PL366120A1 - Sposób wytwarzania paklitakselu - Google Patents

Sposób wytwarzania paklitakselu

Info

Publication number: PL366120A1
Authority: PL; Poland
Prior art keywords: preparation; paclitaxel; deacetylbaccatine iii; starting; paclitaxel starting
Prior art date: 2000-12-06

Application number

PL01366120A

Other languages

English (en)

Other versions

PL195121B1 (pl

Inventor

Arturo Battaglia

Paolo Dambruoso

Andrea Guerrini

Ezio Bombardelli

Alessandro Pontiroli

Original Assignee

Indena S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-06

Filing date

2001-12-03

Publication date

2005-01-24

2001-12-03 Application filed by Indena S.P.A. filed Critical Indena S.P.A.

2005-01-24 Publication of PL366120A1 publication Critical patent/PL366120A1/pl

2007-08-31 Publication of PL195121B1 publication Critical patent/PL195121B1/pl

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

PL01366120A 2000-12-06 2001-12-03 Sposób wytwarzania paklitakselu oraz związek pośredni PL195121B1 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI002654A IT1319682B1 (it)	2000-12-06	2000-12-06	Procedimento di sintesi del paclitaxel.
PCT/EP2001/014084 WO2002046177A1 (en)	2000-12-06	2001-12-03	A process for the preparation of paclitaxel

Publications (2)

Publication Number	Publication Date
PL366120A1 true PL366120A1 (pl)	2005-01-24
PL195121B1 PL195121B1 (pl)	2007-08-31

Family

ID=11446197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL01366120A PL195121B1 (pl)	2000-12-06	2001-12-03	Sposób wytwarzania paklitakselu oraz związek pośredni

Country Status (22)

Country	Link
US (1)	US6768012B2 (pl)
EP (1)	EP1339703B1 (pl)
JP (1)	JP2004515497A (pl)
KR (1)	KR100846891B1 (pl)
CN (1)	CN1286828C (pl)
AT (1)	ATE267820T1 (pl)
AU (2)	AU2002234535B2 (pl)
CA (1)	CA2430814C (pl)
CZ (1)	CZ300024B6 (pl)
DE (1)	DE60103560T2 (pl)
DK (1)	DK1339703T3 (pl)
ES (1)	ES2221656T3 (pl)
HU (1)	HU229373B1 (pl)
IL (2)	IL156331A0 (pl)
IT (1)	IT1319682B1 (pl)
NO (1)	NO328505B1 (pl)
PL (1)	PL195121B1 (pl)
PT (1)	PT1339703E (pl)
RU (1)	RU2276147C2 (pl)
SK (1)	SK286616B6 (pl)
TR (1)	TR200401435T4 (pl)
WO (1)	WO2002046177A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1319682B1 (it) *	2000-12-06	2003-10-23	Indena Spa	Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
WO2004068930A2 (en) *	2003-02-04	2004-08-19	Natural Pharmaceuticals Inc.	Method and composition for preparing a compound using a benzolating agent essentially free of ring chlorination
CN1303077C (zh)	2004-01-16	2007-03-07	桂林晖昂生化药业有限责任公司	合成紫杉烷的制备工艺
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
DE602006021546D1 (de) *	2006-05-12	2011-06-09	Indena Spa	Verfahren zur Herstellung eines Taxanderivats
CN103254187B (zh) *	2012-02-15	2016-05-25	浙江大学宁波理工学院	一种紫杉烷衍生物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6020507A (en)	1998-03-02	2000-02-01	Bristol-Myers Squibb Company	Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
IT1319682B1 (it) *	2000-12-06	2003-10-23	Indena Spa	Procedimento di sintesi del paclitaxel.

2000
- 2000-12-06 IT IT2000MI002654A patent/IT1319682B1/it active
2001
- 2001-12-03 JP JP2002547916A patent/JP2004515497A/ja active Pending
- 2001-12-03 KR KR1020037007262A patent/KR100846891B1/ko not_active Expired - Fee Related
- 2001-12-03 AT AT01985349T patent/ATE267820T1/de active
- 2001-12-03 ES ES01985349T patent/ES2221656T3/es not_active Expired - Lifetime
- 2001-12-03 US US10/433,601 patent/US6768012B2/en not_active Expired - Lifetime
- 2001-12-03 CA CA002430814A patent/CA2430814C/en not_active Expired - Lifetime
- 2001-12-03 AU AU2002234535A patent/AU2002234535B2/en not_active Ceased
- 2001-12-03 CZ CZ20031534A patent/CZ300024B6/cs not_active IP Right Cessation
- 2001-12-03 HU HU0500615A patent/HU229373B1/hu not_active IP Right Cessation
- 2001-12-03 CN CNB018200745A patent/CN1286828C/zh not_active Expired - Fee Related
- 2001-12-03 SK SK697-2003A patent/SK286616B6/sk not_active IP Right Cessation
- 2001-12-03 DK DK01985349T patent/DK1339703T3/da active
- 2001-12-03 TR TR2004/01435T patent/TR200401435T4/xx unknown
- 2001-12-03 IL IL15633101A patent/IL156331A0/xx active IP Right Grant
- 2001-12-03 RU RU2003116901/04A patent/RU2276147C2/ru not_active IP Right Cessation
- 2001-12-03 AU AU3453502A patent/AU3453502A/xx active Pending
- 2001-12-03 PL PL01366120A patent/PL195121B1/pl unknown
- 2001-12-03 WO PCT/EP2001/014084 patent/WO2002046177A1/en not_active Ceased
- 2001-12-03 DE DE60103560T patent/DE60103560T2/de not_active Expired - Lifetime
- 2001-12-03 PT PT01985349T patent/PT1339703E/pt unknown
- 2001-12-03 EP EP01985349A patent/EP1339703B1/en not_active Expired - Lifetime
2003
- 2003-06-05 NO NO20032558A patent/NO328505B1/no not_active IP Right Cessation
- 2003-06-05 IL IL156331A patent/IL156331A/en unknown

Also Published As

Publication number	Publication date
CA2430814A1 (en)	2002-06-13
AU3453502A (en)	2002-06-18
ES2221656T3 (es)	2005-01-01
DK1339703T3 (da)	2004-09-27
CA2430814C (en)	2009-04-07
DE60103560T2 (de)	2004-09-16
IT1319682B1 (it)	2003-10-23
ITMI20002654A1 (it)	2002-06-06
SK286616B6 (sk)	2009-02-05
NO20032558D0 (no)	2003-06-05
CZ20031534A3 (cs)	2003-08-13
HK1063052A1 (en)	2004-12-10
DE60103560D1 (de)	2004-07-01
US6768012B2 (en)	2004-07-27
HU229373B1 (hu)	2013-11-28
WO2002046177A1 (en)	2002-06-13
RU2276147C2 (ru)	2006-05-10
CN1509277A (zh)	2004-06-30
KR100846891B1 (ko)	2008-07-17
NO328505B1 (no)	2010-03-08
US20040049060A1 (en)	2004-03-11
HUP0500615A2 (hu)	2005-11-28
EP1339703A1 (en)	2003-09-03
JP2004515497A (ja)	2004-05-27
IL156331A (en)	2006-10-31
AU2002234535B2 (en)	2006-02-02
CZ300024B6 (cs)	2009-01-14
IL156331A0 (en)	2004-01-04
SK6972003A3 (en)	2003-11-04
PT1339703E (pt)	2004-08-31
ATE267820T1 (de)	2004-06-15
CN1286828C (zh)	2006-11-29
KR20030055332A (ko)	2003-07-02
PL195121B1 (pl)	2007-08-31
EP1339703B1 (en)	2004-05-26
NO20032558L (no)	2003-06-05
TR200401435T4 (tr)	2004-08-23

Legal Events

Date	Code	Title	Description
2008-02-29	RECP	Rectifications of patent specification

Publication	Publication Date	Title
MX255774B (es)	2008-03-31	Un proceso para la produccion de papel.
SG147286A1 (en)	2008-11-28	Manufacture of polyglumate-therapeutic agent conjugates
EG23230A (en)	2004-08-31	Plant for producing tyres of different types simultaneously.
ZA200110179B (en)	2002-12-11	Process for the preparation of pure citalopram.
MXPA03004030A (es)	2004-02-12	Proceso para preparacion de antitrombina iii latente.
MXPA03001800A (es)	2003-06-24	Proceso para la preparacion de fenilacetonitrilos sustituidos.
AU1817902A (en)	2002-03-26	Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)
ZA200108623B (en)	2002-06-07	Process for preparing imidachloprid.
IL156331A0 (en)	2004-01-04	A process for the preparation of paclitaxel
ZA200209168B (en)	2003-10-03	Process for the hydroxylation of aliphatic compounds.
AU2956302A (en)	2002-06-11	A process for the preparation of taxan derivatives
MXPA03002464A (es)	2003-06-19	Proceso para preparar benzotriazoles.
MXPA02006102A (es)	2003-10-06	Metodo para preparar compuestos bormodifluoroaceticos.
MXPA03005569A (es)	2003-10-06	PROCEDIMIENTO MEJORADO PARA LA PREPARACION DE UN FARMACO ANTIMIGRAnOSO.
MXPA03002926A (es)	2003-08-07	Proceso para la sintesis de 2,2,6,6,-tetrametil-4--oxipiperidina.
ZA200104999B (en)	2001-12-13	Method for the production of formaldehyde.
MXPA01012693A (es)	2003-08-20	Produccion mejorada de tequila.
IL152295A0 (en)	2003-05-29	Method for producing 2-alkyl-3-chlorophenols
MXPA02003042A (es)	2003-07-14	Proceso para prevenir formacion de incrustaciones.
MXPA03009210A (es)	2004-01-29	PROCEDIMIENTO PARA LA PREPARACIoN DE OXABISPIDINAS.
ZA200101529B (en)	2001-08-29	Process for the preparation of isoindoline.
ZA200106789B (en)	2002-02-18	Reduction of odor from a process.
MY123576A (en)	2006-05-31	Process for the selective n-formylation of n-hydroxylamines
EG23229A (en)	2004-08-31	Process for the production of olefins.
WO2002020490A3 (en)	2002-06-13	Process to produce halo-4-phenoxyquinolines