PL365281A1 - Sposób wytwarzania Clopidogrelu - Google Patents

Sposób wytwarzania Clopidogrelu

Info

Publication number: PL365281A1
Authority: PL; Poland
Prior art keywords: optically active; compounds; racemic; formula; bromine
Prior art date: 2001-01-24

Application number

PL02365281A

Other languages

English (en)

Inventor

Bipin Pandey

Vidya Bhushan Lohray

Braj Bhushan Lohray

Original Assignee

Cadila Healthcare Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-24

Filing date

2002-01-21

Publication date

2004-12-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26324902&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL365281(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-01-24 Priority claimed from IN84MU2001 external-priority patent/IN191030B/en

2002-01-21 Application filed by Cadila Healthcare Ltd. filed Critical Cadila Healthcare Ltd.

2004-12-27 Publication of PL365281A1 publication Critical patent/PL365281A1/pl

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
239000005552 B01AC04 - Clopidogrel Substances 0.000 title 1
GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 title 1
229960003009 clopidogrel Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052740 iodine Inorganic materials 0.000 abstract 2
239000011630 iodine Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
230000002744 anti-aggregatory effect Effects 0.000 abstract 1
230000002785 anti-thrombosis Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
239000012467 final product Substances 0.000 abstract 1
239000013067 intermediate product Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
MKYRMMMSZSVIGD-UHFFFAOYSA-N thieno[3,2-c]pyridine Chemical class N1=CC=C2SC=CC2=C1 MKYRMMMSZSVIGD-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PL02365281A 2001-01-24 2002-01-21 Sposób wytwarzania Clopidogrelu PL365281A1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN84MU2001 IN191030B (pl)	2001-01-24	2001-01-24
US10/054,101 US6635763B2 (en)	2001-01-24	2001-10-22	Process to prepare clopidogrel

Publications (1)

Publication Number	Publication Date
PL365281A1 true PL365281A1 (pl)	2004-12-27

Family

ID=26324902

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL02365281A PL365281A1 (pl)	2001-01-24	2002-01-21	Sposób wytwarzania Clopidogrelu

Country Status (17)

