PL3645518T3 - Synteza omekamtywu mekarbilu - Google Patents
Synteza omekamtywu mekarbiluInfo
- Publication number
- PL3645518T3 PL3645518T3 PL18743314T PL18743314T PL3645518T3 PL 3645518 T3 PL3645518 T3 PL 3645518T3 PL 18743314 T PL18743314 T PL 18743314T PL 18743314 T PL18743314 T PL 18743314T PL 3645518 T3 PL3645518 T3 PL 3645518T3
- Authority
- PL
- Poland
- Prior art keywords
- synthesis
- omecamtiv mecarbil
- mecarbil
- omecamtiv
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- RFUBTTPMWSKEIW-UHFFFAOYSA-N omecamtiv mecarbil Chemical compound C1CN(C(=O)OC)CCN1CC1=CC=CC(NC(=O)NC=2C=NC(C)=CC=2)=C1F RFUBTTPMWSKEIW-UHFFFAOYSA-N 0.000 title 1
- 229950001617 omecamtiv mecarbil Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762527174P | 2017-06-30 | 2017-06-30 | |
| US201862664363P | 2018-04-30 | 2018-04-30 | |
| EP18743314.9A EP3645518B1 (en) | 2017-06-30 | 2018-06-29 | Synthesis of omecamtiv mecarbil |
| PCT/US2018/040176 WO2019006231A1 (en) | 2017-06-30 | 2018-06-29 | SYNTHESIS OF OMECAMTIV MECARBIL |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3645518T3 true PL3645518T3 (pl) | 2021-12-06 |
Family
ID=62976317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18743314T PL3645518T3 (pl) | 2017-06-30 | 2018-06-29 | Synteza omekamtywu mekarbilu |
Country Status (29)
| Country | Link |
|---|---|
| US (4) | US11040956B2 (pl) |
| EP (3) | EP3645518B1 (pl) |
| JP (2) | JP7181896B2 (pl) |
| KR (1) | KR102625774B1 (pl) |
| CN (1) | CN110799503B (pl) |
| AU (2) | AU2018294254C1 (pl) |
| CA (1) | CA3063102A1 (pl) |
| CL (2) | CL2019003898A1 (pl) |
| CY (1) | CY1124427T1 (pl) |
| DK (1) | DK3645518T3 (pl) |
| ES (1) | ES2882905T3 (pl) |
| GE (5) | GEP20237530B (pl) |
| HR (1) | HRP20211290T1 (pl) |
| HU (1) | HUE055242T2 (pl) |
| IL (2) | IL270663B (pl) |
| LT (1) | LT3645518T (pl) |
| MD (1) | MD3645518T2 (pl) |
| MX (3) | MX2021009594A (pl) |
| PH (1) | PH12019502883A1 (pl) |
| PL (1) | PL3645518T3 (pl) |
| PT (1) | PT3645518T (pl) |
| RS (1) | RS62328B1 (pl) |
| SG (1) | SG10202111790YA (pl) |
| SI (1) | SI3645518T1 (pl) |
| SM (1) | SMT202100472T1 (pl) |
| TW (2) | TWI769272B (pl) |
| UA (1) | UA127517C2 (pl) |
| WO (1) | WO2019006231A1 (pl) |
| ZA (1) | ZA202000534B (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507735B2 (en) | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
| EP3821882A1 (en) | 2013-03-14 | 2021-05-19 | Amgen Inc. | Heterocyclic compounds and their uses |
| JP2020526483A (ja) | 2017-06-30 | 2020-08-31 | アムジエン・インコーポレーテツド | 心筋節活性化剤で心不全を治療する方法 |
| MX2021009594A (es) | 2017-06-30 | 2022-10-24 | Amgen Inc | Sintesis de omecamtiv mecarbil. |
| BR112020004800A2 (pt) | 2017-09-13 | 2020-09-24 | Amgen Inc. | compostos de bisamida ativantes do sarcômero e seus usos |
| DK3594199T3 (da) | 2018-07-09 | 2020-09-14 | Fis Fabbrica Italiana Sintetici Spa | Krystallinsk 2-flour-3-nitrotoluen og proces til forberedelse deraf |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| US12442027B2 (en) | 2018-12-18 | 2025-10-14 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| US20220411374A1 (en) * | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| WO2021070123A1 (en) * | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| IL302850A (en) | 2020-11-12 | 2023-07-01 | Amgen Inc | Methods of treating heart failure by administering OMECAMTIV MECARBIL |
