PL371958A1 - Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej - Google Patents

Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej

Info

Publication number: PL371958A1
Authority: PL; Poland
Prior art keywords: hydroxy; ethylidene; monosodium salt; acid; pyridinyl
Prior art date: 2004-12-28

Application number

PL371958A

Other languages

English (en)

Other versions

PL199215B1 (pl

Inventor

Leszek Dembkowski

Robert Rynkiewicz

Janusz Rachoń

Sławomir Makowiec

Witold Przychodzeń

Dariusz Witt

Original Assignee

Zakłady Farmaceutyczne POLPHARMA S.A.

Politechnika Gdańska

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-28

Filing date

2004-12-28

Publication date

2006-07-10

2004-12-28 Application filed by Zakłady Farmaceutyczne POLPHARMA S.A., Politechnika Gdańska filed Critical Zakłady Farmaceutyczne POLPHARMA S.A.

2004-12-28 Priority to PL371958A priority Critical patent/PL199215B1/pl

2005-12-28 Priority to DE602005010908T priority patent/DE602005010908D1/de

2005-12-28 Priority to KR1020077014055A priority patent/KR100901183B1/ko

2005-12-28 Priority to ES05820284T priority patent/ES2315937T3/es

2005-12-28 Priority to US11/721,334 priority patent/US8450488B2/en

2005-12-28 Priority to JP2007548122A priority patent/JP5015006B2/ja

2005-12-28 Priority to AT05820284T priority patent/ATE413409T1/de

2005-12-28 Priority to PCT/PL2005/000085 priority patent/WO2006071128A1/en

2005-12-28 Priority to SI200530484T priority patent/SI1836210T1/sl

2005-12-28 Priority to EP05820284A priority patent/EP1836210B1/en

2005-12-28 Priority to HR20080619T priority patent/HRP20080619T3/xx

2006-07-10 Publication of PL371958A1 publication Critical patent/PL371958A1/pl

2008-08-29 Publication of PL199215B1 publication Critical patent/PL199215B1/pl

Links

239000002253 acid Substances 0.000 title abstract 2
125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 abstract 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
FGBXDQWECLPOGZ-UHFFFAOYSA-N [Na].O.O.O.O.O.[Na] Chemical compound [Na].O.O.O.O.O.[Na] FGBXDQWECLPOGZ-UHFFFAOYSA-N 0.000 abstract 2
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
XVCCOEWNFXXUEV-UHFFFAOYSA-N 2-pyridin-3-ylacetic acid;hydrochloride Chemical compound Cl.OC(=O)CC1=CC=CN=C1 XVCCOEWNFXXUEV-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Seasonings (AREA)
Pyridine Compounds (AREA)

PL371958A 2004-12-28 2004-12-28 Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej PL199215B1 (pl)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
PL371958A PL199215B1 (pl)	2004-12-28	2004-12-28	Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
DE602005010908T DE602005010908D1 (de)	2004-12-28	2005-12-28	Verfahren zur herstellung von ä1-hydroxy-2-(3-pyridinyl)ethylidenübisphosphonsäure und dem hemipentahydrat-mononatriumsalz davon
KR1020077014055A KR100901183B1 (ko)	2004-12-28	2005-12-28	[1-히드록시-2-(3-피리디닐)에틸리덴]비스포스폰산 및 그의헤미-펜타히드레이트 모노소듐염의 제조방법
ES05820284T ES2315937T3 (es)	2004-12-28	2005-12-28	Procedimiento para la preparacion de acido (1-hidroxi-2-(3-piridinil) etiliden)bifosfonico y de su sal monosodica semi-pentahidratada.
US11/721,334 US8450488B2 (en)	2004-12-28	2005-12-28	Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethylidene] bisphosphonic acid and hemipentahydrate monosodium salt thereof
JP2007548122A JP5015006B2 (ja)	2004-12-28	2005-12-28	〔１−ヒドロキシ−２−（３−ピリジニル）エチリデン〕ビスホスホン酸及びその２．５水和物モノナトリウム塩の製造方法
AT05820284T ATE413409T1 (de)	2004-12-28	2005-12-28	Verfahren zur herstellung von ä1-hydroxy-2-(3- pyridinyl)ethylidenübisphosphonsäure und dem hemipentahydrat-mononatriumsalz davon
PCT/PL2005/000085 WO2006071128A1 (en)	2004-12-28	2005-12-28	Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethyliden] bisphosphonic acid and hemi-pentahydrate monosodium salt thereof
SI200530484T SI1836210T1 (sl)	2004-12-28	2005-12-28	Postopek priprave (1-hidroksi-2-(3-piridinil)etildien)bisfosfonske kisline in njenih hemi-pentahidrat mononatrijevih soli
EP05820284A EP1836210B1 (en)	2004-12-28	2005-12-28	Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethyliden]bisphosphonic acid and hemi-pentahydrate monosodium salt thereof
HR20080619T HRP20080619T3 (en)	2004-12-28	2005-12-28	Process for the preparation of [1-hydroxy-2-(3-pyridinyl)ethyliden]bisphosphonic acid and hemi-pentahydrate monosodium salt thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PL371958A PL199215B1 (pl)	2004-12-28	2004-12-28	Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej

Publications (2)

Publication Number	Publication Date
PL371958A1 true PL371958A1 (pl)	2006-07-10
PL199215B1 PL199215B1 (pl)	2008-08-29

Family

ID=35976399

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL371958A PL199215B1 (pl)	2004-12-28	2004-12-28	Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej

Country Status (11)

Country	Link
US (1)	US8450488B2 (pl)
EP (1)	EP1836210B1 (pl)
JP (1)	JP5015006B2 (pl)
KR (1)	KR100901183B1 (pl)
AT (1)	ATE413409T1 (pl)
DE (1)	DE602005010908D1 (pl)
ES (1)	ES2315937T3 (pl)
HR (1)	HRP20080619T3 (pl)
PL (1)	PL199215B1 (pl)
SI (1)	SI1836210T1 (pl)
WO (1)	WO2006071128A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
WO2007132478A2 (en)	2006-05-11	2007-11-22	Ind-Swift Laboratories Limited	Process for the preparation of pure risedronic acid or salts
CA2656053A1 (en) *	2006-07-03	2008-01-10	Generics [Uk] Limited	Novel process for the preparation of bisphosphonic acids
WO2008044245A2 (en) *	2006-10-10	2008-04-17	Matrix Laboratories Ltd	A process for the preparation of risedronate sodium hemipentahydrate
KR100775440B1 (ko) *	2006-12-20	2007-11-12	동우신테크 주식회사	리세드로네이트 나트륨 헤미펜타히드레이트의 제조방법
KR100798855B1 (ko)	2007-02-14	2008-01-28	주식회사 엔지켐	리세드론산 나트륨 헤미펜타하이드레이트의 제조방법
WO2009050731A2 (en) *	2007-06-20	2009-04-23	Alkem Laboratories Ltd	Novel process for preparing risedronic acid
PL213599B1 (pl) *	2008-10-31	2013-03-29	Politechnika Gdanska	Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
EP2470549B1 (en) *	2009-08-28	2014-07-16	Synthon B.V.	Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
HU230718B1 (hu) *	2011-02-08	2017-11-28	Richter Gedeon Nyrt.	Új eljárás dronsavak gyógyszeripari előállítására
CN107011380A (zh) *	2016-01-28	2017-08-04	臧伟	一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2684286A (en) *	1951-11-26	1954-07-20	Joseph L Krieger	Preparation of phosphorous acid
DE3016289A1 (de) *	1980-04-28	1981-10-29	Henkel KGaA, 4000 Düsseldorf	Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IL77243A (en)	1984-12-21	1996-11-14	Procter & Gamble	Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
SU1719405A1 (ru) *	1985-07-02	1992-03-15	Институт Химической Кинетики И Горения Со Ан Ссср	Способ получени высших 1-оксиалкилиден-1,1-дифосфоновых кислот или их смесей, или солей
DE19855333A1 (de) *	1998-12-01	2000-06-08	Bayer Ag	Phosphonhaltige Mischungen
JP2000281690A (ja) *	1999-03-30	2000-10-10	Yokkaichi Chem Co Ltd	エタン−１−ヒドロキシ−１，１−ジホスホン酸の製造方法
US6410520B2 (en) *	2000-02-01	2002-06-25	The Procter & Gamble Company	Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) *	2000-02-01	2003-05-13	The Procter & Gamble Company	Process for making geminal bisphosphonates
DE10107990A1 (de)	2001-02-19	2002-08-29	Weinmann G Geraete Med	Verfahren und Vorrichtung zur Schalldämmung bei Beatmungsgeräten
PL194770B1 (pl)	2001-03-19	2007-07-31	Adamed Sp Z Oo	Sposób wytwarzania kwasu rizedronowego
US20030195170A1 (en) *	2002-04-11	2003-10-16	Judith Aronhime	Novel polymorphs and pseudopolymorphs of risedronate sodium
ITMI20020908A1 (it) *	2002-04-29	2003-10-29	Chemi Spa	Processo di preparazione di sodio alendronato
AU2003233569A1 (en) *	2002-05-17	2003-12-02	Teva Pharmaceutical Industries Ltd.	Use of certain diluents for making bisphosphonic acids
ATE508134T1 (de) *	2003-12-23	2011-05-15	Alchymars S P A	Amorphe form das natriumsalzes der ibandronsäure

