PL375307A1 - Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania - Google Patents

Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania

Info

Publication number: PL375307A1
Authority: PL; Poland
Prior art keywords: protease inhibitors; hiv protease; substituted oxindole; sulfonamide hiv; broadspectrum
Prior art date: 2002-08-14

Application number

PL03375307A

Other languages

English (en)

Inventor

Abdellah Tahri

Piet Tom Bert Paul Wigerinck

Original Assignee

Tibotec Pharmaceuticals Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-14

Filing date

2003-08-14

Publication date

2005-11-28

2003-08-14 Application filed by Tibotec Pharmaceuticals Ltd. filed Critical Tibotec Pharmaceuticals Ltd.

2005-11-28 Publication of PL375307A1 publication Critical patent/PL375307A1/pl

Links

SPKYQJAFIYJJOX-UHFFFAOYSA-N 2-oxo-3h-indole-1-sulfonamide Chemical class C1=CC=C2N(S(=O)(=O)N)C(=O)CC2=C1 SPKYQJAFIYJJOX-UHFFFAOYSA-N 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PL03375307A 2002-08-14 2003-08-14 Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania PL375307A1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02078384		2002-08-14

Publications (1)

Publication Number	Publication Date
PL375307A1 true PL375307A1 (pl)	2005-11-28

Family

ID=31725465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL03375307A PL375307A1 (pl)	2002-08-14	2003-08-14	Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania

Country Status (18)

Country	Link
US (1)	US7199148B2 (pl)
EP (1)	EP1546153A1 (pl)
JP (1)	JP4681296B2 (pl)
KR (1)	KR100994759B1 (pl)
CN (1)	CN1688586B (pl)
AP (1)	AP2126A (pl)
AU (1)	AU2003262574B2 (pl)
BR (1)	BR0305771A (pl)
CA (1)	CA2493940C (pl)
EA (1)	EA010486B1 (pl)
HR (1)	HRP20050606B1 (pl)
IL (1)	IL166462A (pl)
MX (1)	MXPA05001792A (pl)
NO (1)	NO331846B1 (pl)
NZ (1)	NZ538714A (pl)
PL (1)	PL375307A1 (pl)
WO (1)	WO2004016619A1 (pl)
ZA (1)	ZA200501223B (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
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US7109230B2 (en) *	2002-01-07	2006-09-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
WO2005087728A1 (en) *	2004-03-11	2005-09-22	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AU2005244121B2 (en) *	2004-05-07	2012-01-19	Sequoia Pharmaceuticals, Inc.	Resistance-repellent retroviral protease inhibitors
AR073248A1 (es)	2008-09-01	2010-10-20	Tibotec Pharm Ltd	Proceso para la preparacion de (1s, 2r)-3- ((4-aminofenil) sulfonil) ( isobutil) amino)-1- bencil-2- hidroxipropilcarbamato de (3r, 3as,6ar)- hexahidrofuro-(2,3-b) furan-3- ilo (darunavir) y compuestos intermediarios utiles en dicho proceso.
US8921415B2 (en)	2009-01-29	2014-12-30	Mapi Pharma Ltd.	Polymorphs of darunavir
PL2528923T3 (pl)	2010-01-28	2015-01-30	Mapi Pharma Ltd	Sposób wytwarzania darunawiru i pochodnych darunawiru
US8580294B2 (en)	2010-10-19	2013-11-12	International Partnership For Microbicides	Platinum-catalyzed intravaginal rings
WO2012092168A1 (en) *	2010-12-27	2012-07-05	Purdue Research Foundation	Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv
WO2012092188A1 (en) *	2010-12-27	2012-07-05	Ghosh Arun K	Hydrogen bond forming p1 ligands and methods for treating hiv
US10137031B2 (en)	2013-11-14	2018-11-27	International Partnership For Microbicides, Inc.	Combination therapy intravaginal rings
US20170253607A1 (en) *	2014-09-11	2017-09-07	Shionogi & Co., Ltd.	Long-acting hiv protease inhibitor

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US5145684A (en)	1991-01-25	1992-09-08	Sterling Drug Inc.	Surface modified drug nanoparticles
PH30929A (en)	1992-09-03	1997-12-23	Janssen Pharmaceutica Nv	Beads having a core coated with an antifungal and a polymer.
IS2334B (is) *	1992-09-08	2008-02-15	Vertex Pharmaceuticals Inc., (A Massachusetts Corporation)	Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) *	1992-09-08	1998-03-03	Vertex Pharmaceuticals Incorporated	THF-containing sulfonamide inhibitors of aspartyl protease
ES2127938T3 (es)	1993-08-24	1999-05-01	Searle & Co	Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
ES2166786T3 (es)	1993-10-01	2002-05-01	Astrazeneca Ab	Procedimiento i.
DE69637380T2 (de) *	1995-01-20	2009-09-17	G.D. Searle Llc, Chicago	Bis-sulfonamid-hydroxyethylamino-derivate als inhibitoren retroviraler proteasen
US5756533A (en)	1995-03-10	1998-05-26	G.D. Searle & Co.	Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en)	1995-03-10	1998-01-06	G.D. Searle & Co.	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
CN1149223C (zh) *	1995-03-10	2004-05-12	G·D·瑟尔公司	杂环羰基氨基酸羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
US6150556A (en)	1995-03-10	2000-11-21	G. D. Dearle & Co.	Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en)	1995-11-15	1998-05-19	G. D. Searle & Co.	Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6509038B2 (en)	1996-05-20	2003-01-21	Janssen Pharmaceutica N.V.	Antifungal compositions with improved bioavailability
CZ295502B6 (cs)	1997-03-26	2005-08-17	Janssen Pharmaceutica N. V.	Antifungální peleta, způsob její přípravy a farmaceutická dávková forma s obsahem těchto pelet
EP1042280A2 (en)	1997-12-24	2000-10-11	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
AU2010299A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs os aspartyl protease inhibitors
US6436989B1 (en)	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
AU2012199A (en)	1997-12-24	1999-07-19	Vertex Pharmaceuticals Incorporated	Prodrugs of aspartyl protease inhibitors
BR9912169A (pt) *	1998-06-19	2001-04-10	Vertex Pharma	Inibidores de sulfonamida de protease de aspartil
PT2336134T (pt)	1998-06-23	2016-10-19	The Board Of Trustees Of The Univ Of Illionis	Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
AU4828199A (en)	1998-06-23	2000-01-10	Board Of Trustees Of The University Of Illinois, The	Multi-drug resistant retroviral protease inhibitors and associated methods
US6548517B2 (en) *	2000-03-24	2003-04-15	Millennium Pharmaceuticals, Inc.	Oxindole inhibitors of factor Xa

