PL3697887T3 - Sposoby perfuzyjne - Google Patents

Sposoby perfuzyjne

Info

Publication number
PL3697887T3
PL3697887T3 PL18797333.4T PL18797333T PL3697887T3 PL 3697887 T3 PL3697887 T3 PL 3697887T3 PL 18797333 T PL18797333 T PL 18797333T PL 3697887 T3 PL3697887 T3 PL 3697887T3
Authority
PL
Poland
Prior art keywords
perfusion methods
perfusion
methods
Prior art date
Application number
PL18797333.4T
Other languages
English (en)
Inventor
Matthew ANGELINI
Ashley WITMER
Anthony Debiase
Original Assignee
Regeneron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=64110133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3697887(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.
Publication of PL3697887T3 publication Critical patent/PL3697887T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/14—Incubators; Climatic chambers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/38—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of metabolites or enzymes in the cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M43/00—Combinations of bioreactors or fermenters with other apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL18797333.4T 2017-10-16 2018-10-15 Sposoby perfuzyjne PL3697887T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762572918P 2017-10-16 2017-10-16
PCT/US2018/055891 WO2019079188A1 (en) 2017-10-16 2018-10-15 PERFUSION BIOREACTOR AND METHODS OF USE THEREOF

Publications (1)

Publication Number Publication Date
PL3697887T3 true PL3697887T3 (pl) 2022-08-01

Family

ID=64110133

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18797333.4T PL3697887T3 (pl) 2017-10-16 2018-10-15 Sposoby perfuzyjne

Country Status (18)

Country Link
US (3) US11193103B2 (pl)
EP (2) EP4039786A1 (pl)
JP (3) JP7337784B2 (pl)
KR (2) KR102694992B1 (pl)
CN (6) CN118580925A (pl)
AR (1) AR113772A1 (pl)
AU (2) AU2018350898B9 (pl)
CA (1) CA3075679A1 (pl)
DK (1) DK3697887T3 (pl)
EA (1) EA202090740A1 (pl)
ES (1) ES2919850T3 (pl)
HU (1) HUE058924T2 (pl)
IL (2) IL273150B2 (pl)
MX (2) MX2020002851A (pl)
PL (1) PL3697887T3 (pl)
SG (1) SG11202002339XA (pl)
TW (3) TW202538049A (pl)
WO (1) WO2019079188A1 (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11609120B2 (en) 2017-10-06 2023-03-21 Lonza Ltd Automated control of cell culture using Raman spectroscopy
EP4039786A1 (en) * 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use
CN119264211A (zh) 2018-08-27 2025-01-07 瑞泽恩制药公司 拉曼光谱在下游纯化中的应用
CN113924355B (zh) * 2019-05-28 2024-04-02 上海药明生物技术有限公司 用于监测和自动控制灌流细胞培养的拉曼光谱集成灌流细胞培养系统
MX2021014644A (es) * 2019-06-13 2022-04-06 Amgen Inc Control de perfusion basado en biomasa automatizado en la fabricacion de productos biologicos.
US12460170B2 (en) * 2019-11-07 2025-11-04 Merck Patent Gmbh Methods and systems for performing perfusion cell culture
WO2021097281A1 (en) 2019-11-15 2021-05-20 Lonza Ltd Process and system for producing an inoculum
CN114945659A (zh) * 2020-01-02 2022-08-26 豪夫迈·罗氏有限公司 具有一个或多个原位在线传感器的一次性细胞培养容器
EP4087910A1 (en) * 2020-01-07 2022-11-16 Cytiva Sweden AB Systems and method for controlling fluid flow in bioreactors
KR20220129006A (ko) * 2020-01-15 2022-09-22 우시 바이올로직스 아일랜드 리미티드 배양 세포로부터 생산된 생체 물질을 연속적으로 수확하기 위한 장치 및 방법
KR20230037659A (ko) * 2020-08-21 2023-03-16 메르크 파텐트 게엠베하 생물반응기-기반 청정 육류 생성을 위한 공정 시스템
KR102656244B1 (ko) 2020-10-26 2024-04-09 성균관대학교산학협력단 바이오리액터
EP4255299A4 (en) * 2020-12-01 2024-09-11 The Brigham and Women's Hospital, Inc. SPECTROMETRY SYSTEMS, METHODS AND APPLICATIONS
KR102590857B1 (ko) * 2021-08-25 2023-10-19 재단법인 아산사회복지재단 세포 배양 장치
IL316457A (en) * 2022-04-07 2024-12-01 Mirror Biologics Inc Artificial lymph node bioreactor
US20230383241A1 (en) * 2022-05-25 2023-11-30 Repligen Corporation Recovery of perfusion bleed product via alternating tangential flow filtration in a sedimentation reactor
JP2024030410A (ja) 2022-08-24 2024-03-07 横河電機株式会社 細胞培養システム、及び細胞培養方法
NL2033094B1 (en) * 2022-09-21 2024-03-26 Simabs Nv Method for controlling a perfusion process in a bioreactor
JP2025064520A (ja) 2023-10-06 2025-04-17 横河電機株式会社 装置、方法、コントローラ、細胞培養システム、およびプログラム
WO2025122785A1 (en) * 2023-12-05 2025-06-12 Massachusetts Institute Of Technology Magnetic resonance relaxometry bioreactor monitoring

