PL366852A1 - Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny posiadające działanie antywirusowe - Google Patents

Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny posiadające działanie antywirusowe

Info

Publication number
PL366852A1
PL366852A1 PL02366852A PL36685202A PL366852A1 PL 366852 A1 PL366852 A1 PL 366852A1 PL 02366852 A PL02366852 A PL 02366852A PL 36685202 A PL36685202 A PL 36685202A PL 366852 A1 PL366852 A1 PL 366852A1
Authority
PL
Poland
Prior art keywords
phosphonomethoxy
alkoxy
antiviral activity
pyrimidine derivatives
pyrimidine
Prior art date
Application number
PL02366852A
Other languages
English (en)
Other versions
PL207187B1 (pl
Inventor
Jan M.R. Balzarini
Clercq Erik Desire Alice De
Antonin Holy
Original Assignee
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Rega Stichting V.Z.W.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Rega Stichting V.Z.W. filed Critical Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Publication of PL366852A1 publication Critical patent/PL366852A1/pl
Publication of PL207187B1 publication Critical patent/PL207187B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL366852A 2001-06-29 2002-06-28 Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca te pochodne oraz ich zastosowanie PL207187B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30221201P 2001-06-29 2001-06-29

Publications (2)

Publication Number Publication Date
PL366852A1 true PL366852A1 (pl) 2005-02-07
PL207187B1 PL207187B1 (pl) 2010-11-30

Family

ID=23166777

Family Applications (1)

Application Number Title Priority Date Filing Date
PL366852A PL207187B1 (pl) 2001-06-29 2002-06-28 Pochodne 6-[2-(fosfonometoksy) alkoksy] pirymidyny, sposób ich wytwarzania, kompozycja farmaceutyczna zawierająca te pochodne oraz ich zastosowanie

Country Status (21)

Country Link
US (2) US6818633B2 (pl)
EP (1) EP1406911B1 (pl)
JP (1) JP4545434B2 (pl)
KR (1) KR100891366B1 (pl)
CN (1) CN1329404C (pl)
AP (1) AP1622A (pl)
AU (1) AU2002315625B2 (pl)
BR (1) BRPI0210746B8 (pl)
CA (1) CA2452036C (pl)
CZ (1) CZ297267B6 (pl)
EA (1) EA006020B1 (pl)
ES (1) ES2564144T3 (pl)
HU (1) HU230519B1 (pl)
IL (2) IL159494A0 (pl)
MX (1) MXPA04000138A (pl)
NO (2) NO333788B1 (pl)
NZ (1) NZ530685A (pl)
PL (1) PL207187B1 (pl)
TR (1) TR200302288T2 (pl)
WO (1) WO2003002580A1 (pl)
ZA (1) ZA200400236B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1644389B1 (en) * 2003-06-16 2011-01-19 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
EP1831235B1 (en) 2004-12-16 2013-02-20 The Regents of The University of California Lung-targeted drugs
US20060211650A1 (en) * 2004-12-16 2006-09-21 Forest Laboratories, Inc. Reducing carbohydrate derivatives of adamantane amines, and synthesis and methods of use thereof
JP2009502964A (ja) * 2005-07-27 2009-01-29 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体
US7473683B2 (en) 2005-09-14 2009-01-06 The Board Of Trustees Of The Leland Stanford Junior University Nonpolar thymidine analogs
US20080318986A1 (en) * 2005-10-13 2008-12-25 Schiffman Rhett M Ddc Compositions
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
JP5847296B2 (ja) * 2011-05-10 2016-01-20 アラタナ セラピューティクス エン ヴェー ネコレトロウイルス感染症の治療に使用するための化合物
CN107056838A (zh) 2013-03-15 2017-08-18 加利福尼亚大学董事会 无环核苷膦酸二酯
CN104119385B (zh) * 2014-07-24 2017-04-05 廖国超 核苷类似物的磷酸酯前药及其应用
SG11201701957XA (en) 2014-09-15 2017-04-27 Univ California Nucleotide analogs
WO2017048956A1 (en) 2015-09-15 2017-03-23 The Regents Of The University Of California Nucleotide analogs
WO2019206907A1 (en) * 2018-04-23 2019-10-31 Centre National De La Recherche Scientifique New antiviral acyclonucleoside analogues
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태
CN117430644B (zh) * 2023-10-24 2025-08-01 合肥工业大学 一种钴配合物的制备及用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS233665B1 (en) 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
CS263951B1 (en) 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
CA2001715C (en) 1988-11-14 1999-12-28 Muzammil M. Mansuri Carbocyclic nucleosides and nucleotides
CA2297294C (en) * 1989-05-15 2005-11-08 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxymethylpurine/pyrimidine derivatives
MY104575A (en) 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5302585A (en) 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CZ285420B6 (cs) 1990-04-24 1999-08-11 Ústav Organické Chemie A Biochemie Avčr N-(3-Fluor-2-fosfonylmethoxypropyl)deriváty purinových a pyrimidinových heterocyklických bazí, způsoby jejich přípravy a použití
CA2087446A1 (en) 1990-07-19 1992-01-20 Michael R. Harnden Antiviral phosphono-alken derivatives of purines
EP0468119A1 (en) 1990-07-24 1992-01-29 Merrell Dow Pharmaceuticals Inc. Novel carbocyclic analogs of certain nucleosides
DE69129650T2 (de) 1990-09-14 1999-03-25 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic, Prag/Praha Wirkstoffvorläufer von Phosphonaten
US5208221A (en) 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
CZ284678B6 (cs) 1991-05-20 1999-01-13 Ústav Organické Chemie A Biochemie Avčr Di(2-propyl)estery 1-fluor-2-fosfonomethoxy-3-p -toluensulfonyloxypropanů, způsob jejich přípravy a použití
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
JP3497505B2 (ja) 1991-10-11 2004-02-16 インスティテュート オブ オルガニック ケミストリー アンド バイオケミストリー オブ ザ アカデミー オブ サイエンシズ オブ ザ チェコ パブリック 抗ウイルス性非環式ホスホノメトキシアルキル置換アルケニル及びアルキニルプリン及びピリミジン誘導体
US6057305A (en) 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
EP0618214A1 (en) 1993-04-01 1994-10-05 Merrell Dow Pharmaceuticals Inc. Unsaturated phosphonate derivatives of purines and pyrimidines
WO1995007920A1 (en) 1993-09-17 1995-03-23 Gilead Sciences, Inc. Nucleotide analogs
US5977061A (en) 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use

