PL377472A1 - Bezwodny krystaliczny hemisiarczan pochodnej azydocytozyny - Google Patents

Bezwodny krystaliczny hemisiarczan pochodnej azydocytozyny

Info

Publication number: PL377472A1
Authority: PL; Poland
Prior art keywords: anhydrous crystalline; azido; derivative; cytosine hemisulfate; hemisulfate derivative
Prior art date: 2002-12-09

Application number

PL377472A

Other languages

English (en)

Other versions

PL213734B1 (pl

Inventor

Terrence Joseph Connolly

Joseph Armstrong Martin

Anthony Prince

Keshab Sarma

Original Assignee

F. Hoffmann-La Roche Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-09

Filing date

2003-12-08

Publication date

2006-02-06

2003-12-08 Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag

2006-02-06 Publication of PL377472A1 publication Critical patent/PL377472A1/pl

2013-04-30 Publication of PL213734B1 publication Critical patent/PL213734B1/pl

Links

-1 azido cytosine Chemical compound 0.000 title 1
229940104302 cytosine Drugs 0.000 title 1
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

PL377472A 2002-12-09 2003-12-08 Hemisiarczan 1-[4(S)-azydo-2 (S), 3(R)-dihydroksy-4-(hydroksymetylo)-1 (R)-cyklopentylo] cytozyny, sposób wytwarzania tego hemisiarczanu w polimorficznej postaci C, zastosowanie tego hemisiarczanu i srodek farmaceutyczny PL213734B1 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US43188502P	2002-12-09	2002-12-09

Publications (2)

Publication Number	Publication Date
PL377472A1 true PL377472A1 (pl)	2006-02-06
PL213734B1 PL213734B1 (pl)	2013-04-30

Family

ID=32507815

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL377472A PL213734B1 (pl)	2002-12-09	2003-12-08	Hemisiarczan 1-[4(S)-azydo-2 (S), 3(R)-dihydroksy-4-(hydroksymetylo)-1 (R)-cyklopentylo] cytozyny, sposób wytwarzania tego hemisiarczanu w polimorficznej postaci C, zastosowanie tego hemisiarczanu i srodek farmaceutyczny

Country Status (32)

Country	Link
US (1)	US6864244B2 (pl)
EP (1)	EP1572711B1 (pl)
JP (1)	JP4563818B2 (pl)
KR (1)	KR100675544B1 (pl)
CN (1)	CN1314697C (pl)
AR (1)	AR042312A1 (pl)
AT (1)	ATE430755T1 (pl)
AU (1)	AU2003292212B2 (pl)
BR (1)	BR0317146A (pl)
CA (1)	CA2506532C (pl)
CY (1)	CY1109296T1 (pl)
DE (1)	DE60327554D1 (pl)
DK (1)	DK1572711T3 (pl)
ES (1)	ES2324654T3 (pl)
GT (1)	GT200300276A (pl)
HR (1)	HRP20050503A2 (pl)
IL (1)	IL168685A (pl)
JO (1)	JO2542B1 (pl)
MX (1)	MXPA05006044A (pl)
MY (1)	MY130927A (pl)
NO (1)	NO330454B1 (pl)
NZ (1)	NZ540297A (pl)
PA (1)	PA8590701A1 (pl)
PE (1)	PE20040767A1 (pl)
PL (1)	PL213734B1 (pl)
PT (1)	PT1572711E (pl)
RU (1)	RU2334756C2 (pl)
SI (1)	SI1572711T1 (pl)
TW (1)	TWI294882B (pl)
UY (1)	UY28109A1 (pl)
WO (1)	WO2004052906A1 (pl)
ZA (1)	ZA200504472B (pl)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1219607B1 (en) *	1999-09-02	2011-04-06	Shionogi & Co., Ltd.	Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en)	1999-10-04	2012-12-11	Neokimia Inc.	Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) *	2004-02-13	2005-08-18	Reddy K. R.	Novel 2'-C-methyl nucleoside derivatives
EP1794172B1 (en) *	2004-08-23	2009-07-15	F.Hoffmann-La Roche Ag	Antiviral 4'-azido-nucleosides
CN101573370B (zh) *	2006-10-10	2013-09-11	美迪维尔公司	Hcv核苷类抑制剂
AU2007342367B2 (en)	2007-01-05	2012-12-06	Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A.	Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) *	2007-05-22	2007-06-27	Angeletti P Ist Richerche Bio	Antiviral agents
GB0900914D0 (en)	2009-01-20	2009-03-04	Angeletti P Ist Richerche Bio	Antiviral agents
AU2011305652B2 (en)	2010-09-22	2016-10-20	Janssen Biopharma, Inc.	Azido nucleosides and nucleotide analogs
AU2015217221A1 (en)	2014-02-13	2016-08-11	Ligand Pharmaceuticals, Inc.	Prodrug compounds and their uses
CN103965116B (zh) *	2014-05-06	2016-06-15	中国科学院苏州纳米技术与纳米仿生研究所	半5-氟胞嘧啶盐、其制备方法及应用
WO2016003812A1 (en)	2014-07-02	2016-01-07	Ligand Pharmaceuticals, Inc.	Prodrug compounds and uses therof
DK3265102T3 (da)	2015-03-06	2025-10-13	Atea Pharmaceuticals Inc	Beta-d-2'-deoxy-2'alpha-fluoro-2'-beta-c-substituerede-2-modificerede-n6-substituerede purinnukleotider til hcv-behandling
SMT202200072T1 (it)	2016-09-07	2022-03-21	Atea Pharmaceuticals Inc	Nucleotidi purinici 2'-sostituiti-n6-sostituiti per il trattamento dei virus rna
US10519186B2 (en)	2017-02-01	2019-12-31	Atea Pharmaceuticals, Inc.	Nucleotide hemi-sulfate salt for the treatment of hepatitis C virus
AU2019207625A1 (en)	2018-01-09	2020-07-30	Ligand Pharmaceuticals, Inc.	Acetal compounds and therapeutic uses thereof
CN112351799A (zh)	2018-04-10	2021-02-09	阿堤亚制药公司	具有硬化的hcv感染患者的治疗
US10874687B1 (en)	2020-02-27	2020-12-29	Atea Pharmaceuticals, Inc.	Highly active compounds against COVID-19
BR112023026356A2 (pt)	2021-06-17	2024-03-05	Atea Pharmaceuticals Inc	Método para tratar vírus da hepatite c ou uma condição resultante de uma infecção por hepatite c, combinação, uso da combinação, composição farmacêutica, e, kit para o tratamento de vírus da hepatite c
CN115536710B (zh) *	2022-10-18	2024-04-16	南京工业大学	一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK582489A (da) *	1988-11-21	1990-05-22	Syntex Inc	Substituerede 2'-deoxy-4'-azido-nucleosider, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende samme
US5449664A (en) *	1988-11-21	1995-09-12	Syntex (U.S.A.) Inc.	Antiviral agents
AU7623991A (en) *	1990-05-17	1991-11-21	Syntex (U.S.A.) Inc.	Antiviral agents
EP1027359B9 (en) *	1996-10-16	2003-09-17	Ribapharm, Inc.	Monocyclic l-nucleosides, analogs and uses thereof
US20030008841A1 (en) *	2000-08-30	2003-01-09	Rene Devos	Anti-HCV nucleoside derivatives
IL156641A0 (en) *	2001-01-22	2004-01-04	Merck & Co Inc	Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
GB0114286D0 (en) *	2001-06-12	2001-08-01	Hoffmann La Roche	Nucleoside Derivatives

