PL375307A1 - Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania - Google Patents
Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działaniaInfo
- Publication number
- PL375307A1 PL375307A1 PL03375307A PL37530703A PL375307A1 PL 375307 A1 PL375307 A1 PL 375307A1 PL 03375307 A PL03375307 A PL 03375307A PL 37530703 A PL37530703 A PL 37530703A PL 375307 A1 PL375307 A1 PL 375307A1
- Authority
- PL
- Poland
- Prior art keywords
- protease inhibitors
- hiv protease
- substituted oxindole
- sulfonamide hiv
- broadspectrum
- Prior art date
Links
- SPKYQJAFIYJJOX-UHFFFAOYSA-N 2-oxo-3h-indole-1-sulfonamide Chemical class C1=CC=C2N(S(=O)(=O)N)C(=O)CC2=C1 SPKYQJAFIYJJOX-UHFFFAOYSA-N 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078384 | 2002-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL375307A1 true PL375307A1 (pl) | 2005-11-28 |
Family
ID=31725465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL03375307A PL375307A1 (pl) | 2002-08-14 | 2003-08-14 | Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7199148B2 (pl) |
| EP (1) | EP1546153A1 (pl) |
| JP (1) | JP4681296B2 (pl) |
| KR (1) | KR100994759B1 (pl) |
| CN (1) | CN1688586B (pl) |
| AP (1) | AP2126A (pl) |
| AU (1) | AU2003262574B2 (pl) |
| BR (1) | BR0305771A (pl) |
| CA (1) | CA2493940C (pl) |
| EA (1) | EA010486B1 (pl) |
| HR (1) | HRP20050606B1 (pl) |
| IL (1) | IL166462A (pl) |
| MX (1) | MXPA05001792A (pl) |
| NO (1) | NO331846B1 (pl) |
| NZ (1) | NZ538714A (pl) |
| PL (1) | PL375307A1 (pl) |
| WO (1) | WO2004016619A1 (pl) |
| ZA (1) | ZA200501223B (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003202914A1 (en) * | 2002-01-07 | 2003-07-24 | Sequoia Pharmaceuticals | Broad spectrum inhibitors |
| JP2007528423A (ja) * | 2004-03-11 | 2007-10-11 | セコイア、ファーマシューティカルズ、インコーポレイテッド | 耐性防止レトロウイルスプロテアーゼ阻害薬 |
| US7378441B2 (en) * | 2004-05-07 | 2008-05-27 | Sequoia Pharmaceuticals, Inc. | Resistance-repellent retroviral protease inhibitors |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| EP2528923B1 (en) | 2010-01-28 | 2014-07-30 | Mapi Pharma Limited | Process for the preparation of darunavir and darunavir intermediates |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| WO2012092168A1 (en) * | 2010-12-27 | 2012-07-05 | Purdue Research Foundation | Fused 6,5 bicyclic ring system p2 ligands, and methods for treating hiv |
| WO2012092188A1 (en) * | 2010-12-27 | 2012-07-05 | Ghosh Arun K | Hydrogen bond forming p1 ligands and methods for treating hiv |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| WO2016039403A1 (ja) * | 2014-09-11 | 2016-03-17 | 塩野義製薬株式会社 | 持続性ｈｉｖプロテアーゼ阻害剤 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| PH30929A (en) | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| EP0715618B1 (en) | 1993-08-24 | 1998-12-16 | G.D. Searle & Co. | Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors |
| PT721331E (pt) | 1993-10-01 | 2002-05-31 | Astrazeneca Ab | Processo i |
| CA2210889C (en) * | 1995-01-20 | 2007-08-28 | G.D. Searle & Co. | Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors |
| US5756533A (en) | 1995-03-10 | 1998-05-26 | G.D. Searle & Co. | Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US6150556A (en) | 1995-03-10 | 2000-11-21 | G. D. Dearle & Co. | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors |
| US5705500A (en) | 1995-03-10 | 1998-01-06 | G.D. Searle & Co. | Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| BR9607625A (pt) | 1995-03-10 | 1999-06-15 | Searle & Co | Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila |
| US5753660A (en) | 1995-11-15 | 1998-05-19 | G. D. Searle & Co. | Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors |
| WO1997044014A1 (en) | 1996-05-20 | 1997-11-27 | Janssen Pharmaceutica N.V. | Antifungal compositions with improved bioavailability |
| SK284813B6 (sk) | 1997-03-26 | 2005-12-01 | Janssen Pharmaceutica N. V. | Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| AU2012199A (en) | 1997-12-24 | 1999-07-19 | Vertex Pharmaceuticals Incorporated | Prodrugs of aspartyl protease inhibitors |
| WO1999033792A2 (en) | 1997-12-24 | 1999-07-08 | Vertex Pharmaceuticals Incorporated | Prodrugs os aspartyl protease inhibitors |
| EA200000702A1 (ru) | 1997-12-24 | 2000-12-25 | Вертекс Фармасьютикалз Инкорпорейтед | Пролекарства ингибиторов аспартилпротеаз |
| PT1086076E (pt) * | 1998-06-19 | 2005-05-31 | Vertex Pharma | Inibidores de sulfonamida de aspartil protease |
