PL370294A1 - Sposób ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki 7s sojowej globuliny alfa'do zastosowania jako środek obniżający poziom cholesterolu - Google Patents

Sposób ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki 7s sojowej globuliny alfa'do zastosowania jako środek obniżający poziom cholesterolu

Info

Publication number: PL370294A1
Authority: PL; Poland
Prior art keywords: subunit; soy; extraction; hypocholesterolemizing; purification
Prior art date: 2002-01-29

Application number

PL03370294A

Other languages

English (en)

Other versions

PL209342B1 (pl

Inventor

Marcello Duranti

Paolo Morazzoni

Original Assignee

Indena S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-01-29

Filing date

2003-01-27

Publication date

2005-05-16

2003-01-27 Application filed by Indena S.P.A. filed Critical Indena S.P.A.

2005-05-16 Publication of PL370294A1 publication Critical patent/PL370294A1/pl

2011-08-31 Publication of PL209342B1 publication Critical patent/PL209342B1/pl

Links

238000000605 extraction Methods 0.000 title abstract 2
102000006395 Globulins Human genes 0.000 title 1
108010044091 Globulins Proteins 0.000 title 1
230000009144 enzymatic modification Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
101710094135 Beta-conglycinin alpha' subunit Proteins 0.000 abstract 1
108090000317 Chymotrypsin Proteins 0.000 abstract 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
229960002376 chymotrypsin Drugs 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/14—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from leguminous or other vegetable seeds; from press-cake or oil-bearing seeds
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/14—Vegetable proteins
- A23J3/16—Vegetable proteins from soybean
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Biochemistry (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Nutrition Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Botany (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Mycology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Plant Substances (AREA)
Steroid Compounds (AREA)

PL370294A 2002-01-29 2003-01-27 Sposób selektywnej ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki α' sojowej β-konglicyniny, jej fragmenty polipeptydowe i ich zastosowanie oraz kompozycje farmaceutyczne, dodatki lub produkty spożywcze zawierające te fragmenty polipeptydowe PL209342B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2002MI000147A ITMI20020147A1 (it)	2002-01-29	2002-01-29	Estrazione purificazione e modificazione di polipeptidi da seme di soia

Publications (2)

Publication Number	Publication Date
PL370294A1 true PL370294A1 (pl)	2005-05-16
PL209342B1 PL209342B1 (pl)	2011-08-31

Family

ID=11449014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL370294A PL209342B1 (pl)	2002-01-29	2003-01-27	Sposób selektywnej ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki α' sojowej β-konglicyniny, jej fragmenty polipeptydowe i ich zastosowanie oraz kompozycje farmaceutyczne, dodatki lub produkty spożywcze zawierające te fragmenty polipeptydowe

Country Status (20)

Country	Link
US (3)	US7465467B2 (pl)
EP (1)	EP1469741B1 (pl)
JP (1)	JP4522706B2 (pl)
KR (1)	KR100991641B1 (pl)
CN (1)	CN100558243C (pl)
AT (1)	ATE341943T1 (pl)
AU (1)	AU2003208346B8 (pl)
CA (1)	CA2474106C (pl)
CY (1)	CY1107514T1 (pl)
DE (1)	DE60308994T2 (pl)
DK (1)	DK1469741T3 (pl)
ES (1)	ES2274208T3 (pl)
IL (1)	IL163225A (pl)
IT (1)	ITMI20020147A1 (pl)
NO (1)	NO327156B1 (pl)
PL (1)	PL209342B1 (pl)
PT (1)	PT1469741E (pl)
RU (1)	RU2300898C2 (pl)
SG (1)	SG152048A1 (pl)
WO (1)	WO2003063608A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6171640B1 (en) *	1997-04-04	2001-01-09	Monsanto Company	High beta-conglycinin products and their use
AU2003275628B2 (en) *	2002-11-12	2008-04-03	Fuji Oil Company, Limited	Fractionated soybean protein and process for producing the same
WO2005055735A1 (ja) *	2003-12-11	2005-06-23	Fuji Oil Company, Limited	改良大豆７ｓたん白及びその製造法
JP5382840B2 (ja) *	2005-08-23	2014-01-08	特定非営利活動法人プライメイト・アゴラ	サルモデルで薬効が確認された骨粗鬆症の予防又は治療剤
MX2011007107A (es) *	2008-12-31	2011-08-03	Novozymes As	Composiciones de hidrolizado de proteina.
PT2264055E (pt) *	2009-06-17	2014-05-07	Indena Spa	Clonagem, expressão em levedura, purificação e atividade biológica da região de extensão da subunidade alfa' da globulina 7s da soja implicada na homeostase do colesterol em células hep g2
EP2264054A1 (en) *	2009-06-17	2010-12-22	Indena S.p.A.	Cloning, yeast expression, purification and biological activity of a truncated form of the soybean 7S globulin alfa ' subunit involved in Hep G2 cell cholesterol homeostasis
CN101904406B (zh) *	2010-07-02	2012-07-25	山西大学	一种葵花籽多肽的制备方法和用途
CN104163767B (zh) *	2014-07-25	2017-01-18	湖北泓肽生物科技有限公司	一种氨基酸和多肽水溶性物质的纯化方法
CN114874301A (zh) *	2022-05-10	2022-08-09	吉林农业大学	不同亚基组成β-伴大豆球蛋白的制备方法及应用