2003
- 2003-12-03 TW TW092134038A patent/TWI294882B/zh not_active IP Right Cessation
- 2003-12-04 PA PA20038590701A patent/PA8590701A1/es unknown
- 2003-12-05 AR ARP030104491A patent/AR042312A1/es unknown
- 2003-12-05 PE PE2003001233A patent/PE20040767A1/es not_active Application Discontinuation
- 2003-12-05 MY MYPI20034678A patent/MY130927A/en unknown
- 2003-12-08 HR HR20050503A patent/HRP20050503A2/xx not_active Application Discontinuation
- 2003-12-08 EP EP03767770A patent/EP1572711B1/en not_active Expired - Lifetime
- 2003-12-08 UY UY28109A patent/UY28109A1/es not_active Application Discontinuation
- 2003-12-08 SI SI200331601T patent/SI1572711T1/sl unknown
- 2003-12-08 WO PCT/EP2003/013899 patent/WO2004052906A1/en not_active Ceased
- 2003-12-08 ES ES03767770T patent/ES2324654T3/es not_active Expired - Lifetime
- 2003-12-08 AT AT03767770T patent/ATE430755T1/de active
- 2003-12-08 DE DE60327554T patent/DE60327554D1/de not_active Expired - Lifetime
- 2003-12-08 PL PL377472A patent/PL213734B1/pl not_active IP Right Cessation
- 2003-12-08 PT PT03767770T patent/PT1572711E/pt unknown
- 2003-12-08 BR BR0317146-9A patent/BR0317146A/pt not_active IP Right Cessation
- 2003-12-08 JP JP2004558026A patent/JP4563818B2/ja not_active Expired - Fee Related
- 2003-12-08 NZ NZ540297A patent/NZ540297A/en not_active IP Right Cessation
- 2003-12-08 CA CA2506532A patent/CA2506532C/en not_active Expired - Fee Related
- 2003-12-08 AU AU2003292212A patent/AU2003292212B2/en not_active Ceased
- 2003-12-08 GT GT200300276A patent/GT200300276A/es unknown
- 2003-12-08 KR KR1020057010443A patent/KR100675544B1/ko not_active Expired - Fee Related
- 2003-12-08 DK DK03767770T patent/DK1572711T3/da active
- 2003-12-08 RU RU2005121927/04A patent/RU2334756C2/ru not_active IP Right Cessation
- 2003-12-08 CN CNB2003801053665A patent/CN1314697C/zh not_active Expired - Fee Related
- 2003-12-08 MX MXPA05006044A patent/MXPA05006044A/es active IP Right Grant
- 2003-12-09 US US10/731,582 patent/US6864244B2/en not_active Expired - Fee Related
- 2003-12-09 JO JO2003163A patent/JO2542B1/en active
2005
- 2005-05-19 IL IL168685A patent/IL168685A/en not_active IP Right Cessation
- 2005-05-31 ZA ZA200504472A patent/ZA200504472B/en unknown
- 2005-06-07 NO NO20052732A patent/NO330454B1/no not_active IP Right Cessation
2009
- 2009-07-24 CY CY20091100797T patent/CY1109296T1/el unknown

