ATE267820T1 - Prozess zur herstellung von paclitaxel - Google Patents

Prozess zur herstellung von paclitaxel

Info

Publication number: ATE267820T1
Authority: AT; Austria
Prior art keywords: making paclitaxel; paclitaxel; making; preparation; deacetylbaccatine iii
Prior art date: 2000-12-06

Application number

AT01985349T

Other languages

English (en)

Inventor

Arturo Battaglia

Paolo Dambruoso

Andrea Guerrini

Ezio Bombardelli

Alessandro Pontiroli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-06

Filing date

2001-12-03

Publication date

2004-06-15

2001-12-03 Application filed by Indena Spa filed Critical Indena Spa

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE267820T1 publication Critical patent/ATE267820T1/de

Links

229930012538 Paclitaxel Natural products 0.000 title abstract 2
229960001592 paclitaxel Drugs 0.000 title abstract 2
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title abstract 2
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT01985349T 2000-12-06 2001-12-03 Prozess zur herstellung von paclitaxel ATE267820T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2000MI002654A IT1319682B1 (it)	2000-12-06	2000-12-06	Procedimento di sintesi del paclitaxel.
PCT/EP2001/014084 WO2002046177A1 (en)	2000-12-06	2001-12-03	A process for the preparation of paclitaxel

Publications (1)

Publication Number	Publication Date
ATE267820T1 true ATE267820T1 (de)	2004-06-15

Family

ID=11446197

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01985349T ATE267820T1 (de)	2000-12-06	2001-12-03	Prozess zur herstellung von paclitaxel

Country Status (22)

Country	Link
US (1)	US6768012B2 (de)
EP (1)	EP1339703B1 (de)
JP (1)	JP2004515497A (de)
KR (1)	KR100846891B1 (de)
CN (1)	CN1286828C (de)
AT (1)	ATE267820T1 (de)
AU (2)	AU3453502A (de)
CA (1)	CA2430814C (de)
CZ (1)	CZ300024B6 (de)
DE (1)	DE60103560T2 (de)
DK (1)	DK1339703T3 (de)
ES (1)	ES2221656T3 (de)
HU (1)	HU229373B1 (de)
IL (2)	IL156331A0 (de)
IT (1)	IT1319682B1 (de)
NO (1)	NO328505B1 (de)
PL (1)	PL195121B1 (de)
PT (1)	PT1339703E (de)
RU (1)	RU2276147C2 (de)
SK (1)	SK286616B6 (de)
TR (1)	TR200401435T4 (de)
WO (1)	WO2002046177A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1319682B1 (it) *	2000-12-06	2003-10-23	Indena Spa	Procedimento di sintesi del paclitaxel.
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
WO2004068930A2 (en) *	2003-02-04	2004-08-19	Natural Pharmaceuticals Inc.	Method and composition for preparing a compound using a benzolating agent essentially free of ring chlorination
CN1303077C (zh)	2004-01-16	2007-03-07	桂林晖昂生化药业有限责任公司	合成紫杉烷的制备工艺
ITMI20050614A1 (it) *	2005-04-12	2006-10-13	Indena Spa	Processo per la purificazione della 10-deacetilbaccatina iii dalla 10-deacetil-2-debenzoil-2-pentenoilbaccatina iii
EP1854799B1 (de) *	2006-05-12	2011-04-27	INDENA S.p.A.	Verfahren zur Herstellung eines Taxanderivats
CN103254187B (zh) *	2012-02-15	2016-05-25	浙江大学宁波理工学院	一种紫杉烷衍生物的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2696460B1 (fr) *	1992-10-05	1994-11-25	Rhone Poulenc Rorer Sa	Procédé de préparation de dérivés du taxane.
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
US6020507A (en)	1998-03-02	2000-02-01	Bristol-Myers Squibb Company	Synthesis of paclitaxel from baccatin III by protection of the 7-hydroxyl of baccatin III using a strong base and an electrophile
IT1319682B1 (it) *	2000-12-06	2003-10-23	Indena Spa	Procedimento di sintesi del paclitaxel.

