PL374152A1 - Podstawione benzoimidazolosulfonoamidy jako inhibitory proteazy HIV o szerokim spektrum działania - Google Patents

Podstawione benzoimidazolosulfonoamidy jako inhibitory proteazy HIV o szerokim spektrum działania

Info

Publication number: PL374152A1
Authority: PL; Poland
Prior art keywords: protease inhibitors; hiv protease; substituted benzimidazole; sulfonamide hiv; broadspectrum
Prior art date: 2002-03-12

Application number

PL03374152A

Other languages

English (en)

Other versions

PL213645B1 (pl

Inventor

Dominique Louis Nestor Ghislain Surleraux

Piet Tom Bert Paul Wigerinck

Marieke Christiane Johanna Voets

Sandrine Marie Helene Vendeville

Kock Herman Augustinus De

Bernhard Joanna Bernard Vergouwen

Original Assignee

Tibotec Pharmaceuticals Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-12

Filing date

2003-03-12

Publication date

2005-10-03

2003-03-12 Application filed by Tibotec Pharmaceuticals Ltd. filed Critical Tibotec Pharmaceuticals Ltd.

2005-10-03 Publication of PL374152A1 publication Critical patent/PL374152A1/pl

2013-04-30 Publication of PL213645B1 publication Critical patent/PL213645B1/pl

Links

XRGHQBXKSHAQRB-UHFFFAOYSA-N 1h-benzimidazole-2-sulfonamide Chemical class C1=CC=C2NC(S(=O)(=O)N)=NC2=C1 XRGHQBXKSHAQRB-UHFFFAOYSA-N 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PL374152A 2002-03-12 2003-03-12 Podstawione benzoimidazolosulfonoamidy, ich zastosowanie oraz kompozycja je zawierajaca PL213645B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02075999		2002-03-12

Publications (2)

Publication Number	Publication Date
PL374152A1 true PL374152A1 (pl)	2005-10-03
PL213645B1 PL213645B1 (pl)	2013-04-30

Family

ID=27798870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL374152A PL213645B1 (pl)	2002-03-12	2003-03-12	Podstawione benzoimidazolosulfonoamidy, ich zastosowanie oraz kompozycja je zawierajaca

Country Status (25)

Country	Link
US (2)	US20050171175A1 (pl)
EP (1)	EP1485358B1 (pl)
JP (1)	JP4557552B2 (pl)
KR (3)	KR101302421B1 (pl)
CN (2)	CN101935303B (pl)
AP (1)	AP2111A (pl)
AR (1)	AR038928A1 (pl)
AT (1)	ATE497494T1 (pl)
AU (1)	AU2003219159B2 (pl)
BR (1)	BR0303373A (pl)
CA (1)	CA2479012C (pl)
DE (1)	DE60335939D1 (pl)
DK (1)	DK1485358T3 (pl)
EA (1)	EA011946B1 (pl)
HR (1)	HRP20040936B1 (pl)
IL (1)	IL163960A0 (pl)
MX (1)	MXPA04008929A (pl)
MY (1)	MY142238A (pl)
NO (1)	NO326702B1 (pl)
NZ (1)	NZ535439A (pl)
PL (1)	PL213645B1 (pl)
SI (1)	SI1485358T1 (pl)
TW (1)	TWI329639B (pl)
WO (1)	WO2003076413A1 (pl)
ZA (1)	ZA200407242B (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005030739A1 (en) *	2003-09-30	2005-04-07	Tibotec Pharmaceuticals Ltd.	Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
ES2331257T3 (es)	2005-02-25	2009-12-28	Tibotec Pharmaceuticals	Sintesis de precursores de inhibidores de proteasas.
UA103013C2 (uk)	2007-12-06	2013-09-10	Тиботек Фармасьютикелз	Амідні сполуки як активатори противірусних препаратів
WO2011061590A1 (en)	2009-11-17	2011-05-26	Hetero Research Foundation	Novel carboxamide derivatives as hiv inhibitors
WO2013011485A1 (en) *	2011-07-20	2013-01-24	Ranbaxy Laboratories Limited	Process for the preparation of sulfonamides useful as retroviral protease inhibitors