2004
- 2004-12-28 PL PL371958A patent/PL199215B1/pl unknown
2005
- 2005-12-28 US US11/721,334 patent/US8450488B2/en not_active Expired - Fee Related
- 2005-12-28 WO PCT/PL2005/000085 patent/WO2006071128A1/en not_active Ceased
- 2005-12-28 HR HR20080619T patent/HRP20080619T3/xx unknown
- 2005-12-28 KR KR1020077014055A patent/KR100901183B1/ko not_active Expired - Lifetime
- 2005-12-28 ES ES05820284T patent/ES2315937T3/es not_active Expired - Lifetime
- 2005-12-28 AT AT05820284T patent/ATE413409T1/de not_active IP Right Cessation
- 2005-12-28 EP EP05820284A patent/EP1836210B1/en not_active Expired - Lifetime
- 2005-12-28 SI SI200530484T patent/SI1836210T1/sl unknown
- 2005-12-28 DE DE602005010908T patent/DE602005010908D1/de not_active Expired - Lifetime
- 2005-12-28 JP JP2007548122A patent/JP5015006B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HRP20080619T3 (en)	2009-01-31
KR100901183B1 (ko)	2009-06-04
JP2008525432A (ja)	2008-07-17
WO2006071128A1 (en)	2006-07-06
US20090281320A1 (en)	2009-11-12
PL199215B1 (pl)	2008-08-29
EP1836210A1 (en)	2007-09-26
DE602005010908D1 (de)	2008-12-18
ATE413409T1 (de)	2008-11-15
ES2315937T3 (es)	2009-04-01
JP5015006B2 (ja)	2012-08-29
EP1836210B1 (en)	2008-11-05
KR20070086490A (ko)	2007-08-27
US8450488B2 (en)	2013-05-28
SI1836210T1 (sl)	2009-02-28

Publication	Publication Date	Title
CA2536229C (en)	2012-09-25	A process for preparation of bisphosphonic acid compounds
PL371958A1 (pl)	2006-07-10	Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
IL182690A0 (en)	2007-09-20	Process for the preparation of ibandronate
CY1121703T1 (el)	2020-07-31	Ιατρικη χρηση του πολυμορφου a toy ibanδρονικου
ATE508134T1 (de)	2011-05-15	Amorphe form das natriumsalzes der ibandronsäure
TW200640940A (en)	2006-12-01	Ibandronate polymorph B
ES2153794A1 (es)	2001-03-01	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
WO2008051584A3 (en)	2008-08-14	Process for the preparation of highly purified, dialkydithiophosphinic compounds
WO2007013097A8 (en)	2007-12-06	Improved process for the preparation of ibandronate sodium
WO2007132478A3 (en)	2009-06-04	Process for the preparation of pure risedronic acid or salts
SE9903345D0 (sv)	1999-09-17	Novel process
PT1803727E (pt)	2009-06-15	Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais