PL377236A1 - Indazoloamidy wykazujące działanie przeciwbólowe - Google Patents

Indazoloamidy wykazujące działanie przeciwbólowe

Info

Publication number
PL377236A1
PL377236A1 PL377236A PL37723604A PL377236A1 PL 377236 A1 PL377236 A1 PL 377236A1 PL 377236 A PL377236 A PL 377236A PL 37723604 A PL37723604 A PL 37723604A PL 377236 A1 PL377236 A1 PL 377236A1
Authority
PL
Poland
Prior art keywords
indazolamides
analgesic activity
analgesic
activity
Prior art date
Application number
PL377236A
Other languages
English (en)
Other versions
PL215870B1 (pl
Inventor
Maria Alessandra Alisi
Nicola Cazzolla
Angelo Guglielmotti
Guido Furlotti
Giuseppe Luna
Lorenzo Polenzani
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Publication of PL377236A1 publication Critical patent/PL377236A1/pl
Publication of PL215870B1 publication Critical patent/PL215870B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00Anaesthetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL377236A 2003-02-18 2004-01-26 Indazoloamidy, sposoby ich otrzymywania, kompozycje farmaceutyczne zawierajace te indazoloamidy oraz produkty posrednie powstajace przy wytwarzaniu tych indazoloamidów PL215870B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000287A ITMI20030287A1 (it) 2003-02-18 2003-02-18 Indazolammidi dotate di attivita' analgesica metodo, per

Publications (2)

Publication Number Publication Date
PL377236A1 true PL377236A1 (pl) 2006-01-23
PL215870B1 PL215870B1 (pl) 2014-02-28

Family

ID=32894157

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377236A PL215870B1 (pl) 2003-02-18 2004-01-26 Indazoloamidy, sposoby ich otrzymywania, kompozycje farmaceutyczne zawierajace te indazoloamidy oraz produkty posrednie powstajace przy wytwarzaniu tych indazoloamidów

Country Status (22)

Country Link
US (2) US7632849B2 (pl)
EP (1) EP1594859B1 (pl)
JP (1) JP4724651B2 (pl)
KR (1) KR101108222B1 (pl)
CN (2) CN101139341B (pl)
AR (1) AR043186A1 (pl)
AT (1) ATE471934T1 (pl)
AU (1) AU2004213104B2 (pl)
CA (1) CA2511984C (pl)
DE (1) DE602004027792D1 (pl)
DK (1) DK1594859T3 (pl)
EA (1) EA009077B1 (pl)
ES (1) ES2345983T3 (pl)
GE (1) GEP20074075B (pl)
IL (1) IL169285A (pl)
IT (1) ITMI20030287A1 (pl)
MX (1) MXPA05008730A (pl)
PL (1) PL215870B1 (pl)
PT (1) PT1594859E (pl)
SI (1) SI1594859T1 (pl)
UA (1) UA79537C2 (pl)
WO (1) WO2004074275A1 (pl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20031468A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
BRPI0512046A (pt) * 2004-06-15 2008-02-06 Pfizer derivados de ácido benzimidazolona carboxìlico
US8232290B2 (en) * 2008-03-25 2012-07-31 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
US8815892B2 (en) 2008-03-25 2014-08-26 Affectis Pharmaceuticals Ag P2X7R antagonists and their use
EP2243772B1 (en) * 2009-04-14 2012-01-18 Affectis Pharmaceuticals AG Novel P2X7R antagonists and their use
WO2013124158A1 (en) * 2012-02-21 2013-08-29 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. 1h-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors
PT2817301E (pt) 2012-02-21 2016-03-14 Aziende Chimiche Riunite Angelini Francesco - A C R A F - S P A Utlização de compostos de 1h-indazolo-3-carboxamida como inibidores da cinase 3 beta da sintase do glicogénio
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
MA52557A (fr) 2018-05-07 2021-03-17 Acraf Composés de 1h-indazole-3-carboxamide utilisés en tant qu'inhibiteurs de la glycogène synthase kinase 3 bêta
CN109336890B (zh) * 2018-11-17 2020-03-20 重庆文理学院 一种吲唑类衍生物的合成方法及抗肿瘤应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705175A (en) * 1969-04-01 1972-12-05 Egyt Gyogyszervegyeszeti Gyar Indazole-3-carboxylic amides
US5654320A (en) * 1995-03-16 1997-08-05 Eli Lilly And Company Indazolecarboxamides
IL117438A (en) 1995-03-16 2001-12-23 Lilly Co Eli Indazolecarboxamides, their preparation and pharmaceutical compositions containing them
EP0829474B1 (en) 1995-05-31 2003-04-09 Nisshin Seifun Group Inc. Indazole derivatives having monocyclic amino group
WO1997017208A1 (fr) * 1995-11-08 1997-05-15 Toray Industries, Inc. Plaque planographique originale, sans eau, pour dessin direct
KR100494278B1 (ko) 1996-08-16 2005-06-13 스미스클라인비이참피이엘시이 N-[(1-n-부틸-4-피페리딜)메틸]-3,4-디히드로-2H-[1,3]옥사지노[3,2-a] 인돌-10-카르복사미드 및 그의 염의 제조방법 및 그의 제조 중간체
IT1291569B1 (it) 1997-04-15 1999-01-11 Angelini Ricerche Spa Indazolammidi come agenti serotoninergici
US6339087B1 (en) * 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6069152A (en) * 1997-10-07 2000-05-30 Eli Lilly And Company 5-HT4 agonists and antagonists
NZ507567A (en) * 1998-04-21 2003-08-29 Du Pont Pharm Co 5-aminoindeno(1,2-c)pyrazol-4-ones as anti-cancer and anti-proliferative agents
US6407103B2 (en) * 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses

Also Published As

Publication number Publication date
GEP20074075B (en) 2007-03-26
AU2004213104A1 (en) 2004-09-02
US20060052417A1 (en) 2006-03-09
PL215870B1 (pl) 2014-02-28
IL169285A (en) 2012-08-30
HK1079199A1 (en) 2006-03-31
ATE471934T1 (de) 2010-07-15
KR20050101541A (ko) 2005-10-24
JP2006517932A (ja) 2006-08-03
DE602004027792D1 (de) 2010-08-05
EP1594859A1 (en) 2005-11-16
ES2345983T3 (es) 2010-10-07
ITMI20030287A1 (it) 2004-08-19
PT1594859E (pt) 2010-07-23
US7632849B2 (en) 2009-12-15
WO2004074275A1 (en) 2004-09-02
SI1594859T1 (sl) 2010-10-29
US20100048907A1 (en) 2010-02-25
MXPA05008730A (es) 2005-09-20
CN1742004A (zh) 2006-03-01
CN101139341A (zh) 2008-03-12
CN101139341B (zh) 2010-12-08
KR101108222B1 (ko) 2012-02-08
AU2004213104B2 (en) 2010-07-08
EA200501164A1 (ru) 2005-12-29
AR043186A1 (es) 2005-07-20
UA79537C2 (en) 2007-06-25
CN100347168C (zh) 2007-11-07
JP4724651B2 (ja) 2011-07-13
CA2511984A1 (en) 2004-09-02
CA2511984C (en) 2011-01-18
EP1594859B1 (en) 2010-06-23
US8519139B2 (en) 2013-08-27
DK1594859T3 (da) 2010-10-11
EA009077B1 (ru) 2007-10-26

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