2003
- 2003-08-14 NZ NZ538714A patent/NZ538714A/en not_active IP Right Cessation
- 2003-08-14 BR BR0305771-2A patent/BR0305771A/pt not_active IP Right Cessation
- 2003-08-14 PL PL03375307A patent/PL375307A1/pl unknown
- 2003-08-14 CA CA2493940A patent/CA2493940C/en not_active Expired - Fee Related
- 2003-08-14 CN CN038240955A patent/CN1688586B/zh not_active Expired - Fee Related
- 2003-08-14 EP EP03787818A patent/EP1546153A1/en not_active Withdrawn
- 2003-08-14 AU AU2003262574A patent/AU2003262574B2/en not_active Ceased
- 2003-08-14 MX MXPA05001792A patent/MXPA05001792A/es active IP Right Grant
- 2003-08-14 WO PCT/EP2003/050379 patent/WO2004016619A1/en not_active Ceased
- 2003-08-14 US US10/524,451 patent/US7199148B2/en not_active Expired - Fee Related
- 2003-08-14 AP AP2005003245A patent/AP2126A/xx active
- 2003-08-14 EA EA200500350A patent/EA010486B1/ru not_active IP Right Cessation
- 2003-08-14 KR KR1020057001812A patent/KR100994759B1/ko not_active Expired - Fee Related
- 2003-08-14 JP JP2004528524A patent/JP4681296B2/ja not_active Expired - Fee Related
- 2003-08-14 HR HRP20050606AA patent/HRP20050606B1/hr not_active IP Right Cessation
2005
- 2005-01-24 IL IL166462A patent/IL166462A/en not_active IP Right Cessation
- 2005-02-10 ZA ZA200501223A patent/ZA200501223B/en unknown
- 2005-03-14 NO NO20051291A patent/NO331846B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AP2005003245A0 (en)	2005-03-31
HRP20050606B1 (hr)	2014-04-25
JP2005537305A (ja)	2005-12-08
CA2493940C (en)	2011-11-22
EA200500350A1 (ru)	2005-08-25
HRP20050606A2 (en)	2006-02-28
WO2004016619A1 (en)	2004-02-26
CN1688586A (zh)	2005-10-26
CA2493940A1 (en)	2004-02-26
IL166462A0 (en)	2006-01-15
IL166462A (en)	2012-04-30
NZ538714A (en)	2007-03-30
US7199148B2 (en)	2007-04-03
US20060058368A1 (en)	2006-03-16
BR0305771A (pt)	2004-10-05
KR20050042141A (ko)	2005-05-04
AU2003262574A1 (en)	2004-03-03
EP1546153A1 (en)	2005-06-29
KR100994759B1 (ko)	2010-11-16
CN1688586B (zh)	2012-05-09
AP2126A (en)	2010-06-03
ZA200501223B (en)	2006-07-26
NO331846B1 (no)	2012-04-23
MXPA05001792A (es)	2005-04-25
AU2003262574B2 (en)	2009-07-09
EA010486B1 (ru)	2008-10-30
JP4681296B2 (ja)	2011-05-11
NO20051291L (no)	2005-05-18

Publication	Publication Date	Title
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
EP1483254A4 (en)	2005-06-08	INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE
EP1750696A4 (en)	2009-07-15	RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
IL158093A0 (en)	2004-03-28	Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors
DK1347044T3 (da)	2014-01-13	Alkalisk protease
AP2126A (en)	2010-06-03	Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors
AP1878A (en)	2008-08-13	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors.
ZA200410156B (en)	2005-11-30	Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors
AU2003269984A8 (en)	2004-03-11	Protease inhibitors
AP2004003083A0 (en)	2004-09-30	Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors
AP2004003151A0 (en)	2004-12-31	Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors
AU2003263738A8 (en)	2003-12-02	Protease inhibitors
HK1079769A (zh)	2006-04-13	取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂
AU2003287325A8 (en)	2004-06-03	N-cycloalkylglycines as hiv protease inhibitors
ZA200500926B (en)	2006-03-29	Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors
AU2003304496A8 (en)	2005-04-27	Protease inhibitors
AU2003233642A8 (en)	2003-12-12	Protease inhibitors
HK1079684A (en)	2006-04-13	Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
AU2003265240A8 (en)	2003-12-22	Protease inhibitors
AU2003269878A8 (en)	2003-12-22	Protease inhibitors
HK1071573A (en)	2005-07-22	Resistance-repellent retroviral protease inhibitors
AU2003230545A1 (en)	2003-09-02	Resistance-repellent retroviral protease inhibitors