PL366852A1 - Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny posiadające działanie antywirusowe - Google Patents

Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny posiadające działanie antywirusowe

Info

Publication number: PL366852A1
Authority: PL; Poland
Prior art keywords: phosphonomethoxy; alkoxy; antiviral activity; pyrimidine derivatives; pyrimidine
Prior art date: 2001-06-29

Application number

PL02366852A

Other languages

English (en)

Other versions

PL207187B1 (pl

Inventor

Jan M.R. Balzarini

Clercq Erik Desire Alice De

Antonin Holy

Original Assignee

Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic

Rega Stichting V.Z.W.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-29

Filing date

2002-06-28

Publication date

2005-02-07

2002-06-28 Application filed by Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Rega Stichting V.Z.W. filed Critical Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic

2005-02-07 Publication of PL366852A1 publication Critical patent/PL366852A1/pl

2010-11-30 Publication of PL207187B1 publication Critical patent/PL207187B1/pl

Links

125000003545 alkoxy group Chemical group 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biotechnology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL366852A 2001-06-29 2002-06-28 Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca te pochodne oraz ich zastosowanie PL207187B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US30221201P	2001-06-29	2001-06-29

Publications (2)

Publication Number	Publication Date
PL366852A1 true PL366852A1 (pl)	2005-02-07
PL207187B1 PL207187B1 (pl)	2010-11-30

Family

ID=23166777

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL366852A PL207187B1 (pl)	2001-06-29	2002-06-28	Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca te pochodne oraz ich zastosowanie

Country Status (21)

Country	Link
US (2)	US6818633B2 (pl)
EP (1)	EP1406911B1 (pl)
JP (1)	JP4545434B2 (pl)
KR (1)	KR100891366B1 (pl)
CN (1)	CN1329404C (pl)
AP (1)	AP1622A (pl)
AU (1)	AU2002315625B2 (pl)
BR (1)	BRPI0210746B8 (pl)
CA (1)	CA2452036C (pl)
CZ (1)	CZ297267B6 (pl)
EA (1)	EA006020B1 (pl)
ES (1)	ES2564144T3 (pl)
HU (1)	HU230519B1 (pl)
IL (2)	IL159494A0 (pl)
MX (1)	MXPA04000138A (pl)
NO (2)	NO333788B1 (pl)
NZ (1)	NZ530685A (pl)
PL (1)	PL207187B1 (pl)
TR (1)	TR200302288T2 (pl)
WO (1)	WO2003002580A1 (pl)
ZA (1)	ZA200400236B (pl)

Families Citing this family (15)

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NZ543864A (en) *	2003-06-16	2009-10-30	Leuven K U Res & Dev	Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060211650A1 (en) *	2004-12-16	2006-09-21	Forest Laboratories, Inc.	Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
US8101745B2 (en)	2004-12-16	2012-01-24	The Regents Of The University Of California	Lung-targeted drugs
AU2006272521A1 (en) *	2005-07-27	2007-02-01	Gilead Sciences, Inc.	Antiviral phosphonate conjugates for inhibition of HIV
US7473683B2 (en)	2005-09-14	2009-01-06	The Board Of Trustees Of The Leland Stanford Junior University	Nonpolar thymidine analogs
US20080318986A1 (en) *	2005-10-13	2008-12-25	Schiffman Rhett M	Ddc Compositions
FR2908133B1 (fr) *	2006-11-08	2012-12-14	Centre Nat Rech Scient	Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
US20140073607A1 (en) *	2011-05-10	2014-03-13	Okapi Sciences Nv	Compounds for use in the treatment of feline retroviral infections
KR20150130355A (ko)	2013-03-15	2015-11-23	더 리전트 오브 더 유니버시티 오브 캘리포니아	비환식 뉴클레오사이드 포스포네이트 디에스테르
CN104119385B (zh) *	2014-07-24	2017-04-05	廖国超	核苷类似物的磷酸酯前药及其应用
MX377983B (es)	2014-09-15	2025-03-04	Univ California	Análogos de nucleótidos.
EP3875462A1 (en)	2015-09-15	2021-09-08	The Regents of The University of California	Nucleotide analogs
WO2019206907A1 (en) *	2018-04-23	2019-10-31	Centre National De La Recherche Scientifique	New antiviral acyclonucleoside analogues
KR20250052378A (ko)	2022-07-21	2025-04-18	안티바 바이오사이언시즈, 인크.	Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
CN117430644B (zh) *	2023-10-24	2025-08-01	合肥工业大学	一种钴配合物的制备及用途

