PL362891A1 - Oczyszczony LH - Google Patents

Oczyszczony LH

Info

Publication number: PL362891A1
Authority: PL; Poland
Prior art keywords: purification; ion; reverse phase; phase hplc; exchange chromatography
Prior art date: 2000-02-22

Application number

PL01362891A

Other languages

English (en)

Other versions

PL207728B1 (pl

Inventor

Gianfranco Paradisi

Mara Rossi

Laura Scaglia

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-22

Filing date

2001-01-22

Publication date

2004-11-02

2001-01-22 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2004-11-02 Publication of PL362891A1 publication Critical patent/PL362891A1/pl

2011-01-31 Publication of PL207728B1 publication Critical patent/PL207728B1/pl

Links

102000009151 Luteinizing Hormone Human genes 0.000 abstract 4
108010073521 Luteinizing Hormone Proteins 0.000 abstract 4
229940040129 luteinizing hormone Drugs 0.000 abstract 4
238000004255 ion exchange chromatography Methods 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 2
238000004007 reversed phase HPLC Methods 0.000 abstract 2
210000004978 chinese hamster ovary cell Anatomy 0.000 abstract 1
239000000356 contaminant Substances 0.000 abstract 1
239000006228 supernatant Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)
Semiconductor Lasers (AREA)
Medicinal Preparation (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PL362891A 2000-02-22 2001-01-22 Sposób oczyszczania LH z próbki, zastosowanie rekombinowanego hLH oraz kompozycja farmaceutyczna PL207728B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP00103692		2000-02-22
PCT/EP2001/000666 WO2001062774A2 (en)	2000-02-22	2001-01-22	Purified lh

Publications (2)

Publication Number	Publication Date
PL362891A1 true PL362891A1 (pl)	2004-11-02
PL207728B1 PL207728B1 (pl)	2011-01-31

Family

ID=8167926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL362891A PL207728B1 (pl)	2000-02-22	2001-01-22	Sposób oczyszczania LH z próbki, zastosowanie rekombinowanego hLH oraz kompozycja farmaceutyczna

Country Status (30)

Country	Link
US (2)	US7053054B2 (pl)
EP (2)	EP1261622B1 (pl)
JP (1)	JP4959898B2 (pl)
KR (1)	KR100808149B1 (pl)
CN (1)	CN100480258C (pl)
AT (1)	ATE356138T1 (pl)
AU (1)	AU780377B2 (pl)
BG (1)	BG65761B1 (pl)
BR (2)	BRPI0108553B8 (pl)
CA (1)	CA2399100C (pl)
CY (1)	CY1108056T1 (pl)
CZ (1)	CZ303274B6 (pl)
DE (1)	DE60127100T2 (pl)
DK (1)	DK1261622T3 (pl)
EA (1)	EA004385B1 (pl)
EE (1)	EE04932B1 (pl)
ES (1)	ES2278722T3 (pl)
HR (1)	HRP20020651B1 (pl)
HU (1)	HU227007B1 (pl)
IL (2)	IL151309A0 (pl)
MX (1)	MXPA02007867A (pl)
NO (1)	NO328693B1 (pl)
PL (1)	PL207728B1 (pl)
PT (1)	PT1261622E (pl)
RS (1)	RS50416B (pl)
SI (1)	SI1261622T1 (pl)
SK (1)	SK287041B6 (pl)
UA (2)	UA78676C2 (pl)
WO (1)	WO2001062774A2 (pl)
ZA (1)	ZA200206108B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1261622E (pt) *	2000-02-22	2007-04-30	Applied Research Systems	Lh purificada
DE10235168A1 (de) *	2002-08-01	2004-02-12	Aventis Pharma Deutschland Gmbh	Verfahren zur Reinigung von Preproinsulin
NZ542549A (en) *	2003-03-04	2008-11-28	Aspenbio Pharma Inc	Methods and kits for maintaining pregnancy, treating follicular cysts, and synchronizing ovulation using single-chain luteinizing hormone
CN1283792C (zh) *	2003-11-14	2006-11-08	余伟明	生物大分子组分相分离法
AU2004309040B2 (en) *	2003-12-22	2010-12-16	Ares Trading S.A.	Method for purifying FSH
CA2582083A1 (en) *	2004-10-04	2006-04-20	Novetide, Ltd.	A counterion exchange process for peptides
DE602005009856D1 (de) *	2004-11-09	2008-10-30	Ares Trading Sa	Verfahren zur reinigung von fsh
DK1917276T3 (en)	2005-08-26	2018-05-07	Ares Trading Sa	Process for Preparation of Glycosylated Interferon Beta
AU2006323925B2 (en) *	2005-12-09	2012-08-02	Ares Trading S.A.	Method for purifying FSH or a FSH mutant
AU2008314687A1 (en) *	2007-10-22	2009-04-30	Merck Serono S.A.	Method for purifying Fc-fusion proteins
EP2203465A1 (en) *	2007-10-22	2010-07-07	Merck Serono S.A.	Method for purifying an fc-containing protein
CN101928342B (zh) *	2009-06-18	2013-05-08	上海天伟生物制药有限公司	一种高纯度绝经期促性腺素及其制备方法和用途
WO2015168622A1 (en) *	2014-05-01	2015-11-05	Virginia Tech Intellectual Properties, Inc.	Keratin nanomaterials and methods of production
CN104569441B (zh) *	2015-01-19	2016-02-03	成都大熊猫繁育研究基地	大熊猫尿液促黄体素的酶联检测方法及其应用
EP3969026A1 (en)	2019-05-16	2022-03-23	Ceva Santé Animale	Compositions and methods for increasing reproduction performance in non human mammals using recombinant luteinizing hormone

