BR0307721A - Processo para preparação de derivados de indolinona - Google Patents

Processo para preparação de derivados de indolinona

Info

Publication number
BR0307721A
BR0307721A BR0307721-7A BR0307721A BR0307721A BR 0307721 A BR0307721 A BR 0307721A BR 0307721 A BR0307721 A BR 0307721A BR 0307721 A BR0307721 A BR 0307721A
Authority
BR
Brazil
Prior art keywords
indolinone derivatives
preparing
preparing indolinone
derivatives
intermediates
Prior art date
Application number
BR0307721-7A
Other languages
English (en)
Inventor
Qingwu Jin
Michael A Mauragis
Paul D May
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2002/004407 external-priority patent/WO2002066463A1/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of BR0307721A publication Critical patent/BR0307721A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE DERIVADOS DE INDOLINONA". A presente invenção refere-se a um processo para preparação de derivados de indolinona da fórmula geral (VI) como definida no relatório descritivo e intermediários daquele processo.
BR0307721-7A 2002-02-15 2003-02-14 Processo para preparação de derivados de indolinona BR0307721A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2002/004407 WO2002066463A1 (en) 2001-02-15 2002-02-15 3-(4-amidopyrrol-2-ylmethlidene)-2-indolinone derivatives as protein kinase inhibitors
US41173202P 2002-09-18 2002-09-18
PCT/US2003/004520 WO2003070725A2 (en) 2002-02-15 2003-02-14 Process for preparing indolinone derivatives

Publications (1)

Publication Number Publication Date
BR0307721A true BR0307721A (pt) 2005-01-25

Family

ID=33029733

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307721-7A BR0307721A (pt) 2002-02-15 2003-02-14 Processo para preparação de derivados de indolinona

Country Status (15)