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CS233665B1 (en)	1983-01-06	1985-03-14	Antonin Holy	Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en)	1985-04-25	1989-05-12	Antonin Holy	9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en)	1985-04-25	1989-05-12	Holy Antonin	Remedy with antiviral effect
CS264222B1 (en)	1986-07-18	1989-06-13	Holy Antonin	N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en)	1986-11-18	1995-12-08	Bristol Myers Squibb Co	History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
CA2001715C (en)	1988-11-14	1999-12-28	Muzammil M. Mansuri	Carbocyclic nucleosides and nucleotides
CA2297294C (en) *	1989-05-15	2005-11-08	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en)	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
US5302585A (en)	1990-04-20	1994-04-12	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs)	1990-04-24	1999-08-11	Ústav Organické Chemie A Biochemie Avčr	N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
JPH05509307A (ja)	1990-07-19	1993-12-22	ビーチャム・グループ・パブリック・リミテッド・カンパニー	プリンの抗ウイルス性ホスホノ―アルケン誘導体
EP0468119A1 (en)	1990-07-24	1992-01-29	Merrell Dow Pharmaceuticals Inc.	Novel carbocyclic analogs of certain nucleosides
DK0481214T3 (da)	1990-09-14	1999-02-22	Acad Of Science Czech Republic	Prolægemidler af phosphonater
US5208221A (en)	1990-11-29	1993-05-04	Bristol-Myers Squibb Company	Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ284678B6 (cs)	1991-05-20	1999-01-13	Ústav Organické Chemie A Biochemie Avčr	Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
EP0531597A1 (en) *	1991-09-12	1993-03-17	Merrell Dow Pharmaceuticals Inc.	Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
EP0630381B1 (en)	1991-10-11	1997-04-09	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiviral acyclic phosphonomethoxyalkyl substituted, alkenyl and alkynyl purine and pyrimidine derivatives
US6057305A (en)	1992-08-05	2000-05-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) *	1993-04-01	1994-10-05	Merrell Dow Pharmaceuticals Inc.	Unsaturated phosphonate derivatives of purines and pyrimidines
ATE486882T1 (de)	1993-09-17	2010-11-15	Gilead Sciences Inc	Nukleotidanaloge
US5977061A (en)	1995-04-21	1999-11-02	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	N6 - substituted nucleotide analagues and their use

2002
- 2002-06-28 BR BRPI0210746 patent/BRPI0210746B8/pt not_active IP Right Cessation
- 2002-06-28 WO PCT/CZ2002/000038 patent/WO2003002580A1/en not_active Ceased
- 2002-06-28 EA EA200400117A patent/EA006020B1/ru unknown
- 2002-06-28 HU HU0400345A patent/HU230519B1/hu unknown
- 2002-06-28 TR TR2003/02288T patent/TR200302288T2/xx unknown
- 2002-06-28 AU AU2002315625A patent/AU2002315625B2/en not_active Expired
- 2002-06-28 PL PL366852A patent/PL207187B1/pl unknown
- 2002-06-28 MX MXPA04000138A patent/MXPA04000138A/es active IP Right Grant
- 2002-06-28 US US10/187,166 patent/US6818633B2/en not_active Expired - Lifetime
- 2002-06-28 NZ NZ530685A patent/NZ530685A/en not_active IP Right Cessation
- 2002-06-28 CA CA002452036A patent/CA2452036C/en not_active Expired - Lifetime
- 2002-06-28 AP APAP/P/2004/002953A patent/AP1622A/en active
- 2002-06-28 EP EP02740215.5A patent/EP1406911B1/en not_active Expired - Lifetime
- 2002-06-28 KR KR1020037017181A patent/KR100891366B1/ko not_active Expired - Lifetime
- 2002-06-28 ES ES02740215.5T patent/ES2564144T3/es not_active Expired - Lifetime
- 2002-06-28 CZ CZ20040142A patent/CZ297267B6/cs not_active IP Right Cessation
- 2002-06-28 JP JP2003508961A patent/JP4545434B2/ja not_active Expired - Lifetime
- 2002-06-28 CN CNB028145712A patent/CN1329404C/zh not_active Expired - Lifetime
- 2002-06-28 IL IL15949402A patent/IL159494A0/xx active IP Right Grant
2003
- 2003-12-22 IL IL159494A patent/IL159494A/en unknown
- 2003-12-23 NO NO20035797A patent/NO333788B1/no not_active IP Right Cessation
2004
- 2004-01-13 ZA ZA200400236A patent/ZA200400236B/en unknown
- 2004-09-21 US US10/946,421 patent/US20050038058A1/en not_active Abandoned
2013
- 2013-08-09 NO NO20131091A patent/NO335725B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA200400236B (en)	2004-08-18
JP4545434B2 (ja)	2010-09-15
ES2564144T3 (es)	2016-03-18
HU230519B1 (hu)	2016-10-28
EP1406911B1 (en)	2016-01-06
BR0210746A (pt)	2004-07-20
BRPI0210746B1 (pt)	2018-09-18
EP1406911A1 (en)	2004-04-14
CZ2004142A3 (cs)	2004-05-12
IL159494A (en)	2008-06-05
TR200302288T2 (tr)	2004-12-21
CA2452036A1 (en)	2003-01-09
MXPA04000138A (es)	2005-06-06
IL159494A0 (en)	2004-06-01
NO20035797L (no)	2004-02-24
CN1329404C (zh)	2007-08-01
EA200400117A1 (ru)	2004-08-26
NO20131091L (no)	2004-02-24
KR100891366B1 (ko)	2009-04-02
PL207187B1 (pl)	2010-11-30
KR20040027521A (ko)	2004-04-01
US6818633B2 (en)	2004-11-16
US20050038058A1 (en)	2005-02-17
CN1533397A (zh)	2004-09-29
CZ297267B6 (cs)	2006-10-11
NZ530685A (en)	2006-09-29
NO333788B1 (no)	2013-09-16
BRPI0210746A8 (pt)	2018-07-10
AP2004002953A0 (en)	2004-03-31
AU2002315625B2 (en)	2008-05-01
CA2452036C (en)	2009-09-29
JP2005511490A (ja)	2005-04-28
HUP0400345A3 (en)	2007-05-29
WO2003002580A8 (en)	2003-01-30
BRPI0210746B8 (pt)	2021-05-25
AP1622A (en)	2006-06-16
WO2003002580A1 (en)	2003-01-09
EA006020B1 (ru)	2005-08-25
HUP0400345A2 (hu)	2004-09-28
NO335725B1 (no)	2015-02-02
US20030109499A1 (en)	2003-06-12