Also Published As

Publication number	Publication date
PL213734B1 (pl)	2013-04-30
MXPA05006044A (es)	2005-08-18
TW200502243A (en)	2005-01-16
KR20050084217A (ko)	2005-08-26
HK1085483A1 (en)	2006-08-25
NO20052732L (no)	2005-09-06
GT200300276A (es)	2004-09-02
JO2542B1 (en)	2010-09-05
ES2324654T3 (es)	2009-08-12
JP2006510649A (ja)	2006-03-30
NO330454B1 (no)	2011-04-18
SI1572711T1 (sl)	2009-08-31
AU2003292212A1 (en)	2004-06-30
MY130927A (en)	2007-07-31
PT1572711E (pt)	2009-06-25
RU2334756C2 (ru)	2008-09-27
CN1314697C (zh)	2007-05-09
NO20052732D0 (no)	2005-06-07
PE20040767A1 (es)	2004-11-06
NZ540297A (en)	2007-05-31
CY1109296T1 (el)	2014-07-02
EP1572711A1 (en)	2005-09-14
AR042312A1 (es)	2005-06-15
EP1572711B1 (en)	2009-05-06
BR0317146A (pt)	2005-10-25
US6864244B2 (en)	2005-03-08
CA2506532A1 (en)	2004-06-24
PA8590701A1 (es)	2004-11-26
JP4563818B2 (ja)	2010-10-13
ZA200504472B (en)	2006-02-22
CN1723215A (zh)	2006-01-18
US20040162265A1 (en)	2004-08-19
RU2005121927A (ru)	2006-01-27
KR100675544B1 (ko)	2007-01-30
IL168685A (en)	2010-11-30
CA2506532C (en)	2011-09-20
UY28109A1 (es)	2004-06-30
WO2004052906A1 (en)	2004-06-24
DK1572711T3 (da)	2009-07-13
AU2003292212B2 (en)	2009-10-01
TWI294882B (en)	2008-03-21
DE60327554D1 (de)	2009-06-18
HRP20050503A2 (en)	2006-12-31
ATE430755T1 (de)	2009-05-15

Legal Events

Date	Code	Title	Description
2015-02-27	LAPS	Decisions on the lapse of the protection rights	Effective date: 20131208

Publication	Publication Date	Title
IL168685A (en)	2010-11-30	Anhydrous crystalline azido cytosine hemisulfate derivative
ZA200410320B (en)	2005-08-31	Crystallization of sugars
PL377632A1 (pl)	2006-02-06	Przeciwwirusowe pochodne nukleozydów
GB2392653B (en)	2005-09-21	Subframe mount structure
GB0405884D0 (en)	2004-04-21	Modified nucleotides
GB0205751D0 (en)	2002-04-24	Improvements relating to memory devices
ZA200406858B (en)	2005-09-28	Modified fluorinated nucleoside analoques
IL175702A0 (en)	2006-09-05	Nanoscale crystalline silicon-powder
AU2003301589A8 (en)	2004-05-13	Purine nucleosides
AU2003297594A8 (en)	2004-06-23	Crystalline form
TW569899U (en)	2004-01-01	Improved wrench rack
IL163780A0 (en)	2005-12-18	Crystalline parecoxib sodium
AU2003296601A8 (en)	2004-06-30	Antiviral nucleoside derivatives
AU2003289995A1 (en)	2004-06-30	Anhydrous crystalline form of valacyclovir hydrochloride
AU2003290816A8 (en)	2004-06-03	Modified nucleosides as antiviral agents
NO20044302L (no)	2004-10-11	Krystallinsk parecoxibnatrium
GB2408723B (en)	2005-08-10	Subframe mount structure
GB0228533D0 (en)	2003-01-15	Crystalline form
AU2003298204A1 (en)	2004-07-09	Adenosine derivative in polymorph v form
TW502688U (en)	2002-09-11	Improved structure for wrench rack
TW545498U (en)	2003-08-01	Improved mount structure
TW561965U (en)	2003-11-11	Improved structure for hammer
TW538921U (en)	2003-06-21	Improved structure for rear view mirror
TW519944U (en)	2003-02-01	Improved structure for tool rack
GB0321309D0 (en)	2003-10-15	Crystalline therapeutic agent