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US4409248A (en) *	1981-08-10	1983-10-11	A. E. Staley Manufacturing Company	Heat-gelling and foam-stabilizing enzymatically modified vegetable isolates
JPH06197788A (ja)	1993-01-06	1994-07-19	Fuji Oil Co Ltd	蛋白質の製造法
CN1082345C (zh)	1996-03-28	2002-04-10	不二制油株式会社	蛋白水解产物的制备方法
BR9709697A (pt) *	1996-06-14	1999-10-05	Du Pont	Método para reduzir a quantidade de proteìna de armazenamento em semente de soja, método para reduzir simultaneamente a expressão de dois genes de soja, planta de soja transgênica e sementes transgênicas.
US6171640B1 (en) *	1997-04-04	2001-01-09	Monsanto Company	High beta-conglycinin products and their use
US6365802B2 (en) *	1998-08-14	2002-04-02	Calgene Llc	Methods for increasing stearate content in soybean oil
FR2784029B1 (fr)	1998-10-05	2001-01-05	Pharmascience Lab	Methode de prevention et/ou de traitement cosmetique des vergetures de la peau et utilisation en dermatologie
JP2003527077A (ja) *	1999-04-15	2003-09-16	カルジーンエルエルシー	トコフェロール合成に関与するタンパク質の核酸配列
CA2274414A1 (en)	1999-06-11	2000-12-11	Universite Laval	Dietary fish protein for use in restoring normal insulin function insulin-resistant individuals
AUPQ877300A0 (en) *	2000-07-13	2000-08-03	Johnson & Johnson Pacific Pty Limited	Topical treatment of skin
BRPI0309421B8 (pt) *	2002-04-18	2021-05-25	Monsanto Technology Llc	método de preparar um gênero alimentício e composição para tratar ou prevenir hipercolesterolemia
ATE446969T1 (de) *	2003-08-20	2009-11-15	Seikagaku Kogyo Co Ltd	Stabilisierungsmittel für enzyme
WO2006076425A1 (en) *	2005-01-14	2006-07-20	Solae, Llc	Soy protein for infant formula

2002
- 2002-01-29 IT IT2002MI000147A patent/ITMI20020147A1/it unknown
2003
- 2003-01-27 PT PT03706387T patent/PT1469741E/pt unknown
- 2003-01-27 US US10/502,582 patent/US7465467B2/en not_active Expired - Fee Related
- 2003-01-27 DK DK03706387T patent/DK1469741T3/da active
- 2003-01-27 JP JP2003563319A patent/JP4522706B2/ja not_active Expired - Fee Related
- 2003-01-27 AU AU2003208346A patent/AU2003208346B8/en not_active Ceased
- 2003-01-27 AT AT03706387T patent/ATE341943T1/de active
- 2003-01-27 WO PCT/EP2003/000798 patent/WO2003063608A1/en not_active Ceased
- 2003-01-27 PL PL370294A patent/PL209342B1/pl unknown
- 2003-01-27 KR KR1020047011441A patent/KR100991641B1/ko not_active Expired - Fee Related
- 2003-01-27 DE DE60308994T patent/DE60308994T2/de not_active Expired - Lifetime
- 2003-01-27 SG SG200506973-7A patent/SG152048A1/en unknown
- 2003-01-27 EP EP03706387A patent/EP1469741B1/en not_active Expired - Lifetime
- 2003-01-27 RU RU2004123201/13A patent/RU2300898C2/ru not_active IP Right Cessation
- 2003-01-27 CN CNB038028050A patent/CN100558243C/zh not_active Expired - Fee Related
- 2003-01-27 ES ES03706387T patent/ES2274208T3/es not_active Expired - Lifetime
- 2003-01-27 CA CA2474106A patent/CA2474106C/en not_active Expired - Fee Related
2004
- 2004-07-27 NO NO20043186A patent/NO327156B1/no not_active IP Right Cessation
- 2004-07-27 IL IL163225A patent/IL163225A/en not_active IP Right Cessation
2006
- 2006-11-28 CY CY20061101709T patent/CY1107514T1/el unknown
2008
- 2008-04-17 US US12/104,473 patent/US7901718B2/en not_active Expired - Fee Related
2011
- 2011-01-26 US US13/013,966 patent/US8257758B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL163225A (en)	2007-06-17
WO2003063608A1 (en)	2003-08-07
KR100991641B1 (ko)	2010-11-04
DK1469741T3 (da)	2007-02-19
ITMI20020147A0 (it)	2002-01-29
AU2003208346B2 (en)	2008-03-06
RU2300898C2 (ru)	2007-06-20
JP4522706B2 (ja)	2010-08-11
EP1469741B1 (en)	2006-10-11
ITMI20020147A1 (it)	2003-07-29
NO327156B1 (no)	2009-05-04
SG152048A1 (en)	2009-05-29
JP2005516043A (ja)	2005-06-02
RU2004123201A (ru)	2005-10-27
HK1073590A1 (zh)	2005-10-14
CA2474106C (en)	2011-11-22
DE60308994D1 (de)	2006-11-23
PT1469741E (pt)	2007-01-31
EP1469741A1 (en)	2004-10-27
ATE341943T1 (de)	2006-11-15
CN1622760A (zh)	2005-06-01
DE60308994T2 (de)	2007-06-14
NO20043186L (no)	2004-07-26
US8257758B2 (en)	2012-09-04
US7465467B2 (en)	2008-12-16
CA2474106A1 (en)	2003-08-07
US20080261885A1 (en)	2008-10-23
AU2003208346A2 (en)	2003-09-02
PL209342B1 (pl)	2011-08-31
US20110118182A1 (en)	2011-05-19
CY1107514T1 (el)	2013-03-13
US20050164337A1 (en)	2005-07-28
AU2003208346B8 (en)	2008-07-10
KR20040077786A (ko)	2004-09-06
CN100558243C (zh)	2009-11-11
ES2274208T3 (es)	2007-05-16
US7901718B2 (en)	2011-03-08

