PL3684924T3 - Nieintegrujące się wektory dna do modyfikowania genetycznego komórek - Google Patents

Nieintegrujące się wektory dna do modyfikowania genetycznego komórek

Info

Publication number: PL3684924T3
Authority: PL; Poland
Prior art keywords: cells; genetic modification; dna vectors; integrating dna; integrating
Prior art date: 2017-09-19

Application number

PL18769377.5T

Other languages

English (en)

Inventor

Richard HARBOTTLE

Matthias BOZZA

James A. Williams

Original Assignee

Deutsches Krebsforschungszentrum

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-09-19

Filing date

2018-09-19

Publication date

2023-04-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60037350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3684924(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2018-09-19 Application filed by Deutsches Krebsforschungszentrum filed Critical Deutsches Krebsforschungszentrum

2023-04-17 Publication of PL3684924T3 publication Critical patent/PL3684924T3/pl

Links

238000012239 gene modification Methods 0.000 title 1
230000005017 genetic modification Effects 0.000 title 1
235000013617 genetically modified food Nutrition 0.000 title 1
239000013598 vector Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/106—Plasmid DNA for vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/55—Vectors comprising a special origin of replication system from bacteria
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cell Biology (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Developmental Biology & Embryology (AREA)
Virology (AREA)

PL18769377.5T 2017-09-19 2018-09-19 Nieintegrujące się wektory dna do modyfikowania genetycznego komórek PL3684924T3 (pl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17191829.5A EP3456821B2 (en)	2017-09-19	2017-09-19	Non-integrating dna vectors for the genetic modification of cells
PCT/EP2018/075353 WO2019057773A1 (en)	2017-09-19	2018-09-19	NON-INTEGRATED DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS

Publications (1)

Publication Number	Publication Date
PL3684924T3 true PL3684924T3 (pl)	2023-04-17

Family

ID=60037350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL18769377.5T PL3684924T3 (pl)	2017-09-19	2018-09-19	Nieintegrujące się wektory dna do modyfikowania genetycznego komórek

Country Status (18)

Country	Link
US (3)	US12215335B2 (pl)
EP (4)	EP3456821B2 (pl)
JP (3)	JP7263327B2 (pl)
KR (2)	KR102714302B1 (pl)
CN (2)	CN111278972B (pl)
AU (3)	AU2018337672B2 (pl)
CA (2)	CA3017658A1 (pl)
DK (3)	DK3456821T4 (pl)
ES (3)	ES2821655T5 (pl)
FI (2)	FI3456821T4 (pl)
HU (1)	HUE060893T2 (pl)
IL (2)	IL273267B2 (pl)
LT (1)	LT3684924T (pl)
MX (1)	MX2020003092A (pl)
PL (1)	PL3684924T3 (pl)
PT (1)	PT3684924T (pl)
SG (2)	SG11202002367WA (pl)
WO (2)	WO2019060253A1 (pl)

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US11708572B2 (en)	2015-04-29	2023-07-25	Flodesign Sonics, Inc.	Acoustic cell separation techniques and processes
US11377651B2 (en)	2016-10-19	2022-07-05	Flodesign Sonics, Inc.	Cell therapy processes utilizing acoustophoresis
EP3725092A4 (en)	2017-12-14	2021-09-22	FloDesign Sonics, Inc.	DRIVE AND CONTROL UNIT FOR ACOUSTIC CONVERTER
EP3942035A1 (en) *	2019-03-18	2022-01-26	Deutsches Krebsforschungszentrum	Expression constructs for the genetic modification of cells
WO2021055760A1 (en)	2019-09-18	2021-03-25	Intergalactic Therapeutics, Inc.	Synthetic dna vectors and methods of use
CN116209767A (zh)	2020-07-22	2023-06-02	德国癌症研究中心	5’s/mar应用
CN113025651B (zh) *	2021-03-31	2023-03-24	重庆医科大学	靶向HBV核心启动子的药物筛选细胞模型、Triciribine及结构类似物新应用
WO2022272296A2 (en)	2021-06-25	2022-12-29	Homology Medicines, Inc.	Adeno-associated virus packaging systems
EP4430083A1 (en)	2021-11-11	2024-09-18	Universität Heidelberg	Immunoreactive molecules and uses thereof
EP4430077A1 (en)	2021-11-11	2024-09-18	Patrick Schmidt	Immunoreactive molecules and uses thereof
US20230279433A1 (en)	2021-12-15	2023-09-07	Oxford Biomedica Solutions Llc	Methods and compositions for the production of adeno-associated virus
WO2024064608A2 (en) *	2022-09-20	2024-03-28	Intergalactic Therapeutics, Inc.	Best1 vectors and uses thereof
CN115896172A (zh) *	2022-09-29	2023-04-04	深圳盛源生物技术有限公司	一种快速建立果蝇细胞稳定表达株的共转染载体及其制备方法和应用

