PL3713939T3 - Ulepszony sposób syntezy konstruktu łącznik-lek vc-seco - Google Patents

Ulepszony sposób syntezy konstruktu łącznik-lek vc-seco

Info

Publication number
PL3713939T3
PL3713939T3 PL18811180T PL18811180T PL3713939T3 PL 3713939 T3 PL3713939 T3 PL 3713939T3 PL 18811180 T PL18811180 T PL 18811180T PL 18811180 T PL18811180 T PL 18811180T PL 3713939 T3 PL3713939 T3 PL 3713939T3
Authority
PL
Poland
Prior art keywords
seco
linker
drug
synthesis
improved process
Prior art date
Application number
PL18811180T
Other languages
English (en)
Inventor
Vladimír JANOUSEK
Martin Kás
Original Assignee
Byondis B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byondis B.V. filed Critical Byondis B.V.
Publication of PL3713939T3 publication Critical patent/PL3713939T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
PL18811180T 2017-11-24 2018-11-22 Ulepszony sposób syntezy konstruktu łącznik-lek vc-seco PL3713939T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17203457 2017-11-24
EP18811180.1A EP3713939B1 (en) 2017-11-24 2018-11-22 Improved process for the synthesis of linker-drug vc-seco
PCT/EP2018/082199 WO2019101850A1 (en) 2017-11-24 2018-11-22 Improved process for the synthesis of linker-drug vc-seco-duba

Publications (1)

Publication Number Publication Date
PL3713939T3 true PL3713939T3 (pl) 2021-12-13

Family

ID=60452506

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18811180T PL3713939T3 (pl) 2017-11-24 2018-11-22 Ulepszony sposób syntezy konstruktu łącznik-lek vc-seco

Country Status (15)

Country Link
US (1) US11633492B2 (pl)
EP (1) EP3713939B1 (pl)
JP (1) JP7279042B2 (pl)
KR (1) KR102728434B1 (pl)
CN (1) CN111556870B (pl)
AU (1) AU2018371966B2 (pl)
CY (1) CY1124480T1 (pl)
DK (1) DK3713939T3 (pl)
ES (1) ES2889775T3 (pl)
HR (1) HRP20211435T1 (pl)
HU (1) HUE055305T2 (pl)
LT (1) LT3713939T (pl)
PL (1) PL3713939T3 (pl)
PT (1) PT3713939T (pl)
WO (1) WO2019101850A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3184866A1 (en) * 2020-07-06 2022-01-13 Ronald Christiaan Elgersma Antifolate linker-drugs and antibody-drug conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
JP2013503862A (ja) * 2009-09-08 2013-02-04 シグネーチャー セラピューティクス,インク. 酵素切断可能なケトン修飾オピオイドプロドラッグとその任意選択のインヒビターとを含んでなる組成物
NO3056203T3 (pl) * 2010-04-21 2018-05-12
DK3151865T3 (da) * 2014-05-22 2021-10-25 Byondis Bv Stedsspecifik konjugation af linker medicin til antistof og resulterende adcs
US9890159B2 (en) 2014-06-05 2018-02-13 Synthon Biopharmaceuticals B.V. Process for making duocarmycin prodrugs
JP2015199772A (ja) * 2015-06-25 2015-11-12 シグネーチャー セラピューティクス,インク.Signature Therapeutics, Inc. 酵素切断可能なオピオイドプロドラッグとそのインヒビターとを含んでなる組成物
AU2017218615B2 (en) 2016-02-12 2022-02-10 Byondis B.V. Selective reduction of cysteine-engineered antibodies
EP3546448B1 (en) * 2016-11-25 2022-04-06 Mabwell (Shanghai) Bioscience Co., Ltd. Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof

Also Published As

Publication number Publication date
RU2020120838A3 (pl) 2022-03-03
AU2018371966B2 (en) 2021-02-25
JP7279042B2 (ja) 2023-05-22
CN111556870A (zh) 2020-08-18
KR102728434B1 (ko) 2024-11-08
EP3713939A1 (en) 2020-09-30
US20200368362A1 (en) 2020-11-26
WO2019101850A1 (en) 2019-05-31
KR20200091431A (ko) 2020-07-30
LT3713939T (lt) 2021-10-25
AU2018371966A1 (en) 2020-06-18
CN111556870B (zh) 2023-09-29
HRP20211435T1 (hr) 2022-01-07
HUE055305T2 (hu) 2021-11-29
EP3713939B1 (en) 2021-07-21
RU2020120838A (ru) 2021-12-24
PT3713939T (pt) 2021-09-16
ES2889775T3 (es) 2022-01-13
DK3713939T3 (da) 2021-09-13
JP2021504351A (ja) 2021-02-15
US11633492B2 (en) 2023-04-25
CA3083169A1 (en) 2019-05-31
CY1124480T1 (el) 2022-07-22

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