Publication	Publication Date	Title
PL370294A1 (pl)	2005-05-16	Sposób ekstrakcji, oczyszczania i enzymatycznej modyfikacji podjednostki 7s sojowej globuliny alfa'do zastosowania jako środek obniżający poziom cholesterolu
White Jr et al.	1959	Some relationships of structure to function in ribonuclease
ATE386110T1 (de)	2008-03-15	Prolylendoprotease aus aspergillus niger
IL154009A0 (en)	2003-07-31	Codon-optimized papilloma virus sequences
ES2139420T3 (es)	2000-02-01	Un procedimiento para producir un hidrolizado de proteina de soja.
SI1151007T1 (sl)	2006-10-31	Postopek za pripravo pripravka na osnovi fibrinogena in fibronektina in proteinski sestavki, ki jihlahko dobimo po tem postopku
ATE323759T1 (de)	2006-05-15	Rückgewinnung eines proteins bei hohem ph-wert
MY152824A (en)	2014-11-28	Combination of hcv ns3 protease inhibitor with interferon and ribavirin.
MXPA03010433A (es)	2004-10-15	Metodos para produccion recombinante de peptidos antifusogenicos.
YU50502A (sh)	2005-09-19	Postupak za prečišćavanje farmakološki aktivnih proteina pomoću katjonske izmenjivačke hromatografije
AU7516498A (en)	1998-12-11	Removal of contaminants from gas streams in rayon production
NZ589985A (en)	2012-12-21	Novel canola protein isolate
JP2005516043A5 (pl)	2006-03-09
DK1339735T3 (da)	2007-06-25	Fremgangsmåde til fremstilling af tryptophanrige peptider
IL177286A0 (en)	2006-12-10	Albumin-purification method comprising a nanofiltration step, solution, and composition for therapeutic use containing same
AR042019A1 (es)	2005-06-08	N-acetilgalactosamina-4-sulfatasa precursora, composiciones farmaceuticas que la contienen , metodos de tratamiento que la utilizan y metodos para producirla y purificarla
NZ541231A (en)	2009-03-31	A method of treatment or prophylaxis of symptoms of herpes viral infection
WO2003084908A3 (en)	2004-04-08	Preventing undesired odor in and/or purifying alkanediols
du Vigneaud	1938	The role which insulin has played in our concept of protein hormones, and a consideration of certain phases of the chemistry of insulin
SE0203551D0 (sv)	2002-12-02	Prothrombin purification
ITMI20022409A1 (it)	2004-05-15	Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
NO984365L (no)	1998-11-19	IgAl proteasefragment som bµrerpeptid
BRPI0502744A (pt)	2006-05-02	processo para reduzir a atividade do ativador de pré-calicreìna (pka) em soluções de albumina purificada de origem humana e para estabilizá-la temporalmente; processo para obter albumina; e solução purificada de albumina de origem humana com baixa atividade do ativador de pré-calicreìna (pka) e com estabilidade temporal
Perez et al.	1997	Production and purification of neuraminidase from Vibrio cholerae O 1.
BRPI0502309A (pt)	2007-02-06	processo de recuperação de isoflavonas agliconas a partir de sub-produtos e resìduos da produção de proteìnas concentradas e isoladas de soja e microorganismos geneticamente modificados