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990002757A1 (en) *	1988-09-02	1990-03-22	Integrated Genetics, Inc.	Heteropolymeric protein
ATE148171T1 (de) *	1989-02-21	1997-02-15	Univ Washington	Modifizierte formen von fortpflanzungshormonen
US5087615A (en) *	1989-03-17	1992-02-11	Applied Research Systems Ars Holding N.V.	Novel method of ovulation induction in humans
IT1250075B (it) *	1991-12-18	1995-03-30	Serono Cesare Ist Ricerca	Composizioni farmaceutiche contenenti gonadotropine.
IT1287138B1 (it) *	1996-11-07	1998-08-04	Ibsa Inst Biochimique Sa	Procedimento per la separazione e purificazione di fsh e lh
TW518235B (en) *	1997-01-15	2003-01-21	Akzo Nobel Nv	A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage
BR9810478A (pt)	1997-06-25	2000-09-12	Applied Research Systems	Análogos de hormÈnio glicoproteìna reticulados por dissulfeto e sua preparação e utilização
PT1261622E (pt) *	2000-02-22	2007-04-30	Applied Research Systems	Lh purificada

2001
- 2001-01-22 PT PT01907476T patent/PT1261622E/pt unknown
- 2001-01-22 DK DK01907476T patent/DK1261622T3/da active
- 2001-01-22 EA EA200200893A patent/EA004385B1/ru not_active IP Right Cessation
- 2001-01-22 AU AU35436/01A patent/AU780377B2/en not_active Expired
- 2001-01-22 AT AT01907476T patent/ATE356138T1/de active
- 2001-01-22 WO PCT/EP2001/000666 patent/WO2001062774A2/en not_active Ceased
- 2001-01-22 RS YUP-603/02A patent/RS50416B/sr unknown
- 2001-01-22 EE EEP200200464A patent/EE04932B1/xx unknown
- 2001-01-22 BR BRPI0108553A patent/BRPI0108553B8/pt not_active IP Right Cessation
- 2001-01-22 HR HR20020651A patent/HRP20020651B1/xx not_active IP Right Cessation
- 2001-01-22 US US10/204,554 patent/US7053054B2/en not_active Expired - Lifetime
- 2001-01-22 CA CA2399100A patent/CA2399100C/en not_active Expired - Fee Related
- 2001-01-22 UA UA2002086889A patent/UA78676C2/xx unknown
- 2001-01-22 ES ES01907476T patent/ES2278722T3/es not_active Expired - Lifetime
- 2001-01-22 CZ CZ20022856A patent/CZ303274B6/cs not_active IP Right Cessation
- 2001-01-22 UA UAA200612399A patent/UA92145C2/uk unknown
- 2001-01-22 PL PL362891A patent/PL207728B1/pl unknown
- 2001-01-22 DE DE60127100T patent/DE60127100T2/de not_active Expired - Lifetime
- 2001-01-22 EP EP01907476A patent/EP1261622B1/en not_active Expired - Lifetime
- 2001-01-22 CN CNB018053645A patent/CN100480258C/zh not_active Expired - Lifetime
- 2001-01-22 BR BR122012018280A patent/BR122012018280B8/pt not_active IP Right Cessation
- 2001-01-22 SI SI200130709T patent/SI1261622T1/sl unknown
- 2001-01-22 HU HU0301814A patent/HU227007B1/hu unknown
- 2001-01-22 MX MXPA02007867A patent/MXPA02007867A/es active IP Right Grant
- 2001-01-22 JP JP2001562555A patent/JP4959898B2/ja not_active Expired - Lifetime
- 2001-01-22 IL IL15130901A patent/IL151309A0/xx unknown
- 2001-01-22 SK SK1205-2002A patent/SK287041B6/sk not_active IP Right Cessation
- 2001-01-22 KR KR1020027010624A patent/KR100808149B1/ko not_active Expired - Lifetime
- 2001-01-22 EP EP06016629A patent/EP1777231A3/en not_active Withdrawn
2002
- 2002-07-31 ZA ZA200206108A patent/ZA200206108B/en unknown
- 2002-08-14 BG BG107001A patent/BG65761B1/bg unknown
- 2002-08-18 IL IL151309A patent/IL151309A/en active IP Right Grant
- 2002-08-20 NO NO20023963A patent/NO328693B1/no not_active IP Right Cessation
2005
- 2005-11-28 US US11/287,341 patent/US20060079460A1/en not_active Abandoned
2007
- 2007-05-10 CY CY20071100638T patent/CY1108056T1/el unknown