2000
- 2000-12-06 IT IT2000MI002654A patent/IT1319682B1/it active
2001
- 2001-12-03 IL IL15633101A patent/IL156331A0/xx active IP Right Grant
- 2001-12-03 AU AU3453502A patent/AU3453502A/xx active Pending
- 2001-12-03 AT AT01985349T patent/ATE267820T1/de active
- 2001-12-03 HU HU0500615A patent/HU229373B1/hu not_active IP Right Cessation
- 2001-12-03 KR KR1020037007262A patent/KR100846891B1/ko not_active Expired - Fee Related
- 2001-12-03 US US10/433,601 patent/US6768012B2/en not_active Expired - Lifetime
- 2001-12-03 CA CA002430814A patent/CA2430814C/en not_active Expired - Lifetime
- 2001-12-03 ES ES01985349T patent/ES2221656T3/es not_active Expired - Lifetime
- 2001-12-03 RU RU2003116901/04A patent/RU2276147C2/ru not_active IP Right Cessation
- 2001-12-03 AU AU2002234535A patent/AU2002234535B2/en not_active Ceased
- 2001-12-03 CN CNB018200745A patent/CN1286828C/zh not_active Expired - Fee Related
- 2001-12-03 PL PL01366120A patent/PL195121B1/pl unknown
- 2001-12-03 CZ CZ20031534A patent/CZ300024B6/cs not_active IP Right Cessation
- 2001-12-03 EP EP01985349A patent/EP1339703B1/de not_active Expired - Lifetime
- 2001-12-03 WO PCT/EP2001/014084 patent/WO2002046177A1/en not_active Ceased
- 2001-12-03 SK SK697-2003A patent/SK286616B6/sk not_active IP Right Cessation
- 2001-12-03 DK DK01985349T patent/DK1339703T3/da active
- 2001-12-03 TR TR2004/01435T patent/TR200401435T4/xx unknown
- 2001-12-03 JP JP2002547916A patent/JP2004515497A/ja active Pending
- 2001-12-03 PT PT01985349T patent/PT1339703E/pt unknown
- 2001-12-03 DE DE60103560T patent/DE60103560T2/de not_active Expired - Lifetime
2003
- 2003-06-05 IL IL156331A patent/IL156331A/en unknown
- 2003-06-05 NO NO20032558A patent/NO328505B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE60103560D1 (de)	2004-07-01
HUP0500615A2 (hu)	2005-11-28
AU3453502A (en)	2002-06-18
CZ300024B6 (cs)	2009-01-14
EP1339703B1 (de)	2004-05-26
CN1509277A (zh)	2004-06-30
WO2002046177A1 (en)	2002-06-13
TR200401435T4 (tr)	2004-08-23
RU2276147C2 (ru)	2006-05-10
US20040049060A1 (en)	2004-03-11
PL366120A1 (en)	2005-01-24
HK1063052A1 (en)	2004-12-10
CA2430814A1 (en)	2002-06-13
PL195121B1 (pl)	2007-08-31
SK286616B6 (sk)	2009-02-05
HU229373B1 (hu)	2013-11-28
DE60103560T2 (de)	2004-09-16
IL156331A0 (en)	2004-01-04
ITMI20002654A1 (it)	2002-06-06
ES2221656T3 (es)	2005-01-01
CN1286828C (zh)	2006-11-29
DK1339703T3 (da)	2004-09-27
NO20032558D0 (no)	2003-06-05
IT1319682B1 (it)	2003-10-23
EP1339703A1 (de)	2003-09-03
CA2430814C (en)	2009-04-07
NO20032558L (no)	2003-06-05
KR20030055332A (ko)	2003-07-02
AU2002234535B2 (en)	2006-02-02
PT1339703E (pt)	2004-08-31
SK6972003A3 (en)	2003-11-04
US6768012B2 (en)	2004-07-27
IL156331A (en)	2006-10-31
JP2004515497A (ja)	2004-05-27
NO328505B1 (no)	2010-03-08
KR100846891B1 (ko)	2008-07-17
CZ20031534A3 (cs)	2003-08-13

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1339703

Country of ref document: EP

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