| AU4828199A (en) * | 1998-06-23 | 2000-01-10 | Board Of Trustees Of The University Of Illinois, The | Multi-drug resistant retroviral protease inhibitors and associated methods |
| CA2872424C (en) | 1998-06-23 | 2017-03-07 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Bisfuran derivatives useful in preventing the emergence of multidrug resistant hiv strains and treatment of hiv |
| EP1272483A2 (en) * | 2000-03-24 | 2003-01-08 | Millenium Pharmaceuticals, Inc. | OXINDOLE INHIBITORS OF FACTOR Xa |
-
2003
- 2003-08-14 NZ NZ538714A patent/NZ538714A/en not_active IP Right Cessation
- 2003-08-14 AP AP2005003245A patent/AP2126A/xx active
- 2003-08-14 AU AU2003262574A patent/AU2003262574B2/en not_active Ceased
- 2003-08-14 CA CA2493940A patent/CA2493940C/en not_active Expired - Fee Related
- 2003-08-14 EA EA200500350A patent/EA010486B1/ru not_active IP Right Cessation
- 2003-08-14 HR HRP20050606AA patent/HRP20050606B1/hr not_active IP Right Cessation
- 2003-08-14 PL PL03375307A patent/PL375307A1/pl unknown
- 2003-08-14 BR BR0305771-2A patent/BR0305771A/pt not_active IP Right Cessation
- 2003-08-14 EP EP03787818A patent/EP1546153A1/en not_active Withdrawn
- 2003-08-14 US US10/524,451 patent/US7199148B2/en not_active Expired - Fee Related
- 2003-08-14 KR KR1020057001812A patent/KR100994759B1/ko not_active Expired - Fee Related
- 2003-08-14 MX MXPA05001792A patent/MXPA05001792A/es active IP Right Grant
- 2003-08-14 CN CN038240955A patent/CN1688586B/zh not_active Expired - Fee Related
- 2003-08-14 JP JP2004528524A patent/JP4681296B2/ja not_active Expired - Fee Related
- 2003-08-14 WO PCT/EP2003/050379 patent/WO2004016619A1/en not_active Ceased
-
2005
- 2005-01-24 IL IL166462A patent/IL166462A/en not_active IP Right Cessation
- 2005-02-10 ZA ZA200501223A patent/ZA200501223B/en unknown
- 2005-03-14 NO NO20051291A patent/NO331846B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ538714A (en) | 2007-03-30 |
| NO20051291L (no) | 2005-05-18 |
| NO331846B1 (no) | 2012-04-23 |
| AP2126A (en) | 2010-06-03 |
| EA010486B1 (ru) | 2008-10-30 |
| HRP20050606B1 (hr) | 2014-04-25 |
| CA2493940C (en) | 2011-11-22 |
| US20060058368A1 (en) | 2006-03-16 |
| AU2003262574B2 (en) | 2009-07-09 |
| BR0305771A (pt) | 2004-10-05 |
| EP1546153A1 (en) | 2005-06-29 |
| IL166462A0 (en) | 2006-01-15 |
| IL166462A (en) | 2012-04-30 |
| CN1688586B (zh) | 2012-05-09 |
| MXPA05001792A (es) | 2005-04-25 |
| CA2493940A1 (en) | 2004-02-26 |
| KR20050042141A (ko) | 2005-05-04 |
| JP4681296B2 (ja) | 2011-05-11 |
| CN1688586A (zh) | 2005-10-26 |
| US7199148B2 (en) | 2007-04-03 |
| JP2005537305A (ja) | 2005-12-08 |
| KR100994759B1 (ko) | 2010-11-16 |
| HRP20050606A2 (en) | 2006-02-28 |
| EA200500350A1 (ru) | 2005-08-25 |
| ZA200501223B (en) | 2006-07-26 |
| WO2004016619A1 (en) | 2004-02-26 |
| AU2003262574A1 (en) | 2004-03-03 |
| AP2005003245A0 (en) | 2005-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IS7607A (is) | Ný útskipt indól | |
| EP1499336A4 (en) | PROTEASE INHIBITORS | |
| EP1483254A4 (en) | INHIBITORS OF ANTI-RESISTANCE RETROVIRAL PROTEASE | |
| EP1732891A4 (en) | RESISTANT PREVENTIVE INHIBITORS FOR RETROVIRAL PROTEASES | |
| IL158093A0 (en) | Broadspectrum 2-amino-benzoxazole sulfonamide hiv protease inhibitors | |
| PL375307A1 (pl) | Podstawione oksoindolo sulfonamidy jako inhibitory proteazy HIV o szerokim zakresie działania | |
| DK1347044T3 (da) | Alkalisk protease | |
| AP1878A (en) | Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors. | |
| ZA200410156B (en) | Broadspectrum substituted benzisoxazole sulfonamide hiv protease inhibitors | |
| AU2003269984A8 (en) | Protease inhibitors | |
| AP2004003083A0 (en) | Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors | |
| AP2004003151A0 (en) | Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors | |
| AU2003263738A8 (en) | Protease inhibitors | |
| HK1079769A (zh) | 取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂 | |
| AU2003287325A8 (en) | N-cycloalkylglycines as hiv protease inhibitors | |
| ZA200500926B (en) | Broadspectrum 2-amino-benzothiazole sulfonamide HIV protease inhibitors | |
| AU2003304496A8 (en) | Protease inhibitors | |
| AU2003233642A8 (en) | Protease inhibitors | |
| HK1079684A (en) | Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors | |
| EP1532115A4 (en) | INHIBITORS OF PROTEASE | |
| AU2003265240A1 (en) | Protease inhibitors | |
| HK1071573A (en) | Resistance-repellent retroviral protease inhibitors | |
| AU2003230545A1 (en) | Resistance-repellent retroviral protease inhibitors | |
| HK1073437A (en) | Protease inhibitors |