PL377472A1 - Bezwodny krystaliczny hemisiarczan pochodnej azydocytozyny - Google Patents

Bezwodny krystaliczny hemisiarczan pochodnej azydocytozyny

Info

Publication number
PL377472A1
PL377472A1 PL377472A PL37747203A PL377472A1 PL 377472 A1 PL377472 A1 PL 377472A1 PL 377472 A PL377472 A PL 377472A PL 37747203 A PL37747203 A PL 37747203A PL 377472 A1 PL377472 A1 PL 377472A1
Authority
PL
Poland
Prior art keywords
anhydrous crystalline
azido
derivative
cytosine hemisulfate
hemisulfate derivative
Prior art date
Application number
PL377472A
Other languages
English (en)
Other versions
PL213734B1 (pl
Inventor
Terrence Joseph Connolly
Joseph Armstrong Martin
Anthony Prince
Keshab Sarma
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of PL377472A1 publication Critical patent/PL377472A1/pl
Publication of PL213734B1 publication Critical patent/PL213734B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
PL377472A 2002-12-09 2003-12-08 Hemisiarczan 1-[4(S)-azydo-2 (S), 3(R)-dihydroksy-4-(hydroksymetylo)-1 (R)-cyklopentylo] cytozyny, sposób wytwarzania tego hemisiarczanu w polimorficznej postaci C, zastosowanie tego hemisiarczanu i srodek farmaceutyczny PL213734B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43188502P 2002-12-09 2002-12-09

Publications (2)

Publication Number Publication Date
PL377472A1 true PL377472A1 (pl) 2006-02-06
PL213734B1 PL213734B1 (pl) 2013-04-30

Family

ID=32507815

Family Applications (1)

Application Number Title Priority Date Filing Date
PL377472A PL213734B1 (pl) 2002-12-09 2003-12-08 Hemisiarczan 1-[4(S)-azydo-2 (S), 3(R)-dihydroksy-4-(hydroksymetylo)-1 (R)-cyklopentylo] cytozyny, sposób wytwarzania tego hemisiarczanu w polimorficznej postaci C, zastosowanie tego hemisiarczanu i srodek farmaceutyczny

Country Status (32)

