89978876

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL362029A PL211495B1 (pl)	2000-12-21	2001-12-19	Pochodne 2,3-benzodiazepiny, kompozycja farmaceutyczna zawierająca te pochodne jako składnik aktywny i ich zastosowanie

Country Status (20)

Country	Link
US (1)	US7189711B2 (pl)
EP (1)	EP1351942B1 (pl)
JP (1)	JP4201252B2 (pl)
AT (1)	ATE271548T1 (pl)
AU (1)	AU2002217356A1 (pl)
BG (1)	BG66199B1 (pl)
CA (1)	CA2431761C (pl)
CZ (1)	CZ301371B6 (pl)
DE (1)	DE60104448T2 (pl)
DK (1)	DK1351942T3 (pl)
EA (1)	EA005867B1 (pl)
ES (1)	ES2225412T3 (pl)
HU (1)	HU225100B1 (pl)
PL (1)	PL211495B1 (pl)
PT (1)	PT1351942E (pl)
RO (1)	RO121268B1 (pl)
SK (1)	SK286620B6 (pl)
TR (1)	TR200402493T4 (pl)
UA (1)	UA74615C2 (pl)
WO (1)	WO2002050044A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0302449A3 (en) *	2003-08-04	2005-06-28	Egis Gyogyszergyar Nyilvanosan	8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
EA016087B1 (ru) *	2005-12-30	2012-02-28	Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг	Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез
EP2885286B1 (de) *	2012-08-16	2017-03-22	Bayer Pharma Aktiengesellschaft	2,3-benzodiazepine
WO2014202578A1 (de) *	2013-06-17	2014-12-24	Bayer Pharma Aktiengesellschaft	Substituierte phenyl-2,3-benzodiazepine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU191698B (en) *	1984-07-27	1987-03-30	Gyogyszerkutato Intezet	Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
DE19604920A1 (de) *	1996-02-01	1997-08-07	Schering Ag	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5891871A (en)	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
HU227128B1 (en) *	1999-07-07	2010-07-28	Egyt Gyogyszervegyeszeti Gyar	New 2,3-benzodiazepine derivatives
RU2325811C2 (ru)	2006-06-28	2008-06-10	Общество С Ограниченной Ответственностью "Фито-Маг"	Способ хранения плодоовощной и растениеводческой продукции

2000
- 2000-12-21 HU HU0004994A patent/HU225100B1/hu not_active IP Right Cessation
2001
- 2001-12-19 EP EP01271364A patent/EP1351942B1/en not_active Expired - Lifetime
- 2001-12-19 US US10/450,898 patent/US7189711B2/en not_active Expired - Fee Related
- 2001-12-19 CA CA2431761A patent/CA2431761C/en not_active Expired - Fee Related
- 2001-12-19 DK DK01271364T patent/DK1351942T3/da active
- 2001-12-19 DE DE60104448T patent/DE60104448T2/de not_active Expired - Lifetime
- 2001-12-19 CZ CZ20031680A patent/CZ301371B6/cs not_active IP Right Cessation
- 2001-12-19 SK SK788-2003A patent/SK286620B6/sk not_active IP Right Cessation
- 2001-12-19 EA EA200300691A patent/EA005867B1/ru not_active IP Right Cessation
- 2001-12-19 WO PCT/HU2001/000151 patent/WO2002050044A1/en not_active Ceased
- 2001-12-19 ES ES01271364T patent/ES2225412T3/es not_active Expired - Lifetime
- 2001-12-19 AU AU2002217356A patent/AU2002217356A1/en not_active Abandoned
- 2001-12-19 JP JP2002551541A patent/JP4201252B2/ja not_active Expired - Fee Related
- 2001-12-19 AT AT01271364T patent/ATE271548T1/de not_active IP Right Cessation
- 2001-12-19 PT PT01271364T patent/PT1351942E/pt unknown
- 2001-12-19 TR TR2004/02493T patent/TR200402493T4/xx unknown
- 2001-12-19 RO ROA200300539A patent/RO121268B1/ro unknown
- 2001-12-19 PL PL362029A patent/PL211495B1/pl unknown
- 2001-12-19 UA UA2003076874A patent/UA74615C2/uk unknown
2003
- 2003-06-20 BG BG107932A patent/BG66199B1/bg unknown

