PL363778A1 - 2-(podstawione-amino)-benzotiazolosulfonamidowe inhibitory proteazy HIV - Google Patents

2-(podstawione-amino)-benzotiazolosulfonamidowe inhibitory proteazy HIV

Info

Publication number: PL363778A1
Authority: PL; Poland
Prior art keywords: 4alkyl; 6alkyl; substituted; amino; het2
Prior art date: 2001-02-14

Application number

PL02363778A

Other languages

English (en)

Other versions

PL213327B1 (pl

Inventor

Dominique Louis Nestor Ghislain Surleraux

Piet Tom Bert Paul Wigerinck

Daniel Getman

Wim Gaston Verschueren

Sandrine Marie Helene Vendeville

Bethune Marie-Pierre T.M.M.G. De

Kerpel Jan Octaaf Antoon De

Samuel Leo Christiaan Moors

Kock Herman Augustinus De

Marieke Christiane Johanna Voets

Original Assignee

Tibotec Pharmaceuticals Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-14

Filing date

2002-02-14

Publication date

2004-11-29

2002-02-14 Application filed by Tibotec Pharmaceuticals Ltd. filed Critical Tibotec Pharmaceuticals Ltd.

2004-11-29 Publication of PL363778A1 publication Critical patent/PL363778A1/pl

2013-02-28 Publication of PL213327B1 publication Critical patent/PL213327B1/pl

Links

239000004030 hiv protease inhibitor Substances 0.000 title abstract 2
-1 2-(substituted-amino)-benzothiazole sulfonamide Chemical class 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
238000009007 Diagnostic Kit Methods 0.000 abstract 1
150000001204 N-oxides Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
229940124522 antiretrovirals Drugs 0.000 abstract 1
239000003903 antiretrovirus agent Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

PL363778A 2001-02-14 2002-02-14 Zwiazki 2-(podstawione-amino)-benzotiazolosulfonamidowe, sposób ich wytwarzania oraz ich zastosowanie PL213327B1 (pl)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP01200529		2001-02-14
US28775801P	2001-05-02	2001-05-02
PCT/EP2002/001788 WO2002083657A2 (en)	2001-02-14	2002-02-14	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

Publications (2)

Publication Number	Publication Date
PL363778A1 true PL363778A1 (pl)	2004-11-29
PL213327B1 PL213327B1 (pl)	2013-02-28

Family

ID=26076833

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL363778A PL213327B1 (pl)	2001-02-14	2002-02-14	Zwiazki 2-(podstawione-amino)-benzotiazolosulfonamidowe, sposób ich wytwarzania oraz ich zastosowanie

Country Status (30)

Country	Link
US (1)	US7659404B2 (pl)
EP (1)	EP1370543B1 (pl)
JP (1)	JP4530612B2 (pl)
KR (1)	KR100870184B1 (pl)
CN (2)	CN100369904C (pl)
AP (1)	AP1504A (pl)
AT (1)	ATE343567T1 (pl)
AU (1)	AU2002302363B2 (pl)
BG (1)	BG66301B1 (pl)
BR (1)	BR0207862A (pl)
CA (1)	CA2438304C (pl)
CY (1)	CY1108073T1 (pl)
CZ (1)	CZ304273B6 (pl)
DE (1)	DE60215623T2 (pl)
DK (1)	DK1370543T3 (pl)
EA (1)	EA006096B1 (pl)
EE (1)	EE05385B1 (pl)
ES (1)	ES2275866T3 (pl)
HR (1)	HRP20030735B1 (pl)
HU (1)	HU229224B1 (pl)
IL (2)	IL157171A0 (pl)
MX (1)	MXPA03007236A (pl)
NO (1)	NO326174B1 (pl)
NZ (1)	NZ527391A (pl)
PL (1)	PL213327B1 (pl)
PT (1)	PT1370543E (pl)
SI (1)	SI1370543T1 (pl)
SK (1)	SK287582B6 (pl)
WO (1)	WO2002083657A2 (pl)
ZA (1)	ZA200306086B (pl)