Publication	Publication Date	Title
HUS1500051I1 (hu)	2018-05-28	HIV-gátló pirimidinszármazékok
IL159832A0 (en)	2004-06-20	4-amino-6-phenyl-pyrrolo[2,3-d] pyrimidine derivatives
ATE455107T1 (de)	2010-01-15	Hiv-replikationshemmende pyrimidine
AU6931701A (en)	2002-01-21	Pyrimidine derivatives
IL158697A0 (en)	2004-05-12	4-amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d) pyrimidine derivatives
ATE232521T1 (de)	2003-02-15	Hiv hemmende pyrimidin derivate
SI1487805T1 (sl)	2012-10-30	Pirimidinski derivati
DE69943247D1 (de)	2011-04-14	HIV hemmende Pyrimidin Derivate
GB0112617D0 (en)	2001-07-18	Antiviral nucleoside derivatives
AU1041802A (en)	2002-01-30	Tetrahydro-heterocycloazepinyl pyrimidine derivatives
MXPA03007351A (es)	2003-12-04	Derivados de pirimidina para la inhibicion de la proliferacion celular.
EP1458687A4 (en)	2005-03-23	pyrimidine
NO20035797L (no)	2004-02-24	6-[2-(fosfonometoksy)alkoksy]pyrimidinderivater med antiviral aktivitet
ATE231866T1 (de)	2003-02-15	Pyrazolo(4, 3-d)pyrimidine
AU2002362806A1 (en)	2003-07-03	Pyrimidine derivatives
IL155705A0 (en)	2003-11-23	Pyrimidine derivatives
GB0112802D0 (en)	2001-07-18	Pyrimidine derivatives
GB0112803D0 (en)	2001-07-18	Pyrimidine derivatives
HK1063430A (en)	2004-12-31	6-[2-(phosphonomethoxy)alkoxy]pyrimidine derivatives having antiviral activity
DE50103649D1 (de)	2004-10-21	2-aminoalkyl-thieno[2,3-d]pyrimidine
EP1374911A4 (en)	2007-06-20	MEANS FOR MEASURING THE METABOLIZABILITY OF PYRIMIDINE
DE50106542D1 (de)	2005-07-21	Substituierte 3,4-dihydro-pyrido[1,2-a]pyrimidine
GB0119477D0 (en)	2001-10-03	Pyrimidine derivatives
AU2002238872B2 (en)	2007-03-08	Agents for measuring pyrimidine metabolizability
GB0112805D0 (en)	2001-07-18	Pyrimidine derivatives