Also Published As

Publication number	Publication date
IL151309A0 (en)	2003-04-10
KR100808149B1 (ko)	2008-02-29
ZA200206108B (en)	2003-07-31
EP1777231A2 (en)	2007-04-25
US20060079460A1 (en)	2006-04-13
JP4959898B2 (ja)	2012-06-27
AU3543601A (en)	2001-09-03
DE60127100T2 (de)	2007-06-28
BRPI0108553B8 (pt)	2021-05-25
PL207728B1 (pl)	2011-01-31
CA2399100A1 (en)	2001-08-30
NO20023963L (no)	2002-08-20
EP1261622B1 (en)	2007-03-07
ATE356138T1 (de)	2007-03-15
BR122012018280B8 (pt)	2021-05-25
BR122012018280B1 (pt)	2018-01-09
EA200200893A1 (ru)	2003-02-27
MXPA02007867A (es)	2003-02-10
US20030186893A1 (en)	2003-10-02
HRP20020651B1 (en)	2011-01-31
CZ20022856A3 (cs)	2003-01-15
CN100480258C (zh)	2009-04-22
SK287041B6 (sk)	2009-10-07
NO20023963D0 (no)	2002-08-20
EP1777231A3 (en)	2007-11-07
HUP0301814A2 (hu)	2003-08-28
EE04932B1 (et)	2007-12-17
NO328693B1 (no)	2010-04-26
UA92145C2 (en)	2010-10-11
BRPI0108553B1 (pt)	2016-06-14
PT1261622E (pt)	2007-04-30
WO2001062774A3 (en)	2002-03-14
DK1261622T3 (da)	2007-05-29
RS50416B (sr)	2009-12-31
WO2001062774A2 (en)	2001-08-30
YU60302A (sh)	2005-09-19
EP1261622A2 (en)	2002-12-04
BG107001A (bg)	2003-04-30
CA2399100C (en)	2011-11-08
CN1404486A (zh)	2003-03-19
UA78676C2 (en)	2007-04-25
KR20030001358A (ko)	2003-01-06
HU227007B1 (en)	2010-04-28
HK1052014A1 (zh)	2003-08-29
HRP20020651A2 (en)	2004-12-31
DE60127100D1 (de)	2007-04-19
CY1108056T1 (el)	2013-09-04
IL151309A (en)	2010-11-30
BR0108553A (pt)	2003-12-23
SK12052002A3 (sk)	2002-12-03
JP2003532636A (ja)	2003-11-05
CZ303274B6 (cs)	2012-07-11
EE200200464A (et)	2003-12-15
HUP0301814A3 (en)	2004-10-28
US7053054B2 (en)	2006-05-30
AU780377B2 (en)	2005-03-17
SI1261622T1 (sl)	2007-06-30
EA004385B1 (ru)	2004-04-29
ES2278722T3 (es)	2007-08-16
BG65761B1 (bg)	2009-10-30

Publication	Publication Date	Title
SI1261622T1 (sl)	2007-06-30	Preäśiĺ äśeni rekombinantni hlh s specifiäśno bioaktivnostjo in postopek za njegovo preäśiĺ äśenje
HU1300063D0 (hu)	2003-03-28	Tisztított hCG
EP0701427A4 (en)	1996-11-06	HOSPITALIZED CONVERTIBLE BED
WO1997032607A3 (en)	1997-11-13	Activated linkers and methods for making and purifying the same
ZA932843B (en)	1993-11-23	A method of producing a factor VIII preparation
MXPA01010522A (es)	2003-08-19	Composiciones de gonadotropina altamente purificada y procedimiento para prepararlas.
ES2161790T3 (es)	2001-12-16	Procedimiento de separacion y de purificacion de proteinas dependientes de la vitamina k.
KR900001854A (ko)	1990-02-27	환원형의 비글리코실화 재조합 인체 il₂, 그의 제조방법 및 의약품으로서의 용도
Hooper et al.	1973	Histone III: II. ISOLATION AND SEQUENCES OF CHYMOTRYPTIC PEPTIDES FROM CALF THYMUS HISTONE III
Hocart et al.	1985	Improved antagonists of luteinizing hormone-releasing hormone modified in position 7
PL1697411T3 (pl)	2011-12-30	Sposób oczyszczania interferonu beta