Country Link
US (2) US7119209B2 (pt)
EP (1) EP1476443A2 (pt)
JP (1) JP2005528344A (pt)
KR (1) KR100657110B1 (pt)
CN (1) CN1308326C (pt)
AR (1) AR041247A1 (pt)
AU (1) AU2003216282A1 (pt)
BR (1) BR0307721A (pt)
CA (1) CA2475455A1 (pt)
MX (1) MXPA04006992A (pt)
PL (1) PL372302A1 (pt)
RS (1) RS70904A (pt)
RU (1) RU2299209C2 (pt)
TW (1) TWI289560B (pt)
WO (1) WO2003070725A2 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP1476443A2 (en) * 2002-02-15 2004-11-17 PHARMACIA & UPJOHN COMPANY Process for preparing indolinone derivatives
US7452913B2 (en) * 2003-02-24 2008-11-18 Pharmacia & Upjohn Company Polymorphs of pyrrole substituted 2-indolinone protein kinase inhibitors
WO2005023765A1 (en) * 2003-09-11 2005-03-17 Pharmacia & Upjohn Company Llc Method for catalyzing amidation reactions by the presence of co2
EP1670785B1 (en) * 2003-10-02 2010-07-07 Pharmacia & Upjohn Company LLC Salts and polymorphs of a pyrrole-substituted indolinone compound
US20060009510A1 (en) * 2004-07-09 2006-01-12 Pharmacia & Upjohn Company Llc Method of synthesizing indolinone compounds
CA2610067A1 (en) * 2005-05-26 2006-11-30 The Scripps Research Institute Enhanced indolinone based protein kinase inhibitors
NZ566033A (en) 2005-09-19 2011-04-29 Pfizer Prod Inc Solid salt forms of a pyrrole substituted 2-indolinone
US20090004213A1 (en) * 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
US20100256392A1 (en) * 2007-11-21 2010-10-07 Teva Pharmaceutical Industries Ltd. Polymorphs of sunitinib base and processes for preparation thereof
EP2220071A2 (en) 2007-11-21 2010-08-25 Teva Pharmaceutical Industries Ltd. Sunitinib hemi-l-malate, polymorphs and preparation thereof, polymorphs of racemic sunitinib malate, compositins containing sunitinib base and malic acid and preparation thereof
EP2098521A1 (en) * 2008-03-06 2009-09-09 Ratiopharm GmbH Crystal forms of N-[2-(diethylamino) ethyl]-5-[fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrolle-3-carboxamide and methods for their prepparation
CA2720164A1 (en) * 2008-03-31 2009-10-08 Teva Pharmaceutical Industries Ltd. Processes for preparing sunitinib and salts thereof
KR20100135910A (ko) 2008-04-16 2010-12-27 낫코 파마 리미티드 수니티닙 염기의 신규한 다형 형태
KR20110036055A (ko) 2008-06-23 2011-04-06 낫코 파마 리미티드 고순도의 수니티닙 및 이의 약학적으로 허용가능한 염의 개선된 제조 방법
WO2009156837A2 (en) * 2008-06-26 2009-12-30 Medichem, S.A. Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
WO2010011834A2 (en) * 2008-07-24 2010-01-28 Teva Pharmaceutical Industries Ltd. Sunitinib and salts thereof and their polymorphs
CN102197035A (zh) * 2008-08-25 2011-09-21 基因里克斯(英国)有限公司 舒尼替尼的结晶形式及其制备方法
CA2735084A1 (en) * 2008-08-25 2010-03-04 Generics [Uk] Limited Novel polymorphs of sunitinib and processes for their preparation
WO2011004200A1 (en) 2009-07-10 2011-01-13 Generics [Uk] Limited Novel pyrrole derivatives
WO2011104555A2 (en) 2010-02-25 2011-09-01 Generics [Uk] Limited Novel process
WO2011110199A1 (en) 2010-03-10 2011-09-15 Synthon B.V. A process for amidation of pyrrole carboxylate compounds
WO2011128699A2 (en) 2010-04-16 2011-10-20 Generics [Uk] Limited Novel process
WO2012042421A1 (en) 2010-09-29 2012-04-05 Pfizer Inc. Method of treating abnormal cell growth
WO2012058780A1 (en) 2010-11-01 2012-05-10 Scinopharm (Kunshan) Biochemical Technology Co., Ltd. Processes for the preparation of 3-(pyrrol-2-yl)methylene)-2-pyrrolones using 2-silyloxy-pyrroles
SG193527A1 (en) 2011-04-08 2013-10-30 Beta Pharma Inc New indolinone protein kinase inhibitors
AU2013255511B2 (en) 2012-05-04 2016-01-28 Pfizer Inc. Prostate-associated antigens and vaccine-based immunotherapy regimens
JP2016535989A (ja) 2013-11-01 2016-11-24 ファイザー・インク 前立腺関連抗原を発現させるためのベクター
CN104744442B (zh) * 2013-12-25 2019-05-28 江苏豪森药业集团有限公司 苹果酸舒尼替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1575936A3 (ru) * 1986-04-10 1990-06-30 Е.И.Дюпон Де Немур Энд Ко.(Фирма) Способ получени 3,3-дизамещенных индолин-2-ионов или их солей
US6316635B1 (en) 1995-06-07 2001-11-13 Sugen, Inc. 2-indolinone derivatives as modulators of protein kinase activity
JP4713698B2 (ja) 1997-03-05 2011-06-29 スージェン， インク． 疎水性薬剤の処方
US6316429B1 (en) 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
US6133305A (en) 1997-09-26 2000-10-17 Sugen, Inc. 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity
EP1066257A2 (en) 1998-03-26 2001-01-10 Sugen, Inc. Heterocylic classes of compounds for the modulating tyrosine protein kinase
EP1255536B1 (en) 1999-12-22 2006-06-28 Sugen, Inc. Indolinone derivatives for modulation of c-kit tyrosine protein kinase
SI1255752T1 (sl) 2000-02-15 2007-12-31 Pharmacia & Upjohn Co Llc S pirolom substituirani zaviralci 2-indolinon protein kinaza
JP3558016B2 (ja) * 2000-07-19 2004-08-25 トヨタ自動車株式会社 燃焼式ヒータを有する内燃機関
AR042586A1 (es) * 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
TWI259081B (en) 2001-10-26 2006-08-01 Sugen Inc Treatment of acute myeloid leukemia with indolinone compounds
EP1476443A2 (en) * 2002-02-15 2004-11-17 PHARMACIA & UPJOHN COMPANY Process for preparing indolinone derivatives

Also Published As

Publication number Publication date
MXPA04006992A (es) 2004-11-10
US20050171357A1 (en) 2005-08-04
RS70904A (sr) 2006-10-27
TW200410958A (en) 2004-07-01
KR100657110B1 (ko) 2006-12-12
RU2299209C2 (ru) 2007-05-20
US7119209B2 (en) 2006-10-10
CN1308326C (zh) 2007-04-04
KR20040081203A (ko) 2004-09-20
US20030229229A1 (en) 2003-12-11
RU2004124711A (ru) 2006-01-20
CN1671693A (zh) 2005-09-21
AR041247A1 (es) 2005-05-11
AU2003216282A1 (en) 2003-09-09
WO2003070725A3 (en) 2004-01-15
WO2003070725A2 (en) 2003-08-28
EP1476443A2 (en) 2004-11-17
PL372302A1 (en) 2005-07-11
TWI289560B (en) 2007-11-11
CA2475455A1 (en) 2003-08-28
JP2005528344A (ja) 2005-09-22
HK1078075A1 (en) 2006-03-03

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2116 DE 26/07/2011.