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US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
DE122007000045I2 (de) *	1992-08-25	2011-07-21	Gd Searle Llc Gd Searle Llc	Darunavir oder pharmazeutisch vertragliche Salze, Hydroxyethylaminosulfonamide verwendbar als InhibiEster oder Prodrugs davon. toren retroviraler Proteasen.
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
ES2127938T3 (es)	1993-08-24	1999-05-01	Searle & Co	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
ES2166786T3 (es)	1993-10-01	2002-05-01	Astrazeneca Ab	Procedimiento i.
DE69637380T2 (de) *	1995-01-20	2009-09-17	G.D. Searle Llc, Chicago	Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5756533A (en) *	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6140505A (en) *	1995-03-10	2000-10-31	G. D. Searle & Co.	Synthesis of benzo fused heterocyclic sulfonyl chlorides
US5705500A (en) *	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1149223C (zh) *	1995-03-10	2004-05-12	G·D·瑟尔公司	杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
US5776971A (en) *	1995-03-10	1998-07-07	G.D. Searle & Co.	Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) *	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6509038B2 (en)	1996-05-20	2003-01-21	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
WO1999006587A2 (en) *	1997-08-01	1999-02-11	Morphosys Ag	Novel method and phage for the identification of nucleic acid sequences encoding members of a multimeric (poly)peptide complex
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
EP1042280A2 (en)	1997-12-24	2000-10-11	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
AU2010299A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
BR9912169A (pt) *	1998-06-19	2001-04-10	Vertex Pharma	Inibidores de sulfonamida de protease de aspartil
AU4828199A (en) *	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion