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EP3942035A1 (en) *	2019-03-18	2022-01-26	Deutsches Krebsforschungszentrum	Expression constructs for the genetic modification of cells

2017
- 2017-09-19 EP EP17191829.5A patent/EP3456821B2/en active Active
- 2017-09-19 DK DK17191829.5T patent/DK3456821T4/da active
- 2017-09-19 FI FIEP17191829.5T patent/FI3456821T4/fi active
- 2017-09-19 ES ES17191829T patent/ES2821655T5/es active Active
2018
- 2018-09-17 WO PCT/US2018/051381 patent/WO2019060253A1/en not_active Ceased
- 2018-09-17 US US16/648,885 patent/US12215335B2/en active Active
- 2018-09-18 CA CA3017658A patent/CA3017658A1/en active Pending
- 2018-09-19 EP EP22201555.4A patent/EP4186975A1/en active Pending
- 2018-09-19 EP EP18769377.5A patent/EP3684924B1/en active Active
- 2018-09-19 ES ES18769377T patent/ES2942210T3/es active Active
- 2018-09-19 US US16/648,768 patent/US20210403941A1/en active Pending
- 2018-09-19 CA CA3076285A patent/CA3076285A1/en active Pending
- 2018-09-19 PT PT187693775T patent/PT3684924T/pt unknown
- 2018-09-19 US US16/649,064 patent/US20200263195A1/en not_active Abandoned
- 2018-09-19 SG SG11202002367WA patent/SG11202002367WA/en unknown
- 2018-09-19 KR KR1020207010722A patent/KR102714302B1/ko active Active
- 2018-09-19 DK DK18769377.5T patent/DK3684924T5/da active
- 2018-09-19 AU AU2018337672A patent/AU2018337672B2/en active Active
- 2018-09-19 EP EP18769378.3A patent/EP3684925B1/en active Active
- 2018-09-19 KR KR1020207010863A patent/KR102711571B1/ko active Active
- 2018-09-19 JP JP2020516608A patent/JP7263327B2/ja active Active
- 2018-09-19 AU AU2018337673A patent/AU2018337673B2/en active Active
- 2018-09-19 JP JP2020516915A patent/JP7189943B2/ja active Active
- 2018-09-19 IL IL273267A patent/IL273267B2/en unknown
- 2018-09-19 FI FIEP18769377.5T patent/FI3684924T3/fi active
- 2018-09-19 CN CN201880061036.7A patent/CN111278972B/zh active Active
- 2018-09-19 HU HUE18769377A patent/HUE060893T2/hu unknown
- 2018-09-19 WO PCT/EP2018/075353 patent/WO2019057773A1/en not_active Ceased
- 2018-09-19 DK DK18769378.3T patent/DK3684925T3/da active
- 2018-09-19 ES ES18769378T patent/ES2887776T3/es active Active
- 2018-09-19 SG SG11202001941SA patent/SG11202001941SA/en unknown
- 2018-09-19 LT LTEPPCT/EP2018/075353T patent/LT3684924T/lt unknown
- 2018-09-19 MX MX2020003092A patent/MX2020003092A/es unknown
- 2018-09-19 CN CN201880061037.1A patent/CN111492056B/zh active Active
- 2018-09-19 PL PL18769377.5T patent/PL3684924T3/pl unknown
2020
- 2020-03-17 IL IL273362A patent/IL273362A/en unknown
2023
- 2023-04-12 JP JP2023064820A patent/JP7721589B2/ja active Active
2025
- 2025-05-26 AU AU2025203887A patent/AU2025203887A1/en active Pending