| AU2022232919A1 (en) * | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| WO2023205291A2 (en) * | 2022-04-21 | 2023-10-26 | The Board Of Regents Of The University Of Oklahoma | Targeting myocardial tissue for delivery of therapeutic and imaging agents |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5580872A (en) | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| US6492529B1 (en) * | 2000-01-18 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Bis pyrazole-1H-pyrazole intermediates and their synthesis |
| US7507735B2 (en) | 2004-06-17 | 2009-03-24 | Cytokinetics, Inc. | Compounds, compositions and methods |
| TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
| US20070208000A1 (en) | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
| WO2007078839A2 (en) | 2005-12-19 | 2007-07-12 | Cytokinetics, Inc. | Compounds, compositions and methods |
| WO2008037229A1 (de) * | 2006-09-25 | 2008-04-03 | Siemens Aktiengesellschaft | Sammelschienenkontaktierung mit schienendickenausgleich |
| GEP20125425B (en) | 2006-10-18 | 2012-03-26 | Pfizer Prod Inc | Biaryl ether urea compounds |
| US20090192168A1 (en) | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
| US20120083476A1 (en) | 2009-06-05 | 2012-04-05 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
| KR101566091B1 (ko) * | 2010-11-10 | 2015-11-04 | 에프. 호프만-라 로슈 아게 | Lrrk2 조절제로서 피라졸 아미노피리미딘 유도체 |
| CN104271569B (zh) * | 2012-05-03 | 2016-08-24 | 霍夫曼-拉罗奇有限公司 | 作为lrrk2调节剂的吡唑氨基嘧啶衍生物 |
| EP3821882A1 (en) | 2013-03-14 | 2021-05-19 | Amgen Inc. | Heterocyclic compounds and their uses |
| JP6634368B2 (ja) * | 2013-03-14 | 2020-01-22 | アムジエン・インコーポレーテツド | 複素環式化合物及びそれらの使用 |
| CN106163585B (zh) | 2014-03-31 | 2019-07-16 | 株式会社美迪克 | 血液净化装置及血液净化装置的启动加注方法 |
| ES2713700T3 (es) * | 2014-11-24 | 2019-05-23 | Medifron Dbt Inc | Derivados de carboxamida y urea a base de oxazol y tiazol sustituidos como ligandos del receptor de vainilloide II |
| EP3250557B1 (en) | 2015-01-29 | 2024-11-20 | Signal Pharmaceuticals, LLC | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| JP6858716B2 (ja) | 2015-06-26 | 2021-04-14 | アムジエン・インコーポレーテツド | 心筋ミオシン活性化剤と洞房結節If電流阻害剤の併用療法 |
| MX2021009594A (es) | 2017-06-30 | 2022-10-24 | Amgen Inc | Sintesis de omecamtiv mecarbil. |
| JP2020526483A (ja) | 2017-06-30 | 2020-08-31 | アムジエン・インコーポレーテツド | 心筋節活性化剤で心不全を治療する方法 |
| DK3594199T3 (da) | 2018-07-09 | 2020-09-14 | Fis Fabbrica Italiana Sintetici Spa | Krystallinsk 2-flour-3-nitrotoluen og proces til forberedelse deraf |
| EP3837009A1 (en) | 2018-08-17 | 2021-06-23 | Amgen, Inc | Salts and crystal forms of omecamtiv mecarbil |
| US12442027B2 (en) | 2018-12-18 | 2025-10-14 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| US20220411374A1 (en) | 2019-10-09 | 2022-12-29 | Dr. Reddy's Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| WO2021163172A1 (en) | 2020-02-10 | 2021-08-19 | Amgen Inc. | Omecamtiv mecarbil tablet |
| IL302850A (en) | 2020-11-12 | 2023-07-01 | Amgen Inc | Methods of treating heart failure by administering OMECAMTIV MECARBIL |
| AU2022232919A1 (en) | 2021-03-10 | 2023-10-19 | Amgen Inc. | Synthesis of omecamtiv mecarbil |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
