PL371307A1 - Sposób wytwarzania N-demetyloolanzapiny - Google Patents

Sposób wytwarzania N-demetyloolanzapiny

Info

Publication number: PL371307A1
Authority: PL; Poland
Prior art keywords: demethylolanzapine; olanzapine; manufacture; piperazine; benzodiazepine
Prior art date: 2004-11-22

Application number

PL371307A

Other languages

English (en)

Other versions

PL198589B1 (pl

Inventor

Tomasz Stawiński

Justyna Tatiana Rechnio

Zbigniew Majka

Sławomir Władysław Mirek

Original Assignee

ADAMED Sp.z o.o.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-22

Filing date

2004-11-22

Publication date

2006-05-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35645631&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL371307(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-11-22 Application filed by ADAMED Sp.z o.o. filed Critical ADAMED Sp.z o.o.

2004-11-22 Priority to PL371307A priority Critical patent/PL198589B1/pl

2005-11-15 Priority to EP05810971A priority patent/EP1814886B1/en

2005-11-15 Priority to PT05810971T priority patent/PT1814886E/pt

2005-11-15 Priority to CN2005800399627A priority patent/CN101061124B/zh

2005-11-15 Priority to PCT/EP2005/055981 priority patent/WO2006053870A1/en

2005-11-15 Priority to EP08161324.2A priority patent/EP1988092B1/en

2005-11-15 Priority to SI200530530T priority patent/SI1814886T1/sl

2005-11-15 Priority to AT05810971T priority patent/ATE412000T1/de

2005-11-15 Priority to ES05810971T priority patent/ES2315928T3/es

2005-11-15 Priority to DE602005010606T priority patent/DE602005010606D1/de

2006-05-29 Publication of PL371307A1 publication Critical patent/PL371307A1/pl

2007-06-22 Priority to NO20073165A priority patent/NO20073165L/no

2008-06-30 Publication of PL198589B1 publication Critical patent/PL198589B1/pl

Links

FHPIXVHJEIZKJW-UHFFFAOYSA-N 4'-N-desmethylolanzapine Chemical compound S1C(C)=CC2=C1NC1=CC=CC=C1N=C2N1CCNCC1 FHPIXVHJEIZKJW-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 abstract 2
229960005017 olanzapine Drugs 0.000 abstract 2
230000000561 anti-psychotic effect Effects 0.000 abstract 1
229940049706 benzodiazepine Drugs 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Cephalosporin Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

PL371307A 2004-11-22 2004-11-22 Sposób wytwarzania N-demetyloolanzapiny PL198589B1 (pl)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
PL371307A PL198589B1 (pl)	2004-11-22	2004-11-22	Sposób wytwarzania N-demetyloolanzapiny
DE602005010606T DE602005010606D1 (de)	2004-11-22	2005-11-15	Verfahren zur herstellung von n-demethylolanzapin
PCT/EP2005/055981 WO2006053870A1 (en)	2004-11-22	2005-11-15	A process for the preparation of n-demethylolanzapine
PT05810971T PT1814886E (pt)	2004-11-22	2005-11-15	Processo para a preparação de n-desmetilolanzapina
CN2005800399627A CN101061124B (zh)	2004-11-22	2005-11-15	一种制备n-脱甲基奥氮平的方法
EP05810971A EP1814886B1 (en)	2004-11-22	2005-11-15	A process for the preparation of n-demethylolanzapine
EP08161324.2A EP1988092B1 (en)	2004-11-22	2005-11-15	A process for the preparation of olanzapine
SI200530530T SI1814886T1 (sl)	2004-11-22	2005-11-15	Postopek za pripravo N-demetilolanzapina
AT05810971T ATE412000T1 (de)	2004-11-22	2005-11-15	Verfahren zur herstellung von n-demethylolanzapin
ES05810971T ES2315928T3 (es)	2004-11-22	2005-11-15	Procedimiento para la preparacion de n.desmetilolanzapina.
NO20073165A NO20073165L (no)	2004-11-22	2007-06-22	Fremgangsmate for fremstillingen av N-demetylolanzapin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PL371307A PL198589B1 (pl)	2004-11-22	2004-11-22	Sposób wytwarzania N-demetyloolanzapiny