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AU2002226316B2 (en)	2000-10-20	2008-06-26	Virco Bvba	Mutational profiles in HIV-1 reverse transcriptase correlated with phenotypic drug resistance
EP1370543B1 (en)	2001-02-14	2006-10-25	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors
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WO2005030739A1 (en) *	2003-09-30	2005-04-07	Tibotec Pharmaceuticals Ltd.	Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
DE10360835A1 (de) *	2003-12-23	2005-07-21	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
ES2331257T3 (es)	2005-02-25	2009-12-28	Tibotec Pharmaceuticals	Sintesis de precursores de inhibidores de proteasas.
AR053845A1 (es)	2005-04-15	2007-05-23	Tibotec Pharm Ltd	5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
JO2841B1 (en) *	2006-06-23	2014-09-15	تيبوتيك فارماسيوتيكالز ليمتد	2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
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JO3090B1 (ar) *	2009-12-11	2017-03-15	Janssen Sciences Ireland Uc	5- امينو-4- هيدروكسي-بنتويل اميدات
US9024038B2 (en) *	2010-12-27	2015-05-05	Purdue Research Foundation	Compunds and methods for treating HIV
ES2571479T3 (es)	2012-04-20	2016-05-25	Gilead Sciences Inc	Derivados del ácido benzotiazol-6-il acético y su uso para tratar una infección por VIH
CN104000824B (zh) *	2014-05-28	2016-07-06	中山大学	苯并五元杂环类化合物在制备抗hiv-1病毒药物中的应用
US11439608B2 (en)	2017-09-25	2022-09-13	Qun Lu	Roles of modulators of intersectin-CDC42 signaling in Alzheimer's disease
CN116354903B (zh) *	2021-12-28	2025-09-09	南京药石科技股份有限公司	一种6-苯并噻唑磺酰氯的制备方法
WO2024206093A1 (en) *	2023-03-24	2024-10-03	Purdue Research Foundation	Hiv-1p rotease inhibitors and uses thereof

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EP1370543B1 (en)	2001-02-14	2006-10-25	Tibotec Pharmaceuticals Ltd.	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors

2002
- 2002-02-14 EP EP02729930A patent/EP1370543B1/en not_active Expired - Lifetime
- 2002-02-14 PT PT02729930T patent/PT1370543E/pt unknown
- 2002-02-14 MX MXPA03007236A patent/MXPA03007236A/es active IP Right Grant
- 2002-02-14 SI SI200230467T patent/SI1370543T1/sl unknown
- 2002-02-14 CA CA2438304A patent/CA2438304C/en not_active Expired - Fee Related
- 2002-02-14 AU AU2002302363A patent/AU2002302363B2/en not_active Ceased
- 2002-02-14 NZ NZ527391A patent/NZ527391A/xx not_active IP Right Cessation
- 2002-02-14 SK SK1102-2003A patent/SK287582B6/sk not_active IP Right Cessation
- 2002-02-14 CZ CZ2003-2415A patent/CZ304273B6/cs not_active IP Right Cessation
- 2002-02-14 CN CNB028049829A patent/CN100369904C/zh not_active Expired - Fee Related
- 2002-02-14 WO PCT/EP2002/001788 patent/WO2002083657A2/en not_active Ceased
- 2002-02-14 IL IL15717102A patent/IL157171A0/xx unknown
- 2002-02-14 DE DE60215623T patent/DE60215623T2/de not_active Expired - Lifetime
- 2002-02-14 AP APAP/P/2003/002856A patent/AP1504A/en active
- 2002-02-14 JP JP2002581413A patent/JP4530612B2/ja not_active Expired - Fee Related
- 2002-02-14 ES ES02729930T patent/ES2275866T3/es not_active Expired - Lifetime
- 2002-02-14 CN CN2007101997173A patent/CN101230067B/zh not_active Expired - Fee Related
- 2002-02-14 HU HU0303257A patent/HU229224B1/hu not_active IP Right Cessation
- 2002-02-14 AT AT02729930T patent/ATE343567T1/de active
- 2002-02-14 KR KR1020037010506A patent/KR100870184B1/ko not_active Expired - Fee Related
- 2002-02-14 BR BR0207862-7A patent/BR0207862A/pt not_active IP Right Cessation
- 2002-02-14 DK DK02729930T patent/DK1370543T3/da active
- 2002-02-14 EA EA200300891A patent/EA006096B1/ru not_active IP Right Cessation
- 2002-02-14 HR HR20030735A patent/HRP20030735B1/xx not_active IP Right Cessation
- 2002-02-14 PL PL363778A patent/PL213327B1/pl unknown
- 2002-02-14 US US10/467,609 patent/US7659404B2/en not_active Expired - Fee Related
- 2002-02-14 EE EEP200300381A patent/EE05385B1/xx not_active IP Right Cessation
2003
- 2003-07-30 IL IL157171A patent/IL157171A/en not_active IP Right Cessation
- 2003-08-06 ZA ZA2003/06086A patent/ZA200306086B/en unknown
- 2003-08-13 NO NO20033584A patent/NO326174B1/no not_active IP Right Cessation
- 2003-09-01 BG BG108143A patent/BG66301B1/bg unknown
2007
- 2007-01-25 CY CY20071100088T patent/CY1108073T1/el unknown

Also Published As

Publication number	Publication date
ATE343567T1 (de)	2006-11-15
AU2002302363B2 (en)	2008-05-01
PT1370543E (pt)	2007-02-28
DK1370543T3 (da)	2007-02-19
MXPA03007236A (es)	2003-12-04
BR0207862A (pt)	2004-06-22
NO326174B1 (no)	2008-10-13
HK1061233A1 (en)	2004-09-10
WO2002083657A2 (en)	2002-10-24
HU229224B1 (en)	2013-09-30
AP1504A (en)	2005-12-10
AP2003002856A0 (en)	2003-09-30
ES2275866T3 (es)	2007-06-16
CY1108073T1 (el)	2014-02-12
JP4530612B2 (ja)	2010-08-25
IL157171A (en)	2012-10-31
CN1525962A (zh)	2004-09-01
NO20033584D0 (no)	2003-08-13
CN101230067B (zh)	2011-06-15
JP2004518767A (ja)	2004-06-24
CA2438304C (en)	2011-04-12
PL213327B1 (pl)	2013-02-28
SK11022003A3 (sk)	2004-07-07
IL157171A0 (en)	2004-02-08
BG66301B1 (bg)	2013-03-29
CA2438304A1 (en)	2002-10-24
KR100870184B1 (ko)	2008-11-24
HRP20030735A2 (en)	2005-08-31
BG108143A (en)	2004-07-30
CN101230067A (zh)	2008-07-30
EE05385B1 (et)	2011-02-15
EA200300891A1 (ru)	2004-02-26
EA006096B1 (ru)	2005-08-25
CZ20032415A3 (cs)	2004-04-14
ZA200306086B (en)	2005-01-26
SI1370543T1 (sl)	2007-04-30
KR20030077017A (ko)	2003-09-29
SK287582B6 (sk)	2011-03-04
NZ527391A (en)	2005-04-29
US20040116485A1 (en)	2004-06-17
HUP0303257A2 (hu)	2004-01-28
US7659404B2 (en)	2010-02-09
EP1370543A2 (en)	2003-12-17
NO20033584L (no)	2003-10-14
CN100369904C (zh)	2008-02-20
DE60215623D1 (de)	2006-12-07
EE200300381A (et)	2003-12-15
CZ304273B6 (cs)	2014-02-12
EP1370543B1 (en)	2006-10-25
WO2002083657A3 (en)	2003-02-13
DE60215623T2 (de)	2007-08-30
HRP20030735B1 (en)	2012-02-29

Publication	Publication Date	Title
HRP20030735A2 (en)	2005-08-31	Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors
CY1109247T1 (el)	2014-07-02	Αναστολεις πρωτεασης hiv σουλφοναμιδιου 2-αμινο-βενζοξαζολης ευρεως φασματος
MXPA03009179A (es)	2004-11-22	2-(amino sustituido)-benzoxazol sunfonamidas, inhibidores de amplio espectro de la vih proteasa.
AR047744A1 (es)	2006-02-15	Compuestos de triazol y su uso como antagonistas del receptor de glutamato metabotropico
AR038240A1 (es)	2005-01-05	Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion
PE20010632A1 (es)	2001-07-07	Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen
PE20061305A1 (es)	2006-12-30	Compuestos derivados de fenilacetamidas como inhibidores de proteincinasas
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MY135226A (en)	2008-02-29	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
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TR200102523T2 (tr)	2002-02-21	Alkenil ve alkinil içeren metaloproteaz inhibitörleri
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