Country Link
US (1) US6864244B2 (pl)
EP (1) EP1572711B1 (pl)
JP (1) JP4563818B2 (pl)
KR (1) KR100675544B1 (pl)
CN (1) CN1314697C (pl)
AR (1) AR042312A1 (pl)
AT (1) ATE430755T1 (pl)
AU (1) AU2003292212B2 (pl)
BR (1) BR0317146A (pl)
CA (1) CA2506532C (pl)
CY (1) CY1109296T1 (pl)
DE (1) DE60327554D1 (pl)
DK (1) DK1572711T3 (pl)
ES (1) ES2324654T3 (pl)
GT (1) GT200300276A (pl)
HR (1) HRP20050503A2 (pl)
IL (1) IL168685A (pl)
JO (1) JO2542B1 (pl)
MX (1) MXPA05006044A (pl)
MY (1) MY130927A (pl)
NO (1) NO330454B1 (pl)
NZ (1) NZ540297A (pl)
PA (1) PA8590701A1 (pl)
PE (1) PE20040767A1 (pl)
PL (1) PL213734B1 (pl)
PT (1) PT1572711E (pl)
RU (1) RU2334756C2 (pl)
SI (1) SI1572711T1 (pl)
TW (1) TWI294882B (pl)
UY (1) UY28109A1 (pl)
WO (1) WO2004052906A1 (pl)
ZA (1) ZA200504472B (pl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6731100A (en) * 1999-09-02 2001-04-10 Shionogi & Co., Ltd. Integrase inhibitors containing aromatic heterocycle derivatives
CA2284459C (en) 1999-10-04 2012-12-11 Neokimia Inc. Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
US20050182252A1 (en) * 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
ES2327252T3 (es) * 2004-08-23 2009-10-27 F. Hoffmann-La Roche Ag 4'-azido nucleosidos antivirales.
HRP20110193T1 (hr) * 2006-10-10 2011-05-31 Medivir Ab Inhibitor hcv nukleozida
AU2007342367B2 (en) 2007-01-05 2012-12-06 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection
GB0709791D0 (en) * 2007-05-22 2007-06-27 Angeletti P Ist Richerche Bio Antiviral agents
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
AU2011305652B2 (en) 2010-09-22 2016-10-20 Janssen Biopharma, Inc. Azido nucleosides and nucleotide analogs
EP3623364A1 (en) 2014-02-13 2020-03-18 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN103965116B (zh) * 2014-05-06 2016-06-15 中国科学院苏州纳米技术与纳米仿生研究所 半5-氟胞嘧啶盐、其制备方法及应用
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
FI3265102T3 (fi) 2015-03-06 2025-10-31 Atea Pharmaceuticals Inc Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
CN115477679A (zh) 2017-02-01 2022-12-16 阿堤亚制药公司 用于治疗丙型肝炎病毒的核苷酸半硫酸盐
WO2019139919A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
CN112351799A (zh) 2018-04-10 2021-02-09 阿堤亚制药公司 具有硬化的hcv感染患者的治疗
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2022164941A1 (en) 2021-01-26 2022-08-04 Atea Pharmaceuticals, Inc. Advantageous morphic form of at-527 hemi-sulfate salt
AU2022291927A1 (en) 2021-06-17 2024-01-04 Atea Pharmaceuticals, Inc. Advantageous anti-hcv combination therapy
CN115536710B (zh) * 2022-10-18 2024-04-16 南京工业大学 一种高品质胞苷硫酸盐晶体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
PH27609A (en) * 1988-11-21 1993-08-31 Syntex Inc Antiviral agents
AU7623991A (en) * 1990-05-17 1991-11-21 Syntex (U.S.A.) Inc. Antiviral agents
SK284054B6 (sk) * 1996-10-16 2004-08-03 Icn Pharmaceuticals, Inc. Substituované triazolové nukleozidy, farmaceutický prostriedok s ich obsahom a ich použitie
US20030008841A1 (en) * 2000-08-30 2003-01-09 Rene Devos Anti-HCV nucleoside derivatives
MXPA03006514A (es) * 2001-01-22 2004-12-02 Merck & Co Inc Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico.
GB0114286D0 (en) * 2001-06-12 2001-08-01 Hoffmann La Roche Nucleoside Derivatives

Also Published As

Publication number Publication date
CA2506532A1 (en) 2004-06-24
JP4563818B2 (ja) 2010-10-13
NO20052732L (no) 2005-09-06
EP1572711B1 (en) 2009-05-06
AR042312A1 (es) 2005-06-15
MXPA05006044A (es) 2005-08-18
IL168685A (en) 2010-11-30
CN1723215A (zh) 2006-01-18
RU2005121927A (ru) 2006-01-27
DE60327554D1 (de) 2009-06-18
TW200502243A (en) 2005-01-16
CY1109296T1 (el) 2014-07-02
ATE430755T1 (de) 2009-05-15
PL213734B1 (pl) 2013-04-30
AU2003292212B2 (en) 2009-10-01
JO2542B1 (en) 2010-09-05
RU2334756C2 (ru) 2008-09-27
PT1572711E (pt) 2009-06-25
EP1572711A1 (en) 2005-09-14
KR100675544B1 (ko) 2007-01-30
CN1314697C (zh) 2007-05-09
ES2324654T3 (es) 2009-08-12
TWI294882B (en) 2008-03-21
UY28109A1 (es) 2004-06-30
HK1085483A1 (en) 2006-08-25
KR20050084217A (ko) 2005-08-26
NO330454B1 (no) 2011-04-18
PA8590701A1 (es) 2004-11-26
DK1572711T3 (da) 2009-07-13
NZ540297A (en) 2007-05-31
HRP20050503A2 (en) 2006-12-31
US20040162265A1 (en) 2004-08-19
PE20040767A1 (es) 2004-11-06
US6864244B2 (en) 2005-03-08
BR0317146A (pt) 2005-10-25
AU2003292212A1 (en) 2004-06-30
ZA200504472B (en) 2006-02-22
MY130927A (en) 2007-07-31
WO2004052906A1 (en) 2004-06-24
NO20052732D0 (no) 2005-06-07
SI1572711T1 (sl) 2009-08-31
GT200300276A (es) 2004-09-02
CA2506532C (en) 2011-09-20
JP2006510649A (ja) 2006-03-30

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Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20131208