PL372324A1 - Kompozycje farmaceutyczne rozpuszczalnych w wodzie proleków propofolu - Google Patents

Kompozycje farmaceutyczne rozpuszczalnych w wodzie proleków propofolu

Info

Publication number: PL372324A1
Authority: PL; Poland
Prior art keywords: formulations; propofol; water; aqueous based; pharmaceutical formulations
Prior art date: 2001-12-28

Application number

PL02372324A

Other languages

English (en)

Other versions

PL205271B1 (pl

Inventor

Tracey L. Rogers

Jeffrey A. Williamson

Christopher A. Rhodes

Original Assignee

Guilford Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-28

Filing date

2002-12-26

Publication date

2005-07-11

2002-12-26 Application filed by Guilford Pharmaceuticals, Inc. filed Critical Guilford Pharmaceuticals, Inc.

2005-07-11 Publication of PL372324A1 publication Critical patent/PL372324A1/pl

2010-03-31 Publication of PL205271B1 publication Critical patent/PL205271B1/pl

Links

239000000651 prodrug Substances 0.000 title abstract 4
229940002612 prodrug Drugs 0.000 title abstract 4
OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title abstract 3
229960004134 propofol Drugs 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title 1
238000009472 formulation Methods 0.000 abstract 6
239000000203 mixture Substances 0.000 abstract 6
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
238000010253 intravenous injection Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
239000008181 tonicity modifier Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Anesthesiology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

PL372324A 2001-12-28 2002-12-26 Kompozycja farmaceutyczna rozpuszczalnego w wodzie proleku propofolu PL205271B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34275501P	2001-12-28	2001-12-28

Publications (2)

Publication Number	Publication Date
PL372324A1 true PL372324A1 (pl)	2005-07-11
PL205271B1 PL205271B1 (pl)	2010-03-31

Family

ID=23343142

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL372324A PL205271B1 (pl)	2001-12-28	2002-12-26	Kompozycja farmaceutyczna rozpuszczalnego w wodzie proleku propofolu

Country Status (21)

Country	Link
US (1)	US20050042280A1 (pl)
EP (1)	EP1458355B1 (pl)
JP (2)	JP2005517679A (pl)
KR (2)	KR20040080444A (pl)
CN (1)	CN1329036C (pl)
AT (1)	ATE430571T1 (pl)
AU (1)	AU2002364238B2 (pl)
BR (1)	BR0215303A (pl)
CA (1)	CA2470500C (pl)
DE (1)	DE60232271D1 (pl)
ES (1)	ES2325918T3 (pl)
HU (1)	HU229293B1 (pl)
IL (3)	IL162692A0 (pl)
MX (1)	MXPA04006325A (pl)
NO (1)	NO334424B1 (pl)
NZ (1)	NZ533536A (pl)
PL (1)	PL205271B1 (pl)
RU (1)	RU2316317C2 (pl)
UA (1)	UA76802C2 (pl)
WO (1)	WO2003057153A2 (pl)
ZA (1)	ZA200404616B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005044201A2 (en) *	2003-10-24	2005-05-19	Auspex Pharmaceuticals, Inc.	Ph sensitive prodrugs of 2,6-diisopropylphenol
US7589239B2 (en)	2005-09-02	2009-09-15	Auspex Pharmaceuticals	Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
EP2068630A4 (en) *	2006-10-05	2010-12-29	Eisai Inc	AQUEOUS PHARMACEUTICAL FORMULATIONS OF WATER SOLUBLE PRODRUGS OF PROPOFOL
CA2685813A1 (en)	2007-05-09	2008-11-20	Pharmacofore, Inc.	Therapeutic compounds
EP2810927A1 (en)	2007-05-09	2014-12-10	Sowood Healthcare LLC	Therapeutic compounds
US20090098209A1 (en) *	2007-10-15	2009-04-16	University Of Kansas	Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration
GB0905834D0 (en)	2009-04-03	2009-05-20	Seps Pharma Nv	Phosphonyl-containing phenolic derivatives useful as medicaments
UY34072A (es)	2011-05-17	2013-01-03	Novartis Ag	Derivados sustituidos de indol
CN110063947A (zh) *	2018-01-24	2019-07-30	四川海思科制药有限公司	苯酚衍生物用于制备麻醉药物中的用途
US11439653B1 (en)	2021-03-30	2022-09-13	Epalex Corporation	Fospropofol formulations
US11547714B2 (en)	2020-02-05	2023-01-10	Epalex Corporation	Fospropofol salts, methods and compositions
US11628178B2 (en)	2019-03-26	2023-04-18	Epalex Corporation	Fospropofol methods and compositions
US11478490B1 (en)	2021-03-30	2022-10-25	Epalex Corporation	Fospropofol formulations
JP7608179B2 (ja) *	2021-01-12	2025-01-06	日本光電工業株式会社	生体情報処理装置、生体情報処理方法、プログラム及び記憶媒体
CN114129578A (zh) *	2021-09-28	2022-03-04	瑞普（天津）生物药业有限公司	甲磷丙泊酚钠在制备宠物麻醉、镇静药物中的应用