Publications (2)

Publication Number	Publication Date
PL371307A1 true PL371307A1 (pl)	2006-05-29
PL198589B1 PL198589B1 (pl)	2008-06-30

Family

ID=35645631

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL371307A PL198589B1 (pl)	2004-11-22	2004-11-22	Sposób wytwarzania N-demetyloolanzapiny

Country Status (10)

Country	Link
EP (2)	EP1814886B1 (pl)
CN (1)	CN101061124B (pl)
AT (1)	ATE412000T1 (pl)
DE (1)	DE602005010606D1 (pl)
ES (1)	ES2315928T3 (pl)
NO (1)	NO20073165L (pl)
PL (1)	PL198589B1 (pl)
PT (1)	PT1814886E (pl)
SI (1)	SI1814886T1 (pl)
WO (1)	WO2006053870A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL395468A1 (pl)	2011-06-29	2013-01-07	Adamed Spólka Z Ograniczona Odpowiedzialnoscia	Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego
CN102924470B (zh) *	2011-08-31	2014-12-03	江苏豪森药业股份有限公司	新颖的奥氮平的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9009229D0 (en)	1990-04-25	1990-06-20	Lilly Industries Ltd	Pharmaceutical compounds
PT1133300E (pt)	1998-11-23	2005-04-29	Sepracor Inc	Composicoes de desmetilolanzapina e metodos
CN1420117A (zh) *	2001-11-16	2003-05-28	连云港豪森制药有限公司	一种制备奥氮平的方法
PL199016B1 (pl)	2002-06-20	2008-08-29	Adamed Sp Z Oo	Sposób wytwarzania olanzapiny
AU2003243143A1 (en) *	2003-03-20	2004-11-19	Watson Pharmaceuticals, Inc.	2-methyl-thieno-benzodiazepine process

2004
- 2004-11-22 PL PL371307A patent/PL198589B1/pl unknown
2005
- 2005-11-15 ES ES05810971T patent/ES2315928T3/es not_active Expired - Lifetime
- 2005-11-15 PT PT05810971T patent/PT1814886E/pt unknown
- 2005-11-15 DE DE602005010606T patent/DE602005010606D1/de not_active Expired - Lifetime
- 2005-11-15 AT AT05810971T patent/ATE412000T1/de not_active IP Right Cessation
- 2005-11-15 WO PCT/EP2005/055981 patent/WO2006053870A1/en not_active Ceased
- 2005-11-15 SI SI200530530T patent/SI1814886T1/sl unknown
- 2005-11-15 EP EP05810971A patent/EP1814886B1/en not_active Expired - Lifetime
- 2005-11-15 CN CN2005800399627A patent/CN101061124B/zh not_active Expired - Fee Related
- 2005-11-15 EP EP08161324.2A patent/EP1988092B1/en not_active Ceased
2007
- 2007-06-22 NO NO20073165A patent/NO20073165L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
PT1814886E (pt)	2008-11-04
EP1988092A1 (en)	2008-11-05
ES2315928T3 (es)	2009-04-01
EP1814886B1 (en)	2008-10-22
ATE412000T1 (de)	2008-11-15
EP1988092B1 (en)	2013-11-27
CN101061124A (zh)	2007-10-24
NO20073165L (no)	2007-06-22
SI1814886T1 (sl)	2009-04-30
EP1814886A1 (en)	2007-08-08
CN101061124B (zh)	2010-07-28
PL198589B1 (pl)	2008-06-30
WO2006053870A1 (en)	2006-05-26
DE602005010606D1 (de)	2008-12-04

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