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0211241A3 (de) 1985-07-06 1989-06-28 Forschungszentrum Jülich Gmbh Verfahren zur Exoenzymgewinnung durch Bakterienkultur
EP0567738A3 (en) * 1992-05-01 1995-09-06 American Cyanamid Co Controlling perfusion rates in continuous bioreactor culture of animal cells
WO1997021824A2 (en) 1995-12-15 1997-06-19 Systemix, Inc. Method for obtaining retroviral vector supernatant having high transduction efficiency
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
ITPD20030142A1 (it) 2003-06-27 2004-12-28 Livia Barenghi Bioreattore, in particolare per spettroscopia nmr
CA2532754A1 (en) 2003-07-17 2005-02-03 Global Cell Solutions, Llc Automated cell culture system and process
CA2557046A1 (en) 2004-03-05 2005-10-13 John Crowley Process for cell culturing by continuous perfusion and alternating tangential flow
WO2005084696A1 (en) 2004-03-08 2005-09-15 Universita'degli Studi Di Milano Methods and agents for controlling intestinal inflammation and mucosal immunity using agents interacting with tir8/sigirr
US20090104594A1 (en) 2004-12-29 2009-04-23 Biogen Idec Bioreactor Process Control System and Method
AU2006254103B2 (en) 2005-06-03 2012-09-06 Ares Trading S.A. Production of recombinant IL-18 binding protein
US8003408B2 (en) * 2005-12-29 2011-08-23 Intel Corporation Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS)
WO2007089551A2 (en) * 2006-01-27 2007-08-09 Prescient Medical, Inc. Raman spectroscopic test strip systems
KR101685246B1 (ko) 2006-07-14 2016-12-09 디피엑스 홀딩스 비.브이. 개선된 세포 배양 방법
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
ES2657055T3 (es) 2007-08-09 2018-03-01 Wyeth Llc Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores
WO2010016943A2 (en) 2008-08-08 2010-02-11 Biogen Idec Ma Inc. Nutrient monitoring and feedback control for increased bioproduct production
BR112012000242B1 (pt) 2009-07-06 2019-07-09 Genentech Inc Métodos para cultivo em batelada de células eucariontes
EP3255153A1 (en) 2009-11-17 2017-12-13 E. R. Squibb & Sons, L.L.C. Methods for enhanced protein production
US10118149B2 (en) 2011-01-13 2018-11-06 Patheon Austria Gmbh & Co Kg Oscillating flow minireactor
PT2837680T (pt) 2011-07-01 2020-04-17 Amgen Inc Cultura celular de mamífero
MX344792B (es) * 2011-09-25 2017-01-06 Theranos Inc Sistemas y métodos para múltiples análisis.
WO2013103901A1 (en) 2012-01-06 2013-07-11 Bend Research, Inc. Dielectric spectroscopy methods and apparatus
MX2015004516A (es) 2012-10-10 2015-10-14 Bayer Healthcare Llc Procedimientos y sistemas para optimizar el sistema de cultivo de celulas de perfusion.
AU2014226126B2 (en) * 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
DK2972238T3 (da) * 2013-03-15 2023-06-19 Biogen Ma Inc Anvendelse af raman-spektroskopi til monitorering af dyrkningsmedium
US10214718B2 (en) * 2013-07-01 2019-02-26 University Of Massachusetts Distributed perfusion bioreactor system for continuous culture of biological cells
BR112016005545B1 (pt) * 2013-09-16 2021-06-01 Genzyme Corporation Método de processamento de uma cultura de células de mamífero
KR102243980B1 (ko) 2013-10-11 2021-04-26 리제너론 파마슈티칼스 인코포레이티드 대사적으로 최적화된 세포 배양
WO2015095809A1 (en) 2013-12-20 2015-06-25 Biogen Idec Ma Inc. Use of perfusion seed cultures to improve biopharmaceutical fed-batch production capacity and product quality
EP3164481A4 (en) 2014-07-02 2018-03-21 Biogen MA Inc. Cross-scale modeling of bioreactor cultures using raman spectroscopy
KR20240055117A (ko) 2015-05-29 2024-04-26 베링거 인겔하임 인터내셔날 게엠베하 연속식 배양에서의 세포-제어된 관류
EP3303561A2 (en) 2015-05-29 2018-04-11 Biogen MA Inc. Cell culture methods and systems
CN106834117B (zh) * 2015-10-27 2018-11-23 苏州迪欧益生物科技有限公司 用于解除动物细胞贴附的酶反应器及智能酶反应工作站
AU2016348588A1 (en) 2015-11-02 2018-04-26 Ares Trading S.A. Methods for modulating production profiles of recombinant proteins in perfusion mode
KR20240173213A (ko) 2016-01-26 2024-12-10 베링거 인겔하임 인터내셔날 게엠베하 연결된 관류 대 연속-유동식 교반-탱크 반응기 세포 배양 시스템
CN205528832U (zh) * 2016-02-26 2016-08-31 南京农业大学 一种体外灌流系统
US11609120B2 (en) 2017-10-06 2023-03-21 Lonza Ltd Automated control of cell culture using Raman spectroscopy
EP4039786A1 (en) * 2017-10-16 2022-08-10 Regeneron Pharmaceuticals, Inc. Perfusion bioreactor and related methods of use

Also Published As

Publication number Publication date
TW202538049A (zh) 2025-10-01
CN118580924A (zh) 2024-09-03
KR20240125704A (ko) 2024-08-19
EP3697887A1 (en) 2020-08-26
AU2018350898B9 (en) 2024-07-25
US11193103B2 (en) 2021-12-07
CA3075679A1 (en) 2019-04-25
WO2019079188A1 (en) 2019-04-25
MX2020002851A (es) 2020-07-24
EP3697887B1 (en) 2022-04-06
CN118580925A (zh) 2024-09-03
JP2025128361A (ja) 2025-09-02
KR102694992B1 (ko) 2024-08-14
AU2018350898A1 (en) 2020-04-16
EA202090740A1 (ru) 2020-07-07
US20190153381A1 (en) 2019-05-23
CN118580927A (zh) 2024-09-03
AU2018350898B2 (en) 2024-07-04
IL315801A (en) 2024-11-01
MX2026001872A (es) 2026-04-01
CN111212899A (zh) 2020-05-29
HUE058924T2 (hu) 2022-09-28
JP2023156504A (ja) 2023-10-24
DK3697887T3 (da) 2022-05-02
TWI889045B (zh) 2025-07-01
AU2024227125A1 (en) 2024-10-24
AR113772A1 (es) 2020-06-10
JP2020536521A (ja) 2020-12-17
US20220056398A1 (en) 2022-02-24
US11965153B2 (en) 2024-04-23
IL273150B1 (en) 2024-10-01
CN118580928A (zh) 2024-09-03
ES2919850T3 (es) 2022-07-28
IL273150B2 (en) 2025-02-01
TW201934744A (zh) 2019-09-01
CN111212899B (zh) 2024-07-02
EP4039786A1 (en) 2022-08-10
CN118580926A (zh) 2024-09-03
TW202426623A (zh) 2024-07-01
IL273150A (en) 2020-04-30
BR112020005209A2 (pt) 2020-09-15
TWI827555B (zh) 2024-01-01
JP7700184B2 (ja) 2025-06-30
JP7337784B2 (ja) 2023-09-04
SG11202002339XA (en) 2020-04-29
US20240218313A1 (en) 2024-07-04
KR20200062236A (ko) 2020-06-03

Similar Documents

Publication Publication Date Title
PL3697887T3 (pl) Sposoby perfuzyjne
GB2547727B (en) Perfusion phantom
GB2538731B (en) Methods
SG11202003354VA (en) Perfusion medium
GB2600653B (en) Novel methods
GB201615128D0 (en) Methods
GB201610162D0 (en) Methods
GB201709075D0 (en) Methods
SG11201704788SA (en) Acoustic perfusion devices
GB201518762D0 (en) Methods
GB201508927D0 (en) Methods
GB201621728D0 (en) Methods
GB201615343D0 (en) Methods
GB2562937B (en) Acoustic perfusion devices
GB201703036D0 (en) Methods
GB201621386D0 (en) Methods
ZA201805610B (en) Perfusion system
IL267759B (en) Spraying device
GB201515655D0 (en) Methods
GB201509847D0 (en) Anti-dandruff agents
GB201601868D0 (en) Methods
DK3615520T3 (en) Methods
GB201619945D0 (en) Methods
GB201509848D0 (en) Anti-dandruff Agents
GB201512609D0 (en) Methods