2003
- 2003-03-10 MY MYPI20030825A patent/MY142238A/en unknown
- 2003-03-11 TW TW092105142A patent/TWI329639B/zh not_active IP Right Cessation
- 2003-03-11 AR ARP030100829A patent/AR038928A1/es not_active Application Discontinuation
- 2003-03-12 AU AU2003219159A patent/AU2003219159B2/en not_active Ceased
- 2003-03-12 JP JP2003574633A patent/JP4557552B2/ja not_active Expired - Fee Related
- 2003-03-12 CN CN201010251011.9A patent/CN101935303B/zh not_active Expired - Fee Related
- 2003-03-12 PL PL374152A patent/PL213645B1/pl unknown
- 2003-03-12 EP EP03714954A patent/EP1485358B1/en not_active Expired - Lifetime
- 2003-03-12 HR HRP20040936AA patent/HRP20040936B1/xx not_active IP Right Cessation
- 2003-03-12 MX MXPA04008929A patent/MXPA04008929A/es active IP Right Grant
- 2003-03-12 IL IL16396003A patent/IL163960A0/xx unknown
- 2003-03-12 KR KR1020107018927A patent/KR101302421B1/ko not_active Expired - Fee Related
- 2003-03-12 SI SI200331984T patent/SI1485358T1/sl unknown
- 2003-03-12 CN CNA038104725A patent/CN1653053A/zh active Pending
- 2003-03-12 CA CA2479012A patent/CA2479012C/en not_active Expired - Fee Related
- 2003-03-12 AT AT03714954T patent/ATE497494T1/de not_active IP Right Cessation
- 2003-03-12 US US10/508,561 patent/US20050171175A1/en not_active Abandoned
- 2003-03-12 DE DE60335939T patent/DE60335939D1/de not_active Expired - Lifetime
- 2003-03-12 NZ NZ535439A patent/NZ535439A/en not_active IP Right Cessation
- 2003-03-12 AP APAP/P/2004/003151A patent/AP2111A/en active
- 2003-03-12 KR KR1020127028481A patent/KR20120136411A/ko not_active Ceased
- 2003-03-12 DK DK03714954.9T patent/DK1485358T3/da active
- 2003-03-12 EA EA200401188A patent/EA011946B1/ru not_active IP Right Cessation
- 2003-03-12 KR KR10-2004-7014171A patent/KR20040093119A/ko not_active Ceased
- 2003-03-12 WO PCT/EP2003/050057 patent/WO2003076413A1/en not_active Ceased
- 2003-03-12 BR BR0303373-2A patent/BR0303373A/pt not_active IP Right Cessation
- 2003-11-12 NO NO20035023A patent/NO326702B1/no not_active IP Right Cessation
2004
- 2004-09-09 ZA ZA2004/07242A patent/ZA200407242B/en unknown
2009
- 2009-04-27 US US12/430,547 patent/US8143421B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1485358B1 (en)	2011-02-02
US20050171175A1 (en)	2005-08-04
BR0303373A (pt)	2004-03-23
MXPA04008929A (es)	2004-11-26
TWI329639B (en)	2010-09-01
EP1485358A1 (en)	2004-12-15
HRP20040936B1 (hr)	2012-09-30
IL163960A0 (en)	2005-12-18
MY142238A (en)	2010-11-15
AP2111A (en)	2010-03-03
US8143421B2 (en)	2012-03-27
US20090203743A1 (en)	2009-08-13
DE60335939D1 (de)	2011-03-17
JP4557552B2 (ja)	2010-10-06
SI1485358T1 (sl)	2011-05-31
TW200400945A (en)	2004-01-16
ZA200407242B (en)	2005-12-28
DK1485358T3 (da)	2011-05-09
KR101302421B1 (ko)	2013-09-02
AR038928A1 (es)	2005-02-02
CA2479012A1 (en)	2003-09-18
HK1072053A1 (en)	2005-08-12
AU2003219159B2 (en)	2009-09-03
AU2003219159A1 (en)	2003-09-22
NO20035023D0 (no)	2003-11-12
JP2005519952A (ja)	2005-07-07
KR20120136411A (ko)	2012-12-18
ATE497494T1 (de)	2011-02-15
EA011946B1 (ru)	2009-06-30
CN101935303B (zh)	2014-03-12
PL213645B1 (pl)	2013-04-30
NO326702B1 (no)	2009-02-02
EA200401188A1 (ru)	2005-04-28
KR20040093119A (ko)	2004-11-04
CN1653053A (zh)	2005-08-10
CA2479012C (en)	2011-11-01
KR20100102742A (ko)	2010-09-24
HRP20040936A2 (en)	2005-10-31
AP2004003151A0 (en)	2004-12-31
CN101935303A (zh)	2011-01-05
WO2003076413A1 (en)	2003-09-18
NZ535439A (en)	2009-09-25

Publication	Publication Date	Title
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
EP1483254A4 (en)	2005-06-08	INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
AP2003002856A0 (en)	2003-09-30	Broadspectrum 2-(substitutted-amino)-benzothiazolesulphonamide HIV protease inhibitors.
DK1466962T3 (da)	2011-11-21	Alkalisk protease
IL158093A0 (en)	2004-03-28	Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
AP1878A (en)	2008-08-13	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.
DK1347044T3 (da)	2014-01-13	Alkalisk protease
PL375307A1 (pl)	2005-11-28	Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania
ZA200410156B (en)	2005-11-30	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
HRP20030905A2 (en)	2005-08-31	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
IL162574A0 (en)	2005-11-20	Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
AP2004003151A0 (en)	2004-12-31	Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
NL1026340A1 (nl)	2004-12-07	Beta-lactamaseremmerprodrug.
HK1079769A (zh)	2006-04-13	取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂
HK1079684A (en)	2006-04-13	Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
TWI340135B (en)	2011-04-11	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide hiv protease inhibitors
ITBO20020064A1 (it)	2003-08-06	Accoppiatore di sicurezza
ITBO20020408A1 (it)	2003-12-29	Accoppiatore di sicurezza