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2018
- 2018-06-29 MX MX2021009594A patent/MX2021009594A/es unknown
- 2018-06-29 GE GEAP202315463A patent/GEP20237530B/en unknown
- 2018-06-29 PH PH1/2019/502883A patent/PH12019502883A1/en unknown
- 2018-06-29 EP EP18743314.9A patent/EP3645518B1/en active Active
- 2018-06-29 MX MX2021013326A patent/MX394683B/es unknown
- 2018-06-29 MD MDE20200486T patent/MD3645518T2/ro unknown
- 2018-06-29 PL PL18743314T patent/PL3645518T3/pl unknown
- 2018-06-29 TW TW107122465A patent/TWI769272B/zh active
- 2018-06-29 CA CA3063102A patent/CA3063102A1/en active Pending
- 2018-06-29 GE GEAP202416116A patent/GEAP202416116A/en unknown
- 2018-06-29 GE GEAP201816116A patent/GEP20247675B/en unknown
- 2018-06-29 KR KR1020207001578A patent/KR102625774B1/ko active Active
- 2018-06-29 EP EP23189293.6A patent/EP4265597A3/en active Pending
- 2018-06-29 CN CN201880043674.6A patent/CN110799503B/zh active Active
- 2018-06-29 GE GEAP201815258A patent/GEP20227340B/en unknown
- 2018-06-29 UA UAA202000509A patent/UA127517C2/uk unknown
- 2018-06-29 LT LTEP18743314.9T patent/LT3645518T/lt unknown
- 2018-06-29 PT PT187433149T patent/PT3645518T/pt unknown
- 2018-06-29 MX MX2019015547A patent/MX387531B/es unknown
- 2018-06-29 DK DK18743314.9T patent/DK3645518T3/da active
- 2018-06-29 HR HRP20211290TT patent/HRP20211290T1/hr unknown
- 2018-06-29 EP EP21174262.2A patent/EP3925950B1/en active Active
- 2018-06-29 SG SG10202111790YA patent/SG10202111790YA/en unknown
- 2018-06-29 ES ES18743314T patent/ES2882905T3/es active Active
- 2018-06-29 US US16/607,940 patent/US11040956B2/en active Active
- 2018-06-29 SI SI201830350T patent/SI3645518T1/sl unknown
- 2018-06-29 TW TW111120441A patent/TWI847144B/zh active
- 2018-06-29 RS RS20210965A patent/RS62328B1/sr unknown
- 2018-06-29 HU HUE18743314A patent/HUE055242T2/hu unknown
- 2018-06-29 IL IL270663A patent/IL270663B/en unknown
- 2018-06-29 WO PCT/US2018/040176 patent/WO2019006231A1/en not_active Ceased
- 2018-06-29 SM SM20210472T patent/SMT202100472T1/it unknown
- 2018-06-29 IL IL294834A patent/IL294834B2/en unknown
- 2018-06-29 JP JP2019561794A patent/JP7181896B2/ja active Active
- 2018-06-29 GE GEAP202115258A patent/GEAP202115258A/en unknown
- 2018-06-29 AU AU2018294254A patent/AU2018294254C1/en active Active
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2019
- 2019-12-30 CL CL2019003898A patent/CL2019003898A1/es unknown
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2020
- 2020-01-27 ZA ZA2020/00534A patent/ZA202000534B/en unknown
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2021
- 2021-05-19 US US17/324,867 patent/US11753394B2/en active Active
- 2021-08-10 CY CY20211100714T patent/CY1124427T1/el unknown
- 2021-08-16 CL CL2021002167A patent/CL2021002167A1/es unknown
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2022
- 2022-06-29 AU AU2022204648A patent/AU2022204648B2/en active Active
- 2022-08-19 JP JP2022130911A patent/JP7522799B2/ja active Active
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2023
- 2023-07-26 US US18/359,467 patent/US12269811B2/en active Active
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2025
- 2025-01-17 US US19/029,945 patent/US20250163023A1/en active Pending
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