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US2829151A (en) *	1952-11-03	1958-04-01	Dow Chemical Co	Chlorotoloxy-ethyl phosphates
US3271314A (en) *	1958-12-04	1966-09-06	Ethyl Corp	2, 6-diisopropylphenol
GB1146173A (en) *	1966-06-18	1969-03-19	Geigy Uk Ltd	Production of triaryl phosphates
US3723578A (en) *	1970-10-13	1973-03-27	Gaf Corp	Phosphate esters of ethers of thiol substituted phenols
GB1472793A (en) *	1974-03-28	1977-05-04	Ici Ltd	Pharmaceutical compositions
US4171272A (en) *	1977-12-02	1979-10-16	Fmc Corporation	Turbine lubricant
FR2601259B1 (fr) *	1986-07-11	1990-06-22	Rhone Poulenc Chimie	Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
MY103951A (en) *	1988-01-12	1993-10-30	Kao Corp	Detergent composition
US5091211A (en) *	1989-08-17	1992-02-25	Lord Corporation	Coating method utilizing phosphoric acid esters
ES2076263T3 (es) *	1989-08-21	1995-11-01	American Cyanamid Co	Formulacion farmaceutica inyectable estable, para acido folico y sales de leucovorina y procedimiento.
US5110503A (en) *	1990-05-15	1992-05-05	Elliot Cohen	Demulsifying
ES2088435T3 (es) *	1990-10-17	1996-08-16	Tomen Corp	Procedimiento y composicion para mejorar la absorcion y transporte de agentes bioactivos en plantas.
CA2151515A1 (en) *	1992-12-11	1994-06-23	Mervyn Thompson	Bicyclic compounds with pharmaceutical activity
US5646176A (en) *	1992-12-24	1997-07-08	Bristol-Myers Squibb Company	Phosphonooxymethyl ethers of taxane derivatives
KR960008645B1 (ko) *	1993-09-08	1996-06-28	동국제약 주식회사	오르토-이소프로필화 페놀 유도체의 제조방법
US5731355A (en) *	1994-03-22	1998-03-24	Zeneca Limited	Pharmaceutical compositions of propofol and edetate
GB9405593D0 (en) *	1994-03-22	1994-05-11	Zeneca Ltd	Pharmaceutical compositions
IT1270093B (it) *	1994-09-28	1997-04-28	Zambon Spa	Processo per la purificazione di 2,6-diisopropilfenolo
US5804682A (en) *	1995-11-29	1998-09-08	Henkel Corporation	Aqueous dispersions of polyamides
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US6204257B1 (en) *	1998-08-07	2001-03-20	Universtiy Of Kansas	Water soluble prodrugs of hindered alcohols
US6177477B1 (en) *	1999-03-24	2001-01-23	American Home Products Corporation	Propofol formulation containing TRIS
CZ20022654A3 (cs) *	2000-02-04	2003-01-15	Eli Lilly And Company	Farmaceutická kompozice, obsahující Pemetrexed společně s monothioglycerolem, L-cysteinem nebo kyselinou thioglykolovou
AU2001258592A1 (en) *	2000-05-25	2001-12-03	Astrazeneca Ab	Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent
IN187686B (pl) *	2000-06-21	2002-06-08	Bharat Serums & Vaccines Ltd
US6362234B1 (en) *	2000-08-15	2002-03-26	Vyrex Corporation	Water-soluble prodrugs of propofol for treatment of migrane
US7034013B2 (en) *	2001-03-20	2006-04-25	Cydex, Inc.	Formulations containing propofol and a sulfoalkyl ether cyclodextrin

2002
- 2002-12-26 KR KR10-2004-7009936A patent/KR20040080444A/ko not_active Ceased
- 2002-12-26 US US10/498,801 patent/US20050042280A1/en not_active Abandoned
- 2002-12-26 CA CA2470500A patent/CA2470500C/en not_active Expired - Fee Related
- 2002-12-26 DE DE60232271T patent/DE60232271D1/de not_active Expired - Lifetime
- 2002-12-26 ES ES02799315T patent/ES2325918T3/es not_active Expired - Lifetime
- 2002-12-26 BR BR0215303-3A patent/BR0215303A/pt active Search and Examination
- 2002-12-26 AU AU2002364238A patent/AU2002364238B2/en not_active Ceased
- 2002-12-26 HU HU0500439A patent/HU229293B1/hu not_active IP Right Cessation
- 2002-12-26 JP JP2003557512A patent/JP2005517679A/ja not_active Withdrawn
- 2002-12-26 MX MXPA04006325A patent/MXPA04006325A/es not_active Application Discontinuation
- 2002-12-26 CN CNB028259955A patent/CN1329036C/zh not_active Expired - Fee Related
- 2002-12-26 NZ NZ533536A patent/NZ533536A/en not_active IP Right Cessation
- 2002-12-26 EP EP02799315A patent/EP1458355B1/en not_active Expired - Lifetime
- 2002-12-26 KR KR1020107018913A patent/KR20100112632A/ko not_active Ceased
- 2002-12-26 IL IL16269202A patent/IL162692A0/xx active IP Right Grant
- 2002-12-26 PL PL372324A patent/PL205271B1/pl unknown
- 2002-12-26 WO PCT/US2002/041468 patent/WO2003057153A2/en not_active Ceased
- 2002-12-26 RU RU2004119056/15A patent/RU2316317C2/ru not_active IP Right Cessation
- 2002-12-26 AT AT02799315T patent/ATE430571T1/de not_active IP Right Cessation
- 2002-12-26 UA UA20040604686A patent/UA76802C2/uk unknown
2004
- 2004-06-10 ZA ZA2004/04616A patent/ZA200404616B/en unknown
- 2004-06-14 NO NO20042459A patent/NO334424B1/no not_active IP Right Cessation
- 2004-06-23 IL IL162692A patent/IL162692A/en not_active IP Right Cessation
2010
- 2010-06-23 JP JP2010142118A patent/JP2010235622A/ja active Pending
- 2010-10-14 IL IL208697A patent/IL208697A0/en unknown