Country	Link
EP (1)	EP1353928B1 (pl)
JP (1)	JP5000841B2 (pl)
KR (1)	KR20060040758A (pl)
CN (1)	CN100338068C (pl)
AT (1)	ATE349451T1 (pl)
AU (1)	AU2002228325B2 (pl)
BR (1)	BR0207064A (pl)
CA (1)	CA2436323C (pl)
CY (1)	CY1106346T1 (pl)
DE (1)	DE60217062T2 (pl)
DK (1)	DK1353928T3 (pl)
EA (1)	EA006198B2 (pl)
ES (1)	ES2278010T3 (pl)
MX (1)	MXPA03006133A (pl)
NO (1)	NO327807B1 (pl)
PL (1)	PL365281A1 (pl)
WO (1)	WO2002059128A2 (pl)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN191030B (pl) *	2001-01-24	2003-09-13	Cadila Healthcare Ltd
GB0125708D0 (en) *	2001-10-26	2001-12-19	Generics Uk Ltd	Novel compounds and processes
US6767913B2 (en)	2001-12-18	2004-07-27	Teva Pharmaceutical Industries Ltd.	Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en)	2002-01-11	2006-07-11	Teva Pharmaceutical Industries, Ltd.	Polymorphs of clopidogrel hydrogensulfate
IL166593A0 (en)	2002-08-02	2006-01-15		Racemization and enantiomer separation of clopidogrel
US6800759B2 (en)	2002-08-02	2004-10-05	Teva Pharmaceutical Industries Ltd.	Racemization and enantiomer separation of clopidogrel
EP1606231A1 (en) *	2003-02-03	2005-12-21	Nadkarni, Sunil Sadanand	Process for preparation of clopidogrel, its salts and pharmaceutical compositions
PL1644381T3 (pl) *	2003-07-02	2010-08-31	Egis Gyogyszergyar Nyilvanosan Muekoedo Reszvenytarsasag	Proces wytwarzania krystalicznego polimorfu jako leku do hamowania agregacji płytek krwi
JP2007516166A (ja)	2003-07-02	2007-06-21	エギシュ　ヂョヂセルヂャール　エルテー	血小板凝集阻害剤の無晶形の製法
ATE455778T1 (de)	2003-11-03	2010-02-15	Cadila Healthcare Ltd	Verfahren zur herstellung form i von (s)-(+)- clopidogrelbisulfat
CA2457459A1 (en) *	2004-02-11	2005-08-11	Brantford Chemicals Inc.	Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
KR100553398B1 (ko)	2004-03-12	2006-02-16	한미약품 주식회사	티에노[3,2-ｃ]피리딘 유도체의 제조 방법 및 이에사용되는 중간체
CA2562532C (en)	2004-04-09	2010-02-16	Hanmi Pharm. Co., Ltd.	Crystalline clopidogrel naphthalenesulfonate or hydrate thereof, method for preparing same and pharmaceutical composition containing same
CZ20041048A3 (cs) *	2004-10-18	2005-11-16	Zentiva, A. S	Způsob výroby klopidogrelu
CN100406568C (zh) *	2005-02-18	2008-07-30	淮北市辉克药业有限公司	氯吡格雷新生产工艺
CZ299213B6 (cs) *	2005-03-08	2008-05-21	Zentiva, A. S	Zpusob racemizace R(-) izomeru methylesteru kyseliny (2-chlorfenyl)-6,7-dihydro-thieno[3,2-c]pyridin-5(4H)-octové
KR100678287B1 (ko) *	2005-06-23	2007-02-02	한미약품 주식회사	클로피도그렐의 제조방법 및 이에 사용되는 중간체
CN100463909C (zh) *	2005-09-08	2009-02-25	浙江华海药业股份有限公司	一种噻吩并四氢吡啶乙腈化合物的合成方法
CN100417653C (zh) *	2005-09-08	2008-09-10	浙江华海药业股份有限公司	噻吩并四氢吡啶乙酸及其盐的制备方法
US7932391B2 (en)	2005-09-08	2011-04-26	Zhejiang Hauhai Pharmaceutical Co., Ltd.	Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate
CN100390180C (zh) *	2005-12-15	2008-05-28	上海应用技术学院	氯吡格雷及其盐的制备方法
KR101235117B1 (ko)	2005-12-26	2013-02-20	에스케이케미칼주식회사	광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
CN100396687C (zh) *	2006-05-26	2008-06-25	浙江海翔药业股份有限公司	(+)-(s-)-氯吡格雷硫酸氢盐(i型)的制备方法
WO2007144895A1 (en) *	2006-06-12	2007-12-21	Cadila Healthcare Limited	Process for the preparation of (s) - (+)-clopidogrel
SI22383A (sl) *	2006-09-22	2008-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
PL380849A1 (pl) *	2006-10-17	2008-04-28	Adamed Spółka Z Ograniczoną Odpowiedzialnością	Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie
WO2008146249A1 (en) *	2007-05-30	2008-12-04	Wockhardt Research Centre	Processes for the preparation of clopidogrel
CA2709262A1 (en) *	2007-12-14	2009-06-25	Generics [Uk] Limited	New hplc method
EP2107061A1 (en)	2008-04-02	2009-10-07	Krka Tovarna Zdravil, D.D., Novo Mesto	Process for the preparation of optically enriched clopidogrel
KR100990949B1 (ko) *	2008-06-09	2010-10-29	엔자이텍 주식회사	클로피도그렐 및 그의 유도체의 제조방법
CN101787033B (zh) *	2010-03-16	2011-08-31	天津市中央药业有限公司	一种硫酸氢氯吡格雷有关物质c的合成方法
CN101812071A (zh) *	2010-05-10	2010-08-25	杭州和素化学技术有限公司	硫酸氢氯吡格雷中间体拆分后的母液处理方法
CN102241690B (zh)	2010-05-13	2015-08-12	天津药物研究院	一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途
CN101845050A (zh) *	2010-06-01	2010-09-29	上虞京新药业有限公司	一种氯吡格雷的制备方法
CN101974016A (zh) *	2010-10-14	2011-02-16	天津药物研究院	酰胺类化合物及其制备方法和用途
CN101962388B (zh) *	2010-10-14	2012-12-19	天津药物研究院	乙酰胺衍生物及其制备方法和用途
CN104045652A (zh) *	2014-07-09	2014-09-17	沈健芬	一种氯吡格雷中间体的制备方法
CN110627808B (zh) *	2018-06-21	2022-04-01	江苏同禾药业有限公司	一种硫酸氢氯吡格雷拆分母液的回收处理工艺

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FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
JPS5980664A (ja) *	1982-09-30	1984-05-10	Fujisawa Pharmaceut Co Ltd	α−アリ−ル−α−ピリジル脂肪酸誘導体およびその製法
JPS60112762A (ja) *	1983-11-21	1985-06-19	Fujisawa Pharmaceut Co Ltd	α−アリ−ル−α−ピリジル脂肪酸誘導体およびその製法
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2652575B1 (fr) *	1989-09-29	1992-01-24	Sanofi Sa	Procede de preparation d'acides alpha-bromo phenylacetiques.
FR2664276B1 (fr) *	1990-07-04	1992-10-23	Sanofi Sa	Derive thienyl-2 glycidique, son procede de preparation et son utilisation comme intermediaire de synthese.

2002
- 2002-01-21 WO PCT/IN2002/000012 patent/WO2002059128A2/en not_active Ceased
- 2002-01-21 DK DK02710298T patent/DK1353928T3/da active
- 2002-01-21 KR KR1020067008009A patent/KR20060040758A/ko not_active Withdrawn
- 2002-01-21 PL PL02365281A patent/PL365281A1/pl not_active Application Discontinuation
- 2002-01-21 CN CNB02803998XA patent/CN100338068C/zh not_active Expired - Fee Related
- 2002-01-21 EP EP02710298A patent/EP1353928B1/en not_active Expired - Lifetime
- 2002-01-21 AT AT02710298T patent/ATE349451T1/de active
- 2002-01-21 ES ES02710298T patent/ES2278010T3/es not_active Expired - Lifetime
- 2002-01-21 CA CA2436323A patent/CA2436323C/en not_active Expired - Fee Related
- 2002-01-21 EA EA200300831A patent/EA006198B2/ru not_active IP Right Cessation
- 2002-01-21 MX MXPA03006133A patent/MXPA03006133A/es active IP Right Grant
- 2002-01-21 AU AU2002228325A patent/AU2002228325B2/en not_active Ceased
- 2002-01-21 DE DE60217062T patent/DE60217062T2/de not_active Expired - Lifetime
- 2002-01-21 BR BR0207064-2A patent/BR0207064A/pt active Search and Examination
- 2002-01-21 JP JP2002559430A patent/JP5000841B2/ja not_active Expired - Fee Related
2003
- 2003-06-24 NO NO20032898A patent/NO327807B1/no not_active IP Right Cessation
2007
- 2007-02-28 CY CY20071100280T patent/CY1106346T1/el unknown

Also Published As

Publication number	Publication date
BR0207064A (pt)	2004-03-30
AU2002228325B2 (en)	2006-05-04
CA2436323C (en)	2012-02-21
CY1106346T1 (el)	2011-10-12
NO327807B1 (no)	2009-09-28
EA006198B2 (ru)	2007-10-26
JP2004522744A (ja)	2004-07-29
DE60217062T2 (de)	2007-06-21
CN100338068C (zh)	2007-09-19
EP1353928A2 (en)	2003-10-22
KR20060040758A (ko)	2006-05-10
NO20032898D0 (no)	2003-06-24
ES2278010T3 (es)	2007-08-01
EP1353928B1 (en)	2006-12-27
EA200300831A1 (ru)	2003-12-25
CA2436323A1 (en)	2002-08-01
JP5000841B2 (ja)	2012-08-15
NO20032898L (no)	2003-09-03
ATE349451T1 (de)	2007-01-15
MXPA03006133A (es)	2004-05-04
DK1353928T3 (da)	2007-03-26
WO2002059128A3 (en)	2002-12-19
CN1487943A (zh)	2004-04-07
DE60217062D1 (de)	2007-02-08
WO2002059128A2 (en)	2002-08-01
EA006198B1 (ru)	2005-10-27

Legal Events

Date	Code	Title	Description
2011-01-31	REFS	Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)

Publication	Publication Date	Title
PL365281A1 (pl)	2004-12-27	Sposób wytwarzania Clopidogrelu
HU9503719D0 (en)	1996-02-28	Piperidine derivatives and process for their production
ATE373656T1 (de)	2007-10-15	Azaindolderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel
DK1159279T3 (da)	2003-02-17	4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler
WO2007018738A3 (en)	2007-03-29	Fused bicycloheterocycle substituted quinuclidine derivatives
WO2006098961A3 (en)	2007-03-22	Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b] pyridine compounds for inhibiting ksp kinesin activity
AP2001002309A0 (en)	2001-12-31	1-amino triazolo[4,3-A] quinazoline-5-ones and/or-5-thiones inhibiting phosphodiesterase IV.
YU72000A (sh)	2002-10-18	Kompleks platine, njegovo dobijanje i terapeutska primena
DK1440075T3 (da)	2005-08-22	Hidtil ukendte heteroaromatiske 3beta-aminio-azabicyclooctan-amidderivater, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf
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ATE299506T1 (de)	2005-07-15	Verfahren zur herstellung von pyrazolo(1,5- b)pyridazin-derivaten
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HUP0104045A2 (hu)	2002-05-29	Eljárás 4-[(2',5'-diamino-6'-halogén-pirimidin-4'-il)-amino]-ciklopent-2-enilmetanol-származékok előállítására
EP1496059A4 (en)	2006-02-08	CONDENSED BICYCLIC PYRIMIDINE DERIVATIVES
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HK1017357A1 (en)	1999-11-19	Azabicyclic esters of carbamic acids useful in therapy