Also Published As

Publication number	Publication date
JP7263327B2 (ja)	2023-04-24
KR102711571B1 (ko)	2024-09-27
IL273267B2 (en)	2025-03-01
EP3456821A1 (en)	2019-03-20
EP3684924A1 (en)	2020-07-29
KR20200079244A (ko)	2020-07-02
EP3456821B1 (en)	2020-08-12
IL273267A (en)	2020-04-30
JP2020535805A (ja)	2020-12-10
EP3684925B1 (en)	2021-08-18
KR20200054278A (ko)	2020-05-19
AU2018337673A1 (en)	2020-04-02
FI3684924T3 (fi)	2023-02-22
ES2821655T5 (es)	2024-08-06
MX2020003092A (es)	2020-07-28
US20200263195A1 (en)	2020-08-20
DK3684925T3 (da)	2021-11-22
IL273267B1 (en)	2024-11-01
HUE060893T2 (hu)	2023-04-28
CN111278972A (zh)	2020-06-12
DK3684924T3 (da)	2023-02-06
KR102714302B1 (ko)	2024-10-07
CA3076285A1 (en)	2019-03-28
EP3684925A1 (en)	2020-07-29
JP2023089132A (ja)	2023-06-27
WO2019057773A1 (en)	2019-03-28
CN111492056B (zh)	2024-06-21
DK3456821T4 (da)	2024-04-15
AU2018337672A1 (en)	2020-03-19
LT3684924T (lt)	2023-02-10
ES2942210T3 (es)	2023-05-30
CN111278972B (zh)	2024-04-19
JP7721589B2 (ja)	2025-08-12
EP3456821B2 (en)	2024-01-24
EP4186975A1 (en)	2023-05-31
SG11202002367WA (en)	2020-04-29
US12215335B2 (en)	2025-02-04
AU2018337673B2 (en)	2025-04-17
SG11202001941SA (en)	2020-04-29
CN111492056A (zh)	2020-08-04
AU2018337672B2 (en)	2025-02-27
JP7189943B2 (ja)	2022-12-14
FI3456821T4 (fi)	2024-04-24
PT3684924T (pt)	2023-02-03
US20200277624A1 (en)	2020-09-03
ES2821655T3 (es)	2021-04-27
WO2019060253A1 (en)	2019-03-28
DK3684924T5 (da)	2024-08-26
IL273362A (en)	2020-05-31
DK3456821T3 (da)	2020-11-16
CA3017658A1 (en)	2019-03-19
ES2887776T3 (es)	2021-12-27
US20210403941A1 (en)	2021-12-30
EP3684924B1 (en)	2022-11-02
JP2020536510A (ja)	2020-12-17
AU2025203887A1 (en)	2025-06-19

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SG10201913505WA (en)	2020-02-27	Truncated crispr-cas proteins for dna targeting
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EP3222728A4 (en)	2018-09-12	Method for regulating gene expression using cas9 protein expressed from two vectors
PT3568483T (pt)	2025-11-18	Polinucleótidos e vetores para a expressão de transgenes
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SG10201913278PA (en)	2020-02-27	Optimized factor viii genes
EP3262214A4 (en)	2018-07-25	Single-cell nucleic acids for high-throughput studies
GB201611982D0 (en)	2016-08-24	Cell culture
HUE056009T2 (hu)	2022-01-28	DNS vektorok, transzpozonok és transzpozázok eukarióta genom módosítására
GB201705484D0 (en)	2017-05-17	Genetic construct
ZA201902370B (en)	2019-12-18	Novel paratransgenic system for the biocontrol of disease-transmitting mosquitos
PL3630961T3 (pl)	2024-12-02	Konstrukt genetyczny
GB201812474D0 (en)	2018-09-12	Nucleic acid construct
EP3535400A4 (en)	2020-07-01	PLASMIDIC VECTORS FOR EXPRESSION OF LARGE NUCLEIC ACID TRANSGENES
LT3277807T (lt)	2020-01-10	Eukariotiniai ekspresijos vektoriai, apimantys globino genų klasterių reguliavimo elementus
PL3287521T3 (pl)	2021-12-20	Hodowla komórkowa
EP3295959A4 (en)	2019-01-02	Cmlck gene introduction
EP3794129A4 (en)	2022-09-14	DNA VACCINE VECTORS
PL3621596T3 (pl)	2022-10-24	Tabletki z wektorami kwasów nukleinowych
GB201819021D0 (en)	2019-01-09	Genetic construct
AU2017900050A0 (en)	2017-01-19	Polynucleotides and vectors for the expression of transgenes