Also Published As

Publication number	Publication date
ES2325918T3 (es)	2009-09-24
UA76802C2 (uk)	2006-09-15
JP2010235622A (ja)	2010-10-21
AU2002364238B2 (en)	2007-01-18
BR0215303A (pt)	2005-04-05
WO2003057153A2 (en)	2003-07-17
US20050042280A1 (en)	2005-02-24
EP1458355A4 (en)	2005-04-20
HU229293B1 (hu)	2013-10-28
IL162692A0 (en)	2005-11-20
EP1458355B1 (en)	2009-05-06
JP2005517679A (ja)	2005-06-16
ATE430571T1 (de)	2009-05-15
CA2470500C (en)	2012-05-15
DE60232271D1 (de)	2009-06-18
IL208697A0 (en)	2010-12-30
NZ533536A (en)	2006-11-30
IL162692A (en)	2011-03-31
NO20042459L (no)	2004-08-25
HUP0500439A2 (hu)	2005-08-29
AU2002364238A1 (en)	2003-07-24
CA2470500A1 (en)	2003-07-17
ZA200404616B (en)	2005-10-26
KR20040080444A (ko)	2004-09-18
CN1607938A (zh)	2005-04-20
RU2316317C2 (ru)	2008-02-10
HK1069976A1 (en)	2005-06-10
MXPA04006325A (es)	2005-03-31
EP1458355A2 (en)	2004-09-22
RU2004119056A (ru)	2005-04-20
WO2003057153A3 (en)	2004-01-29
KR20100112632A (ko)	2010-10-19
NO334424B1 (no)	2014-03-03
PL205271B1 (pl)	2010-03-31
CN1329036C (zh)	2007-08-01

Publication	Publication Date	Title
IL208697A0 (en)	2010-12-30	Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
TW200509983A (en)	2005-03-16	The dermal external agent for inhibiting or repairing the dermal damage due to drying
CY1108532T1 (el)	2014-04-09	Ενωσεις και συνθεσεις για την παροχη δραστικων παραγοντων
DE60236541D1 (de)	2010-07-08	Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
MXPA04001256A (es)	2004-05-27	Productos de combinacion de derivados de propanolamina aril substituidos con otros ingredientes activos y su uso.
AU1729600A (en)	2000-06-05	Formulation of adenovirus for gene therapy
PT1093819E (pt)	2006-09-29	Compostos e composicoes para fornecimento de agentes activos
NO20025590D0 (no)	2002-11-21	Fenylglycin-derivater
MXPA03007857A (es)	2004-05-24	Compuestos y composiciones para entregar agentes activos.
MXPA03011480A (es)	2004-03-18	Una preparacion farmaceutica acuosa de cilostazol para uso parenteral.
ATE409065T1 (de)	2008-10-15	Inhibitoren der 17 beta- hydroxysteroiddehydrogenase des typs 3 zur behandlung androgenabhängiger krankheiten
WO2008045189A3 (en)	2008-07-31	Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
MEP24008A (en)	2010-06-10	Esters of l-carnitine or alkanoyl l-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
AP2003002716A0 (en)	2003-06-30	Medicinal compositions containing propenone derivatives.
ATE367165T1 (de)	2007-08-15	Xanthangummi enthaltende reepithelialisierende pharmazeutische zubereitungen
WO2002015959A3 (en)	2002-08-22	Compounds and compositions for delivering active agents
MY138172A (en)	2009-04-30	Pharmaceutical compositions based on azetidine derivatives
MXPA03011128A (es)	2004-03-19	Composicion de sabor y fragancia.
AU3548901A (en)	2001-09-12	Veterinary compositions for the treatment of parasitic diseases
GB0020486D0 (en)	2000-10-11	Pharmaceutical composition
DE60231385D1 (de)	2009-04-16	Formulierungen, die eingeschlossene wirkstoffe enthalten, und ihre verwendung
ATE242966T1 (de)	2003-07-15	Herbizide zusammensetzung enthaltend dmso
CO5261624A1 (es)	2003-03-31	Novedosos derivados fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia
WO2005011565A3 (fr)	2005-03-31	Vernis a ongles a action antimycosique
MXPA04005033A (es)	2004-08-11	Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes.