PL372302A1 - Sposób wytwarzania pochodnych indolinonu - Google Patents

Sposób wytwarzania pochodnych indolinonu

Info

Publication number
PL372302A1
PL372302A1 PL03372302A PL37230203A PL372302A1 PL 372302 A1 PL372302 A1 PL 372302A1 PL 03372302 A PL03372302 A PL 03372302A PL 37230203 A PL37230203 A PL 37230203A PL 372302 A1 PL372302 A1 PL 372302A1
Authority
PL
Poland
Prior art keywords
indolinone derivatives
preparing
preparing indolinone
derivatives
indolinone
Prior art date
Application number
PL03372302A
Other languages
English (en)
Inventor
Qingwu Jin
Michael A. Mauragis
Paul D. May
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/004407 external-priority patent/WO2002066463A1/en
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of PL372302A1 publication Critical patent/PL372302A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PL03372302A 2002-02-15 2003-02-14 Sposób wytwarzania pochodnych indolinonu PL372302A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2002/004407 WO2002066463A1 (en) 2001-02-15 2002-02-15 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US41173202P 2002-09-18 2002-09-18

Publications (1)

Publication Number Publication Date
PL372302A1 true PL372302A1 (pl) 2005-07-11

Family

ID=33029733

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03372302A PL372302A1 (pl) 2002-02-15 2003-02-14 Sposób wytwarzania pochodnych indolinonu

Country Status (15)

Country Link
US (2) US7119209B2 (pl)
EP (1) EP1476443A2 (pl)
JP (1) JP2005528344A (pl)
KR (1) KR100657110B1 (pl)
CN (1) CN1308326C (pl)
AR (1) AR041247A1 (pl)
AU (1) AU2003216282A1 (pl)
BR (1) BR0307721A (pl)
CA (1) CA2475455A1 (pl)
MX (1) MXPA04006992A (pl)
PL (1) PL372302A1 (pl)
RS (1) RS70904A (pl)
RU (1) RU2299209C2 (pl)
TW (1) TWI289560B (pl)
WO (1) WO2003070725A2 (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
BR0307721A (pt) * 2002-02-15 2005-01-25 Upjohn Co Processo para preparação de derivados de indolinona
US7452913B2 (en) * 2003-02-24 2008-11-18 Pharmacia & Upjohn Company Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
WO2005023765A1 (en) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Method for catalyzing amidation reactions by the presence of co2
KR20060058728A (ko) * 2003-10-02 2006-05-30 파마시아 앤드 업존 캄파니 엘엘씨 피롤-치환된 인돌리논 화합물의 염 및 다형체
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
AU2006249790A1 (en) * 2005-05-26 2006-11-30 The Scripps Research Institute Enhanced indolinone based protein kinase inhibitors
NZ566033A (en) * 2005-09-19 2011-04-29 Pfizer Prod Inc Solid salt forms of a pyrrole substituted 2-indolinone
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
EP2253629A1 (en) 2007-11-21 2010-11-24 Teva Pharmaceutical Industries Ltd. Polymorphs of racemic sunitinib malate, compositions containing them and preparation thereof
US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2098521A1 (en) * 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
EP2274303B1 (en) * 2008-03-31 2012-08-29 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
US8466190B2 (en) 2008-04-16 2013-06-18 Natco Pharma Limited Polymorphic forms of Sunitinib base
US8501962B2 (en) 2008-06-23 2013-08-06 Natco Pharma Limited Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
WO2009156837A2 (en) * 2008-06-26 2009-12-30 Medichem, S.A. Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
US8618309B2 (en) * 2008-07-24 2013-12-31 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
EP2315764A2 (en) * 2008-08-25 2011-05-04 Generics [UK] Limited Crystalline form of sunitinib and processes for its preparation
EP2318393A1 (en) * 2008-08-25 2011-05-11 Generics [UK] Limited Novel polymorphs of sunitinib and processes for their preparation
WO2011004200A1 (en) 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
WO2011110199A1 (en) 2010-03-10 2011-09-15 Synthon B.V. A process for amidation of pyrrole carboxylate compounds
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
CA2816559C (en) 2010-11-01 2018-02-13 Scinopharm (Kunshan) Biochemical Technology Co., Ltd. Processes for the preparation of 3-((pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
WO2012139019A2 (en) * 2011-04-08 2012-10-11 Beta Pharma, Inc. New indolinone protein kinase inhibitors
CA2871711A1 (en) 2012-05-04 2013-11-07 Pfizer Inc. Prostate-associated antigens and vaccine-based immunotherapy regimens
CA2928908C (en) 2013-11-01 2021-01-12 Pfizer Inc. Vectors for expression of prostate-associated antigens
CN104744442B (zh) * 2013-12-25 2019-05-28 江苏豪森药业集团有限公司 苹果酸舒尼替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
US6316635B1 (en) * 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JP4713698B2 (ja) * 1997-03-05 2011-06-29 スージェン， インク． 疎水性薬剤の処方
US6316429B1 (en) * 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6133305A (en) * 1997-09-26 2000-10-17 Sugen, Inc. 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
WO1999048868A2 (en) 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
PT1255536E (pt) 1999-12-22 2006-09-29 Sugen Inc Derivados de indolinona para a modulacao da tirosina proteina cinase de tipo c-kit
DE122008000002I1 (de) * 2000-02-15 2008-04-17 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
JP3558016B2 (ja) * 2000-07-19 2004-08-25 トヨタ自動車株式会社 燃焼式ヒータを有する内燃機関
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
BR0307721A (pt) * 2002-02-15 2005-01-25 Upjohn Co Processo para preparação de derivados de indolinona

Also Published As

Publication number Publication date
US20030229229A1 (en) 2003-12-11
AR041247A1 (es) 2005-05-11
WO2003070725A2 (en) 2003-08-28
CA2475455A1 (en) 2003-08-28
RU2299209C2 (ru) 2007-05-20
BR0307721A (pt) 2005-01-25
KR100657110B1 (ko) 2006-12-12
TW200410958A (en) 2004-07-01
KR20040081203A (ko) 2004-09-20
CN1671693A (zh) 2005-09-21
CN1308326C (zh) 2007-04-04
RU2004124711A (ru) 2006-01-20
MXPA04006992A (es) 2004-11-10
WO2003070725A3 (en) 2004-01-15
US7119209B2 (en) 2006-10-10
AU2003216282A1 (en) 2003-09-09
RS70904A (sr) 2006-10-27
HK1078075A1 (en) 2006-03-03
JP2005528344A (ja) 2005-09-22
TWI289560B (en) 2007-11-11
EP1476443A2 (en) 2004-11-17
US20050171357A1 (en) 2005-08-04

Similar Documents

Publication Publication Date Title
PL372302A1 (pl) Sposób wytwarzania pochodnych indolinonu
IL195011A0 (en) Process for preparing piperidine derivatives
IL165985A0 (en) Process for preparing pyrrolotriazine derivatives
IL183568A (en) Process for making 7,8-dihydro-5 h-patridine-6-onh
PT1720832E (pt) Processo de preparação de derivados de 4-cetoprolina n-protegidos
EP1467758A4 (en) PREPARATION OF IMMUNOCONJUGATES
IL178233A0 (en) Process for producing 5-hydroxy-4-thiomethylpyrazole derivatives
IL174029A0 (en) Process for preparing 2-oxo-1-pyrrolidine derivatives
IL169879A0 (en) Process for preparing pyrrolotriazine derivatives
AU2003261774A1 (en) PROCESS FOR PRODUCING L-Alpha-METHYLCYSTEINE DERIVATIVE
SG137677A1 (en) Improved process for preparing polyalkenylsuccinimides
SI1575941T1 (sl) Postopek za pripravo (S)-pantoprazola
SG115596A1 (en) Process for preparing tert-butanol
IL172444A0 (en) Process for preparing 3-acylaminobenzofuran-2-carboxylic acid derivative
AU2003218704A8 (en) Process for preparing 2-aminoindan derivatives
AU2003262383A8 (en) Process for preparing gabapentin
EP1507781A4 (en) METHOD OF PREPARING MAYTANSINOL
IL165137A0 (en) Process for the preparation of thioalkylamine derivatives
AU2003260942A8 (en) A process for the preparation of oxindole derivatives
IL178069A0 (en) Process for preparing n-aryl-piperazine derivatives
MY136467A (en) Process for preparing (3-oxo-2,3-dihydro-1h-isoindol-1-yl)acetylguanidine derivatives
IL166793A0 (en) Process for producing indolopyrrolocarbazole derivative
IL166374A0 (en) Novel process for producing imidazoÄ1,2-bÜpyridazine derivative
AU2003222342A8 (en) Method for preparing $g(v)-bromoalkylcarboxylic compounds
IL166514A0 (en) A process for preparing hydroxyazapirone derivatives

Legal Events

Date Code Title Description
REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)