PL372302A1 - Sposób wytwarzania pochodnych indolinonu - Google Patents

Sposób wytwarzania pochodnych indolinonu

Info

Publication number
PL372302A1
PL372302A1 PL03372302A PL37230203A PL372302A1 PL 372302 A1 PL372302 A1 PL 372302A1 PL 03372302 A PL03372302 A PL 03372302A PL 37230203 A PL37230203 A PL 37230203A PL 372302 A1 PL372302 A1 PL 372302A1
Authority
PL
Poland
Prior art keywords
indolinone derivatives
preparing
preparing indolinone
derivatives
indolinone
Prior art date
Application number
PL03372302A
Other languages
English (en)
Inventor
Qingwu Jin
Michael A. Mauragis
Paul D. May
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/004407 external-priority patent/WO2002066463A1/en
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of PL372302A1 publication Critical patent/PL372302A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
PL03372302A 2002-02-15 2003-02-14 Sposób wytwarzania pochodnych indolinonu PL372302A1 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2002/004407 WO2002066463A1 (en) 2001-02-15 2002-02-15 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US41173202P 2002-09-18 2002-09-18

Publications (1)

Publication Number Publication Date
PL372302A1 true PL372302A1 (pl) 2005-07-11

Family

ID=33029733

Family Applications (1)

Application Number Title Priority Date Filing Date
PL03372302A PL372302A1 (pl) 2002-02-15 2003-02-14 Sposób wytwarzania pochodnych indolinonu

Country Status (15)

Country Link
US (2) US7119209B2 (pl)
EP (1) EP1476443A2 (pl)
JP (1) JP2005528344A (pl)
KR (1) KR100657110B1 (pl)
CN (1) CN1308326C (pl)
AR (1) AR041247A1 (pl)
AU (1) AU2003216282A1 (pl)
BR (1) BR0307721A (pl)
CA (1) CA2475455A1 (pl)
MX (1) MXPA04006992A (pl)
PL (1) PL372302A1 (pl)
RS (1) RS70904A (pl)
RU (1) RU2299209C2 (pl)
TW (1) TWI289560B (pl)
WO (1) WO2003070725A2 (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
US7119209B2 (en) * 2002-02-15 2006-10-10 Pharmacia & Upjohn Company Process for preparing indolinone derivatives
US7452913B2 (en) * 2003-02-24 2008-11-18 Pharmacia & Upjohn Company Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
WO2005023765A1 (en) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Method for catalyzing amidation reactions by the presence of co2
NZ546001A (en) * 2003-10-02 2009-09-25 Pharmacia & Upjohn Co Llc Salts and polymorphs of a pyrrole-substituted indolinone compound
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
EP1893194A4 (en) * 2005-05-26 2009-07-01 Scripps Research Inst IMPROVED PROTEIN KINASE HEMMER ON INDOLINON BASE
KR101050906B1 (ko) 2005-09-19 2011-07-20 화이자 프로덕츠 인크. 피롤 치환된 2-인돌리논의 고체 염 형태
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2220071A2 (en) * 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof
EP2098521A1 (en) * 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
WO2009124037A1 (en) * 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
WO2009128083A1 (en) * 2008-04-16 2009-10-22 Natco Pharma Limited Novel polymorphic forms of sunitinib base
CA2724310A1 (en) 2008-06-23 2009-12-30 Natco Pharma Limited Process for the preparation of high purity sunitinib and its pharmaceutically acceptable salt
WO2009156837A2 (en) * 2008-06-26 2009-12-30 Medichem, S.A. Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
CA2731605A1 (en) * 2008-07-24 2010-01-28 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
JP2012500837A (ja) * 2008-08-25 2012-01-12 ジェネリクス・（ユーケー）・リミテッド 新規な結晶型およびその調製方法
CN102197034A (zh) * 2008-08-25 2011-09-21 基因里克斯(英国)有限公司 舒尼替尼的新型多晶型物及其制备方法
WO2011004200A1 (en) 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
EP2545034A1 (en) 2010-03-10 2013-01-16 Synthon B.V. A process for amidation of pyrrole carboxylate compounds
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
CA2816559C (en) 2010-11-01 2018-02-13 Scinopharm (Kunshan) Biochemical Technology Co., Ltd. Processes for the preparation of 3-((pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
MX2013011481A (es) * 2011-04-08 2014-02-17 Beta Pharma Inc Nuevos inhibidores de cinasa de proteina de indolinona.
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
WO2015063647A1 (en) 2013-11-01 2015-05-07 Pfizer Inc. Vectors for expression of prostate-associated antigens
CN104744442B (zh) * 2013-12-25 2019-05-28 江苏豪森药业集团有限公司 苹果酸舒尼替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
AU743024B2 (en) 1997-03-05 2002-01-17 Sugen, Inc. Formulations for hydrophobic pharmaceutical agents
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6133305A (en) 1997-09-26 2000-10-17 Sugen, Inc. 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
WO1999048868A2 (en) 1998-03-26 1999-09-30 Sugen, Inc. Heterocyclic classes of compounds for the modulating tyrosine protein kinase
ATE331514T1 (de) 1999-12-22 2006-07-15 Sugen Inc Indolinonderivate zur abänderung der c-kit tyrosinproteinkinase
JP3663382B2 (ja) * 2000-02-15 2005-06-22 スージェン・インコーポレーテッド ピロール置換２−インドリノン蛋白質キナーゼ阻害剤
JP3558016B2 (ja) * 2000-07-19 2004-08-25 トヨタ自動車株式会社 燃焼式ヒータを有する内燃機関
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI259081B (en) * 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
US7119209B2 (en) * 2002-02-15 2006-10-10 Pharmacia & Upjohn Company Process for preparing indolinone derivatives

Also Published As

Publication number Publication date
WO2003070725A3 (en) 2004-01-15
RS70904A (sr) 2006-10-27
JP2005528344A (ja) 2005-09-22
CN1308326C (zh) 2007-04-04
TWI289560B (en) 2007-11-11
HK1078075A1 (en) 2006-03-03
EP1476443A2 (en) 2004-11-17
TW200410958A (en) 2004-07-01
CA2475455A1 (en) 2003-08-28
US7119209B2 (en) 2006-10-10
US20050171357A1 (en) 2005-08-04
CN1671693A (zh) 2005-09-21
AU2003216282A1 (en) 2003-09-09
BR0307721A (pt) 2005-01-25
RU2004124711A (ru) 2006-01-20
RU2299209C2 (ru) 2007-05-20
KR20040081203A (ko) 2004-09-20
KR100657110B1 (ko) 2006-12-12
AR041247A1 (es) 2005-05-11
US20030229229A1 (en) 2003-12-11
MXPA04006992A (es) 2004-11-10
WO2003070725A2 (en) 2003-08-28

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Legal Events

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REFS Decisions on refusal to grant patents (taken after the publication of the particulars of the applications)