Also Published As

Publication number Publication date
CN1533397A (zh) 2004-09-29
EP1406911B1 (en) 2016-01-06
ZA200400236B (en) 2004-08-18
KR20040027521A (ko) 2004-04-01
NO20131091L (no) 2004-02-24
HU230519B1 (hu) 2016-10-28
JP2005511490A (ja) 2005-04-28
IL159494A (en) 2008-06-05
NZ530685A (en) 2006-09-29
BRPI0210746B1 (pt) 2018-09-18
AP2004002953A0 (en) 2004-03-31
AU2002315625B2 (en) 2008-05-01
NO20035797L (no) 2004-02-24
HUP0400345A2 (hu) 2004-09-28
US20050038058A1 (en) 2005-02-17
CA2452036A1 (en) 2003-01-09
ES2564144T3 (es) 2016-03-18
CA2452036C (en) 2009-09-29
JP4545434B2 (ja) 2010-09-15
TR200302288T2 (tr) 2004-12-21
CZ297267B6 (cs) 2006-10-11
EA006020B1 (ru) 2005-08-25
KR100891366B1 (ko) 2009-04-02
BR0210746A (pt) 2004-07-20
IL159494A0 (en) 2004-06-01
US6818633B2 (en) 2004-11-16
NO335725B1 (no) 2015-02-02
NO333788B1 (no) 2013-09-16
US20030109499A1 (en) 2003-06-12
HUP0400345A3 (en) 2007-05-29
WO2003002580A1 (en) 2003-01-09
WO2003002580A8 (en) 2003-01-30
EA200400117A1 (ru) 2004-08-26
MXPA04000138A (es) 2005-06-06
AP1622A (en) 2006-06-16
CN1329404C (zh) 2007-08-01
EP1406911A1 (en) 2004-04-14
BRPI0210746A8 (pt) 2018-07-10
PL207187B1 (pl) 2010-11-30
CZ2004142A3 (cs) 2004-05-12
BRPI0210746B8 (pt) 2021-05-25

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