Also Published As

Publication number	Publication date
CA2431761A1 (en)	2002-06-27
RO121268B1 (ro)	2007-02-28
EA005867B1 (ru)	2005-06-30
US20040092510A1 (en)	2004-05-13
JP2004516284A (ja)	2004-06-03
DK1351942T3 (da)	2004-11-22
DE60104448T2 (de)	2005-07-28
EP1351942B1 (en)	2004-07-21
HU0004994D0 (en)	2001-03-28
CA2431761C (en)	2010-05-25
ATE271548T1 (de)	2004-08-15
AU2002217356A1 (en)	2002-07-01
HUP0004994A2 (hu)	2002-11-28
HU225100B1 (hu)	2006-06-28
PL211495B1 (pl)	2012-05-31
TR200402493T4 (tr)	2004-12-21
EA200300691A1 (ru)	2003-12-25
BG107932A (bg)	2004-02-27
CZ20031680A3 (cs)	2003-11-12
EP1351942A1 (en)	2003-10-15
UA74615C2 (en)	2006-01-16
US7189711B2 (en)	2007-03-13
WO2002050044A1 (en)	2002-06-27
JP4201252B2 (ja)	2008-12-24
ES2225412T3 (es)	2005-03-16
PT1351942E (pt)	2004-11-30
DE60104448D1 (de)	2004-08-26
SK286620B6 (sk)	2009-02-05
CZ301371B6 (cs)	2010-02-03
SK7882003A3 (en)	2003-11-04
BG66199B1 (bg)	2012-01-31

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WO2001009103A3 (en)	2001-05-31	Imidazole antiproliferative agents
MXPA02012033A (es)	2003-04-25	Derivados de 2-aminocarbonil-9h-purina.
KR20050085991A (en)	2005-08-29	Compounds exhibiting thrombopoietin receptor agonism
NZ511903A (en)	2002-12-20	Use of alpha-keto enamine derivatives as ingredients
GB9905075D0 (en)	1999-04-28	Chemical compounds
CA2238430A1 (en)	1997-05-29	Pyrazole derivatives, method for preparing same, and pharmaceutical compositions containing said derivatives
MXPA04006322A (es)	2004-10-04	Derivados de 6-fluorobiciclo[3.1.0]hexano.
IL124537A0 (en)	1998-12-06	Naphthyl-substituted benzimidazole derivatives and pharmaceutical compositions containing the same
PL310467A1 (en)	1995-12-11	Derivatives of dihalogenotriazolopyrimidine as fungicides
IL105909A0 (en)	1993-10-20	Fungicidal compositions comprising indole derivatives,certain such novel compounds and their preparation
ATE250622T1 (de)	2003-10-15	4'-c-ethynyl-pyrimidine nukleoside
MXPA04011914A (es)	2005-03-31	Formulacion farmaceutica de liberacion modificada.
EP0765865A4 (en)	1997-08-13	2-ACYLAMINOPROPANOL COMPOUND AND MEDICINAL COMPOSITION
DE60117847D1 (de)	2006-05-04	Farnesyltransferase hemmende, in der 4-stellung substituierte chinolin- und chinazolinderivate
IL154964A0 (en)	2003-10-31	Benzsulfonamide derivatives, their preparation and pharmaceutical compositions containing them
NZ516100A (en)	2004-01-30	Streptogramin derivatives, preparation and compositions containing them
AU1366802A (en)	2002-05-15	3-oxadiazol-5-yl-1-aminoalkyl-1h-indole derivatives
WO2002000638A8 (en)	2003-08-28	Substituted phthalides as anti-convulsive drugs
PL362029A1 (pl)	2004-10-18	Nowe pochodne 2,3-benzodiazepiny oraz kompozycje farmaceutyczne zawierające te pochodne jako składnik aktywny
WO2001051004A3 (en)	2002-01-17	Anti-cancer agent containing naphthoquinone compound
DE60119383D1 (de)	2006-06-08	Farnesyltransferasehemmende 4-heterocyclylchinolin- und chinazolinderivate
CA2374643A1 (en)	2000-11-30	1-trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives as substance p antagonists
WO2000024389A3 (en)	2000-09-28	Benzoquinoline derivatives useful as antibacterial agents
AU2002214056A1 (en)	2002-06-03	Farnesyl transferase inhibiting benzoheterocyclic derivatives
WO2003027077A1 (en)	2003-04-03	Water-soluble phenylpyridazine derivatives and drugs containing the same